The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101 18,278 108,866 SH   SOLE   108,866 0 0
ABBOTT LABS COM 002824100 49,208 467,902 SH   SOLE   467,902 0 0
ABBOTT LABS COM 002824100 2 19 SH   OTR 1 0 0 19
ABBVIE INC COM 00287Y109 54,556 530,067 SH   SOLE   530,067 0 0
ABBVIE INC COM 00287Y109 2 14 SH   OTR 1 0 0 14
ABIOMED INC COM 003654100 1,007 3,234 SH   SOLE   3,234 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 15,348 298,888 SH   SOLE   298,888 0 0
ACCELERON PHARMA INC COM 00434H108 68,442 556,914 SH   SOLE   556,914 0 0
ACCELERON PHARMA INC COM 00434H108 3 20 SH   OTR 1 0 0 20
ACCURAY INC COM 004397105 288 71,884 SH   SOLE   71,884 0 0
ACTIVISION BLIZZARD INC COM 00507V109 32,409 364,536 SH   SOLE   364,536 0 0
ADC THERAPEUTICS SA SHS H0036K147 0 8 SH   OTR 1 0 0 8
ADOBE SYSTEMS INCORPORATED COM 00724F101 3 6 SH   OTR 1 0 0 6
ADOBE SYSTEMS INCORPORATED COM 00724F101 73,561 153,161 SH   SOLE   153,161 0 0
ADVANCE AUTO PARTS INC COM 00751Y106 470 3,105 SH   SOLE   3,105 0 0
ADVANCED DRAIN SYS INC DEL COM 00790R104 26,763 333,350 SH   SOLE   333,350 0 0
ADVANCED DRAIN SYS INC DEL COM 00790R104 4 35 SH   OTR 1 0 0 35
ADVANCED MICRO DEVICES INC COM 007903107 31,326 355,612 SH   SOLE   355,612 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 3,108 298,492 SH   SOLE   298,492 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 7,481 576,495 SH   SOLE   576,495 0 0
AFLAC INC COM 001055102 3,297 77,194 SH   SOLE   77,194 0 0
AFLAC INC COM 001055102 3 67 SH   OTR 1 0 0 67
AFYA LTD CL A COM G01125106 1,458 60,000 SH   SOLE   60,000 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 6 47 SH   OTR 1 0 0 47
AGILENT TECHNOLOGIES INC COM 00846U101 9,639 84,689 SH   SOLE   84,689 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 10,072 241,987 SH   SOLE   241,987 0 0
AGNICO EAGLE MINES LTD COM 008474108 479 7,087 SH   SOLE   7,087 0 0
AIR PRODS & CHEMS INC COM 009158106 6 21 SH   OTR 1 0 0 21
AIR PRODS & CHEMS INC COM 009158106 49,040 186,857 SH   SOLE   186,857 0 0
AKAMAI TECHNOLOGIES INC COM 00971T101 5,229 51,853 SH   SOLE   51,853 0 0
AKAMAI TECHNOLOGIES INC NOTE 0.125% 5/0 00971TAJ0 3,570 3,000 PRN   SOLE   3,000 0 0
AKERO THERAPEUTICS INC COM 00973Y108 2,389 96,398 SH   SOLE   96,398 0 0
AKERS BIOSCIENCES INC COM 00973E409 69 36,146 SH   SOLE   36,146 0 0
ALBEMARLE CORP COM 012653101 1,035 7,307 SH   SOLE   7,307 0 0
ALECTOR INC COM 014442107 2,250 154,783 SH   SOLE   154,783 0 0
ALEXANDRIA REAL ESTATE EQ IN COM 015271109 1,543 9,013 SH   SOLE   9,013 0 0
ALEXANDRIA REAL ESTATE EQ IN COM 015271109 2,904 2,625 PRN   SOLE   2,625 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 91,590 610,282 SH   SOLE   610,282 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 2 7 SH   OTR 1 0 0 7
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 96,015 429,659 SH   SOLE   429,659 0 0
ALIGN TECHNOLOGY INC COM 016255101 2,291 4,464 SH   SOLE   4,464 0 0
ALLAKOS INC COM 01671P100 9,272 68,951 SH   SOLE   68,951 0 0
ALLSTATE CORP COM 020002101 46,235 437,848 SH   SOLE   437,848 0 0
ALLSTATE CORP COM 020002101 2 15 SH   OTR 1 0 0 15
ALLY FINL INC COM 02005N100 6,659 194,447 SH   SOLE   194,447 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 20,295 162,558 SH   SOLE   162,558 0 0
ALPHABET INC CAP STK CL A 02079K305 14 7 SH   OTR 1 0 0 7
ALPHABET INC CAP STK CL A 02079K305 294,588 175,012 SH   SOLE   175,012 0 0
ALPHABET INC CAP STK CL C 02079K107 61,705 36,686 SH   SOLE   36,686 0 0
ALTERYX INC COM CL A 02156B103 936 8,045 SH   SOLE   8,045 0 0
AMAZON COM INC COM 023135106 167,547 53,576 SH   SOLE   53,576 0 0
AMBARELLA INC SHS G037AX101 22,249 252,262 SH   SOLE   252,262 0 0
AMERESCO INC CL A 02361E108 2 37 SH   OTR 1 0 0 37
AMERESCO INC CL A 02361E108 12,493 248,965 SH   SOLE   248,965 0 0
AMERICAN AIRLS GROUP INC COM 02376R102 2,940 194,139 SH   SOLE   194,139 0 0
AMERICAN EXPRESS CO COM 025816109 10,470 90,145 SH   SOLE   90,145 0 0
AMERICAN EXPRESS CO COM 025816109 2 17 SH   OTR 1 0 0 17
AMERICAN INTL GROUP INC COM NEW 026874784 5,385 148,094 SH   SOLE   148,094 0 0
AMERICAN TOWER CORP NEW COM 03027X100 16,144 74,876 SH   SOLE   74,876 0 0
AMERICAN WTR WKS CO INC NEW COM 030420103 4 29 SH   OTR 1 0 0 29
AMERICAN WTR WKS CO INC NEW COM 030420103 46,941 318,423 SH   SOLE   318,423 0 0
AMERIPRISE FINL INC COM 03076C106 11,474 61,468 SH   SOLE   61,468 0 0
AMERIPRISE FINL INC COM 03076C106 2 9 SH   OTR 1 0 0 9
AMERISOURCEBERGEN CORP COM 03073E105 1,306 13,910 SH   SOLE   13,910 0 0
AMETEK INC COM 031100100 2,654 22,843 SH   SOLE   22,843 0 0
AMGEN INC COM 031162100 292,443 1,324,150 SH   SOLE   1,324,150 0 0
AMGEN INC COM 031162100 14 55 SH   OTR 1 0 0 55
AMICUS THERAPEUTICS INC COM 03152W109 13,643 615,124 SH   SOLE   615,124 0 0
AMPHENOL CORP NEW CL A 032095101 2,723 21,679 SH   SOLE   21,679 0 0
ANALOG DEVICES INC COM 032654105 62,076 437,454 SH   SOLE   437,454 0 0
ANGIODYNAMICS INC COM 03475V101 1,512 102,687 SH   SOLE   102,687 0 0
ANNALY CAPITAL MANAGEMENT IN COM 035710409 909 111,974 SH   SOLE   111,974 0 0
ANSYS INC COM 03662Q105 36,224 103,658 SH   SOLE   103,658 0 0
ANSYS INC COM 03662Q105 2 6 SH   OTR 1 0 0 6
ANTHEM INC COM 036752103 20,872 67,672 SH   SOLE   67,672 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 30,515 555,374 SH   SOLE   555,374 0 0
APOLLO GLOBAL MGMT INC COM CL A 03768E105 822 17,570 SH   SOLE   17,570 0 0
APPLE INC COM 037833100 409,529 3,213,246 SH   SOLE   3,213,246 0 0
APPLE INC COM 037833100 19 153 SH   OTR 1 0 0 153
APPLIED MATLS INC COM 038222105 47,631 574,864 SH   SOLE   574,864 0 0
APPLIED MATLS INC COM 038222105 2 13 SH   OTR 1 0 0 13
APREA THERAPEUTICS INC COM 03836J102 1,712 362,319 SH   SOLE   362,319 0 0
APTIV PLC SHS G6095L109 4 32 SH   OTR 1 0 0 32
ARCH CAP GROUP LTD ORD G0450A105 888 25,616 SH   SOLE   25,616 0 0
ARCHER DANIELS MIDLAND CO COM 039483102 2 39 SH   OTR 1 0 0 39
ARCHER DANIELS MIDLAND CO COM 039483102 1,986 41,024 SH   SOLE   41,024 0 0
ARCTURUS THERAPEUTICS HLDGS COM 03969T109 2,235 53,633 SH   SOLE   53,633 0 0
ARCUS BIOSCIENCES INC COM 03969F109 10,198 408,977 SH   SOLE   408,977 0 0
ARCUS BIOSCIENCES INC COM 03969F109 0 14 SH   OTR 1 0 0 14
ARDELYX INC COM 039697107 8,528 1,372,217 SH   SOLE   1,372,217 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 31,885 432,049 SH   SOLE   432,049 0 0
ARGENX SE SPONSORED ADR 04016X101 10,953 38,773 SH   SOLE   38,773 0 0
ARISTA NETWORKS INC COM 040413106 2,383 8,538 SH   SOLE   8,538 0 0
ARK ETF TR GENOMIC REV ETF 00214Q302 668 7,500 SH   SOLE   7,500 0 0
ARK ETF TR INNOVATION ETF 00214Q104 755 6,350 SH   SOLE   6,350 0 0
ARRAY TECHNOLOGIES INC COM SHS 04271T100 13,280 320,484 SH   SOLE   320,484 0 0
ARROW ELECTRS INC COM 042735100 3 31 SH   OTR 1 0 0 31
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 12,084 163,958 SH   SOLE   163,958 0 0
ARVINAS INC COM 04335A105 1 13 SH   OTR 1 0 0 13
ARVINAS INC COM 04335A105 23,610 289,401 SH   SOLE   289,401 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 38,556 240,671 SH   SOLE   240,671 0 0
ASE TECHNOLOGY HLDG CO LTD SPONSORED ADS 00215W100 186 33,156 SH   SOLE   33,156 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 6,605 1,136,545 SH   SOLE   1,136,545 0 0
ASSURANT INC COM 04621X108 6,569 50,200 SH   SOLE   50,200 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 7,842 163,312 SH   SOLE   163,312 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 14 272 SH   OTR 1 0 0 272
ASURE SOFTWARE INC COM 04649U102 176 26,000 SH   SOLE   26,000 0 0
AT&T INC COM 00206R102 30,924 1,119,463 SH   SOLE   1,119,463 0 0
AT&T INC COM 00206R102 6 198 SH   OTR 1 0 0 198
ATMOS ENERGY CORP COM 049560105 2 22 SH   OTR 1 0 0 22
ATMOS ENERGY CORP COM 049560105 9,352 102,017 SH   SOLE   102,017 0 0
ATRECA INC CL A COM 04965G109 0 25 SH   OTR 1 0 0 25
AUTODESK INC COM 052769106 75,988 259,083 SH   SOLE   259,083 0 0
AUTODESK INC COM 052769106 2 7 SH   OTR 1 0 0 7
AUTOLIV INC COM 052800109 4,023 45,469 SH   SOLE   45,469 0 0
AUTOMATIC DATA PROCESSING IN COM 053015103 13,824 81,676 SH   SOLE   81,676 0 0
AUTOZONE INC COM 053332102 5,929 5,207 SH   SOLE   5,207 0 0
AVALARA INC COM 05338G106 711 4,510 SH   SOLE   4,510 0 0
AVALONBAY CMNTYS INC COM 053484101 2,079 13,494 SH   SOLE   13,494 0 0
AVANTOR INC COM 05352A100 5,973 220,878 SH   SOLE   220,878 0 0
AVERY DENNISON CORP COM 053611109 3,695 24,797 SH   SOLE   24,797 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 478 19,497 SH   SOLE   19,497 0 0
AXALTA COATING SYS LTD COM G0750C108 1,545 56,334 SH   SOLE   56,334 0 0
AXSOME THERAPEUTICS INC COM 05464T104 9,062 115,802 SH   SOLE   115,802 0 0
B2GOLD CORP COM 11777Q209 141 26,281 SH   SOLE   26,281 0 0
BAIDU INC SPON ADR REP A 056752108 31,037 149,472 SH   SOLE   149,472 0 0
BAKER HUGHES COMPANY CL A 05722G100 8,441 421,457 SH   SOLE   421,457 0 0
BALL CORP COM 058498106 46,012 514,064 SH   SOLE   514,064 0 0
BALL CORP COM 058498106 4 44 SH   OTR 1 0 0 44
BALLARD PWR SYS INC NEW COM 058586108 4,085 181,941 SH   SOLE   181,941 0 0
BANCO BILBAO VIZCAYA ARGENTA SPONSORED ADR 05946K101 1 120 SH   OTR 1 0 0 120
BANCO BRADESCO S A SP ADR PFD NEW 059460303 1,285 254,295 SH   SOLE   254,295 0 0
BANCOLOMBIA S A SPON ADR PREF 05968L102 352 9,130 SH   SOLE   9,130 0 0
BANK MONTREAL QUE COM 063671101 1,668 22,862 SH   SOLE   22,862 0 0
BANK NEW YORK MELLON CORP COM 064058100 1 27 SH   OTR 1 0 0 27
BANK NEW YORK MELLON CORP COM 064058100 9,467 232,215 SH   SOLE   232,215 0 0
BANK NOVA SCOTIA B C COM 064149107 2,562 49,389 SH   SOLE   49,389 0 0
BAOZUN INC SPONSORED ADR 06684L103 330 10,000 SH   SOLE   10,000 0 0
BARRICK GOLD CORP COM 067901108 2,073 94,838 SH   SOLE   94,838 0 0
BAXTER INTL INC COM 071813109 9,353 121,346 SH   SOLE   121,346 0 0
BCE INC COM NEW 05534B760 3,394 82,694 SH   SOLE   82,694 0 0
BECTON DICKINSON & CO COM 075887109 10,346 43,045 SH   SOLE   43,045 0 0
BEIGENE LTD SPONSORED ADR 07725L102 47,491 191,340 SH   SOLE   191,340 0 0
BEIGENE LTD SPONSORED ADR 07725L102 1 4 SH   OTR 1 0 0 4
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 8,836 39,765 SH   SOLE   39,765 0 0
BEST BUY INC COM 086516101 21,941 228,894 SH   SOLE   228,894 0 0
BEYOND MEAT INC COM 08862E109 1,466 12,209 SH   SOLE   12,209 0 0
BHP GROUP PLC SPONSORED ADR 05545E209 3 46 SH   OTR 1 0 0 46
BILIBILI INC SPONS ADS REP Z 090040106 28,159 341,998 SH   SOLE   341,998 0 0
BIO RAD LABS INC CL A 090572207 73,224 130,769 SH   SOLE   130,769 0 0
BIO RAD LABS INC CL A 090572207 2 3 SH   OTR 1 0 0 3
BIOGEN INC COM 09062X103 91,933 390,870 SH   SOLE   390,870 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 4,040 49,067 SH   SOLE   49,067 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 30,158 358,030 SH   SOLE   358,030 0 0
BIOMARIN PHARMACEUTICAL INC NOTE 0.599% 8/0 09061GAH4 830 800 PRN   SOLE   800 0 0
BIONTECH SE SPONSORED ADS 09075V102 6,870 87,761 SH   SOLE   87,761 0 0
BIO-TECHNE CORP COM 09073M104 33,028 108,279 SH   SOLE   108,279 0 0
BIO-TECHNE CORP COM 09073M104 2 4 SH   OTR 1 0 0 4
BK OF AMERICA CORP COM 060505104 7 188 SH   OTR 1 0 0 188
BK OF AMERICA CORP COM 060505104 27,664 950,186 SH   SOLE   950,186 0 0
BLACKBERRY LTD COM 09228F103 141 22,191 SH   SOLE   22,191 0 0
BLACKROCK INC COM 09247X101 13,036 18,810 SH   SOLE   18,810 0 0
BLACKSTONE GROUP INC COM 09260D107 2,119 34,031 SH   SOLE   34,031 0 0
BLINK CHARGING CO COM 09354A100 1 22 SH   OTR 1 0 0 22
BLOOM ENERGY CORP COM CL A 093712107 2 65 SH   OTR 1 0 0 65
BLOOM ENERGY CORP COM CL A 093712107 11,920 432,994 SH   SOLE   432,994 0 0
BLUEBIRD BIO INC COM 09609G100 17,586 423,098 SH   SOLE   423,098 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 1 14 SH   OTR 1 0 0 14
BLUEPRINT MEDICINES CORP COM 09627Y109 37,906 351,867 SH   SOLE   351,867 0 0
BOEING CO COM 097023105 1,064 5,179 SH   SOLE   5,179 0 0
BOOKING HOLDINGS INC COM 09857L108 12,550 5,866 SH   SOLE   5,866 0 0
BOOKING HOLDINGS INC COM 09857L108 2 1 SH   OTR 1 0 0 1
BOOKING HOLDINGS INC COM 09857L108 975 1,000 PRN   SOLE   1,000 0 0
BOSTON PROPERTIES INC COM 101121101 1,407 15,490 SH   SOLE   15,490 0 0
BOSTON SCIENTIFIC CORP COM 101137107 2,981 86,333 SH   SOLE   86,333 0 0
BP PLC SPONSORED ADR 055622104 3 110 SH   OTR 1 0 0 110
BRISTOL-MYERS SQUIBB CO COM 110122108 106,343 1,784,782 SH   SOLE   1,784,782 0 0
BROADCOM INC COM 11135F101 47,743 113,531 SH   SOLE   113,531 0 0
BROADRIDGE FINL SOLUTIONS IN COM 11133T103 2,527 17,169 SH   SOLE   17,169 0 0
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104 1,621 40,851 SH   SOLE   40,851 0 0
BROOKFIELD RENEWABLE PARTNER PARTNERSHIP UNIT G16258108 1,792 43,227 SH   SOLE   43,227 0 0
BROWN FORMAN CORP CL B 115637209 1,702 22,301 SH   SOLE   22,301 0 0
BRUKER CORP COM 116794108 3,286 63,199 SH   SOLE   63,199 0 0
BUNGE LIMITED COM G16962105 1,135 18,022 SH   SOLE   18,022 0 0
BURLINGTON STORES INC COM 122017106 898 3,574 SH   SOLE   3,574 0 0
CABOT OIL & GAS CORP COM 127097103 2,339 149,580 SH   SOLE   149,580 0 0
CADENCE DESIGN SYSTEM INC COM 127387108 24,955 190,425 SH   SOLE   190,425 0 0
CADENCE DESIGN SYSTEM INC COM 127387108 4 30 SH   OTR 1 0 0 30
CAMECO CORP COM 13321L108 236 18,346 SH   SOLE   18,346 0 0
CAMPBELL SOUP CO COM 134429109 6,814 146,723 SH   SOLE   146,723 0 0
CANADIAN IMP BK COMM COM 136069101 929 11,334 SH   SOLE   11,334 0 0
CANADIAN NAT RES LTD COM 136385101 614 26,649 SH   SOLE   26,649 0 0
CANADIAN NATL RY CO COM 136375102 8,014 75,955 SH   SOLE   75,955 0 0
CANADIAN PAC RY LTD COM 13645T100 4,576 13,747 SH   SOLE   13,747 0 0
CAPITAL ONE FINL CORP COM 14040H105 2,554 26,894 SH   SOLE   26,894 0 0
CARDINAL HEALTH INC COM 14149Y108 2,457 47,753 SH   SOLE   47,753 0 0
CARDINAL HEALTH INC COM 14149Y108 2 26 SH   OTR 1 0 0 26
CARMAX INC COM 143130102 800 8,815 SH   SOLE   8,815 0 0
CARNIVAL CORP UNIT 99/99/9999 143658300 831 39,928 SH   SOLE   39,928 0 0
CARRIER GLOBAL CORPORATION COM 14448C104 1,971 54,405 SH   SOLE   54,405 0 0
CATALENT INC COM 148806102 1,057 10,570 SH   SOLE   10,570 0 0
CATERPILLAR INC COM 149123101 10,397 59,469 SH   SOLE   59,469 0 0
CBOE GLOBAL MKTS INC COM 12503M108 712 7,962 SH   SOLE   7,962 0 0
CBRE GROUP INC CL A 12504L109 24,413 405,219 SH   SOLE   405,219 0 0
CDW CORP COM 12514G108 4,550 35,946 SH   SOLE   35,946 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 5,792 344,139 SH   SOLE   344,139 0 0
CEMEX SAB DE CV SPON ADR NEW 151290889 377 76,375 SH   SOLE   76,375 0 0
CENOVUS ENERGY INC COM 15135U109 75 12,886 SH   SOLE   12,886 0 0
CENTENE CORP DEL COM 15135B101 2,022 35,073 SH   SOLE   35,073 0 0
CENTERPOINT ENERGY INC COM 15189T107 1,254 60,348 SH   SOLE   60,348 0 0
CERIDIAN HCM HLDG INC COM 15677J108 723 7,068 SH   SOLE   7,068 0 0
CERNER CORP COM 156782104 17,803 236,156 SH   SOLE   236,156 0 0
CERNER CORP COM 156782104 431 400 PRN   SOLE   400 0 0
CEVA INC COM 157210105 13,098 299,691 SH   SOLE   299,691 0 0
CF INDS HLDGS INC COM 125269100 2,338 62,869 SH   SOLE   62,869 0 0
CGI INC CL A SUB VTG 12532H104 457 6,007 SH   SOLE   6,007 0 0
CHARLES RIV LABS INTL INC COM 159864107 3 11 SH   OTR 1 0 0 11
CHARLES RIV LABS INTL INC COM 159864107 16,841 70,169 SH   SOLE   70,169 0 0
CHARTER COMMUNICATIONS INC N CL A 16119P108 14,019 22,061 SH   SOLE   22,061 0 0
CHENIERE ENERGY INC COM NEW 16411R208 7,228 125,347 SH   SOLE   125,347 0 0
CHEVRON CORP NEW COM 166764100 2,632 32,453 SH   SOLE   32,453 0 0
CHIASMA INC COM 16706W102 98 23,500 SH   SOLE   23,500 0 0
CHIPOTLE MEXICAN GRILL INC COM 169656105 7,258 5,449 SH   SOLE   5,449 0 0
CHUNGHWA TELECOM CO LTD SPON ADR NEW11 17133Q502 449 12,093 SH   SOLE   12,093 0 0
CHURCH & DWIGHT INC COM 171340102 14,259 170,172 SH   SOLE   170,172 0 0
CHURCH & DWIGHT INC COM 171340102 1 16 SH   OTR 1 0 0 16
CI FINL CORP COM 125491100 8,527 716,686 SH   SOLE   716,686 0 0
CIA ENERGETICA DE MINAS GERA SP ADR N-V PFD 204409601 287 103,718 SH   SOLE   103,718 0 0
CIGNA CORP NEW COM 125523100 19,010 95,065 SH   SOLE   95,065 0 0
CIGNA CORP NEW COM 125523100 2 8 SH   OTR 1 0 0 8
CINCINNATI BELL INC NEW COM NEW 171871502 1,777 121,050 SH   SOLE   121,050 0 0
CINCINNATI FINL CORP COM 172062101 692 8,251 SH   SOLE   8,251 0 0
CINTAS CORP COM 172908105 2,337 6,882 SH   SOLE   6,882 0 0
CISCO SYS INC COM 17275R102 3 61 SH   OTR 1 0 0 61
CISCO SYS INC COM 17275R102 56,152 1,306,471 SH   SOLE   1,306,471 0 0
CITIGROUP INC COM NEW 172967424 5 70 SH   OTR 1 0 0 70
CITIGROUP INC COM NEW 172967424 85,641 1,445,998 SH   SOLE   1,445,998 0 0
CITIZENS FINANCIAL GROUP INC COM 174610105 4,284 124,718 SH   SOLE   124,718 0 0
CITRIX SYS INC COM 177376100 16,466 131,758 SH   SOLE   131,758 0 0
CLOROX CO DEL COM 189054109 24,278 125,173 SH   SOLE   125,173 0 0
CLOROX CO DEL COM 189054109 2 8 SH   OTR 1 0 0 8
CLOVIS ONCOLOGY INC COM 189464100 2,461 533,832 SH   SOLE   533,832 0 0
CME GROUP INC COM 12572Q105 4,271 24,422 SH   SOLE   24,422 0 0
COCA COLA CO COM 191216100 35,883 681,232 SH   SOLE   681,232 0 0
COGNEX CORP COM 192422103 625 8,108 SH   SOLE   8,108 0 0
COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102 4,369 55,508 SH   SOLE   55,508 0 0
COHERUS BIOSCIENCES INC COM 19249H103 11,366 680,812 SH   SOLE   680,812 0 0
COLGATE PALMOLIVE CO COM 194162103 3 36 SH   OTR 1 0 0 36
COLGATE PALMOLIVE CO COM 194162103 10,906 132,781 SH   SOLE   132,781 0 0
COMCAST CORP NEW CL A 20030N101 15,919 316,323 SH   SOLE   316,323 0 0
COMCAST CORP NEW CL A 20030N101 5 101 SH   OTR 1 0 0 101
COMERICA INC COM 200340107 666 12,416 SH   SOLE   12,416 0 0
CONAGRA BRANDS INC COM 205887102 1,214 34,843 SH   SOLE   34,843 0 0
CONOCOPHILLIPS COM 20825C104 3,259 84,854 SH   SOLE   84,854 0 0
CONSOLIDATED EDISON INC COM 209115104 3,770 54,308 SH   SOLE   54,308 0 0
CONSTELLATION BRANDS INC CL A 21036P108 6,588 31,309 SH   SOLE   31,309 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 0 21 SH   OTR 1 0 0 21
CONSTELLATION PHARMCETICLS I COM 210373106 11,384 411,494 SH   SOLE   411,494 0 0
COPART INC COM 217204106 4,051 33,158 SH   SOLE   33,158 0 0
CORNING INC COM 219350105 1,573 45,486 SH   SOLE   45,486 0 0
CORTEVA INC COM 22052L104 1,503 40,407 SH   SOLE   40,407 0 0
COSTAR GROUP INC COM 22160N109 1,704 1,919 SH   SOLE   1,919 0 0
COSTCO WHSL CORP NEW COM 22160K105 12,672 35,014 SH   SOLE   35,014 0 0
COUPA SOFTWARE INC COM 22266L106 1,483 4,560 SH   SOLE   4,560 0 0
CRH PLC ADR 12626K203 3 73 SH   OTR 1 0 0 73
CRH PLC ADR 12626K203 1,413 34,547 SH   SOLE   34,547 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 11,312 73,976 SH   SOLE   73,976 0 0
CROWN HLDGS INC COM 228368106 2 18 SH   OTR 1 0 0 18
CRYOLIFE INC COM 228903100 661 29,166 SH   SOLE   29,166 0 0
CSX CORP COM 126408103 2 21 SH   OTR 1 0 0 21
CSX CORP COM 126408103 5,055 57,992 SH   SOLE   57,992 0 0
CUMMINS INC COM 231021106 3,646 16,713 SH   SOLE   16,713 0 0
CURIS INC COM NEW 231269200 1 61 SH   OTR 1 0 0 61
CVS HEALTH CORP COM 126650100 4 58 SH   OTR 1 0 0 58
CVS HEALTH CORP COM 126650100 16,345 249,171 SH   SOLE   249,171 0 0
CYTOKINETICS INC COM NEW 23282W605 7,502 375,853 SH   SOLE   375,853 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 1 146 SH   OTR 1 0 0 146
D R HORTON INC COM 23331A109 6,284 94,901 SH   SOLE   94,901 0 0
DANAHER CORPORATION COM 235851102 14 63 SH   OTR 1 0 0 63
DANAHER CORPORATION COM 235851102 169,522 794,463 SH   SOLE   794,463 0 0
DARDEN RESTAURANTS INC COM 237194105 814 7,115 SH   SOLE   7,115 0 0
DARLING INGREDIENTS INC COM 237266101 1 19 SH   OTR 1 0 0 19
DATADOG INC CL A COM 23804L103 936 9,899 SH   SOLE   9,899 0 0
DAVITA INC COM 23918K108 4,580 40,617 SH   SOLE   40,617 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 9,683 176,628 SH   SOLE   176,628 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 1 27 SH   OTR 1 0 0 27
DEERE & CO COM 244199105 13,620 52,700 SH   SOLE   52,700 0 0
DELL TECHNOLOGIES INC CL C 24703L202 8,356 118,717 SH   SOLE   118,717 0 0
DENTSPLY SIRONA INC COM 24906P109 1,015 20,193 SH   SOLE   20,193 0 0
DEVON ENERGY CORP NEW COM 25179M103 326 21,498 SH   SOLE   21,498 0 0
DEXCOM INC COM 252131107 5,229 14,725 SH   SOLE   14,725 0 0
DIAGEO PLC SPON ADR NEW 25243Q205 1 8 SH   OTR 1 0 0 8
DIAMONDBACK ENERGY INC COM 25278X109 314 6,752 SH   SOLE   6,752 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 29,816 1,408,993 SH   SOLE   1,408,993 0 0
DIGITAL RLTY TR INC COM 253868103 2,093 15,627 SH   SOLE   15,627 0 0
DIGITAL TURBINE INC COM NEW 25400W102 1,475 27,300 SH   SOLE   27,300 0 0
DISCOVER FINL SVCS COM 254709108 2,337 26,873 SH   SOLE   26,873 0 0
DISCOVERY INC COM SER C 25470F302 1,118 44,460 SH   SOLE   44,460 0 0
DISNEY WALT CO COM 254687106 95,949 551,460 SH   SOLE   551,460 0 0
DISNEY WALT CO COM 254687106 7 39 SH   OTR 1 0 0 39
DOCUSIGN INC COM 256163106 2,861 13,408 SH   SOLE   13,408 0 0
DOLLAR GEN CORP NEW COM 256677105 13,163 65,162 SH   SOLE   65,162 0 0
DOLLAR TREE INC COM 256746108 1,305 12,578 SH   SOLE   12,578 0 0
DOMINION ENERGY INC COM 25746U109 4,471 61,891 SH   SOLE   61,891 0 0
DOMINOS PIZZA INC COM 25754A201 4,434 12,039 SH   SOLE   12,039 0 0
DOVER CORP COM 260003108 2,257 18,615 SH   SOLE   18,615 0 0
DOW INC COM 260557103 3,800 71,280 SH   SOLE   71,280 0 0
DROPBOX INC CL A 26210C104 1 45 SH   OTR 1 0 0 45
DUKE REALTY CORP COM NEW 264411505 256 6,676 SH   SOLE   6,676 0 0
DUPONT DE NEMOURS INC COM 26614N102 4,754 69,604 SH   SOLE   69,604 0 0
EARGO INC COM 270087109 1,326 30,806 SH   SOLE   30,806 0 0
EATON CORP PLC SHS G29183103 2 17 SH   OTR 1 0 0 17
EBAY INC. COM 278642103 27,177 563,059 SH   SOLE   563,059 0 0
ECOLAB INC COM 278865100 2 9 SH   OTR 1 0 0 9
ECOLAB INC COM 278865100 29,898 143,860 SH   SOLE   143,860 0 0
EDISON INTL COM 281020107 2,351 38,968 SH   SOLE   38,968 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 8,429 96,190 SH   SOLE   96,190 0 0
ELANCO ANIMAL HEALTH INC COM 28414H103 643 21,840 SH   SOLE   21,840 0 0
ELECTRONIC ARTS INC COM 285512109 1 10 SH   OTR 1 0 0 10
ELECTRONIC ARTS INC COM 285512109 33,561 243,318 SH   SOLE   243,318 0 0
EMERSON ELEC CO COM 291011104 51,889 672,176 SH   SOLE   672,176 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106 7,236 178,941 SH   SOLE   178,941 0 0
ENBRIDGE INC COM 29250N105 1,151 37,494 SH   SOLE   37,494 0 0
ENPHASE ENERGY INC COM 29355A107 3 17 SH   OTR 1 0 0 17
ENPHASE ENERGY INC COM 29355A107 27,350 162,265 SH   SOLE   162,265 0 0
ENTERGY CORP NEW COM 29364G103 3,436 35,829 SH   SOLE   35,829 0 0
ENVIVA PARTNERS LP COM UNIT 29414J107 1,209 27,711 SH   SOLE   27,711 0 0
EOG RES INC COM 26875P101 1,295 1,000 PRN   SOLE   1,000 0 0
EOG RES INC COM 26875P101 1,522 31,772 SH   SOLE   31,772 0 0
EPAM SYS INC COM 29414B104 8,709 25,300 SH   SOLE   25,300 0 0
EPIZYME INC COM 29428V104 1,105 105,890 SH   SOLE   105,890 0 0
EQUIFAX INC COM 294429105 1,394 7,527 SH   SOLE   7,527 0 0
EQUINIX INC COM 29444U700 3 4 SH   OTR 1 0 0 4
EQUINIX INC COM 29444U700 59,231 86,559 SH   SOLE   86,559 0 0
EQUINOR ASA SPONSORED ADR 29446M102 1 72 SH   OTR 1 0 0 72
EQUITABLE HLDGS INC COM 29452E101 303 12,310 SH   SOLE   12,310 0 0
EQUITY LIFESTYLE PPTYS INC COM 29472R108 745 12,246 SH   SOLE   12,246 0 0
EQUITY RESIDENTIAL SH BEN INT 29476L107 2,119 37,221 SH   SOLE   37,221 0 0
ERICSSON ADR B SEK 10 294821608 2 125 SH   OTR 1 0 0 125
ERICSSON ADR B SEK 10 294821608 2,071 180,451 SH   SOLE   180,451 0 0
ESSA PHARMA INC COM NEW 29668H708 0 17 SH   OTR 1 0 0 17
ESSENTIAL UTILS INC COM 29670G102 1,622 35,712 SH   SOLE   35,712 0 0
ESSEX PPTY TR INC COM 297178105 1,396 6,122 SH   SOLE   6,122 0 0
ETF MANAGERS TR PRIME CYBR SCRTY 26924G201 1,648 29,965 SH   SOLE   29,965 0 0
ETF MANAGERS TR WEDBUSH VID GAME 26924G706 276 3,655 SH   SOLE   3,655 0 0
ETSY INC COM 29786A106 8,400 49,152 SH   SOLE   49,152 0 0
EVERSOURCE ENERGY COM 30040W108 5,263 63,339 SH   SOLE   63,339 0 0
EXACT SCIENCES CORP COM 30063P105 22,382 175,865 SH   SOLE   175,865 0 0
EXACT SCIENCES CORP COM 30063P105 1 9 SH   OTR 1 0 0 9
EXACT SCIENCES CORP NOTE 0.375% 3/0 30063PAC9 1,384 1,100 PRN   SOLE   1,100 0 0
EXACT SCIENCES CORP NOTE 0.375% 3/1 30063PAB1 267 200 PRN   SOLE   200 0 0
EXCHANGE TRADED CONCEPTS TR EMQQ EM INTERN 301505889 1,583 26,060 SH   SOLE   26,060 0 0
EXELIXIS INC COM 30161Q104 44,519 2,309,242 SH   SOLE   2,309,242 0 0
EXELIXIS INC COM 30161Q104 3 137 SH   OTR 1 0 0 137
EXELON CORP COM 30161N101 4,971 122,565 SH   SOLE   122,565 0 0
EXPEDIA GROUP INC COM NEW 30212P303 932 7,328 SH   SOLE   7,328 0 0
EXPEDITORS INTL WASH INC COM 302130109 2 15 SH   OTR 1 0 0 15
EXPEDITORS INTL WASH INC COM 302130109 5,554 60,793 SH   SOLE   60,793 0 0
EXTRA SPACE STORAGE INC COM 30225T102 752 6,753 SH   SOLE   6,753 0 0
EXXON MOBIL CORP COM 30231G102 13,244 334,520 SH   SOLE   334,520 0 0
F5 NETWORKS INC COM 315616102 14,236 84,236 SH   SOLE   84,236 0 0
FACEBOOK INC CL A 30303M102 119,386 455,011 SH   SOLE   455,011 0 0
FACEBOOK INC CL A 30303M102 2 8 SH   OTR 1 0 0 8
FAIR ISAAC CORP COM 303250104 8,045 16,389 SH   SOLE   16,389 0 0
FASTENAL CO COM 311900104 8,421 179,535 SH   SOLE   179,535 0 0
FATE THERAPEUTICS INC COM 31189P102 0 6 SH   OTR 1 0 0 6
FATE THERAPEUTICS INC COM 31189P102 23,592 270,101 SH   SOLE   270,101 0 0
FEDEX CORP COM 31428X106 4,525 18,146 SH   SOLE   18,146 0 0
FIBROGEN INC COM 31572Q808 6,578 184,625 SH   SOLE   184,625 0 0
FIDELITY NATIONAL FINANCIAL FNF GROUP COM 31620R303 565 15,041 SH   SOLE   15,041 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 7,565 55,670 SH   SOLE   55,670 0 0
FIFTH THIRD BANCORP COM 316773100 5,040 190,296 SH   SOLE   190,296 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 6,691 47,407 SH   SOLE   47,407 0 0
FIRST SOLAR INC COM 336433107 2,889 30,405 SH   SOLE   30,405 0 0
FISERV INC COM 337738108 3,683 33,677 SH   SOLE   33,677 0 0
FLEETCOR TECHNOLOGIES INC COM 339041105 1,207 4,606 SH   SOLE   4,606 0 0
FLUIDIGM CORP DEL COM 34385P108 1,835 318,331 SH   SOLE   318,331 0 0
FMC CORP COM NEW 302491303 1,132 10,251 SH   SOLE   10,251 0 0
FOMENTO ECONOMICO MEXICANO S SPON ADR UNITS 344419106 254 3,484 SH   SOLE   3,484 0 0
FORD MTR CO DEL COM 345370860 6,567 777,815 SH   SOLE   777,815 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 4,124 123,004 SH   SOLE   123,004 0 0
FORTINET INC COM 34959E109 16,865 118,207 SH   SOLE   118,207 0 0
FORTIVE CORP COM 34959J108 2,563 37,673 SH   SOLE   37,673 0 0
FORTIVE CORP NOTE 0.875% 2/1 34959JAK4 11,397 11,500 PRN   SOLE   11,500 0 0
FORTRESS BIOTECH INC COM 34960Q109 68 22,500 SH   SOLE   22,500 0 0
FORTUNE BRANDS HOME & SEC IN COM 34964C106 305 3,707 SH   SOLE   3,707 0 0
FOX CORP CL A COM 35137L105 290 10,379 SH   SOLE   10,379 0 0
FOX CORP CL B COM 35137L204 978 35,256 SH   SOLE   35,256 0 0
FRANCO NEV CORP COM 351858105 744 6,186 SH   SOLE   6,186 0 0
FRANKLIN RESOURCES INC COM 354613101 1,048 43,666 SH   SOLE   43,666 0 0
FREEPORT-MCMORAN INC CL B 35671D857 4,115 164,660 SH   SOLE   164,660 0 0
FRESHPET INC COM 358039105 1,711 12,548 SH   SOLE   12,548 0 0
GALLAGHER ARTHUR J & CO COM 363576109 1,061 8,931 SH   SOLE   8,931 0 0
GAP INC COM 364760108 321 16,601 SH   SOLE   16,601 0 0
GARMIN LTD SHS H2906T109 1 9 SH   OTR 1 0 0 9
GENERAC HLDGS INC COM 368736104 23,925 109,525 SH   SOLE   109,525 0 0
GENERAL ELECTRIC CO COM 369604103 7,751 747,223 SH   SOLE   747,223 0 0
GENERAL MLS INC COM 370334104 16,065 284,433 SH   SOLE   284,433 0 0
GENERAL MTRS CO COM 37045V100 4,453 111,325 SH   SOLE   111,325 0 0
GENMAB A/S SPONSORED ADS 372303206 5 142 SH   OTR 1 0 0 142
GENMAB A/S SPONSORED ADS 372303206 2,980 76,307 SH   SOLE   76,307 0 0
GENUINE PARTS CO COM 372460105 1,044 10,818 SH   SOLE   10,818 0 0
GILDAN ACTIVEWEAR INC COM 375916103 1,630 60,748 SH   SOLE   60,748 0 0
GILEAD SCIENCES INC COM 375558103 123,391 2,204,889 SH   SOLE   2,204,889 0 0
GILEAD SCIENCES INC COM 375558103 3 47 SH   OTR 1 0 0 47
GLADSTONE COMMERCIAL CORP COM 376536108 173 10,000 SH   SOLE   10,000 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 3 97 SH   OTR 1 0 0 97
GLOBAL PMTS INC COM 37940X102 3,305 15,979 SH   SOLE   15,979 0 0
GODADDY INC CL A 380237107 692 8,690 SH   SOLE   8,690 0 0
GOLD FIELDS LTD SPONSORED ADR 38059T106 292 32,809 SH   SOLE   32,809 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 12,510 49,386 SH   SOLE   49,386 0 0
GOODYEAR TIRE & RUBR CO COM 382550101 136 13,031 SH   SOLE   13,031 0 0
GRACE W R & CO DEL NEW COM 38388F108 2,116 40,189 SH   SOLE   40,189 0 0
GRAINGER W W INC COM 384802104 3,844 9,801 SH   SOLE   9,801 0 0
GRUBHUB INC COM 400110102 17,331 242,931 SH   SOLE   242,931 0 0
GUARDANT HEALTH INC COM 40131M109 1 5 SH   OTR 1 0 0 5
GUARDANT HEALTH INC COM 40131M109 10,933 88,347 SH   SOLE   88,347 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 14,472 130,547 SH   SOLE   130,547 0 0
HALLIBURTON CO COM 406216101 2,086 115,125 SH   SOLE   115,125 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 30,101 733,720 SH   SOLE   733,720 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 1 22 SH   OTR 1 0 0 22
HANNON ARMSTRONG SUST INFR C COM 41068X100 15,023 246,562 SH   SOLE   246,562 0 0
HANNON ARMSTRONG SUST INFR C COM 41068X100 2 40 SH   OTR 1 0 0 40
HARPOON THERAPEUTICS INC COM 41358P106 1 26 SH   OTR 1 0 0 26
HARTFORD FINL SVCS GROUP INC COM 416515104 9,394 199,656 SH   SOLE   199,656 0 0
HASBRO INC COM 418056107 8,691 96,727 SH   SOLE   96,727 0 0
HCA HEALTHCARE INC COM 40412C101 10,229 64,755 SH   SOLE   64,755 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 17,666 254,515 SH   SOLE   254,515 0 0
HEALTHPEAK PROPERTIES INC COM 42250P103 1,288 44,360 SH   SOLE   44,360 0 0
HEICO CORP NEW CL A 422806208 852 7,577 SH   SOLE   7,577 0 0
HENRY JACK & ASSOC INC COM 426281101 678 4,357 SH   SOLE   4,357 0 0
HENRY SCHEIN INC COM 806407102 772 12,022 SH   SOLE   12,022 0 0
HERON THERAPEUTICS INC COM 427746102 26,221 1,289,773 SH   SOLE   1,289,773 0 0
HERSHEY CO COM 427866108 2,543 17,377 SH   SOLE   17,377 0 0
HERSHEY CO COM 427866108 4 23 SH   OTR 1 0 0 23
HESS CORP COM 42809H107 1,253 24,709 SH   SOLE   24,709 0 0
HEWLETT PACKARD ENTERPRISE C COM 42824C109 1,788 157,107 SH   SOLE   157,107 0 0
HILL ROM HLDGS INC COM 431475102 16,579 176,171 SH   SOLE   176,171 0 0
HILTON WORLDWIDE HLDGS INC COM 43300A203 2,785 26,056 SH   SOLE   26,056 0 0
HMS HLDGS CORP COM 40425J101 8,682 245,943 SH   SOLE   245,943 0 0
HOLLYSYS AUTOMATION TCHNGY L SHS G45667105 11,913 844,237 SH   SOLE   844,237 0 0
HOLOGIC INC COM 436440101 66,859 955,700 SH   SOLE   955,700 0 0
HOLOGIC INC COM 436440101 2 31 SH   OTR 1 0 0 31
HOME DEPOT INC COM 437076102 5 16 SH   OTR 1 0 0 16
HOME DEPOT INC COM 437076102 56,904 223,027 SH   SOLE   223,027 0 0
HONEYWELL INTL INC COM 438516106 3,764 18,427 SH   SOLE   18,427 0 0
HORMEL FOODS CORP COM 440452100 1,199 26,788 SH   SOLE   26,788 0 0
HOST HOTELS & RESORTS INC COM 44107P104 2,016 143,432 SH   SOLE   143,432 0 0
HOWMET AEROSPACE INC COM 443201108 904 32,967 SH   SOLE   32,967 0 0
HP INC COM 40434L105 7,734 327,409 SH   SOLE   327,409 0 0
HP INC COM 40434L105 2 59 SH   OTR 1 0 0 59
HUAZHU GROUP LTD NOTE 0.375%11/0 16949NAC3 890 800 PRN   SOLE   800 0 0
HUBSPOT INC COM 443573100 2,131 5,613 SH   SOLE   5,613 0 0
HUMANA INC COM 444859102 13,329 33,821 SH   SOLE   33,821 0 0
HUNTINGTON BANCSHARES INC COM 446150104 3,237 266,831 SH   SOLE   266,831 0 0
HUNTINGTON INGALLS INDS INC COM 446413106 5,173 31,589 SH   SOLE   31,589 0 0
ICICI BANK LIMITED ADR 45104G104 13,981 979,441 SH   SOLE   979,441 0 0
IDEX CORP COM 45167R104 1,672 8,737 SH   SOLE   8,737 0 0
IDEXX LABS INC COM 45168D104 3,041 6,334 SH   SOLE   6,334 0 0
IGM BIOSCIENCES INC COM 449585108 9,235 108,887 SH   SOLE   108,887 0 0
IGM BIOSCIENCES INC COM 449585108 0 5 SH   OTR 1 0 0 5
IHS MARKIT LTD SHS G47567105 14,937 173,107 SH   SOLE   173,107 0 0
ILLINOIS TOOL WKS INC COM 452308109 5,441 27,785 SH   SOLE   27,785 0 0
ILLUMINA INC COM 452327109 84,172 236,832 SH   SOLE   236,832 0 0
ILLUMINA INC COM 452327109 1 2 SH   OTR 1 0 0 2
ILLUMINA INC NOTE 8/1 452327AK5 14,045 13,000 PRN   SOLE   13,000 0 0
IMMUNOVANT INC COM 45258J102 8,064 181,749 SH   SOLE   181,749 0 0
INCYTE CORP COM 45337C102 1 15 SH   OTR 1 0 0 15
INCYTE CORP COM 45337C102 47,898 573,283 SH   SOLE   573,283 0 0
INFOSYS LTD SPONSORED ADR 456788108 5,230 321,238 SH   SOLE   321,238 0 0
INGERSOLL RAND INC COM 45687V106 1,139 26,019 SH   SOLE   26,019 0 0
INGREDION INC COM 457187102 228 3,011 SH   SOLE   3,011 0 0
INPHI CORP COM 45772F107 9,750 63,252 SH   SOLE   63,252 0 0
INSMED INC COM PAR $.01 457669307 9,046 282,901 SH   SOLE   282,901 0 0
INSULET CORP COM 45784P101 859 3,498 SH   SOLE   3,498 0 0
INTEL CORP COM 458140100 4 59 SH   OTR 1 0 0 59
INTEL CORP COM 458140100 32,411 677,335 SH   SOLE   677,335 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 9,558 182,917 SH   SOLE   182,917 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 4,130 37,299 SH   SOLE   37,299 0 0
INTERNATIONAL BUSINESS MACHS COM 459200101 3 22 SH   OTR 1 0 0 22
INTERNATIONAL BUSINESS MACHS COM 459200101 14,598 120,771 SH   SOLE   120,771 0 0
INTERNATIONAL FLAVORS&FRAGRA COM 459506101 1,210 11,581 SH   SOLE   11,581 0 0
INTERNATIONAL PAPER CO COM 460146103 2 33 SH   OTR 1 0 0 33
INTERNATIONAL PAPER CO COM 460146103 1,649 34,521 SH   SOLE   34,521 0 0
INTERPUBLIC GROUP COS INC COM 460690100 5,367 237,553 SH   SOLE   237,553 0 0
INTERPUBLIC GROUP COS INC COM 460690100 1 47 SH   OTR 1 0 0 47
INTRA CELLULAR THERAPIES INC COM 46116X101 13,930 456,022 SH   SOLE   456,022 0 0
INTUIT COM 461202103 28,634 78,478 SH   SOLE   78,478 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 33,314 42,394 SH   SOLE   42,394 0 0
INVESCO EXCHANGE TRADED FD T WILDERHIL CLAN 46137V134 504 5,100 SH   SOLE   5,100 0 0
INVITATION HOMES INC COM 46187W107 736 25,784 SH   SOLE   25,784 0 0
IONIS PHARMACEUTICALS INC COM 462222100 13,412 246,954 SH   SOLE   246,954 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 0 13 SH   OTR 1 0 0 13
IOVANCE BIOTHERAPEUTICS INC COM 462260100 26,387 592,037 SH   SOLE   592,037 0 0
IQVIA HLDGS INC COM 46266C105 2,408 13,993 SH   SOLE   13,993 0 0
IQVIA HLDGS INC COM 46266C105 2 10 SH   OTR 1 0 0 10
IRON MTN INC NEW COM 46284V101 929 32,821 SH   SOLE   32,821 0 0
ISHARES INC MSCI CDA ETF 464286509 3,424 115,591 SH   SOLE   115,591 0 0
ISHARES TR GL CLEAN ENE ETF 464288224 200 7,400 SH   SOLE   7,400 0 0
ISHARES TR MSCI CHINA ETF 46429B671 1,160 15,000 SH   SOLE   15,000 0 0
ISHARES TR U.S. MED DVC ETF 464288810 216 690 SH   SOLE   690 0 0
ISIS PHARMACEUTICALS INC DEL NOTE 1.000%11/1 464337AJ3 1,992 1,900 PRN   SOLE   1,900 0 0
ITAU UNIBANCO HLDG S A SPON ADR REP PFD 465562106 1,276 218,200 SH   SOLE   218,200 0 0
ITEOS THERAPEUTICS INC COM 46565G104 1 18 SH   OTR 1 0 0 18
JD.COM INC SPON ADR CL A 47215P106 53,224 630,404 SH   SOLE   630,404 0 0
JOHNSON & JOHNSON COM 478160104 91,286 603,907 SH   SOLE   603,907 0 0
JOHNSON & JOHNSON COM 478160104 6 38 SH   OTR 1 0 0 38
JOUNCE THERAPEUTICS INC COM 481116101 0 5 SH   OTR 1 0 0 5
JPMORGAN CHASE & CO COM 46625H100 48,068 393,893 SH   SOLE   393,893 0 0
KANSAS CITY SOUTHERN COM NEW 485170302 8,716 44,450 SH   SOLE   44,450 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 0 44 SH   OTR 1 0 0 44
KARYOPHARM THERAPEUTICS INC COM 48576U106 14,149 951,530 SH   SOLE   951,530 0 0
KB FINL GROUP INC SPONSORED ADR 48241A105 258 6,776 SH   SOLE   6,776 0 0
KELLOGG CO COM 487836108 3,504 58,624 SH   SOLE   58,624 0 0
KEURIG DR PEPPER INC COM 49271V100 1 30 SH   OTR 1 0 0 30
KEURIG DR PEPPER INC COM 49271V100 1,064 34,619 SH   SOLE   34,619 0 0
KEYCORP COM 493267108 6,845 434,278 SH   SOLE   434,278 0 0
KEYSIGHT TECHNOLOGIES INC COM 49338L103 39,736 313,332 SH   SOLE   313,332 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 2,933 584,956 SH   SOLE   584,956 0 0
KIMBERLY-CLARK CORP COM 494368103 8,178 63,142 SH   SOLE   63,142 0 0
KIMCO RLTY CORP COM 49446R109 193 13,400 SH   SOLE   13,400 0 0
KINDER MORGAN INC DEL COM 49456B101 9,266 705,671 SH   SOLE   705,671 0 0
KINROSS GOLD CORP COM 496902404 320 45,375 SH   SOLE   45,375 0 0
KLA CORP COM NEW 482480100 11,479 46,169 SH   SOLE   46,169 0 0
KODIAK SCIENCES INC COM 50015M109 20,556 145,669 SH   SOLE   145,669 0 0
KRAFT HEINZ CO COM 500754106 1,766 53,104 SH   SOLE   53,104 0 0
KROGER CO COM 501044101 3 79 SH   OTR 1 0 0 79
KROGER CO COM 501044101 5,964 195,485 SH   SOLE   195,485 0 0
KURA ONCOLOGY INC COM 50127T109 1 36 SH   OTR 1 0 0 36
KURA ONCOLOGY INC COM 50127T109 29,152 929,241 SH   SOLE   929,241 0 0
KYMERA THERAPEUTICS INC COM 501575104 0 7 SH   OTR 1 0 0 7
LABORATORY CORP AMER HLDGS COM NEW 50540R409 2 7 SH   OTR 1 0 0 7
LABORATORY CORP AMER HLDGS COM NEW 50540R409 41,107 210,239 SH   SOLE   210,239 0 0
LAM RESEARCH CORP COM 512807108 6,289 13,874 SH   SOLE   13,874 0 0
LAMB WESTON HLDGS INC COM 513272104 753 9,954 SH   SOLE   9,954 0 0
LAS VEGAS SANDS CORP COM 517834107 1,178 20,578 SH   SOLE   20,578 0 0
LAUDER ESTEE COS INC CL A 518439104 23,464 91,770 SH   SOLE   91,770 0 0
LEMONADE INC COM 52567D107 644 5,500 SH   SOLE   5,500 0 0
LENNAR CORP CL A 526057104 1,013 13,832 SH   SOLE   13,832 0 0
LIBERTY BROADBAND CORP COM SER C 530307305 25,487 167,543 SH   SOLE   167,543 0 0
LIBERTY MEDIA CORP DEL COM C SIRIUSXM 531229607 680 16,259 SH   SOLE   16,259 0 0
LILLY ELI & CO COM 532457108 32,555 200,735 SH   SOLE   200,735 0 0
LINCOLN NATL CORP IND COM 534187109 1,047 21,668 SH   SOLE   21,668 0 0
LINDE PLC SHS G5494J103 1 4 SH   OTR 1 0 0 4
LITHIUM AMERS CORP NEW COM NEW 53680Q207 252 21,000 SH   SOLE   21,000 0 0
LIVE NATION ENTERTAINMENT IN COM 538034109 5,107 72,353 SH   SOLE   72,353 0 0
LOEWS CORP COM 540424108 940 21,743 SH   SOLE   21,743 0 0
LOOP INDS INC COM 543518104 828 103,898 SH   SOLE   103,898 0 0
LOWES COS INC COM 548661107 37,783 245,059 SH   SOLE   245,059 0 0
LULULEMON ATHLETICA INC COM 550021109 13,634 40,784 SH   SOLE   40,784 0 0
LUMENTUM HLDGS INC NOTE 0.500%12/1 55024UAD1 1,996 1,700 PRN   SOLE   1,700 0 0
LYFT INC CL A COM 55087P104 391 8,293 SH   SOLE   8,293 0 0
M & T BK CORP COM 55261F104 1,607 13,146 SH   SOLE   13,146 0 0
MACROGENICS INC COM 556099109 1 35 SH   OTR 1 0 0 35
MACROGENICS INC COM 556099109 14,846 676,095 SH   SOLE   676,095 0 0
MACYS INC COM 55616P104 269 25,000 SH   SOLE   25,000 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 3,387 31,722 SH   SOLE   31,722 0 0
MAGNA INTL INC COM 559222401 3,715 54,674 SH   SOLE   54,674 0 0
MANULIFE FINL CORP COM 56501R106 8,308 486,491 SH   SOLE   486,491 0 0
MARATHON OIL CORP COM 565849106 2,618 408,640 SH   SOLE   408,640 0 0
MARATHON PETE CORP COM 56585A102 1,641 41,307 SH   SOLE   41,307 0 0
MARKEL CORP COM 570535104 805 811 SH   SOLE   811 0 0
MARRIOTT INTL INC NEW CL A 571903202 2,639 20,829 SH   SOLE   20,829 0 0
MARSH & MCLENNAN COS INC COM 571748102 6,418 57,104 SH   SOLE   57,104 0 0
MARTIN MARIETTA MATLS INC COM 573284106 3,254 11,931 SH   SOLE   11,931 0 0
MARVELL TECHNOLOGY GROUP LTD ORD G5876H105 3,025 66,262 SH   SOLE   66,262 0 0
MASCO CORP COM 574599106 33,863 641,793 SH   SOLE   641,793 0 0
MASCO CORP COM 574599106 2 36 SH   OTR 1 0 0 36
MASIMO CORP COM 574795100 4,686 18,179 SH   SOLE   18,179 0 0
MASTERCARD INCORPORATED CL A 57636Q104 45,767 133,504 SH   SOLE   133,504 0 0
MATCH GROUP INC NEW COM 57667L107 1,838 12,654 SH   SOLE   12,654 0 0
MAXIM INTEGRATED PRODS INC COM 57772K101 2 19 SH   OTR 1 0 0 19
MAXIM INTEGRATED PRODS INC COM 57772K101 16,832 197,664 SH   SOLE   197,664 0 0
MCCORMICK & CO INC COM NON VTG 579780206 5,522 60,136 SH   SOLE   60,136 0 0
MCDONALDS CORP COM 580135101 10,395 50,434 SH   SOLE   50,434 0 0
MCDONALDS CORP COM 580135101 1 6 SH   OTR 1 0 0 6
MCKESSON CORP COM 58155Q103 5,893 35,275 SH   SOLE   35,275 0 0
MEDTRONIC PLC SHS G5960L103 4 38 SH   OTR 1 0 0 38
MERCADOLIBRE INC COM 58733R102 38,933 24,196 SH   SOLE   24,196 0 0
MERCK & CO. INC COM 58933Y105 17 224 SH   OTR 1 0 0 224
MERCK & CO. INC COM 58933Y105 287,291 3,656,397 SH   SOLE   3,656,397 0 0
MERSANA THERAPEUTICS INC COM 59045L106 1 79 SH   OTR 1 0 0 79
MERSANA THERAPEUTICS INC COM 59045L106 28,681 1,122,094 SH   SOLE   1,122,094 0 0
MESA LABS INC COM 59064R109 1,809 6,571 SH   SOLE   6,571 0 0
METLIFE INC COM 59156R108 3 47 SH   OTR 1 0 0 47
METLIFE INC COM 59156R108 14,029 311,082 SH   SOLE   311,082 0 0
METTLER TOLEDO INTERNATIONAL COM 592688105 2,324 2,123 SH   SOLE   2,123 0 0
MGM RESORTS INTERNATIONAL COM 552953101 1,344 44,429 SH   SOLE   44,429 0 0
MICROCHIP TECHNOLOGY INC. COM 595017104 11,191 84,358 SH   SOLE   84,358 0 0
MICRON TECHNOLOGY INC COM 595112103 713 500 PRN   SOLE   500 0 0
MICRON TECHNOLOGY INC COM 595112103 7,593 105,155 SH   SOLE   105,155 0 0
MICRON TECHNOLOGY INC COM 595112103 2 18 SH   OTR 1 0 0 18
MICROSOFT CORP COM 594918104 417,252 1,953,491 SH   SOLE   1,953,491 0 0
MICROSOFT CORP COM 594918104 24 102 SH   OTR 1 0 0 102
MID-AMER APT CMNTYS INC COM 59522J103 848 6,967 SH   SOLE   6,967 0 0
MIRATI THERAPEUTICS INC COM 60468T105 39,894 189,091 SH   SOLE   189,091 0 0
MIRATI THERAPEUTICS INC COM 60468T105 2 9 SH   OTR 1 0 0 9
MITSUBISHI UFJ FINL GROUP IN SPONSORED ADS 606822104 1 230 SH   OTR 1 0 0 230
MIZUHO FINANCIAL GROUP INC SPONSORED ADR 60687Y109 0 18 SH   OTR 1 0 0 18
MODERNA INC COM 60770K107 39,753 396,167 SH   SOLE   396,167 0 0
MOHAWK INDS INC COM 608190104 284 2,112 SH   SOLE   2,112 0 0
MOLINA HEALTHCARE INC COM 60855R100 539 2,636 SH   SOLE   2,636 0 0
MOLSON COORS BEVERAGE CO CL B 60871R209 732 16,858 SH   SOLE   16,858 0 0
MONDELEZ INTL INC CL A 609207105 8,379 149,200 SH   SOLE   149,200 0 0
MONGODB INC CL A 60937P106 1,063 3,086 SH   SOLE   3,086 0 0
MONSTER BEVERAGE CORP NEW COM 61174X109 8,436 94,968 SH   SOLE   94,968 0 0
MOODYS CORP COM 615369105 8,046 28,861 SH   SOLE   28,861 0 0
MORGAN STANLEY COM NEW 617446448 2,480 2,050 PRN   SOLE   2,050 0 0
MORGAN STANLEY COM NEW 617446448 29,300 445,107 SH   SOLE   445,107 0 0
MORGAN STANLEY COM NEW 617446448 6 73 SH   OTR 1 0 0 73
MORPHOSYS AG SPONSORED ADS 617760202 7,661 281,424 SH   SOLE   281,424 0 0
MORPHOSYS AG SPONSORED ADS 617760202 1 57 SH   OTR 1 0 0 57
MOSAIC CO NEW COM 61945C103 327 14,784 SH   SOLE   14,784 0 0
MOTOROLA SOLUTIONS INC COM NEW 620076307 5,662 34,658 SH   SOLE   34,658 0 0
MSCI INC COM 55354G100 2,166 5,050 SH   SOLE   5,050 0 0
NATIONAL FUEL GAS CO COM 636180101 433 10,958 SH   SOLE   10,958 0 0
NAVISTAR INTL CORP NEW COM 63934E108 12,886 305,169 SH   SOLE   305,169 0 0
NEKTAR THERAPEUTICS COM 640268108 4,998 306,085 SH   SOLE   306,085 0 0
NEOGENOMICS INC COM NEW 64049M209 15,334 296,506 SH   SOLE   296,506 0 0
NEOGENOMICS INC COM NEW 64049M209 1 13 SH   OTR 1 0 0 13
NEOLEUKIN THERAPEUTICS INC COM 64049K104 0 35 SH   OTR 1 0 0 35
NETAPP INC COM 64110D104 5,021 78,918 SH   SOLE   78,918 0 0
NETEASE INC SPONSORED ADS 64110W102 4,061 44,150 SH   SOLE   44,150 0 0
NETFLIX INC COM 64110L106 23,153 44,577 SH   SOLE   44,577 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 14,903 161,869 SH   SOLE   161,869 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 1,042 600 PRN   SOLE   600 0 0
NEW ORIENTAL ED & TECHNOLOGY SPON ADR 647581107 40,127 224,830 SH   SOLE   224,830 0 0
NEWMONT CORP COM 651639106 11,917 207,176 SH   SOLE   207,176 0 0
NEWMONT CORP COM 651639106 2 25 SH   OTR 1 0 0 25
NEXTERA ENERGY INC COM 65339F101 20,513 276,806 SH   SOLE   276,806 0 0
NEXTERA ENERGY PARTNERS LP COM UNIT PART IN 65341B106 16,093 249,866 SH   SOLE   249,866 0 0
NEXTERA ENERGY PARTNERS LP COM UNIT PART IN 65341B106 2 31 SH   OTR 1 0 0 31
NGM BIOPHARMACEUTICALS INC COM 62921N105 6,450 221,634 SH   SOLE   221,634 0 0
NIKE INC CL B 654106103 4 27 SH   OTR 1 0 0 27
NIKE INC CL B 654106103 71,979 529,697 SH   SOLE   529,697 0 0
NIO INC SPON ADS 62914V106 16,920 361,449 SH   SOLE   361,449 0 0
NKARTA INC COM 65487U108 0 4 SH   OTR 1 0 0 4
NKARTA INC COM 65487U108 3,964 67,142 SH   SOLE   67,142 0 0
NOMAD FOODS LTD USD ORD SHS G6564A105 2,096 85,859 SH   SOLE   85,859 0 0
NORFOLK SOUTHN CORP COM 655844108 8,232 36,069 SH   SOLE   36,069 0 0
NORTHERN TR CORP COM 665859104 14,554 162,673 SH   SOLE   162,673 0 0
NORTONLIFELOCK INC COM 668771108 7,557 378,597 SH   SOLE   378,597 0 0
NOVAVAX INC COM NEW 670002401 7,771 72,549 SH   SOLE   72,549 0 0
NOVOCURE LTD ORD SHS G6674U108 0 2 SH   OTR 1 0 0 2
NOVO-NORDISK A S ADR 670100205 2 29 SH   OTR 1 0 0 29
NU SKIN ENTERPRISES INC CL A 67018T105 1,762 33,575 SH   SOLE   33,575 0 0
NUANCE COMMUNICATIONS INC COM 67020Y100 3,479 82,150 SH   SOLE   82,150 0 0
NUCOR CORP COM 670346105 2,634 51,554 SH   SOLE   51,554 0 0
NURIX THERAPEUTICS INC COM 67080M103 0 13 SH   OTR 1 0 0 13
NUTRIEN LTD COM 67077M108 663 14,370 SH   SOLE   14,370 0 0
NVIDIA CORPORATION COM 67066G104 76,391 152,300 SH   SOLE   152,300 0 0
NVR INC COM 62944T105 1,030 263 SH   SOLE   263 0 0
OCCIDENTAL PETE CORP COM 674599105 3,077 185,084 SH   SOLE   185,084 0 0
OKTA INC CL A 679295105 5,366 21,976 SH   SOLE   21,976 0 0
OKTA INC NOTE 0.125% 9/0 679295AD7 864 600 PRN   SOLE   600 0 0
OLD DOMINION FREIGHT LINE IN COM 679580100 6,411 34,199 SH   SOLE   34,199 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 0 13 SH   OTR 1 0 0 13
OMNICOM GROUP INC COM 681919106 2,881 48,083 SH   SOLE   48,083 0 0
OMNICOM GROUP INC COM 681919106 2 23 SH   OTR 1 0 0 23
ON SEMICONDUCTOR CORP COM 682189105 3 78 SH   OTR 1 0 0 78
ON SEMICONDUCTOR CORP COM 682189105 40,488 1,287,831 SH   SOLE   1,287,831 0 0
ON SEMICONDUCTOR CORP NOTE 1.625%10/1 682189AP0 815 500 PRN   SOLE   500 0 0
ONEOK INC NEW COM 682680103 988 800 PRN   SOLE   800 0 0
ONEOK INC NEW COM 682680103 8,375 227,174 SH   SOLE   227,174 0 0
ORACLE CORP COM 68389X105 17,907 288,177 SH   SOLE   288,177 0 0
OREILLY AUTOMOTIVE INC COM 67103H107 1,753 4,032 SH   SOLE   4,032 0 0
ORMAT TECHNOLOGIES INC COM 686688102 7,621 87,885 SH   SOLE   87,885 0 0
OTIS WORLDWIDE CORP COM 68902V107 5,105 78,675 SH   SOLE   78,675 0 0
OUTSET MED INC COM 690145107 2,803 51,343 SH   SOLE   51,343 0 0
OWENS CORNING NEW COM 690742101 2 18 SH   OTR 1 0 0 18
OWENS CORNING NEW COM 690742101 5,441 74,764 SH   SOLE   74,764 0 0
PACCAR INC COM 693718108 3,472 41,896 SH   SOLE   41,896 0 0
PACKAGING CORP AMER COM 695156109 13,041 98,444 SH   SOLE   98,444 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 12,833 234,950 SH   SOLE   234,950 0 0
PALO ALTO NETWORKS INC COM 697435105 73,210 214,599 SH   SOLE   214,599 0 0
PALO ALTO NETWORKS INC COM 697435105 2 5 SH   OTR 1 0 0 5
PALO ALTO NETWORKS INC NOTE 0.750% 7/0 697435AD7 4,545 3,500 PRN   SOLE   3,500 0 0
PARKER-HANNIFIN CORP COM 701094104 3 8 SH   OTR 1 0 0 8
PARKER-HANNIFIN CORP COM 701094104 14,229 54,404 SH   SOLE   54,404 0 0
PAYCHEX INC COM 704326107 1,944 21,716 SH   SOLE   21,716 0 0
PAYCOM SOFTWARE INC COM 70432V102 1,260 2,901 SH   SOLE   2,901 0 0
PAYPAL HLDGS INC COM 70450Y103 121,060 538,730 SH   SOLE   538,730 0 0
PELOTON INTERACTIVE INC CL A COM 70614W100 3,621 24,847 SH   SOLE   24,847 0 0
PEMBINA PIPELINE CORP COM 706327103 6,399 281,978 SH   SOLE   281,978 0 0
PEOPLES UNITED FINANCIAL INC COM 712704105 151 12,163 SH   SOLE   12,163 0 0
PEPSICO INC COM 713448108 4 28 SH   OTR 1 0 0 28
PEPSICO INC COM 713448108 64,267 451,154 SH   SOLE   451,154 0 0
PERKINELMER INC COM 714046109 2 17 SH   OTR 1 0 0 17
PERSONALIS INC COM 71535D106 7,431 211,316 SH   SOLE   211,316 0 0
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408 270 25,150 SH   SOLE   25,150 0 0
PFIZER INC COM 717081103 5,286 149,694 SH   SOLE   149,694 0 0
PHILLIPS 66 COM 718546104 1 17 SH   OTR 1 0 0 17
PHILLIPS 66 COM 718546104 2,689 40,021 SH   SOLE   40,021 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 0 85 SH   OTR 1 0 0 85
PIERIS PHARMACEUTICALS INC COM 720795103 5,458 2,272,642 SH   SOLE   2,272,642 0 0
PINDUODUO INC NOTE 12/0 722304AC6 1,664 1,400 PRN   SOLE   1,400 0 0
PINDUODUO INC SPONSORED ADS 722304102 56,182 329,200 SH   SOLE   329,200 0 0
PINTEREST INC CL A 72352L106 1,380 21,794 SH   SOLE   21,794 0 0
PIONEER NAT RES CO COM 723787107 1,038 9,486 SH   SOLE   9,486 0 0
PLANET FITNESS INC CL A 72703H101 6,245 83,743 SH   SOLE   83,743 0 0
PLURALSIGHT INC COM CL A 72941B106 4,411 219,098 SH   SOLE   219,098 0 0
PNC FINL SVCS GROUP INC COM 693475105 14,807 103,458 SH   SOLE   103,458 0 0
POSCO SPONSORED ADR 693483109 223 3,720 SH   SOLE   3,720 0 0
POWER INTEGRATIONS INC COM 739276103 3 33 SH   OTR 1 0 0 33
POWER INTEGRATIONS INC COM 739276103 16,033 203,902 SH   SOLE   203,902 0 0
PPG INDS INC COM 693506107 4,624 33,377 SH   SOLE   33,377 0 0
PPG INDS INC COM 693506107 2 12 SH   OTR 1 0 0 12
PRICE T ROWE GROUP INC COM 74144T108 10,114 69,553 SH   SOLE   69,553 0 0
PRICELINE GRP INC NOTE 0.900% 9/1 741503AX4 19,732 17,522 PRN   SOLE   17,522 0 0
PRINCIPAL FINANCIAL GROUP IN COM 74251V102 1,254 26,320 SH   SOLE   26,320 0 0
PROCTER AND GAMBLE CO COM 742718109 150,803 1,128,327 SH   SOLE   1,128,327 0 0
PROCTER AND GAMBLE CO COM 742718109 7 50 SH   OTR 1 0 0 50
PROGRESSIVE CORP COM 743315103 8,857 93,246 SH   SOLE   93,246 0 0
PROGRESSIVE CORP COM 743315103 9,024 7,100 PRN   SOLE   7,100 0 0
PROLOGIS INC. COM 74340W103 19,420 202,866 SH   SOLE   202,866 0 0
PROOFPOINT INC NOTE 0.250% 8/1 743424AF0 2,797 2,600 PRN   SOLE   2,600 0 0
PRUDENTIAL FINL INC COM 744320102 3 37 SH   OTR 1 0 0 37
PRUDENTIAL FINL INC COM 744320102 16,671 222,308 SH   SOLE   222,308 0 0
PTC INC COM 69370C100 35,162 306,039 SH   SOLE   306,039 0 0
PTC THERAPEUTICS INC COM 69366J200 35,139 599,397 SH   SOLE   599,397 0 0
PUBLIC STORAGE COM 74460D109 2,163 9,749 SH   SOLE   9,749 0 0
PUBLIC SVC ENTERPRISE GRP IN COM 744573106 2,520 45,000 SH   SOLE   45,000 0 0
PULTE GROUP INC COM 745867101 3,185 76,899 SH   SOLE   76,899 0 0
QIWI PLC SPON ADR REP B 74735M108 594 60,000 SH   SOLE   60,000 0 0
QORVO INC COM 74736K101 26,049 163,099 SH   SOLE   163,099 0 0
QUALCOMM INC COM 747525103 2 14 SH   OTR 1 0 0 14
QUALCOMM INC COM 747525103 106,023 724,565 SH   SOLE   724,565 0 0
QUEST DIAGNOSTICS INC COM 74834L100 6,405 56,010 SH   SOLE   56,010 0 0
RADIUS HEALTH INC COM NEW 750469207 6,048 352,567 SH   SOLE   352,567 0 0
RAYMOND JAMES FINL INC COM 754730109 245 2,666 SH   SOLE   2,666 0 0
RAYTHEON TECHNOLOGIES CORP COM 75513E101 222 3,250 SH   SOLE   3,250 0 0
REALPAGE INC COM 75606N109 17,264 206,012 SH   SOLE   206,012 0 0
REALTY INCOME CORP COM 756109104 1,193 19,976 SH   SOLE   19,976 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 18,014 151,707 SH   SOLE   151,707 0 0
REDHILL BIOPHARMA LTD SPONSORED ADS 757468103 637 82,523 SH   SOLE   82,523 0 0
REGENERON PHARMACEUTICALS COM 75886F107 187,305 403,624 SH   SOLE   403,624 0 0
REGENERON PHARMACEUTICALS COM 75886F107 8 17 SH   OTR 1 0 0 17
REGIONS FINANCIAL CORP NEW COM 7591EP100 11,356 733,357 SH   SOLE   733,357 0 0
REINSURANCE GRP OF AMERICA I COM NEW 759351604 740 6,648 SH   SOLE   6,648 0 0
RELAY THERAPEUTICS INC COM 75943R102 0 11 SH   OTR 1 0 0 11
RENEWABLE ENERGY GROUP INC COM NEW 75972A301 2,879 42,316 SH   SOLE   42,316 0 0
REPLIMUNE GROUP INC COM 76029N106 1 18 SH   OTR 1 0 0 18
REPLIMUNE GROUP INC COM 76029N106 5,942 162,142 SH   SOLE   162,142 0 0
REPUBLIC SVCS INC COM 760759100 1,634 17,662 SH   SOLE   17,662 0 0
REPUBLIC SVCS INC COM 760759100 4 45 SH   OTR 1 0 0 45
RESMED INC COM 761152107 3,629 17,775 SH   SOLE   17,775 0 0
RESTAURANT BRANDS INTL INC COM 76131D103 9,504 161,949 SH   SOLE   161,949 0 0
REVOLUTION MEDICINES INC COM 76155X100 0 10 SH   OTR 1 0 0 10
RINGCENTRAL INC CL A 76680R206 1,655 4,546 SH   SOLE   4,546 0 0
RIO TINTO PLC SPONSORED ADR 767204100 4 54 SH   OTR 1 0 0 54
RIO TINTO PLC SPONSORED ADR 767204100 771 10,665 SH   SOLE   10,665 0 0
ROBERT HALF INTL INC COM 770323103 282 4,702 SH   SOLE   4,702 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 6,782 128,749 SH   SOLE   128,749 0 0
ROCKWELL AUTOMATION INC COM 773903109 3 13 SH   OTR 1 0 0 13
ROCKWELL AUTOMATION INC COM 773903109 44,601 185,130 SH   SOLE   185,130 0 0
ROGERS COMMUNICATIONS INC CL B 775109200 592 13,245 SH   SOLE   13,245 0 0
ROGERS CORP COM 775133101 210 1,406 SH   SOLE   1,406 0 0
ROGERS CORP COM 775133101 1,218 1,000 PRN   SOLE   1,000 0 0
ROKU INC COM CL A 77543R102 1,741 5,458 SH   SOLE   5,458 0 0
ROPER TECHNOLOGIES INC COM 776696106 7,064 17,058 SH   SOLE   17,058 0 0
ROSS STORES INC COM 778296103 2,485 21,065 SH   SOLE   21,065 0 0
ROYAL BK CDA COM 780087102 6,951 88,150 SH   SOLE   88,150 0 0
ROYAL BK CDA COM 780087102 4 47 SH   OTR 1 0 0 47
ROYAL DUTCH SHELL PLC SPON ADR B 780259107 257 8,000 SH   SOLE   8,000 0 0
ROYAL DUTCH SHELL PLC SPONS ADR A 780259206 1 24 SH   OTR 1 0 0 24
S&P GLOBAL INC COM 78409V104 1 4 SH   OTR 1 0 0 4
S&P GLOBAL INC COM 78409V104 41,256 130,659 SH   SOLE   130,659 0 0
SAGE THERAPEUTICS INC COM 78667J108 12,020 144,647 SH   SOLE   144,647 0 0
SALESFORCE COM INC COM 79466L302 1 7 SH   OTR 1 0 0 7
SALESFORCE COM INC COM 79466L302 57,507 269,070 SH   SOLE   269,070 0 0
SANOFI SPONSORED ADR 80105N105 3,269 70,048 SH   SOLE   70,048 0 0
SAREPTA THERAPEUTICS INC COM 803607100 26,859 164,008 SH   SOLE   164,008 0 0
SBA COMMUNICATIONS CORP NEW CL A 78410G104 6,889 25,421 SH   SOLE   25,421 0 0
SCHLUMBERGER LTD COM 806857108 11,172 532,942 SH   SOLE   532,942 0 0
SCHWAB CHARLES CORP COM 808513105 4,920 96,577 SH   SOLE   96,577 0 0
SEA LTD SPONSORD ADS 81141R100 238 1,250 SH   SOLE   1,250 0 0
SEAGEN INC COM 81181C104 4 30 SH   OTR 1 0 0 30
SEAGEN INC COM 81181C104 86,241 512,627 SH   SOLE   512,627 0 0
SEMPRA ENERGY COM 816851109 4,571 37,347 SH   SOLE   37,347 0 0
SERVICENOW INC COM 81762P102 17,032 32,219 SH   SOLE   32,219 0 0
SHERWIN WILLIAMS CO COM 824348106 12,698 17,987 SH   SOLE   17,987 0 0
SHINHAN FINANCIAL GROUP CO L SPN ADR RESTRD 824596100 520 18,184 SH   SOLE   18,184 0 0
SHOPIFY INC CL A 82509L107 1,519 1,402 SH   SOLE   1,402 0 0
SHOPIFY INC NOTE 0.125%11/0 82509LAA5 2,886 2,450 PRN   SOLE   2,450 0 0
SILICON LABORATORIES INC COM 826919102 27,238 222,686 SH   SOLE   222,686 0 0
SILVERBACK THERAPEUTICS INC COM 82835W108 1 13 SH   OTR 1 0 0 13
SIMON PPTY GROUP INC NEW COM 828806109 1,742 21,263 SH   SOLE   21,263 0 0
SIRIUS XM HOLDINGS INC COM 82968B103 63 10,254 SH   SOLE   10,254 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 1,642 11,180 SH   SOLE   11,180 0 0
SLACK TECHNOLOGIES INC COM CL A 83088V102 21,767 536,463 SH   SOLE   536,463 0 0
SLEEP NUMBER CORP COM 83125X103 805 750 PRN   SOLE   750 0 0
SLEEP NUMBER CORP COM 83125X103 1,219 15,507 SH   SOLE   15,507 0 0
SMITH A O CORP COM 831865209 386 7,334 SH   SOLE   7,334 0 0
SMUCKER J M CO COM NEW 832696405 1,204 10,845 SH   SOLE   10,845 0 0
SNAP INC CL A 83304A106 2,325 48,350 SH   SOLE   48,350 0 0
SNAP INC NOTE 0.750% 8/0 83304AAB2 3,525 2,600 PRN   SOLE   2,600 0 0
SNAP ON INC COM 833034101 1,171 7,123 SH   SOLE   7,123 0 0
SOCIEDAD QUIMICA Y MINERA DE SPON ADR SER B 833635105 33,329 706,800 SH   SOLE   706,800 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104 3 10 SH   OTR 1 0 0 10
SOLAREDGE TECHNOLOGIES INC COM 83417M104 27,031 88,184 SH   SOLE   88,184 0 0
SONY CORP SPONSORED ADR 835699307 2,408 24,820 SH   SOLE   24,820 0 0
SONY CORP SPONSORED ADR 835699307 4 36 SH   OTR 1 0 0 36
SOUTHERN COPPER CORP COM 84265V105 5,505 88,000 SH   SOLE   88,000 0 0
SOUTHWEST AIRLS CO NOTE 1.250% 5/0 844741BG2 4,493 3,200 PRN   SOLE   3,200 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 2,433 590,800 SH Put SOLE   590,800 0 0
SPLUNK INC COM 848637104 38,860 238,200 SH   SOLE   238,200 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 9,465 135,870 SH   SOLE   135,870 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 1 9 SH   OTR 1 0 0 9
SQUARE INC CL A 852234103 4,885 23,368 SH   SOLE   23,368 0 0
STANLEY BLACK & DECKER INC COM 854502101 3,106 18,109 SH   SOLE   18,109 0 0
STARBUCKS CORP COM 855244109 65,070 633,214 SH   SOLE   633,214 0 0
STARBUCKS CORP COM 855244109 2 14 SH   OTR 1 0 0 14
STATE STR CORP COM 857477103 9,077 129,832 SH   SOLE   129,832 0 0
STEEL DYNAMICS INC COM 858119100 978 27,611 SH   SOLE   27,611 0 0
STRYKER CORPORATION COM 863667101 7,634 32,432 SH   SOLE   32,432 0 0
SUMITOMO MITSUI FINL GROUP I SPONSORED ADR 86562M209 0 6 SH   OTR 1 0 0 6
SUN CMNTYS INC COM 866674104 848 5,808 SH   SOLE   5,808 0 0
SUN LIFE FINANCIAL INC. COM 866796105 10,421 244,201 SH   SOLE   244,201 0 0
SUNCOR ENERGY INC NEW COM 867224107 819 50,853 SH   SOLE   50,853 0 0
SUTRO BIOPHARMA INC COM 869367102 7,676 368,086 SH   SOLE   368,086 0 0
SUTRO BIOPHARMA INC COM 869367102 1 24 SH   OTR 1 0 0 24
SVB FINANCIAL GROUP COM 78486Q101 6,044 16,224 SH   SOLE   16,224 0 0
SYNCHRONY FINANCIAL COM 87165B103 3,775 113,238 SH   SOLE   113,238 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 548 25,671 SH   SOLE   25,671 0 0
SYNOPSYS INC COM 871607107 3 12 SH   OTR 1 0 0 12
SYNOPSYS INC COM 871607107 23,665 95,035 SH   SOLE   95,035 0 0
SYSCO CORP COM 871829107 2,610 36,583 SH   SOLE   36,583 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 2 19 SH   OTR 1 0 0 19
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 108,683 1,037,755 SH   SOLE   1,037,755 0 0
TAKE-TWO INTERACTIVE SOFTWAR COM 874054109 6,654 33,341 SH   SOLE   33,341 0 0
TAL EDUCATION GROUP SPONSORED ADS 874080104 13,788 200,812 SH   SOLE   200,812 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 4,813 52,370 SH   SOLE   52,370 0 0
TANGER FACTORY OUTLET CTRS I COM 875465106 134 14,000 SH   SOLE   14,000 0 0
TARGET CORP COM 87612E106 5,386 31,765 SH   SOLE   31,765 0 0
TARGET CORP COM 87612E106 2 9 SH   OTR 1 0 0 9
TC ENERGY CORP COM 87807B107 921 23,613 SH   SOLE   23,613 0 0
TCR2 THERAPEUTICS INC COM 87808K106 1 26 SH   OTR 1 0 0 26
TCR2 THERAPEUTICS INC COM 87808K106 11,714 394,262 SH   SOLE   394,262 0 0
TE CONNECTIVITY LTD REG SHS H84989104 4 32 SH   OTR 1 0 0 32
TEAM INC NOTE 5.000% 8/0 878155AE0 179 200,000 PRN   SOLE   200,000 0 0
TECK RESOURCES LTD CL B 878742204 525 30,135 SH   SOLE   30,135 0 0
TELADOC HEALTH INC COM 87918A105 5,192 27,034 SH   SOLE   27,034 0 0
TELEDYNE TECHNOLOGIES INC COM 879360105 1,067 2,834 SH   SOLE   2,834 0 0
TELEFLEX INCORPORATED COM 879369106 906 2,292 SH   SOLE   2,292 0 0
TELEFONICA S A SPONSORED ADR 879382208 2 542 SH   OTR 1 0 0 542
TELUS CORPORATION COM 87971M103 7,030 369,843 SH   SOLE   369,843 0 0
TENABLE HLDGS INC COM 88025T102 31,550 628,489 SH   SOLE   628,489 0 0
TERNIUM SA SPONSORED ADS 880890108 22,296 798,200 SH   SOLE   798,200 0 0
TESLA INC COM 88160R101 105,200 154,968 SH   SOLE   154,968 0 0
TESLA INC COM 88160R101 1,019 889 PRN   SOLE   889 0 0
TESLA INC COM 88160R101 2 3 SH   OTR 1 0 0 3
TETRA TECH INC NEW COM 88162G103 15,274 137,334 SH   SOLE   137,334 0 0
TETRA TECH INC NEW COM 88162G103 4 26 SH   OTR 1 0 0 26
TEXAS INSTRS INC COM 882508104 27,430 174,003 SH   SOLE   174,003 0 0
TEXAS INSTRS INC COM 882508104 4 19 SH   OTR 1 0 0 19
TG THERAPEUTICS INC COM 88322Q108 2 37 SH   OTR 1 0 0 37
TG THERAPEUTICS INC COM 88322Q108 50,478 1,010,190 SH   SOLE   1,010,190 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 9 19 SH   OTR 1 0 0 19
THERMO FISHER SCIENTIFIC INC COM 883556102 163,648 365,807 SH   SOLE   365,807 0 0
THOMSON REUTERS CORP. COM NEW 884903709 7,420 94,467 SH   SOLE   94,467 0 0
TILLYS INC CL A 886885102 936 120,000 SH   SOLE   120,000 0 0
TJX COS INC NEW COM 872540109 13,931 212,372 SH   SOLE   212,372 0 0
T-MOBILE US INC COM 872590104 1 6 SH   OTR 1 0 0 6
T-MOBILE US INC COM 872590104 3,585 27,679 SH   SOLE   27,679 0 0
TOPBUILD CORP COM 89055F103 5 25 SH   OTR 1 0 0 25
TOPBUILD CORP COM 89055F103 32,411 183,296 SH   SOLE   183,296 0 0
TORONTO DOMINION BK ONT COM NEW 891160509 7,750 142,913 SH   SOLE   142,913 0 0
TOYOTA MOTOR CORP SP ADR REP2COM 892331307 6 36 SH   OTR 1 0 0 36
TPI COMPOSITES INC COM 87266J104 2,050 40,443 SH   SOLE   40,443 0 0
TRACTOR SUPPLY CO COM 892356106 5,637 41,742 SH   SOLE   41,742 0 0
TRANE TECHNOLOGIES PLC SHS G8994E103 3 20 SH   OTR 1 0 0 20
TRANSUNION COM 89400J107 1,152 12,089 SH   SOLE   12,089 0 0
TRAVELERS COMPANIES INC COM 89417E109 1 8 SH   OTR 1 0 0 8
TRAVELERS COMPANIES INC COM 89417E109 16,468 122,137 SH   SOLE   122,137 0 0
TREX CO INC COM 89531P105 2 22 SH   OTR 1 0 0 22
TREX CO INC COM 89531P105 11,954 148,650 SH   SOLE   148,650 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 0 42 SH   OTR 1 0 0 42
TRIMBLE INC COM 896239100 55,094 859,007 SH   SOLE   859,007 0 0
TRIMBLE INC COM 896239100 4 51 SH   OTR 1 0 0 51
TRUIST FINL CORP COM 89832Q109 3,941 85,593 SH   SOLE   85,593 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 1 13 SH   OTR 1 0 0 13
TURNING POINT THERAPEUTICS I COM 90041T108 53,481 456,928 SH   SOLE   456,928 0 0
TWILIO INC CL A 90138F102 3,745 11,538 SH   SOLE   11,538 0 0
TWITTER INC COM 90184L102 10,639 204,005 SH   SOLE   204,005 0 0
TWITTER INC NOTE 0.250% 6/1 90184LAF9 7,462 6,400 PRN   SOLE   6,400 0 0
TWITTER INC NOTE 1.000% 9/1 90184LAD4 8,078 208,000 PRN   SOLE   208,000 0 0
TYLER TECHNOLOGIES INC COM 902252105 995 2,374 SH   SOLE   2,374 0 0
UBER TECHNOLOGIES INC COM 90353T100 1,261 25,875 SH   SOLE   25,875 0 0
UDR INC COM 902653104 240 6,499 SH   SOLE   6,499 0 0
UGI CORP NEW COM 902681105 1,477 43,985 SH   SOLE   43,985 0 0
ULTA BEAUTY INC COM 90384S303 4,445 16,114 SH   SOLE   16,114 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 13,088 98,429 SH   SOLE   98,429 0 0
UNILEVER PLC SPON ADR NEW 904767704 4 77 SH   OTR 1 0 0 77
UNILEVER PLC SPON ADR NEW 904767704 2,664 45,955 SH   SOLE   45,955 0 0
UNION PAC CORP COM 907818108 56,025 280,111 SH   SOLE   280,111 0 0
UNITED MICROELECTRONICS CORP SPON ADR NEW 910873405 525 64,827 SH   SOLE   64,827 0 0
UNITED PARCEL SERVICE INC CL B 911312106 23,768 146,937 SH   SOLE   146,937 0 0
UNITED RENTALS INC COM 911363109 10,704 48,052 SH   SOLE   48,052 0 0
UNITEDHEALTH GROUP INC COM 91324P102 55,206 163,891 SH   SOLE   163,891 0 0
UNITEDHEALTH GROUP INC COM 91324P102 4 12 SH   OTR 1 0 0 12
UNITEDHEALTH GROUP INC COM 91324P102 993 1,000 PRN   SOLE   1,000 0 0
UNIVERSAL DISPLAY CORP COM 91347P105 32,664 147,978 SH   SOLE   147,978 0 0
UNIVERSAL DISPLAY CORP COM 91347P105 2 9 SH   OTR 1 0 0 9
UNUM THERAPEUTICS INC COM 19240Q201 5,121 474,701 SH   SOLE   474,701 0 0
UNUM THERAPEUTICS INC COM 19240Q201 1 108 SH   OTR 1 0 0 108
US BANCORP DEL COM NEW 902973304 4,289 95,840 SH   SOLE   95,840 0 0
V F CORP COM 918204108 16,168 197,069 SH   SOLE   197,069 0 0
V F CORP COM 918204108 1 17 SH   OTR 1 0 0 17
VAIL RESORTS INC COM 91879Q109 200 746 SH   SOLE   746 0 0
VALE S A SPONSORED ADS 91912E105 220 13,710 SH   SOLE   13,710 0 0
VALERO ENERGY CORP COM 91913Y100 1,607 29,573 SH   SOLE   29,573 0 0
VANGUARD INDEX FDS LARGE CAP ETF 922908637 198 1,180 SH   SOLE   1,180 0 0
VARIAN MED SYS INC COM 92220P105 31,373 186,621 SH   SOLE   186,621 0 0
VARONIS SYS INC COM 922280102 23,279 148,122 SH   SOLE   148,122 0 0
VEEVA SYS INC CL A COM 922475108 4,086 15,626 SH   SOLE   15,626 0 0
VENTAS INC COM 92276F100 1,693 35,930 SH   SOLE   35,930 0 0
VEREIT INC COM 92339V308 595 16,378 SH   SOLE   16,378 0 0
VERICEL CORP COM 92346J108 1,066 35,941 SH   SOLE   35,941 0 0
VERISIGN INC COM 92343E102 1,462 7,035 SH   SOLE   7,035 0 0
VERISIGN INC COM 92343E102 2 10 SH   OTR 1 0 0 10
VERISK ANALYTICS INC COM 92345Y106 15,859 79,533 SH   SOLE   79,533 0 0
VERISK ANALYTICS INC COM 92345Y106 2 11 SH   OTR 1 0 0 11
VERIZON COMMUNICATIONS INC COM 92343V104 37,523 664,918 SH   SOLE   664,918 0 0
VERIZON COMMUNICATIONS INC COM 92343V104 5 83 SH   OTR 1 0 0 83
VERTEX PHARMACEUTICALS INC COM 92532F100 176,969 779,532 SH   SOLE   779,532 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 3 14 SH   OTR 1 0 0 14
VIACOMCBS INC CL B 92556H206 1,178 32,908 SH   SOLE   32,908 0 0
VIATRIS INC COM 92556V106 4,618 256,550 SH   SOLE   256,550 0 0
VIEWRAY INC COM 92672L107 3,159 860,887 SH   SOLE   860,887 0 0
VIEWRAY INC COM 92672L107 0 75 SH   OTR 1 0 0 75
VIPSHOP HOLDINGS LIMITED SPONSORED ADS A 92763W103 43,205 1,600,094 SH   SOLE   1,600,094 0 0
VIR BIOTECHNOLOGY INC COM 92764N102 5,820 226,238 SH   SOLE   226,238 0 0
VISA INC COM CL A 92826C839 82,853 394,422 SH   SOLE   394,422 0 0
VISA INC COM CL A 92826C839 5 24 SH   OTR 1 0 0 24
VMWARE INC CL A COM 928563402 2 11 SH   OTR 1 0 0 11
VMWARE INC CL A COM 928563402 29,027 215,449 SH   SOLE   215,449 0 0
VODAFONE GROUP PLC NEW SPONSORED ADR 92857W308 1 48 SH   OTR 1 0 0 48
VONAGE HLDGS CORP COM 92886T201 1,329 79,500 SH   SOLE   79,500 0 0
VORNADO RLTY TR SH BEN INT 929042109 1,200 33,459 SH   SOLE   33,459 0 0
VOYA FINANCIAL INC COM 929089100 467 8,265 SH   SOLE   8,265 0 0
VULCAN MATLS CO COM 929160109 1,254 8,804 SH   SOLE   8,804 0 0
WABTEC COM 929740108 4,341 61,732 SH   SOLE   61,732 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 1 25 SH   OTR 1 0 0 25
WALGREENS BOOTS ALLIANCE INC COM 931427108 2,805 73,216 SH   SOLE   73,216 0 0
WALMART INC COM 931142103 2,572 18,579 SH   SOLE   18,579 0 0
WASTE CONNECTIONS INC COM 94106B101 16,611 168,598 SH   SOLE   168,598 0 0
WASTE CONNECTIONS INC COM 94106B101 2 21 SH   OTR 1 0 0 21
WASTE MGMT INC DEL COM 94106L109 9 71 SH   OTR 1 0 0 71
WASTE MGMT INC DEL COM 94106L109 78,418 692,452 SH   SOLE   692,452 0 0
WATERS CORP COM 941848103 1,455 6,124 SH   SOLE   6,124 0 0
WAYFAIR INC CL A 94419L101 759 3,500 SH   SOLE   3,500 0 0
WEIBO CORP NOTE 1.250%11/1 948596AC5 3,748 4,000 PRN   SOLE   4,000 0 0
WELLS FARGO CO NEW COM 949746101 6,597 227,589 SH   SOLE   227,589 0 0
WELLTOWER INC COM 95040Q104 2,766 44,556 SH   SOLE   44,556 0 0
WEST PHARMACEUTICAL SVSC INC COM 955306105 6,700 24,620 SH   SOLE   24,620 0 0
WESTERN DIGITAL CORP. COM 958102105 1,124 21,134 SH   SOLE   21,134 0 0
WESTERN DIGITAL CORP. NOTE 1.500% 2/0 958102AP0 6,935 7,000 PRN   SOLE   7,000 0 0
WESTERN UN CO COM 959802109 912 1,000 PRN   SOLE   1,000 0 0
WESTERN UN CO COM 959802109 638 30,285 SH   SOLE   30,285 0 0
WESTPAC BANKING CORP SPONSORED ADR 961214301 2 97 SH   OTR 1 0 0 97
WESTROCK CO COM 96145D105 2,308 55,192 SH   SOLE   55,192 0 0
WEYERHAEUSER CO MTN BE COM NEW 962166104 3,887 120,700 SH   SOLE   120,700 0 0
WHEATON PRECIOUS METALS CORP COM 962879102 449 11,191 SH   SOLE   11,191 0 0
WHIRLPOOL CORP COM 963320106 614 3,543 SH   SOLE   3,543 0 0
WILLIAMS COS INC COM 969457100 1,412 1,000 PRN   SOLE   1,000 0 0
WILLIAMS COS INC COM 969457100 8,161 423,768 SH   SOLE   423,768 0 0
WIPRO LTD SPON ADR 1 SH 97651M109 108 19,929 SH   SOLE   19,929 0 0
WORKDAY INC CL A 98138H101 9,085 39,472 SH   SOLE   39,472 0 0
WORKDAY INC NOTE 0.250%10/0 98138HAF8 3,273 2,130 PRN   SOLE   2,130 0 0
WORKIVA INC COM CL A 98139A105 785 8,970 SH   SOLE   8,970 0 0
WP CAREY INC COM 92936U109 868 12,809 SH   SOLE   12,809 0 0
WYNN RESORTS LTD COM 983134107 998 9,215 SH   SOLE   9,215 0 0
XENCOR INC COM 98401F105 21,600 515,390 SH   SOLE   515,390 0 0
XENCOR INC COM 98401F105 1 22 SH   OTR 1 0 0 22
XILINX INC COM 983919101 12,310 90,396 SH   SOLE   90,396 0 0
XP INC CL A G98239109 1,905 50,000 SH   SOLE   50,000 0 0
XPO LOGISTICS INC COM 983793100 580 5,068 SH   SOLE   5,068 0 0
XYLEM INC COM 98419M100 34,129 349,081 SH   SOLE   349,081 0 0
XYLEM INC COM 98419M100 4 34 SH   OTR 1 0 0 34
YAMANA GOLD INC COM 98462Y100 100 18,273 SH   SOLE   18,273 0 0
YETI HLDGS INC COM 98585X104 2,009 30,544 SH   SOLE   30,544 0 0
Y-MABS THERAPEUTICS INC COM 984241109 0 12 SH   OTR 1 0 0 12
Y-MABS THERAPEUTICS INC COM 984241109 8,557 179,933 SH   SOLE   179,933 0 0
YUM BRANDS INC COM 988498101 3,354 32,166 SH   SOLE   32,166 0 0
YUM CHINA HLDGS INC COM 98850P109 3,311 60,382 SH   SOLE   60,382 0 0
ZAI LAB LTD ADR 98887Q104 1 5 SH   OTR 1 0 0 5
ZEBRA TECHNOLOGIES CORPORATI CL A 989207105 4,424 11,983 SH   SOLE   11,983 0 0
ZENDESK INC COM 98936J101 447 3,270 SH   SOLE   3,270 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 0 11 SH   OTR 1 0 0 11
ZILLOW GROUP INC CL C CAP STK 98954M200 1,241 9,957 SH   SOLE   9,957 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 1 9 SH   OTR 1 0 0 9
ZIMMER BIOMET HOLDINGS INC COM 98956P102 1,751 11,833 SH   SOLE   11,833 0 0
ZIONS BANCORPORATION N A COM 989701107 628 15,042 SH   SOLE   15,042 0 0
ZOETIS INC CL A 98978V103 5,624 35,379 SH   SOLE   35,379 0 0
ZOGENIX INC COM NEW 98978L204 16,600 864,526 SH   SOLE   864,526 0 0
ZOOM VIDEO COMMUNICATIONS IN CL A 98980L101 3,022 9,328 SH   SOLE   9,328 0 0
ZSCALER INC COM 98980G102 1,238 6,469 SH   SOLE   6,469 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADS A 98980A105 1,882 67,199 SH   SOLE   67,199 0 0
ZYMEWORKS INC COM 98985W102 16,412 361,522 SH   SOLE   361,522 0 0
ZYMEWORKS INC COM 98985W102 1 19 SH   OTR 1 0 0 19
ZYNGA INC NOTE 0.250% 6/0 98986TAB4 2,540 2,300 PRN   SOLE   2,300 0 0