The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
4D MOLECULAR THERAPEUTICS IN COM 35104E100 6,507 150,000 SH   DFND 1 150,000 0 0
ACCELERON PHARMA INC COM 00434H108 29,766 219,500 SH   DFND 1 219,500 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 13,240 800,000 SH   DFND 1 800,000 0 0
ACUTUS MED INC COM 005111109 58,050 4,341,799 SH   DFND 1 4,341,799 0 0
ADAPTHEALTH CORP COM CL A 00653Q102 83,735 2,277,871 SH   DFND 1 2,277,871 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 23,708 2,404,439 SH   DFND 1 2,404,439 0 0
AERIE PHARMACEUTICALS INC NOTE 1.500%10/0 00771VAB4 154,446 149,600,000 PRN   DFND 1 149,600,000 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 8,832 494,216 SH   DFND 1 494,216 0 0
ALECTOR INC COM 014442107 21,252 1,055,192 SH   DFND 1 1,055,192 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 88,573 579,248 SH   DFND 1 579,248 0 0
ALPHATEC HLDGS INC COM NEW 02081G201 50,558 3,201,916 SH   DFND 1 3,201,916 0 0
AMERICAN WELL CORP CL A 03044L105 17,216 991,115 SH   DFND 1 991,115 0 0
AMICUS THERAPEUTICS INC COM 03152W109 26,661 2,698,497 SH   DFND 1 2,698,497 0 0
ANNEXON INC COM 03589W102 16,256 583,913 SH   DFND 1 583,913 0 0
APELLIS PHARMACEUTICALS INC NOTE 3.500% 9/1 03753UAB2 30,574 21,825,000 PRN   DFND 1 21,825,000 0 0
APRIA INC COM 03836A101 33,516 1,200,000 SH   DFND 1 1,200,000 0 0
ARDELYX INC COM 039697107 16,957 2,561,554 SH   DFND 1 2,561,554 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 12,279 2,142,857 SH   DFND 1 2,142,857 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 9,901 453,973 SH   DFND 1 453,973 0 0
BENEFITFOCUS INC NOTE 1.250%12/1 08180DAB2 5,936 6,500,000 PRN   DFND 1 6,500,000 0 0
BIOATLA INC COM 09077B104 10,444 205,422 SH   DFND 1 205,422 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 26,497 2,605,380 SH   DFND 1 2,605,380 0 0
BIODELIVERY SCIENCES INTL IN COM 09060J106 37,262 9,530,000 SH   DFND 1 9,530,000 0 0
BIOGEN INC COM 09062X103 86,723 310,000 SH   DFND 1 310,000 0 0
BIOVENTUS INC COM CL A 09075A108 14,623 957,000 SH   DFND 1 957,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 25,415 1,047,599 SH   DFND 1 1,047,599 0 0
BLUEBIRD BIO INC COM 09609G100 14,481 480,300 SH   DFND 1 480,300 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 20,321 209,000 SH   DFND 1 209,000 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104 11,519 350,000 SH   DFND 1 350,000 0 0
BOSTON SCIENTIFIC CORP COM 101137107 110,423 2,857,000 SH   DFND 1 2,857,000 0 0
BRIDGEBIO PHARMA INC NOTE 2.500% 3/1 10806XAB8 131,952 80,000,000 PRN   DFND 1 80,000,000 0 0
BROOKDALE SR LIVING INC COM 112463104 45,320 7,490,845 SH   DFND 1 7,490,845 0 0
BUTTERFLY NETWORK INC *W EXP 05/27/202 124155110 4,730 733,333 SH   DFND 1 733,333 0 0
CABALETTA BIO INC COM 12674W109 5,153 464,252 SH   DFND 1 464,252 0 0
CENTENE CORP DEL COM 15135B101 126,901 1,985,619 SH   DFND 1 1,985,619 0 0
CEREVEL THERAPEUTICS HLDNG I *W EXP 06/09/202 15678U102 718 166,666 SH   DFND 1 166,666 0 0
CERTARA INC COM 15687V109 16,380 600,000 SH   DFND 1 600,000 0 0
CHIMERIX INC COM 16934W106 17,508 1,816,221 SH   DFND 1 1,816,221 0 0
CLOVIS ONCOLOGY INC NOTE 2.500% 9/1 189464AB6 46,323 49,064,000 PRN   DFND 1 49,064,000 0 0
CM LIFE SCIENCES II INC UNIT 02/25/2028 125842203 7,680 600,000 SH   DFND 1 600,000 0 0
COGENT BIOSCIENCES INC COM 19240Q201 8,780 1,000,000 SH   DFND 1 1,000,000 0 0
CONSONANCE HFW ACQUISITION C UNIT 99/99/9999 G2445M129 4,880 500,000 SH   DFND 1 500,000 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 39,973 1,708,957 SH   DFND 1 1,708,957 0 0
CYTOKINETICS INC COM NEW 23282W605 59,569 2,561,000 SH   DFND 1 2,561,000 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 23,702 528,585 SH   DFND 1 528,585 0 0
DEERFIELD HEALTHCARE TECH AC COM CL A 244413100 82,158 6,778,750 SH   DFND 1 6,778,750 0 0
DEERFIELD HEALTHCARE TECH AC *W EXP 07/16/202 244413118 1,552 672,000 SH   DFND 1 672,000 0 0
DELCATH SYS INC COM NEW 24661P807 6,210 500,000 SH   DFND 1 500,000 0 0
DFP HEALTHCARE ACQUISITNS CO COM CL A 23343Q100 104,182 10,460,000 SH   DFND 1 10,460,000 0 0
DFP HEALTHCARE ACQUISITNS CO *W EXP 03/31/202 23343Q118 1,688 1,250,000 SH   DFND 1 1,250,000 0 0
DYNE THERAPEUTICS INC COM 26818M108 10,654 686,000 SH   DFND 1 686,000 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 127,827 3,933,137 SH   DFND 1 3,933,137 0 0
EUCRATES BIOMEDICAL ACQU COR UNIT 10/23/2027 G3141W114 10,012 1,000,000 SH   DFND 1 1,000,000 0 0
FATE THERAPEUTICS INC COM 31189P102 25,065 304,000 SH   DFND 1 304,000 0 0
GENERATION BIO CO COM 37148K100 25,551 897,779 SH   DFND 1 897,779 0 0
GRACELL BIOTECHNOLOGIES INC SPONSORED ADS 38406L103 6,160 400,000 SH   DFND 1 400,000 0 0
GRAYBUG VISION INC COM SHS 38942Q103 29,314 5,281,713 SH   DFND 1 5,281,713 0 0
HIGHCAPE CAP ACQUISITION COR UNIT 09/30/2027 42984L204 12,920 1,000,000 SH   DFND 1 1,000,000 0 0
HILL ROM HLDGS INC COM 431475102 30,920 279,870 SH   DFND 1 279,870 0 0
IGNYTE ACQUISITION CORP UNIT 01/05/2026 45175H205 7,265 725,000 SH   DFND 1 725,000 0 0
IMARA INC COM 45249V107 671 79,465 SH   DFND 1 79,465 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105 7,318 171,908 SH   DFND 1 171,908 0 0
INNOVAGE HLDG CORP COM 45784A104 7,737 300,000 SH   DFND 1 300,000 0 0
INOZYME PHARMA INC COM 45790W108 38,887 1,964,000 SH   DFND 1 1,964,000 0 0
INSMED INC NOTE 1.750% 1/1 457669AA7 67,986 61,000,000 PRN   DFND 1 61,000,000 0 0
INSTIL BIO INC COM 45783C101 27,983 1,115,739 SH   DFND 1 1,115,739 0 0
INSULET CORP NOTE 0.375% 9/0 45784PAK7 76,117 57,581,000 PRN   DFND 1 57,581,000 0 0
INTERCEPT PHARMACEUTICALS IN NOTE 3.250% 7/0 45845PAA6 47,537 57,791,000 PRN   DFND 1 57,791,000 0 0
INTERSECT ENT INC COM 46071F103 5,334 255,456 SH   DFND 1 255,456 0 0
ITAMAR MED LTD SPONSORED ADS 465437101 28,592 1,193,803 SH   DFND 1 1,193,803 0 0
IVERIC BIO INC COM 46583P102 35,643 5,767,409 SH   DFND 1 5,767,409 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 26,204 1,020,005 SH   DFND 1 1,020,005 0 0
KINNATE BIOPHARMA INC COM 49705R105 10,750 345,000 SH   DFND 1 345,000 0 0
LANDOS BIOPHARMA INC COM 515069102 4,334 450,000 SH   DFND 1 450,000 0 0
LARIMAR THERAPEUTICS INC COM 517125100 75,162 5,144,539 SH   DFND 1 5,144,539 0 0
LUMOS PHARMA INC COM 55028X109 4,365 373,117 SH   DFND 1 373,117 0 0
MEDAVAIL HOLDINGS INC COM 58406B103 15,996 1,142,552 SH   DFND 1 1,142,552 0 0
MEDTECH ACQUISITION CORP UNIT 12/18/2025 58507N204 10,050 1,000,000 SH   DFND 1 1,000,000 0 0
MERIDIAN BIOSCIENCE INC COM 589584101 23,343 889,269 SH   DFND 1 889,269 0 0
METACRINE INC COM 59101E103 1,720 277,469 SH   DFND 1 277,469 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 68,357 3,448,912 SH   DFND 1 3,448,912 0 0
MOLINA HEALTHCARE INC COM 60855R100 54,180 231,776 SH   DFND 1 231,776 0 0
MONTES ARCHIMEDES ACQUISITIO UNIT 09/30/2025 612657205 20,400 2,000,000 PRN   DFND 1 2,000,000 0 0
NEOGENOMICS INC NOTE 0.250% 1/1 64049MAB6 2,524 2,500,000 PRN   DFND 1 2,500,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 70,506 725,000 SH   DFND 1 725,000 0 0
NEURONETICS INC COM 64131A105 11,368 919,000 SH   DFND 1 919,000 0 0
NEVRO CORP NOTE 1.750% 6/0 64157FAA1 168,437 115,776,000 PRN   DFND 1 115,776,000 0 0
NEVRO CORP NOTE 2.750% 4/0 64157FAC7 18,208 12,000,000 PRN   DFND 1 12,000,000 0 0
NOVAVAX INC NOTE 3.750% 2/0 670002AB0 41,054 25,000,000 PRN   DFND 1 25,000,000 0 0
NUVASIVE INC NOTE 0.375% 3/1 670704AJ4 40,857 40,000,000 PRN   DFND 1 40,000,000 0 0
NUVATION BIO INC COM CL A 67080N101 31,350 3,000,000 SH   DFND 1 3,000,000 0 0
NUVATION BIO INC *W EXP 07/07/202 67080N119 445 166,666 SH   DFND 1 166,666 0 0
INVITAE CORP NOTE 2.000% 9/0 46185LAB9 245,760 163,385,000 PRN   DFND 1 163,385,000 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 8,998 271,191 SH   DFND 1 271,191 0 0
ONCORUS INC COM 68236R103 43,834 3,148,977 SH   DFND 1 3,148,977 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 50,453 6,949,416 SH   DFND 1 6,949,416 0 0
ORGANOGENESIS HLDGS INC COM 68621F102 54,581 2,995,638 SH   DFND 1 2,995,638 0 0
ORION ACQUISITION CORP UNIT 02/19/2026 68626A207 5,000 500,000 SH   DFND 1 500,000 0 0
ORTHO CLINICAL DIAGNOSTICS H ORD SHS G6829J107 45,400 2,352,941 SH   DFND 1 2,352,941 0 0
OWENS & MINOR INC NEW COM 690732102 58,227 1,549,000 SH   DFND 1 1,549,000 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 15,589 468,000 SH   DFND 1 468,000 0 0
PACIRA BIOSCIENCES INC COM 695127100 81,653 1,164,973 SH   DFND 1 1,164,973 0 0
PETCO HEALTH & WELLNESS CO I COM 71601V105 11,080 500,000 SH   DFND 1 500,000 0 0
PHARVARIS N V COM N69605108 28,897 1,032,757 SH   DFND 1 1,032,757 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 13,935 423,680 SH   DFND 1 423,680 0 0
PROFOUND MED CORP COM NEW 74319B502 26,138 1,297,797 SH   DFND 1 1,297,797 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 32,603 1,258,790 SH   DFND 1 1,258,790 0 0
PTC THERAPEUTICS INC NOTE 3.000% 8/1 69366JAB7 16,688 14,527,000 PRN   DFND 1 14,527,000 0 0
PULMONX CORP COM 745848101 42,860 937,032 SH   DFND 1 937,032 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 36,642 3,769,795 SH   DFND 1 3,769,795 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 41,874 420,000 SH   DFND 1 420,000 0 0
REVOLUTION HEALTHCAR AQ CORP UNIT 03/18/20266 76155Y207 10,054 1,000,000 SH   DFND 1 1,000,000 0 0
REVOLUTION MEDICINES INC COM 76155X100 65,916 1,436,712 SH   DFND 1 1,436,712 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 42,319 1,989,625 SH   DFND 1 1,989,625 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 14,575 550,000 SH   DFND 1 550,000 0 0
SARISSA CAPITAL ACQUISITN CO UNIT 10/23/2027 G7823W128 10,830 1,000,000 SH   DFND 1 1,000,000 0 0
SENIOR CONNECT ACQUISITN COR UNIT 12/09/2023 81723H207 10,010 1,000,000 SH   DFND 1 1,000,000 0 0
SENSEI BIOTHERAPEUTICS INC COM 81728A108 5,449 375,000 SH   DFND 1 375,000 0 0
SIGNIFY HEALTH INC CL A COM 82671G100 11,704 400,000 SH   DFND 1 400,000 0 0
SILK RD MED INC COM 82710M100 24,745 488,545 SH   DFND 1 488,545 0 0
SOTERA HEALTH CO COM 83601L102 27,731 1,111,000 SH   DFND 1 1,111,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 41,094 558,574 SH   DFND 1 558,574 0 0
STRYKER CORPORATION COM 863667101 14,371 59,000 SH   DFND 1 59,000 0 0
TABULA RASA HEALTHCARE INC NOTE 1.750% 2/1 873379AA9 44,718 45,000,000 PRN   DFND 1 45,000,000 0 0
TERNS PHARMACEUTICALS INC COM 880881107 51,611 2,345,959 SH   DFND 1 2,345,959 0 0
TURMERIC ACQUISITION CORP UNIT 10/08/2025 G9127T116 7,500 750,000 SH   DFND 1 750,000 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 7,931 83,846 SH   DFND 1 83,846 0 0
VIATRIS INC COM 92556V106 240,619 17,224,000 SH   DFND 1 17,224,000 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 19,652 3,502,970 SH   DFND 1 3,502,970 0 0
WINDTREE THERAPEUTICS INC COM 97382D303 49 20,148 SH   DFND 1 20,148 0 0
XERIS PHARMACEUTICALS INC NOTE 5.000% 7/1 98422LAA5 30,417 18,000,000 PRN   DFND 1 18,000,000 0 0
XERIS PHARMACEUTICALS INC COM 98422L107 29,556 6,553,398 SH   DFND 1 6,553,398 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 57,149 357,000 SH   DFND 1 357,000 0 0