The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1LIFE HEALTHCARE INC COM 68269G107 5,676 171,689 SH   DFND   0 171,689 0
ABBVIE INC COM 00287Y109 104,397 926,823 SH   DFND   0 926,823 0
ACADIA PHARMACEUTICALS INC COM 004225108 14,685 602,100 SH Call DFND   0 602,100 0
ACADIA PHARMACEUTICALS INC COM 004225108 68,470 2,807,310 SH   DFND   0 2,807,310 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 15,455 3,627,900 SH   DFND   0 3,627,900 0
AERIE PHARMACEUTICALS INC COM 00771V108 34,945 2,182,684 SH   DFND   0 2,182,684 0
AERIE PHARMACEUTICALS INC NOTE 1.500%10/0 00771VAB4 48,140 48,150,000 PRN   DFND   0 48,150,000 0
ALEXION PHARMACEUTICALS INC COM 015351109 165,604 901,441 SH   DFND   0 901,441 0
ALLENA PHARMACEUTICALS COM 018119107 370 284,285 SH   DFND   0 284,285 0
ALLOGENE THERAPEUTICS INC COM 019770106 15,825 606,800 SH   DFND   0 606,800 0
ARCUS BIOSCIENCES INC COM 03969F109 96,062 3,498,260 SH   DFND   0 3,498,260 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 23,565 345,523 SH   DFND   0 345,523 0
ASTRAZENECA PLC SPONSORED ADR 046353108 12,495 208,600 SH   DFND   0 208,600 0
ATHIRA PHARMA INC COM 04746L104 6,945 678,247 SH   DFND   0 678,247 0
AVANTOR INC COM 05352A100 73,849 2,079,657 SH   DFND   0 2,079,657 0
BAXTER INTL INC COM 071813109 36,923 458,667 SH   DFND   0 458,667 0
BCLS ACQUISITION CORP COM CL A G0904B105 4,887 464,103 SH   DFND   0 464,103 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 11,208 708,927 SH   DFND   0 708,927 0
BIOGEN INC COM 09062X103 45,802 132,272 SH   DFND   0 132,272 0
BIOMARIN PHARMACEUTICAL INC NOTE 0.599% 8/0 09061GAH4 47,834 45,910,000 PRN   DFND   0 45,910,000 0
BUTTERFLY NETWORK INC COM CL A 124155102 26,474 1,828,311 SH   DFND   0 1,828,311 0
CANO HEALTH INC COM CL A 13781Y103 25,341 2,094,279 SH   DFND   0 2,094,279 0
CENTENE CORP DEL COM 15135B101 16,409 225,000 SH Call DFND   0 225,000 0
CENTENE CORP DEL COM 15135B101 76,246 1,045,473 SH   DFND   0 1,045,473 0
CERTARA INC COM 15687V109 4,052 143,028 SH   DFND   0 143,028 0
CONSTELLATION PHARMCETICLS I COM 210373106 15,875 469,664 SH   DFND   0 469,664 0
CYTOKINETICS INC COM NEW 23282W605 5,316 268,600 SH Call DFND   0 268,600 0
CYTOKINETICS INC COM NEW 23282W605 33,386 1,687,012 SH   DFND   0 1,687,012 0
DANAHER CORPORATION COM 235851102 47,148 175,690 SH   DFND   0 175,690 0
DOXIMITY INC CL A 26622P107 1,746 30,000 SH   DFND   0 30,000 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 29,459 2,990,770 SH   DFND   0 2,990,770 0
EDWARDS LIFESCIENCES CORP COM 28176E108 53,132 513,005 SH   DFND   0 513,005 0
FLUIDIGM CORP DEL COM 34385P108 6,040 980,505 SH   DFND   0 980,505 0
FS DEVELOPMENT CORP II COM CL A 30318F100 10,000 1,000,000 SH   DFND   0 1,000,000 0
GALAPAGOS NV SPON ADR B44170106 10,406 177,934 SH   DFND   0 177,934 0
GILEAD SCIENCES INC COM 375558103 45,902 666,601 SH   DFND   0 666,601 0
GUARDANT HEALTH INC COM 40131M109 46,463 374,131 SH   DFND   0 374,131 0
HCA HEALTHCARE INC COM 40412C101 80,733 390,507 SH   DFND   0 390,507 0
HERON THERAPEUTICS INC COM 427746102 34,129 2,199,057 SH   DFND   0 2,199,057 0
HORIZON THERAPEUTICS PUB L SHS G46188101 148,639 1,587,348 SH   DFND   0 1,587,348 0
HUMANA INC COM 444859102 63,046 142,406 SH   DFND   0 142,406 0
ICON PLC SHS G4705A100 29,813 144,227 SH   DFND   0 144,227 0
ICU MED INC COM 44930G107 52,625 255,708 SH   DFND   0 255,708 0
INNOVAGE HLDG CORP COM 45784A104 9,157 429,699 SH   DFND   0 429,699 0
INTELLIA THERAPEUTICS INC COM 45826J105 13,762 85,000 SH Call DFND   0 85,000 0
INTELLIA THERAPEUTICS INC COM 45826J105 28,856 178,222 SH   DFND   0 178,222 0
IONIS PHARMACEUTICALS INC NOTE 0.125%12/1 462222AB6 21,372 23,000,000 PRN   DFND   0 23,000,000 0
IQVIA HLDGS INC COM 46266C105 86,730 357,916 SH   DFND   0 357,916 0
JIYA ACQUISITION CORP COM CL A 47760M102 4,613 464,103 SH   DFND   0 464,103 0
JOUNCE THERAPEUTICS INC COM 481116101 22,187 3,262,833 SH   DFND   0 3,262,833 0
KARUNA THERAPEUTICS INC COM 48576A100 22,044 193,386 SH   DFND   0 193,386 0
KINNATE BIOPHARMA INC COM 49705R105 6,153 264,293 SH   DFND   0 264,293 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 17,555 63,640 SH   DFND   0 63,640 0
LIFESTANCE HEALTH GROUP INC COM 53228F101 12,359 443,595 SH   DFND   0 443,595 0
LILLY ELI & CO COM 532457108 120,602 525,455 SH   DFND   0 525,455 0
MCKESSON CORP COM 58155Q103 68,126 356,231 SH   DFND   0 356,231 0
MIRATI THERAPEUTICS INC COM 60468T105 46,367 287,046 SH   DFND   0 287,046 0
MODERNA INC COM 60770K107 33,132 141,000 SH Put DFND   0 141,000 0
MOLINA HEALTHCARE INC COM 60855R100 17,736 70,088 SH   DFND   0 70,088 0
MYOVANT SCIENCES LTD COM G637AM102 43,541 1,912,188 SH   DFND   0 1,912,188 0
MYRIAD GENETICS INC COM 62855J104 94,466 3,089,152 SH   DFND   0 3,089,152 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 108,610 1,116,004 SH   DFND   0 1,116,004 0
NEVRO CORP COM 64157F103 69,407 418,645 SH   DFND   0 418,645 0
NEVRO CORP NOTE 2.750% 4/0 64157FAC7 3,480 2,000,000 PRN   DFND   0 2,000,000 0
NOVAVAX INC COM NEW 670002401 31,656 149,104 SH   DFND   0 149,104 0
NOVAVAX INC NOTE 3.750% 2/0 670002AB0 7,612 4,250,000 PRN   DFND   0 4,250,000 0
OAK STR HEALTH INC COM 67181A107 3,939 67,250 SH   DFND   0 67,250 0
OUTSET MED INC COM 690145107 148,276 2,966,712 SH   DFND   0 2,966,712 0
PENUMBRA INC COM 70975L107 36,658 133,759 SH   DFND   0 133,759 0
PMV PHARMACEUTICALS INC COM 69353Y103 9,849 288,334 SH   DFND   0 288,334 0
PRAXIS PRECISION MEDICINES I COM 74006W108 8,324 455,374 SH   DFND   0 455,374 0
PULMONX CORP COM 745848101 6,026 136,576 SH   DFND   0 136,576 0
SEAGEN INC COM 81181C104 76,254 482,985 SH   DFND   0 482,985 0
SHATTUCK LABS INC COM 82024L103 9,474 326,813 SH   DFND   0 326,813 0
SILVERBACK THERAPEUTICS INC COM 82835W108 5,815 188,243 SH   DFND   0 188,243 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 36,828 2,144,881 SH   DFND   0 2,144,881 0
TENET HEALTHCARE CORP COM NEW 88033G407 44,687 667,073 SH   DFND   0 667,073 0
THERMO FISHER SCIENTIFIC INC COM 883556102 17,570 34,829 SH   DFND   0 34,829 0
UNITEDHEALTH GROUP INC COM 91324P102 58,182 145,295 SH   DFND   0 145,295 0
UNIVERSAL HLTH SVCS INC CL B 913903100 71,311 487,000 SH   DFND   0 487,000 0
VECTIVBIO HLDG AG ORD SHS H9060V101 7,125 611,074 SH   DFND   0 611,074 0
WATERS CORP COM 941848103 40,655 117,634 SH   DFND   0 117,634 0
WEREWOLF THERAPEUTICS INC COM 95075A107 6,976 400,000 SH   DFND   0 400,000 0
ZAI LAB LTD ADR 98887Q104 17,588 99,375 SH   DFND   0 99,375 0