Filed by Cohen & Steers MLP Income and Energy Opportunity Fund, Inc.

pursuant to Rule 425 of the Securities Act of 1933, as amended,

and deemed filed pursuant to Rule 14a-6 under

the Securities and Exchange Act of 1934, as amended

Subject Company: Cohen & Steers MLP Income and Energy Opportunity Fund, Inc.

Commission File No. 333-185483

Your Response is Urgently Needed.

Dear Valued Cohen & Steers MLP Income and Energy Opportunity Fund, Inc. Stockholder:

As an important stockholder in Cohen & Steers MLP Income and Energy Opportunity Fund, Inc. (the “Fund”), I am writing today to personally ask for your help with the Fund’s stockholder proxy that has been underway for the last few months. The Special Meeting of Stockholders for the Fund has been adjourned to permit stockholders additional time to vote regarding the proposal to approve the liquidation and dissolution of the Fund. The Board of Directors has approved the proposed liquidation and dissolution of the Fund and recommends that stockholders approve the proposal.

You are an important stockholder of the Fund and your vote is critical. The next stockholder meeting is scheduled for Wednesday, June 30, 2021.

Voting now will allow us to complete the business of the Special Meeting of Stockholders without delay.

If you need assistance voting your shares, please call Cohen & Steers’ proxy solicitor, Broadridge, toll-free at

1-855-200-8122.

The Fund offers three easy methods for you to vote:

On behalf of your Board of Directors, thank you for your cooperation and partnership.

Sincerely,

Adam M. Derechin President of the Funds