The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
APPLE INC COM 037833100 32,552 237,918 SH   SOLE   0 0 237,918
ALPHABET INC-CL C COM 02079K107 170,767 68,197 SH   SOLE   17,024 0 51,173
AMAZON.COM INC COM 023135106 94,175 27,398 SH   SOLE   0 0 27,398
FACEBOOK INC-CLASS A COM 30303M102 364,357 1,048,872 SH   SOLE   109,361 0 939,511
TESLA INC COM 88160R101 1,398,601 2,047,283 SH   SOLE   1,900,460 0 146,823
ALIBABA GROUP HOLDING-SP ADR COM 01609W102 146,904 647,666 SH   SOLE   0 0 647,666
NVIDIA CORP COM 67066G104 74,292 92,590 SH   SOLE   0 0 92,590
PAYPAL HOLDINGS INC COM 70450Y103 604,283 2,078,644 SH   SOLE   395,406 0 1,683,238
WALT DISNEY CO/THE COM 254687106 145,298 825,556 SH   SOLE   0 0 825,556
ADOBE INC COM 00724F101 35,605 61,177 SH   SOLE   0 0 61,177
EXXON MOBIL CORP COM 30231G102 10,937 171,404 SH   SOLE   171,404 0 0
NETFLIX INC COM 64110L106 148,722 282,737 SH   SOLE   0 0 282,737
CHEVRON CORP COM 166764100 9,681 91,131 SH   SOLE   91,131 0 0
SHOPIFY INC - CLASS A COM 82509L107 1,010,391 692,044 SH   SOLE   287,761 0 404,283
BHP GROUP PLC-ADR COM 05545E209 13,027 216,940 SH   SOLE   216,940 0 0
UNITED PARCEL SERVICE-CL B COM 911312106 8,845 42,668 SH   SOLE   0 0 42,668
SEA LTD-ADR COM 81141R100 792,081 2,900,335 SH   SOLE   1,180,137 0 1,720,198
ROYAL DUTCH SHELL-SPON ADR-A COM 780259206 5,923 144,016 SH   SOLE   144,016 0 0
HONEYWELL INTERNATIONAL INC COM 438516106 4,322 19,703 SH   SOLE   0 0 19,703
LINDE PLC COM G5494J103 4,908 17,003 SH   SOLE   17,003 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 12,894 194,780 SH   SOLE   0 0 194,780
INTUIT INC COM 461202103 119,778 245,170 SH   SOLE   84,639 0 160,531
UNION PACIFIC CORP COM 907818108 1,472 6,796 SH   SOLE   6,796 0 0
RIO TINTO PLC-SPON ADR COM 767204100 6,339 75,684 SH   SOLE   75,684 0 0
HDFC BANK LTD-ADR COM 40415F101 24,774 343,076 SH   SOLE   0 0 343,076
BOEING CO/THE COM 097023105 9,973 41,321 SH   SOLE   0 0 41,321
SCHWAB (CHARLES) CORP COM 808513105 51,840 717,806 SH   SOLE   0 0 717,806
SQUARE INC - A COM 852234103 1,341,553 5,500,423 SH   SOLE   3,121,390 0 2,379,033
SNAP INC - A COM 83304A106 244,304 3,584,793 SH   SOLE   0 0 3,584,793
ZOOM VIDEO COMMUNICATIONS-A COM 98980L101 678,100 1,756,737 SH   SOLE   1,225,359 0 531,378
TOTALENERGIES SE -SPON ADR COM 89151E109 9,089 197,116 SH   SOLE   197,116 0 0
DEERE & CO COM 244199105 56,522 160,118 SH   SOLE   86,284 0 73,834
CATERPILLAR INC COM 149123101 44,654 204,423 SH   SOLE   147,329 0 57,094
PINDUODUO INC-ADR COM 722304102 288,825 2,263,515 SH   SOLE   286,238 0 1,977,277
VALE SA-SP ADR COM 91912E105 9,280 406,663 SH   SOLE   406,663 0 0
JD.COM INC-ADR COM 47215P106 395,533 4,949,733 SH   SOLE   531,346 0 4,418,387
LOCKHEED MARTIN CORP COM 539830109 17,096 45,228 SH   SOLE   0 0 45,228
MERCADOLIBRE INC COM 58733R102 383,339 249,245 SH   SOLE   61,770 0 187,475
BP PLC-SPONS ADR COM 055622104 4,378 162,753 SH   SOLE   162,753 0 0
CONOCOPHILLIPS COM 20825C104 4,815 77,735 SH   SOLE   77,735 0 0
PETROLEO BRASILEIRO-SPON ADR COM 71654V408 645 51,825 SH   SOLE   51,825 0 0
CHINA PETROLEUM & CHEM-ADR COM 16941R108 720 14,082 SH   SOLE   14,082 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 199,820 1,692,386 SH   SOLE   620,066 0 1,072,320
TWILIO INC - A COM 90138F102 948,956 2,409,154 SH   SOLE   1,189,397 0 1,219,757
AIR PRODUCTS & CHEMICALS INC COM 009158106 3,787 13,382 SH   SOLE   13,382 0 0
REGENERON PHARMACEUTICALS COM 75886F107 87,100 157,513 SH   SOLE   104,236 0 53,277
ACTIVISION BLIZZARD INC COM 00507V109 66,530 700,320 SH   SOLE   0 0 700,320
DOCUSIGN INC COM 256163106 443,988 1,596,927 SH   SOLE   701,717 0 895,210
BAIDU INC - SPON ADR COM 056752108 105,357 515,447 SH   SOLE   313,523 0 201,924
WORKDAY INC-CLASS A COM 98138H101 97,147 408,921 SH   SOLE   0 0 408,921
NXP SEMICONDUCTORS NV COM N6596X109 40,155 195,544 SH   SOLE   103,205 0 92,339
TWITTER INC COM 90184L102 499,148 7,268,794 SH   SOLE   3,944,903 0 3,323,891
COINBASE GLOBAL INC -CLASS A COM 19260Q107 859,736 3,425,242 SH   SOLE   1,914,025 0 1,511,217
ROKU INC COM 77543R102 1,014,912 2,213,307 SH   SOLE   1,694,585 0 518,722
FREEPORT-MCMORAN INC COM 35671D857 11,235 299,193 SH   SOLE   299,193 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 21,670 108,081 SH   SOLE   0 0 108,081
VEEVA SYSTEMS INC-CLASS A COM 922475108 19,063 63,640 SH   SOLE   0 0 63,640
SOUTHERN COPPER CORP COM 84265V105 1,778 27,780 SH   SOLE   27,780 0 0
NEWMONT CORP COM 651639106 4,614 72,343 SH   SOLE   72,343 0 0
L3HARRIS TECHNOLOGIES INC COM 502431109 20,044 94,600 SH   SOLE   0 0 94,600
ROBLOX CORP -CLASS A COM 771049103 74,781 827,864 SH   SOLE   0 0 827,864
SYNOPSYS INC COM 871607107 15,116 55,345 SH   SOLE   0 0 55,345
APTIV PLC COM G6095L109 50,899 333,764 SH   SOLE   229,086 0 104,678
PALANTIR TECHNOLOGIES INC-A COM 69608A108 254,800 9,777,441 SH   SOLE   9,677,852 0 99,589
SPOTIFY TECHNOLOGY SA COM L8681T102 576,537 2,095,431 SH   SOLE   1,416,626 0 678,805
EOG RESOURCES INC COM 26875P101 2,435 28,664 SH   SOLE   28,664 0 0
BANCO BRADESCO-ADR COM 059460303 685 133,450 SH   SOLE   0 0 133,450
SCHLUMBERGER LTD COM 806857108 2,369 72,366 SH   SOLE   72,366 0 0
CANADIAN NATURAL RESOURCES COM 136385101 2,736 74,761 SH   SOLE   74,761 0 0
PINTEREST INC- CLASS A COM 72352L106 171,411 2,180,799 SH   SOLE   0 0 2,180,799
OKTA INC COM 679295105 101,595 418,085 SH   SOLE   0 0 418,085
BARRICK GOLD CORP COM 067901108 5,067 243,351 SH   SOLE   243,351 0 0
CLOUDFLARE INC - CLASS A COM 18915M107 71,245 677,235 SH   SOLE   0 0 677,235
PIONEER NATURAL RESOURCES CO COM 723787107 1,636 9,915 SH   SOLE   9,915 0 0
MARATHON PETROLEUM CORP COM 56585A102 1,912 31,290 SH   SOLE   31,290 0 0
PELOTON INTERACTIVE INC-A COM 70614W100 246,922 1,982,510 SH   SOLE   0 0 1,982,510
NUTRIEN LTD COM 67077M108 10,997 179,927 SH   SOLE   179,927 0 0
ARCHER-DANIELS-MIDLAND CO COM 039483102 3,665 60,755 SH   SOLE   60,755 0 0
ANSYS INC COM 03662Q105 27,842 92,758 SH   SOLE   46,086 0 46,672
UIPATH INC - CLASS A COM 90364P105 411,517 6,024,694 SH   SOLE   3,277,064 0 2,747,630
PHILLIPS 66 COM 718546104 1,657 19,004 SH   SOLE   19,004 0 0
GARMIN LTD COM H2906T109 12,729 89,643 SH   SOLE   0 0 89,643
BILIBILI INC-SPONSORED ADR COM 090040106 64,985 533,360 SH   SOLE   0 0 533,360
CORTEVA INC COM 22052L104 16,775 386,532 SH   SOLE   142,888 0 243,644
UNITY SOFTWARE INC COM 91332U101 546,428 4,990,206 SH   SOLE   3,343,304 0 1,646,902
NUCOR CORP COM 670346105 4,113 42,888 SH   SOLE   42,888 0 0
WILLIAMS COS INC COM 969457100 1,650 61,664 SH   SOLE   61,664 0 0
SUNCOR ENERGY INC COM 867224107 4,375 178,992 SH   SOLE   178,992 0 0
ZILLOW GROUP INC - C COM 98954M200 678,335 5,600,501 SH   SOLE   2,988,311 0 2,612,190
VALERO ENERGY CORP COM 91913Y100 1,343 17,020 SH   SOLE   17,020 0 0
WEYERHAEUSER CO COM 962166104 3,989 118,207 SH   SOLE   118,207 0 0
ALBEMARLE CORP COM 012653101 1,589 9,415 SH   SOLE   9,415 0 0
MAGNA INTERNATIONAL INC COM 559222401 14,888 160,415 SH   SOLE   0 0 160,415
OCCIDENTAL PETROLEUM CORP COM 674599105 1,865 58,118 SH   SOLE   58,118 0 0
TELADOC HEALTH INC COM 87918A105 946,335 5,690,529 SH   SOLE   4,399,178 0 1,291,351
MONGODB INC COM 60937P106 70,492 196,356 SH   SOLE   0 0 196,356
SPLUNK INC COM 848637104 35,188 244,363 SH   SOLE   0 0 244,363
KE HOLDINGS INC-ADR COM 482497104 220,447 4,611,868 SH   SOLE   958,931 0 3,652,937
ETSY INC COM 29786A106 111,997 539,484 SH   SOLE   0 0 539,484
XYLEM INC COM 98419M100 1,692 14,127 SH   SOLE   14,127 0 0
HESS CORP COM 42809H107 2,263 25,603 SH   SOLE   25,603 0 0
INTERNATIONAL PAPER CO COM 460146103 5,947 101,018 SH   SOLE   101,018 0 0
TRIMBLE INC COM 896239100 262,269 3,237,885 SH   SOLE   1,920,536 0 1,317,349
BAKER HUGHES CO COM 05722G100 3,332 143,330 SH   SOLE   143,330 0 0
TELEDYNE TECHNOLOGIES INC COM 879360105 0 9,073 SH   SOLE   0 0 9,073
TERADYNE INC COM 880770102 142,209 1,077,343 SH   SOLE   941,601 0 135,742
DRAFTKINGS INC - CL A COM 26142R104 371,146 7,100,563 SH   SOLE   3,372,599 0 3,727,964
DOMINO'S PIZZA INC COM 25754A201 21,674 47,066 SH   SOLE   0 0 47,066
BILL.COM HOLDINGS INC COM 090043100 35,771 198,674 SH   SOLE   0 0 198,674
10X GENOMICS INC-CLASS A COM 88025U109 299,376 1,541,588 SH   SOLE   1,447,243 0 94,345
EXACT SCIENCES CORP COM 30063P105 401,677 3,244,562 SH   SOLE   3,101,265 0 143,297
DEVON ENERGY CORP COM 25179M103 747 24,818 SH   SOLE   24,818 0 0
STONECO LTD-A COM G85158106 59,582 887,698 SH   SOLE   0 0 887,698
HALLIBURTON CO COM 406216101 1,644 69,503 SH   SOLE   69,503 0 0
INCYTE CORP COM 45337C102 15,762 189,909 SH   SOLE   0 0 189,909
HEICO CORP COM 422806109 3,920 28,120 SH   SOLE   0 0 28,120
AGNICO EAGLE MINES LTD COM 008474108 2,873 47,213 SH   SOLE   47,213 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104 37,743 136,974 SH   SOLE   136,974 0 0
PACKAGING CORP OF AMERICA COM 695156109 2,061 15,872 SH   SOLE   15,872 0 0
STEEL DYNAMICS INC COM 858119100 4,706 79,004 SH   SOLE   79,004 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 507,307 3,063,449 SH   SOLE   2,255,551 0 807,898
MOSAIC CO/THE COM 61945C103 1,762 54,435 SH   SOLE   54,435 0 0
TECK RESOURCES LTD-CLS B COM 878742204 2,982 129,330 SH   SOLE   129,330 0 0
DARLING INGREDIENTS INC COM 237266101 1,257 18,624 SH   SOLE   18,624 0 0
BUNGE LTD COM G16962105 1,927 24,657 SH   SOLE   24,657 0 0
CRISPR THERAPEUTICS AG COM H17182108 548,120 3,383,456 SH   SOLE   2,889,584 0 493,872
MONDAY.COM LTD COM M7S64H106 47,316 225,313 SH   SOLE   0 0 225,313
CF INDUSTRIES HOLDINGS INC COM 125269100 2,335 44,347 SH   SOLE   44,347 0 0
FATE THERAPEUTICS INC COM 31189P102 87,313 1,025,519 SH   SOLE   495,094 0 530,425
OPENDOOR TECHNOLOGIES INC COM 683712103 254,196 14,264,639 SH   SOLE   2,448,106 0 11,816,533
ANGLOGOLD ASHANTI-SPON ADR COM 035128206 2,281 120,686 SH   SOLE   120,686 0 0
TUSIMPLE HOLDINGS INC - A COM 90089L108 145,652 2,015,938 SH   SOLE   1,823,276 0 192,662
PACIFIC BIOSCIENCES OF CALIF COM 69404D108 284,273 8,122,072 SH   SOLE   6,935,478 0 1,186,594
BEAM THERAPEUTICS INC COM 07373V105 32,972 253,631 SH   SOLE   0 0 253,631
CABOT OIL & GAS CORP COM 127097103 2,651 151,512 SH   SOLE   151,512 0 0
SIGNIFY HEALTH INC -CLASS A COM 82671G100 12,713 493,723 SH   SOLE   0 0 493,723
INVITAE CORP COM 46185L103 498,516 14,863,341 SH   SOLE   12,863,022 0 2,000,319
TWIST BIOSCIENCE CORP COM 90184D100 325,371 2,524,602 SH   SOLE   2,219,008 0 305,594
ELBIT SYSTEMS LTD COM M3760D101 11,099 86,486 SH   SOLE   0 0 86,486
PURE STORAGE INC - CLASS A COM 74624M102 124,684 6,477,114 SH   SOLE   5,194,878 0 1,282,236
PERFORMANCE FOOD GROUP CO COM 71377A103 1,343 31,978 SH   SOLE   31,978 0 0
IRIDIUM COMMUNICATIONS INC COM 46269C102 178,553 4,463,818 SH   SOLE   3,832,465 0 631,353
HUNTSMAN CORP COM 447011107 2,022 77,184 SH   SOLE   77,184 0 0
IONIS PHARMACEUTICALS INC COM 462222100 20,381 508,374 SH   SOLE   0 0 508,374
ADAPTIVE BIOTECHNOLOGIES COM 00650F109 71,289 1,782,219 SH   SOLE   1,258,460 0 523,759
RECURSION PHARMACEUTICALS-A COM 75629V104 8,613 235,846 SH   SOLE   0 0 235,846
SHOALS TECHNOLOGIES GROUP -A COM 82489W107 1,168 34,360 SH   SOLE   34,360 0 0
SKILLZ INC COM 83067L109 133,800 6,143,241 SH   SOLE   6,081,082 0 62,159
SCHRODINGER INC COM 80810D103 13,963 184,455 SH   SOLE   0 0 184,455
NOMAD FOODS LTD COM G6564A105 1,653 61,106 SH   SOLE   61,106 0 0
CHAMPIONX CORP COM 15872M104 1,294 50,345 SH   SOLE   50,345 0 0
CAREDX INC COM 14167L103 104,663 1,169,416 SH   SOLE   621,427 0 547,989
SPIRIT AEROSYSTEMS HOLD-CL A COM 848574109 8,864 187,131 SH   SOLE   0 0 187,131
B2GOLD CORP COM 11777Q209 1,662 391,996 SH   SOLE   391,996 0 0
UNIVAR SOLUTIONS INC COM 91336L107 2,770 114,209 SH   SOLE   114,209 0 0
1LIFE HEALTHCARE INC COM 68269G107 10,567 335,678 SH   SOLE   0 0 335,678
EDITAS MEDICINE INC COM 28106W103 285,684 4,869,696 SH   SOLE   4,150,661 0 719,035
SSR MINING INC COM 784730103 2,401 153,301 SH   SOLE   153,301 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 198,527 7,724,788 SH   SOLE   6,731,345 0 993,443
PAGERDUTY INC COM 69553P100 337,651 8,027,844 SH   SOLE   4,539,284 0 3,488,560
3D SYSTEMS CORP COM 88554D205 9,665 241,020 SH   SOLE   0 0 241,020
VERACYTE INC COM 92337F107 126,449 3,162,812 SH   SOLE   2,650,854 0 511,958
ACCOLADE INC COM 00437E102 17,386 428,232 SH   SOLE   0 0 428,232
BERKELEY LIGHTS INC COM 084310101 5,880 134,345 SH   SOLE   0 0 134,345
ALAMOS GOLD INC-CLASS A COM 011532108 3,506 455,323 SH   SOLE   455,323 0 0
2U INC COM 90214J101 202,420 4,889,380 SH   SOLE   3,397,934 0 1,491,446
TECHNIPFMC PLC COM G87110105 1,453 156,044 SH   SOLE   156,044 0 0
KRATOS DEFENSE & SECURITY COM 50077B207 72,062 2,505,636 SH   SOLE   0 0 2,505,636
DICERNA PHARMACEUTICALS INC COM 253031108 16,875 452,167 SH   SOLE   0 0 452,167
HELMERICH & PAYNE COM 423452101 940 28,205 SH   SOLE   28,205 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 18,263 320,397 SH   SOLE   310,050 0 10,347
LENDINGCLUB CORP COM 52603A208 77,878 4,581,060 SH   SOLE   2,812,360 0 1,768,700
CACTUS INC - A COM 127203107 431 22,672 SH   SOLE   22,672 0 0
BURNING ROCK BIOTECH LTD-ADR COM 12233L107 21,718 761,503 SH   SOLE   0 0 761,503
AEROVIRONMENT INC COM 008073108 39,697 403,019 SH   SOLE   279,965 0 123,054
PROTO LABS INC COM 743713109 189,692 2,086,823 SH   SOLE   1,920,319 0 166,504
PROTERRA INC COM 74374T109 964 56,069 SH   SOLE   56,069 0 0
RAVEN INDUSTRIES INC COM 754212108 13,593 237,026 SH   SOLE   0 0 237,026
SEER INC COM 81578P106 4,451 135,796 SH   SOLE   0 0 135,796
ONE - CLASS A COM 57064N102 14,468 1,452,176 SH   SOLE   0 0 1,452,176
NIU TECHNOLOGIES-SPONS ADR COM 65481N100 62,463 1,903,794 SH   SOLE   1,082,294 0 821,500
CASTLE BIOSCIENCES INC COM 14843C105 28,403 445,112 SH   SOLE   445,112 0 0
LIBERTY OILFIELD SERVICES -A COM 53115L104 1,138 79,860 SH   SOLE   79,860 0 0
TPI COMPOSITES INC COM 87266J104 1,332 28,338 SH   SOLE   28,338 0 0
STRATASYS LTD COM M85548101 121,166 4,678,235 SH   SOLE   4,076,406 0 601,829
CODEXIS INC COM 192005106 20,201 978,252 SH   SOLE   0 0 978,252
ARCTURUS THERAPEUTICS HOLDIN COM 03969T109 41,185 1,214,901 SH   SOLE   935,584 0 279,317
QUANTUM-SI INC COM 74765K105 16,012 1,283,001 SH   SOLE   0 0 1,283,001
OCEANEERING INTL INC COM 675232102 1,136 71,506 SH   SOLE   71,506 0 0
MATERIALISE NV-ADR COM 57667T100 63,509 2,640,699 SH   SOLE   2,602,652 0 38,047
CERUS CORP COM 157085101 77,723 13,151,108 SH   SOLE   10,889,301 0 2,261,807
PERSONALIS INC COM 71535D106 26,818 1,072,717 SH   SOLE   0 0 1,072,717
908 DEVICES INC COM 65443P102 9,183 241,013 SH   SOLE   0 0 241,013
REINVENT TECHNOLOGY-CLASS A COM G7483N129 10,956 1,097,793 SH   SOLE   0 0 1,097,793
SERES THERAPEUTICS INC COM 81750R102 118,856 5,280,154 SH   SOLE   4,263,881 0 1,016,273
CELLECTIS - ADR COM 15117K103 11,976 786,883 SH   SOLE   0 0 786,883
ATLAS CREST INVESTMENT COR-A COM 049284102 3,817 383,234 SH   SOLE   0 0 383,234
COMPUGEN LTD COM M25722105 59,090 7,162,406 SH   SOLE   5,851,942 0 1,310,464
BLADE AIR MOBILITY INC COM 092667104 17,528 1,652,020 SH   SOLE   0 0 1,652,020
JAWS SPITFIRE ACQUISITION-A COM G50740102 4,588 458,777 SH   SOLE   0 0 458,777
EXONE CO/THE COM 302104104 31,732 1,475,897 SH   SOLE   1,457,036 0 18,861
AQUABOUNTY TECHNOLOGIES COM 03842K200 1,155 207,765 SH   SOLE   0 0 207,765
OIL STATES INTERNATIONAL INC COM 678026105 1,150 143,519 SH   SOLE   143,519 0 0
CALYXT INC COM 13173L107 10,007 2,539,936 SH   SOLE   0 0 2,539,936
PLURISTEM THERAPEUTICS INC COM 72940R300 473 120,729 SH   SOLE   0 0 120,729
ORGANOVO HOLDINGS INC COM 68620A203 4,379 478,570 SH   SOLE   371,410 0 107,160