The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101 204 1,057 SH   DFND   1,057 0 0
ABBOTT LABS COM 002824100 964 8,034 SH   DFND   8,034 0 0
ABBVIE INC COM 00287Y109 2,172 20,081 SH   DFND   20,081 0 0
ACCENTURE PLC IRELAND SHS CLASS A G1151C101 148 535 SH   DFND   535 0 0
ACTIVISION BLIZZARD INC COM 00507V109 28 300 SH   DFND   300 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 833 1,750 SH   DFND   1,750 0 0
ALCON AG ORD SHS H01301128 330 4,708 SH   DFND   4,708 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 603 2,661 SH   DFND   2,661 0 0
ALPHABET INC CAP STK CL A 02079K305 3,544 1,716 SH   DFND   1,716 0 0
ALPHABET INC CAP STK CL C 02079K107 27 13 SH   DFND   13 0 0
ALPS ETF TR ALERIAN MLP 00162Q452 3 100 SH   DFND   100 0 0
ALTRA INDL MOTION CORP COM 02208R106 0 0 SH   DFND   0 0 0
ALTRIA GROUP INC COM 02209S103 0 0 SH   DFND   0 0 0
AMAZON COM INC COM 023135106 2,676 865 SH   DFND   865 0 0
AMC ENTMT HLDGS INC CL A COM 00165C104 39 3,785 SH   DFND   3,785 0 0
AMETEK INC COM 031100100 443 3,463 SH   DFND   3,463 0 0
AMGEN INC COM 031162100 580 2,328 SH   DFND   2,328 0 0
APPLE INC COM 037833100 1,400 11,460 SH   DFND   11,460 0 0
ARISTA NETWORKS INC COM 040413106 144 477 SH   DFND   477 0 0
AT&T INC COM 00206R102 131 4,325 SH   DFND   4,325 0 0
AUTODESK INC COM 052769106 1,025 3,700 SH   DFND   3,700 0 0
AUTOMATIC DATA PROCESSING IN COM 053015103 78 416 SH   DFND   416 0 0
BAIDU INC SPON ADR REP A 056752108 608 2,794 SH   DFND   2,794 0 0
BALL CORP COM 058498106 435 5,135 SH   DFND   5,135 0 0
BANCO SANTANDER S.A. ADR 05964H105 55 15,992 SH   DFND   15,992 0 0
BEST BUY INC COM 086516101 56 491 SH   DFND   491 0 0
BIONTECH SE SPONSORED ADS 09075V102 88 810 SH   DFND   810 0 0
BLACKSTONE GROUP INC COM 09260D107 832 11,165 SH   DFND   11,165 0 0
BOEING CO COM 097023105 102 400 SH   DFND   400 0 0
CHEVRON CORP NEW COM 166764100 66 637 SH   DFND   637 0 0
CHUBB LIMITED COM H1467J104 251 1,585 SH   DFND   1,585 0 0
CISCO SYS INC COM 17275R102 139 2,691 SH   DFND   2,691 0 0
COCA COLA CO COM 191216100 832 15,799 SH   DFND   15,799 0 0
COMCAST CORP NEW CL A 20030N101 61 1,131 SH   DFND   1,131 0 0
COPA HOLDINGS SA CL A P31076105 18 217 SH   DFND   217 0 0
COSTCO WHSL CORP NEW COM 22160K105 48 137 SH   DFND   137 0 0
CSX CORP COM 126408103 541 5,620 SH   DFND   5,620 0 0
CUMMINS INC COM 231021106 113 435 SH   DFND   435 0 0
DARDEN RESTAURANTS INC COM 237194105 97 686 SH   DFND   686 0 0
DEUTSCHE BANK A G NAMEN AKT D18190898 120 10,000 SH   DFND   10,000 0 0
DISNEY WALT CO COM 254687106 1,140 6,179 SH   DFND   6,179 0 0
EATON CORP PLC SHS G29183103 144 1,041 SH   DFND   1,041 0 0
EMERSON ELEC CO COM 291011104 114 1,261 SH   DFND   1,261 0 0
EOG RES INC COM 26875P101 185 2,559 SH   DFND   2,559 0 0
EQUINIX INC COM 29444U700 27 40 SH   DFND   40 0 0
EXELON CORP COM 30161N101 601 13,733 SH   DFND   13,733 0 0
FACEBOOK INC CL A 30303M102 191 650 SH   DFND   650 0 0
FIRST SOLAR INC COM 336433107 13 150 SH   DFND   150 0 0
FISKER INC CL A COM STK 33813J106 827 48,000 SH   DFND   48,000 0 0
FIVERR INTL LTD ORD SHS M4R82T106 1,255 5,780 SH   DFND   5,780 0 0
FUTU HLDGS LTD SPON ADS CL A 36118L106 0 0 SH   DFND   0 0 0
GENERAL MLS INC COM 370334104 124 2,028 SH   DFND   2,028 0 0
GENERAL MTRS CO COM 37045V100 58 1,004 SH   DFND   1,004 0 0
GILEAD SCIENCES INC COM 375558103 50 780 SH   DFND   780 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 39 1,100 SH   DFND   1,100 0 0
HOME DEPOT INC COM 437076102 453 1,485 SH   DFND   1,485 0 0
HONEYWELL INTL INC COM 438516106 543 2,500 SH   DFND   2,500 0 0
INOVIO PHARMACEUTICALS INC COM NEW 45773H201 10 1,100 SH   DFND   1,100 0 0
INTEL CORP COM 458140100 156 2,441 SH   DFND   2,441 0 0
INTERNATIONAL BUSINESS MACHS COM 459200101 138 1,039 SH   DFND   1,039 0 0
IQVIA HLDGS INC COM 46266C105 802 4,152 SH   DFND   4,152 0 0
ISHARES INC MSCI THAILND ETF 464286624 41 500 SH   DFND   500 0 0
JOHNSON & JOHNSON COM 478160104 103 626 SH   DFND   626 0 0
JPMORGAN CHASE & CO COM 46625H100 1,087 7,140 SH   DFND   7,140 0 0
KOHLS CORP COM 500255104 37 615 SH   DFND   615 0 0
LAUDER ESTEE COS INC CL A 518439104 121 417 SH   DFND   417 0 0
LEIDOS HOLDINGS INC COM 525327102 0 0 SH   DFND   0 0 0
LENNAR CORP CL A 526057104 1,134 11,200 SH   DFND   11,200 0 0
LILLY ELI & CO COM 532457108 141 755 SH   DFND   755 0 0
LINDE PLC SHS G5494J103 428 1,523 SH   DFND   1,523 0 0
LOGITECH INTL S A SHS H50430232 53 500 SH   DFND   500 0 0
LYONDELLBASELL INDUSTRIES N SHS - A - N53745100 53 512 SH   DFND   512 0 0
MARATHON PETE CORP COM 56585A102 53 982 SH   DFND   982 0 0
MAXIM INTEGRATED PRODS INC COM 57772K101 151 1,649 SH   DFND   1,649 0 0
MCDONALDS CORP COM 580135101 375 1,672 SH   DFND   1,672 0 0
MICROSOFT CORP COM 594918104 3,073 13,037 SH   DFND   13,037 0 0
MODERNA INC COM 60770K107 37 280 SH   DFND   280 0 0
MONDELEZ INTL INC CL A 609207105 649 11,072 SH   DFND   11,072 0 0
NETFLIX INC COM 64110L106 44 85 SH   DFND   85 0 0
NEXTERA ENERGY INC COM 65339F101 96 1,265 SH   DFND   1,265 0 0
OCCIDENTAL PETE CORP *W EXP 08/03/202 674599162 2 190 SH   DFND   190 0 0
OCCIDENTAL PETE CORP COM 674599105 186 7,021 SH   DFND   7,021 0 0
PALO ALTO NETWORKS INC COM 697435105 1,345 4,176 SH   DFND   4,176 0 0
PAYCHEX INC COM 704326107 127 1,292 SH   DFND   1,292 0 0
PAYPAL HLDGS INC COM 70450Y103 62 255 SH   DFND   255 0 0
PFIZER INC COM 717081103 106 2,924 SH   DFND   2,924 0 0
PHILLIPS 66 COM 718546104 73 893 SH   DFND   893 0 0
PINTEREST INC CL A 72352L106 1,081 14,623 SH   DFND   14,623 0 0
PPG INDS INC COM 693506107 451 3,003 SH   DFND   3,003 0 0
PRINCIPAL FINANCIAL GROUP IN COM 74251V102 65 1,090 SH   DFND   1,090 0 0
PROCTER AND GAMBLE CO COM 742718109 295 2,177 SH   DFND   2,177 0 0
PROGRESSIVE CORP COM 743315103 143 1,492 SH   DFND   1,492 0 0
PUBLIC SVC ENTERPRISE GRP IN COM 744573106 65 1,086 SH   DFND   1,086 0 0
QUALCOMM INC COM 747525103 148 1,119 SH   DFND   1,119 0 0
RANGE RES CORP COM 75281A109 5 491 SH   DFND   491 0 0
RAYTHEON TECHNOLOGIES CORP COM 75513E101 90 1,167 SH   DFND   1,167 0 0
RESTAURANT BRANDS INTL INC COM 76131D103 130 2,000 SH   DFND   2,000 0 0
ROYAL CARIBBEAN GROUP COM V7780T103 96 1,120 SH   DFND   1,120 0 0
S&P GLOBAL INC COM 78409V104 333 945 SH   DFND   945 0 0
SEMPRA ENERGY COM 816851109 491 3,706 SH   DFND   3,706 0 0
SIMON PPTY GROUP INC NEW COM 828806109 102 900 SH   DFND   900 0 0
SPOTIFY TECHNOLOGY S A SHS L8681T102 1,129 4,208 SH   DFND   4,208 0 0
SPROUTS FMRS MKT INC COM 85208M102 263 9,890 SH   DFND   9,890 0 0
STARBUCKS CORP COM 855244109 110 1,008 SH   DFND   1,008 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 259 2,189 SH   DFND   2,189 0 0
TAL EDUCATION GROUP SPONSORED ADS 874080104 504 9,372 SH   DFND   9,372 0 0
TE CONNECTIVITY LTD REG SHS H84989104 37 290 SH   DFND   290 0 0
TESLA INC COM 88160R101 126 189 SH   DFND   189 0 0
TEXAS INSTRS INC COM 882508104 169 893 SH   DFND   893 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 1,312 2,876 SH   DFND   2,876 0 0
TOYOTA MOTOR CORP SP ADR REP2COM 892331307 0 0 SH   DFND   0 0 0
TRANE TECHNOLOGIES PLC SHS G8994E103 345 2,084 SH   DFND   2,084 0 0
TRIP COM GROUP LTD ADS 89677Q107 727 18,357 SH   DFND   18,357 0 0
UBS GROUP AG SHS H42097107 173 11,110 SH   DFND   11,110 0 0
UNITED AIRLS HLDGS INC COM 910047109 94 1,630 SH   DFND   1,630 0 0
VANECK VECTORS ETF TR GOLD MINERS ETF 92189F106 32 1,000 SH   DFND   1,000 0 0
VANGUARD SCOTTSDALE FDS LONG TERM TREAS 92206C847 268 3,240 SH   DFND   3,240 0 0
VERIZON COMMUNICATIONS INC COM 92343V104 734 12,628 SH   DFND   12,628 0 0
VIATRIS INC COM 92556V106 0 0 SH   DFND   0 0 0
VISA INC COM CL A 92826C839 2,047 9,659 SH   DFND   9,659 0 0
WALMART INC COM 931142103 131 966 SH   DFND   966 0 0
WASTE MGMT INC DEL COM 94106L109 516 4,001 SH   DFND   4,001 0 0
YUM CHINA HLDGS INC COM 98850P109 800 13,529 SH   DFND   13,529 0 0
10X GENOMICS INC CL A COM 88025U109 17,880 98,783 SH   DFND 1 98,783 0 0
3-D SYS CORP DEL COM NEW 88554D205 0 0 SH   DFND 1 0 0 0
3M CO COM 88579Y101 6,854 35,574 SH   DFND 1 35,574 0 0
ABBOTT LABS COM 002824100 91,760 765,468 SH   DFND 1 765,468 0 0
ABBVIE INC CALL 00287Y909 0 0 SH Call DFND 1 0 0 0
ABBVIE INC COM 00287Y109 100,548 929,118 SH   DFND 1 929,118 0 0
ABBVIE INC PUT 00287Y959 0 0 SH Put DFND 1 0 0 0
ABERDEEN JAPAN EQUITY FD INC COM 00306J109 18 2,023 SH   DFND 1 2,023 0 0
ABERDEEN STD PRECIOUS METALS PHYSCL PM BASKET 003263100 232 2,500 SH   DFND 1 2,500 0 0
ABERDEEN STD SILVER ETF TR PHYSCL SILVR SHS 003264108 9 400 SH   DFND 1 400 0 0
AC IMMUNE SA SHS H00263105 1,715 225,359 SH   DFND 1 225,359 0 0
ACCENTURE PLC IRELAND SHS CLASS A G1151C101 3,829 13,860 SH   DFND 1 13,860 0 0
ACTIVISION BLIZZARD INC COM 00507V109 2,689 28,923 SH   DFND 1 28,923 0 0
ACTIVISION BLIZZARD INC PUT 00507V959 0 0 SH Put DFND 1 0 0 0
ADOBE SYSTEMS INCORPORATED CALL 00724F901 0 0 SH Call DFND 1 0 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 85,187 179,137 SH   DFND 1 179,137 0 0
ADOBE SYSTEMS INCORPORATED PUT 00724F951 0 0 SH Put DFND 1 0 0 0
ADVANCED MICRO DEVICES INC COM 007903107 2,988 38,050 SH   DFND 1 38,050 0 0
ADVANSIX INC COM 00773T101 0 39 SH   DFND 1 39 0 0
AFFIRM HLDGS INC COM CL A 00827B106 0 0 SH   DFND 1 0 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 1,362 10,713 SH   DFND 1 10,713 0 0
AGNICO EAGLE MINES LTD COM 008474108 2,417 41,821 SH   DFND 1 41,821 0 0
AIR PRODS & CHEMS INC COM 009158106 799 2,839 SH   DFND 1 2,839 0 0
AIRBNB INC COM CL A 009066101 777 4,135 SH   DFND 1 4,135 0 0
AKAMAI TECHNOLOGIES INC COM 00971T101 204 2,000 SH   DFND 1 2,000 0 0
AKAMAI TECHNOLOGIES INC NOTE 0.375% 9/0 00971TAL5 2,547 2,335,000 PRN   DFND 1 2,335,000 0 0
AKOUSTIS TECHNOLOGIES INC COM 00973N102 19 1,390 SH   DFND 1 1,390 0 0
ALAMOS GOLD INC NEW COM CL A 011532108 20 2,500 SH   DFND 1 2,500 0 0
ALASKA AIR GROUP INC COM 011659109 171 2,467 SH   DFND 1 2,467 0 0
ALCON AG ORD SHS H01301128 76,102 1,082,251 SH   DFND 1 1,082,251 0 0
ALCON AG PUT H01301958 0 0 SH Put DFND 1 0 0 0
ALIBABA GROUP HLDG LTD CALL 01609W902 296 9,500 SH Call DFND 1 9,500 0 0
ALIBABA GROUP HLDG LTD PUT 01609W952 0 0 SH Put DFND 1 0 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 87,086 384,124 SH   DFND 1 384,124 0 0
ALIGN TECHNOLOGY INC COM 016255101 449 830 SH   DFND 1 830 0 0
ALLIANCE DATA SYSTEMS CORP COM 018581108 613 5,469 SH   DFND 1 5,469 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 18,947 536,738 SH   DFND 1 536,738 0 0
ALLSCRIPTS HEALTHCARE SOLUTN COM 01988P108 12,605 839,521 SH   DFND 1 839,521 0 0
ALLSTATE CORP COM 020002101 23 200 SH   DFND 1 200 0 0
ALLY FINL INC COM 02005N100 208 4,595 SH   DFND 1 4,595 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 0 0 SH   DFND 1 0 0 0
ALPHA METALLURGICAL RESOUR I COM 020764106 0 27 SH   DFND 1 27 0 0
ALPHABET INC CAP STK CL A 02079K305 289,774 140,477 SH   DFND 1 140,477 0 0
ALPHABET INC CAP STK CL C 02079K107 25,544 12,349 SH   DFND 1 12,349 0 0
ALPHABET INC PUT 02079K955 3 300 SH Put DFND 1 300 0 0
ALTERYX INC COM CL A 02156B103 406 4,900 SH   DFND 1 4,900 0 0
ALTICE USA INC CL A 02156K103 339 10,407 SH   DFND 1 10,407 0 0
ALTRIA GROUP INC COM 02209S103 2,336 45,660 SH   DFND 1 45,660 0 0
AMAZON COM INC CALL 023135906 7 100 SH Call DFND 1 100 0 0
AMAZON COM INC COM 023135106 211,954 68,509 SH   DFND 1 68,509 0 0
AMAZON COM INC PUT 023135956 0 0 SH Put DFND 1 0 0 0
AMBEV SA SPONSORED ADR 02319V103 548 200,000 SH   DFND 1 200,000 0 0
AMC ENTMT HLDGS INC CL A COM 00165C104 41 4,000 SH   DFND 1 4,000 0 0
AMERICAN AIRLS GROUP INC COM 02376R102 795 33,263 SH   DFND 1 33,263 0 0
AMERICAN ELEC PWR CO INC COM 025537101 51 600 SH   DFND 1 600 0 0
AMERICAN EXPRESS CO COM 025816109 634 4,480 SH   DFND 1 4,480 0 0
AMERICAN INTL GROUP INC COM NEW 026874784 100 2,157 SH   DFND 1 2,157 0 0
AMERICAN TOWER CORP NEW COM 03027X100 402 1,682 SH   DFND 1 1,682 0 0
AMERICAN WELL CORP CL A 03044L105 10,335 595,021 SH   DFND 1 595,021 0 0
AMERICAN WTR WKS CO INC NEW COM 030420103 480 3,200 SH   DFND 1 3,200 0 0
AMETEK INC COM 031100100 36,731 287,543 SH   DFND 1 287,543 0 0
AMGEN INC COM 031162100 18,995 76,341 SH   DFND 1 76,341 0 0
ANALOG DEVICES INC COM 032654105 96 620 SH   DFND 1 620 0 0
ANGLOGOLD ASHANTI LIMITED SPONSORED ADR 035128206 209 9,500 SH   DFND 1 9,500 0 0
ANHEUSER BUSCH INBEV SA/NV SPONSORED ADR 03524A108 627 10,000 SH   DFND 1 10,000 0 0
ANTHEM INC COM 036752103 767 2,138 SH   DFND 1 2,138 0 0
AON PLC SHS CL A G0403H108 807 3,510 SH   DFND 1 3,510 0 0
APA CORPORATION COM 03743Q108 20 1,100 SH   DFND 1 1,100 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 16,554 385,795 SH   DFND 1 385,795 0 0
APHRIA INC COM 03765K104 15 800 SH   DFND 1 800 0 0
APOLLO COML REAL EST FIN INC COM 03762U105 437 31,310 SH   DFND 1 31,310 0 0
APPLE INC CALL 037833900 0 0 SH Call DFND 1 0 0 0
APPLE INC COM 037833100 130,263 1,066,393 SH   DFND 1 1,066,393 0 0
APPLE INC PUT 037833950 0 0 SH Put DFND 1 0 0 0
ARCHER DANIELS MIDLAND CO COM 039483102 27 480 SH   DFND 1 480 0 0
ARES CAPITAL CORP NOTE 4.625% 3/0 04010LAW3 2,093 1,907,000 PRN   DFND 1 1,907,000 0 0
ARISTA NETWORKS INC COM 040413106 27,633 91,555 SH   DFND 1 91,555 0 0
ARISTA NETWORKS INC PUT 040413956 0 0 SH Put DFND 1 0 0 0
ARK ETF TR ARK SPACE EXPL 00214Q807 505 24,650 SH   DFND 1 24,650 0 0
ARK ETF TR AUTNMUS TECHNLGY 00214Q203 84 1,000 SH   DFND 1 1,000 0 0
ARK ETF TR FINTECH INNOVA 00214Q708 197 3,850 SH   DFND 1 3,850 0 0
ARK ETF TR GENOMIC REV ETF 00214Q302 765 8,620 SH   DFND 1 8,620 0 0
ARK ETF TR INNOVATION ETF 00214Q104 179 1,496 SH   DFND 1 1,496 0 0
ARK ETF TR NEXT GNRTN INTER 00214Q401 282 1,913 SH   DFND 1 1,913 0 0
ASANA INC CL A 04342Y104 0 0 SH   DFND 1 0 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 40 800 SH   DFND 1 800 0 0
AT&T INC COM 00206R102 3,481 115,085 SH   DFND 1 115,085 0 0
ATMOS ENERGY CORP COM 049560105 30 300 SH   DFND 1 300 0 0
AURORA CANNABIS INC COM 05156X884 9 958 SH   DFND 1 958 0 0
AUTOMATIC DATA PROCESSING IN COM 053015103 168 894 SH   DFND 1 894 0 0
AUTOZONE INC COM 053332102 391 278 SH   DFND 1 278 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 54 6,000 SH   DFND 1 6,000 0 0
AZUL S A SPONSR ADR PFD 05501U106 128 6,341 SH   DFND 1 6,341 0 0
BAIDU INC PUT 056752958 0 0 SH Put DFND 1 0 0 0
BAIDU INC SPON ADR REP A 056752108 53,282 244,901 SH   DFND 1 244,901 0 0
BAKER HUGHES COMPANY CL A 05722G100 985 45,582 SH   DFND 1 45,582 0 0
BALL CORP COM 058498106 32,495 383,441 SH   DFND 1 383,441 0 0
BALL CORP PUT 058498956 0 0 SH Put DFND 1 0 0 0
BALLARD PWR SYS INC NEW COM 058586108 4,085 167,500 SH   DFND 1 167,500 0 0
BANCO BRADESCO S A SP ADR PFD NEW 059460303 271 57,556 SH   DFND 1 57,556 0 0
BANCO SANTANDER BRASIL S A ADS REP 1 UNIT 05967A107 400 56,707 SH   DFND 1 56,707 0 0
BANDWIDTH INC COM CL A 05988J103 5 40 SH   DFND 1 40 0 0
BANK MONTREAL QUE COM 063671101 30 340 SH   DFND 1 340 0 0
BANK NEW YORK MELLON CORP COM 064058100 1,357 28,700 SH   DFND 1 28,700 0 0
BANK NOVA SCOTIA B C COM 064149107 378 6,035 SH   DFND 1 6,035 0 0
BAOZUN INC SPONSORED ADR 06684L103 0 0 SH   DFND 1 0 0 0
BARCLAYS PLC ADR 06738E204 420 41,007 SH   DFND 1 41,007 0 0
BARRICK GOLD CORP COM 067901108 877 44,154 SH   DFND 1 44,154 0 0
BAUSCH HEALTH COS INC COM 071734107 46 1,446 SH   DFND 1 1,446 0 0
BAXTER INTL INC COM 071813109 587 6,964 SH   DFND 1 6,964 0 0
BAXTER INTL INC PUT 071813959 0 0 SH Put DFND 1 0 0 0
BCE INC COM NEW 05534B760 58 1,280 SH   DFND 1 1,280 0 0
BECTON DICKINSON & CO COM 075887109 73 300 SH   DFND 1 300 0 0
BERKSHIRE HATHAWAY INC DEL CL A 084670108 386 1 SH   DFND 1 1 0 0
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 4,817 18,857 SH   DFND 1 18,857 0 0
BEYOND MEAT INC COM 08862E109 511 3,920 SH   DFND 1 3,920 0 0
BEYOND MEAT INC PUT 08862E959 0 0 SH Put DFND 1 0 0 0
BHP GROUP LTD SPONSORED ADS 088606108 45 650 SH   DFND 1 650 0 0
BIOGEN INC COM 09062X103 42 150 SH   DFND 1 150 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 16,028 234,498 SH   DFND 1 234,498 0 0
BIOLIFE SOLUTIONS INC COM NEW 09062W204 324 9,000 SH   DFND 1 9,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 0 0 SH   DFND 1 0 0 0
BIONANO GENOMICS INC COM 09075F107 2 200 SH   DFND 1 200 0 0
BIONTECH SE SPONSORED ADS 09075V102 162 1,500 SH   DFND 1 1,500 0 0
BIOVIE INC CL A NEW 09074F207 0 0 SH   DFND 1 0 0 0
BK OF AMERICA CORP COM 060505104 2,560 66,137 SH   DFND 1 66,137 0 0
BLACKLINE INC COM 09239B109 5 50 SH   DFND 1 50 0 0
BLACKROCK INC COM 09247X101 925 1,227 SH   DFND 1 1,227 0 0
BLACKSTONE GROUP INC COM 09260D107 63,098 846,508 SH   DFND 1 846,508 0 0
BLACKSTONE MTG TR INC COM CL A 09257W100 53 1,705 SH   DFND 1 1,705 0 0
BOEING CO COM 097023105 1,758 6,905 SH   DFND 1 6,905 0 0
BOOKING HOLDINGS INC COM 09857L108 15,829 6,794 SH   DFND 1 6,794 0 0
BOSTON PROPERTIES INC COM 101121101 0 0 SH   DFND 1 0 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 189 3,000 SH   DFND 1 3,000 0 0
BROADCOM INC COM 11135F101 529 1,140 SH   DFND 1 1,140 0 0
BROADRIDGE FINL SOLUTIONS IN COM 11133T103 669 4,370 SH   DFND 1 4,370 0 0
BUNGE LIMITED COM G16962105 2,144 27,045 SH   DFND 1 27,045 0 0
BURFORD CAP LTD ORD SHS G17977110 390 45,000 SH   DFND 1 45,000 0 0
CADENCE DESIGN SYSTEM INC COM 127387108 21 152 SH   DFND 1 152 0 0
CADIZ INC COM NEW 127537207 68 7,100 SH   DFND 1 7,100 0 0
CAMECO CORP COM 13321L108 17 1,000 SH   DFND 1 1,000 0 0
CANADIAN IMP BK COMM COM 136069101 100 1,020 SH   DFND 1 1,020 0 0
CANADIAN NATL RY CO COM 136375102 208 1,790 SH   DFND 1 1,790 0 0
CANOO INC COM CL A 13803R102 114 12,600 SH   DFND 1 12,600 0 0
CANOPY GROWTH CORP COM 138035100 122 3,800 SH   DFND 1 3,800 0 0
CAPITAL ONE FINL CORP COM 14040H105 70 553 SH   DFND 1 553 0 0
CAPRI HOLDINGS LIMITED SHS G1890L107 8 150 SH   DFND 1 150 0 0
CARLYLE GROUP INC COM 14316J108 3,933 107,005 SH   DFND 1 107,005 0 0
CASTOR MARITIME INC SHS Y1146L109 18 23,700 SH   DFND 1 23,700 0 0
CATERPILLAR INC COM 149123101 2,938 12,675 SH   DFND 1 12,675 0 0
CBOE GLOBAL MKTS INC COM 12503M108 41 420 SH   DFND 1 420 0 0
CERNER CORP COM 156782104 43 600 SH   DFND 1 600 0 0
CEVA INC COM 157210105 56 1,000 SH   DFND 1 1,000 0 0
CHART INDS INC COM 16115Q308 256 1,800 SH   DFND 1 1,800 0 0
CHECK POINT SOFTWARE TECH LT ORD M22465104 1,244 11,108 SH   DFND 1 11,108 0 0
CHENIERE ENERGY INC COM NEW 16411R208 130 1,800 SH   DFND 1 1,800 0 0
CHEVRON CORP NEW COM 166764100 2,623 25,005 SH   DFND 1 25,005 0 0
CHEWY INC CL A 16679L109 475 5,610 SH   DFND 1 5,610 0 0
CHUBB LIMITED COM H1467J104 6,380 40,390 SH   DFND 1 40,390 0 0
CINEMARK HLDGS INC COM 17243V102 239 11,704 SH   DFND 1 11,704 0 0
CIRRUS LOGIC INC COM 172755100 212 2,500 SH   DFND 1 2,500 0 0
CISCO SYS INC COM 17275R102 27,842 538,418 SH   DFND 1 538,418 0 0
CISCO SYS INC PUT 17275R952 0 0 SH Put DFND 1 0 0 0
CIT GROUP INC COM NEW 125581801 232 4,504 SH   DFND 1 4,504 0 0
CITIGROUP INC COM NEW 172967424 2,623 36,063 SH   DFND 1 36,063 0 0
CITIZENS FINANCIAL GROUP INC COM 174610105 67 1,521 SH   DFND 1 1,521 0 0
CITRIX SYS INC COM 177376100 60 430 SH   DFND 1 430 0 0
CLOROX CO DEL COM 189054109 41 215 SH   DFND 1 215 0 0
CLOVER HEALTH INVESTMENTS CO COM CL A 18914F103 4 500 SH   DFND 1 500 0 0
CME GROUP INC COM 12572Q105 53 260 SH   DFND 1 260 0 0
COCA COLA CO COM 191216100 130,343 2,472,836 SH   DFND 1 2,472,836 0 0
CO-DIAGNOSTICS INC COM 189763105 19 2,000 SH   DFND 1 2,000 0 0
COEUR MNG INC COM NEW 192108504 6 620 SH   DFND 1 620 0 0
COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102 350 4,487 SH   DFND 1 4,487 0 0
COLGATE PALMOLIVE CO COM 194162103 401 5,083 SH   DFND 1 5,083 0 0
COLLABORATIVE INVESTMNT SER THE SPAC AND NEW 19423L672 151 5,300 SH   DFND 1 5,300 0 0
COMCAST CORP NEW CL A 20030N101 1,264 23,362 SH   DFND 1 23,362 0 0
COMERICA INC COM 200340107 440 6,136 SH   DFND 1 6,136 0 0
CONOCOPHILLIPS COM 20825C104 962 18,160 SH   DFND 1 18,160 0 0
COSTCO WHSL CORP NEW COM 22160K105 421 1,195 SH   DFND 1 1,195 0 0
COTY INC COM CL A 222070203 94 10,389 SH   DFND 1 10,389 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 95 775 SH   DFND 1 775 0 0
CROWDSTRIKE HLDGS INC CL A 22788C105 253 1,385 SH   DFND 1 1,385 0 0
CROWN HLDGS INC COM 228368106 717 7,390 SH   DFND 1 7,390 0 0
CSX CORP COM 126408103 43,752 453,828 SH   DFND 1 453,828 0 0
CUMMINS INC COM 231021106 161 621 SH   DFND 1 621 0 0
CUREVAC N V COM N2451R105 226 2,475 SH   DFND 1 2,475 0 0
CVS HEALTH CORP COM 126650100 676 8,993 SH   DFND 1 8,993 0 0
D R HORTON INC COM 23331A109 267 3,000 SH   DFND 1 3,000 0 0
DANA INC COM 235825205 170 7,000 SH   DFND 1 7,000 0 0
DANAHER CORPORATION COM 235851102 5,700 25,330 SH   DFND 1 25,330 0 0
DAVE & BUSTERS ENTMT INC COM 238337109 247 5,147 SH   DFND 1 5,147 0 0
DECARBONIZATION PLUS ACQU CO COM CL A 242797108 367 35,000 SH   DFND 1 35,000 0 0
DEERE & CO COM 244199105 7,538 20,148 SH   DFND 1 20,148 0 0
DELTA AIR LINES INC DEL COM NEW 247361702 523 10,829 SH   DFND 1 10,829 0 0
DENALI THERAPEUTICS INC COM 24823R105 171 3,000 SH   DFND 1 3,000 0 0
DENTSPLY SIRONA INC COM 24906P109 96 1,500 SH   DFND 1 1,500 0 0
DEXCOM INC COM 252131107 97 270 SH   DFND 1 270 0 0
DEXCOM INC NOTE 0.750%12/0 252131AH0 547 247,000 PRN   DFND 1 247,000 0 0
DIAMONDBACK ENERGY INC COM 25278X109 73 1,000 SH   DFND 1 1,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 13,451 526,058 SH   DFND 1 526,058 0 0
DISCOVER FINL SVCS COM 254709108 142 1,498 SH   DFND 1 1,498 0 0
DISNEY WALT CO CALL 254687906 750 19,300 SH Call DFND 1 19,300 0 0
DISNEY WALT CO COM 254687106 83,165 450,643 SH   DFND 1 450,643 0 0
DISNEY WALT CO PUT 254687956 0 0 SH Put DFND 1 0 0 0
DOCUSIGN INC PUT 256163956 0 0 SH Put DFND 1 0 0 0
DOLLAR GEN CORP NEW COM 256677105 5,827 28,755 SH   DFND 1 28,755 0 0
DRAFTKINGS INC COM CL A 26142R104 76 1,250 SH   DFND 1 1,250 0 0
DROPBOX INC CL A 26210C104 131 4,900 SH   DFND 1 4,900 0 0
DUKE ENERGY CORP NEW COM NEW 26441C204 121 1,250 SH   DFND 1 1,250 0 0
DUPONT DE NEMOURS INC COM 26614N102 180 2,334 SH   DFND 1 2,334 0 0
EATON CORP PLC SHS G29183103 28 200 SH   DFND 1 200 0 0
EBAY INC. COM 278642103 501 8,170 SH   DFND 1 8,170 0 0
ECOLAB INC COM 278865100 214 1,000 SH   DFND 1 1,000 0 0
ECOPETROL S A SPONSORED ADS 279158109 112 8,732 SH   DFND 1 8,732 0 0
EDITAS MEDICINE INC COM 28106W103 7,950 189,294 SH   DFND 1 189,294 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 592 7,080 SH   DFND 1 7,080 0 0
EKSO BIONICS HLDGS INC COM 282644301 216 35,000 SH   DFND 1 35,000 0 0
ELASTIC N V ORD SHS N14506104 37 340 SH   DFND 1 340 0 0
ELECTRAMECCANICA VEHS CORP COM NEW 284849205 0 0 SH   DFND 1 0 0 0
ELECTRONIC ARTS INC COM 285512109 7,852 58,000 SH   DFND 1 58,000 0 0
EMBRAER S.A. SPONSORED ADS 29082A107 454 45,366 SH   DFND 1 45,366 0 0
EMERSON ELEC CO COM 291011104 78 870 SH   DFND 1 870 0 0
ENBRIDGE INC COM 29250N105 438 12,028 SH   DFND 1 12,028 0 0
ENDEAVOUR SILVER CORP COM 29258Y103 16 3,400 SH   DFND 1 3,400 0 0
ENLIVEX THERAPEUTICS LTD COM M4130Y106 267 25,000 SH   DFND 1 25,000 0 0
ENPHASE ENERGY INC COM 29355A107 49 300 SH   DFND 1 300 0 0
EOG RES INC CALL 26875P901 0 0 SH Call DFND 1 0 0 0
EOG RES INC COM 26875P101 690 9,508 SH   DFND 1 9,508 0 0
EQUIFAX INC COM 294429105 60 330 SH   DFND 1 330 0 0
EQUINIX INC COM 29444U700 300 441 SH   DFND 1 441 0 0
ETF MANAGERS TR PRIME CYBR SCRTY 26924G201 165 3,000 SH   DFND 1 3,000 0 0
ETF SER SOLUTIONS US GLB JETS 26922A842 215 8,000 SH   DFND 1 8,000 0 0
EVENTBRITE INC COM CL A 29975E109 414 18,684 SH   DFND 1 18,684 0 0
EVERBRIDGE INC COM 29978A104 9 75 SH   DFND 1 75 0 0
EXACT SCIENCES CORP COM 30063P105 19,380 147,060 SH   DFND 1 147,060 0 0
EXACT SCIENCES CORP NOTE 0.375% 3/0 30063PAC9 646 500,000 PRN   DFND 1 500,000 0 0
EXACT SCIENCES CORP NOTE 0.375% 3/1 30063PAB1 1,556 1,139,000 PRN   DFND 1 1,139,000 0 0
EXCHANGE TRADED CONCEPTS TR ROBO GLB ETF 301505707 54 850 SH   DFND 1 850 0 0
EXELON CORP COM 30161N101 4,503 103,010 SH   DFND 1 103,010 0 0
EXONE CO COM 302104104 0 0 SH   DFND 1 0 0 0
EXPEDIA GROUP INC COM NEW 30212P303 902 5,240 SH   DFND 1 5,240 0 0
EXXON MOBIL CORP CALL 30231G902 0 0 SH Call DFND 1 0 0 0
EXXON MOBIL CORP COM 30231G102 10,234 183,372 SH   DFND 1 183,372 0 0
FACEBOOK INC CL A 30303M102 69,855 237,151 SH   DFND 1 237,151 0 0
FACEBOOK INC PUT 30303M952 0 0 SH Put DFND 1 0 0 0
FEDEX CORP COM 31428X106 363 1,282 SH   DFND 1 1,282 0 0
FERRARI N V COM N3167Y103 28,261 134,809 SH   DFND 1 134,809 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 1,030 7,329 SH   DFND 1 7,329 0 0
FIRST MAJESTIC SILVER CORP COM 32076V103 66 4,200 SH   DFND 1 4,200 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 1,130 6,776 SH   DFND 1 6,776 0 0
FIRST SOLAR INC COM 336433107 262 3,000 SH   DFND 1 3,000 0 0
FIRST TR EXCHANGE TRADED FD CLOUD COMPUTING 33734X192 232 2,425 SH   DFND 1 2,425 0 0
FIRST TR EXCHANGE TRADED FD NASDAQ CYB ETF 33734X846 73 1,750 SH   DFND 1 1,750 0 0
FIRST TR EXCHANGE-TRADED FD DJ INTERNT IDX 33733E302 13 60 SH   DFND 1 60 0 0
FISERV INC COM 337738108 440 3,700 SH   DFND 1 3,700 0 0
FIVERR INTL LTD ORD SHS M4R82T106 68 310 SH   DFND 1 310 0 0
FLUOR CORP NEW COM 343412102 20 850 SH   DFND 1 850 0 0
FORTUNA SILVER MINES INC COM 349915108 40 6,200 SH   DFND 1 6,200 0 0
FRANCO NEV CORP COM 351858105 207 1,650 SH   DFND 1 1,650 0 0
FREEPORT-MCMORAN INC CL B 35671D857 14,559 442,126 SH   DFND 1 442,126 0 0
FREEPORT-MCMORAN INC PUT 35671D957 0 0 SH Put DFND 1 0 0 0
FREQUENCY THERAPEUTICS INC COM 35803L108 2,501 263,249 SH   DFND 1 263,249 0 0
G1 THERAPEUTICS INC COM 3621LQ109 14,474 601,591 SH   DFND 1 601,591 0 0
GARMIN LTD SHS H2906T109 13,225 100,300 SH   DFND 1 100,300 0 0
GARTNER INC COM 366651107 57 310 SH   DFND 1 310 0 0
GDS HLDGS LTD SPONSORED ADS 36165L108 243 3,000 SH   DFND 1 3,000 0 0
GENERAL DYNAMICS CORP COM 369550108 314 1,730 SH   DFND 1 1,730 0 0
GENERAL ELECTRIC CO COM 369604103 522 39,785 SH   DFND 1 39,785 0 0
GENERAL MLS INC COM 370334104 1,625 26,500 SH   DFND 1 26,500 0 0
GENERAL MTRS CO COM 37045V100 1,311 22,832 SH   DFND 1 22,832 0 0
GENERATION BIO CO COM 37148K100 30 1,050 SH   DFND 1 1,050 0 0
GILEAD SCIENCES INC COM 375558103 2,452 37,929 SH   DFND 1 37,929 0 0
GLOBAL X FDS FINTECH ETF 37954Y814 46 1,050 SH   DFND 1 1,050 0 0
GLOBAL X FDS GLOBAL X SILVER 37954Y848 20 500 SH   DFND 1 500 0 0
GLOBAL X FDS LITHIUM BTRY ETF 37954Y855 111 1,900 SH   DFND 1 1,900 0 0
GLOBAL X FDS MSCI GREECE ETF 37954Y319 0 0 SH   DFND 1 0 0 0
GODADDY INC CL A 380237107 226 2,900 SH   DFND 1 2,900 0 0
GOL LINHAS AEREAS INTELIGENT SPON ADR PFD NEW 38045R206 85 11,173 SH   DFND 1 11,173 0 0
GOLAR LNG LTD SHS G9456A100 10 1,000 SH   DFND 1 1,000 0 0
GOLDEN MINERALS CO COM 381119106 7 10,160 SH   DFND 1 10,160 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 3,989 12,200 SH   DFND 1 12,200 0 0
GOODRX HLDGS INC COM CL A 38246G108 12,283 314,779 SH   DFND 1 314,779 0 0
GOODYEAR TIRE & RUBR CO COM 382550101 20 1,150 SH   DFND 1 1,150 0 0
GREAT PANTHER MNG LTD COM 39115V101 6 7,900 SH   DFND 1 7,900 0 0
GROWGENERATION CORP COM 39986L109 27 550 SH   DFND 1 550 0 0
HALLIBURTON CO COM 406216101 2,479 115,503 SH   DFND 1 115,503 0 0
HARLEY DAVIDSON INC COM 412822108 20 500 SH   DFND 1 500 0 0
HELMERICH & PAYNE INC COM 423452101 669 24,803 SH   DFND 1 24,803 0 0
HENRY SCHEIN INC COM 806407102 83 1,200 SH   DFND 1 1,200 0 0
HOME DEPOT INC COM 437076102 64,721 212,036 SH   DFND 1 212,036 0 0
HOME DEPOT INC PUT 437076952 0 0 SH Put DFND 1 0 0 0
HONEYWELL INTL INC COM 438516106 33,522 154,449 SH   DFND 1 154,449 0 0
HOST HOTELS & RESORTS INC COM 44107P104 51 3,000 SH   DFND 1 3,000 0 0
HUBSPOT INC COM 443573100 45 100 SH   DFND 1 100 0 0
HUNTINGTON INGALLS INDS INC COM 446413106 281 1,365 SH   DFND 1 1,365 0 0
HYATT HOTELS CORP COM CL A 448579102 451 5,450 SH   DFND 1 5,450 0 0
IDEXX LABS INC COM 45168D104 20 40 SH   DFND 1 40 0 0
IHS MARKIT LTD SHS G47567105 15,258 157,669 SH   DFND 1 157,669 0 0
ILLINOIS TOOL WKS INC COM 452308109 3,389 15,300 SH   DFND 1 15,300 0 0
ILLUMINA INC COM 452327109 444 1,155 SH   DFND 1 1,155 0 0
ILLUMINA INC NOTE 0.500% 6/1 452327AH2 1,210 802,000 PRN   DFND 1 802,000 0 0
IMMUNOGEN INC COM 45253H101 14,983 1,849,772 SH   DFND 1 1,849,772 0 0
INARI MED INC COM 45332Y109 110 1,030 SH   DFND 1 1,030 0 0
INCYTE CORP COM 45337C102 52 640 SH   DFND 1 640 0 0
ING GROEP N.V. SPONSORED ADR 456837103 357 29,152 SH   DFND 1 29,152 0 0
INGERSOLL RAND INC COM 45687V106 671 13,637 SH   DFND 1 13,637 0 0
INNOVAGE HLDG CORP COM 45784A104 0 0 SH   DFND 1 0 0 0
INOZYME PHARMA INC COM 45790W108 50 2,525 SH   DFND 1 2,525 0 0
INSEEGO CORP CALL 45782B904 0 0 SH Call DFND 1 0 0 0
INSEEGO CORP COM 45782B104 25 2,500 SH   DFND 1 2,500 0 0
INTEL CORP CALL 458140900 0 0 SH Call DFND 1 0 0 0
INTEL CORP COM 458140100 31,932 498,949 SH   DFND 1 498,949 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 22,914 285,520 SH   DFND 1 285,520 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 23 1,000 SH   DFND 1 1,000 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 176 1,570 SH   DFND 1 1,570 0 0
INTERNATIONAL BUSINESS MACHS COM 459200101 4,064 30,510 SH   DFND 1 30,510 0 0
INTERNATIONAL FLAVORS&FRAGRA COM 459506101 7,470 53,500 SH   DFND 1 53,500 0 0
INTUIT COM 461202103 1,146 2,990 SH   DFND 1 2,990 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 1,273 1,723 SH   DFND 1 1,723 0 0
INVESCO EXCH TRADED FD TR II CHINA TECHNLGY 46138E800 913 11,216 SH   DFND 1 11,216 0 0
INVESCO QQQ TR UNIT SER 1 46090E103 5,876 18,406 SH   DFND 1 18,406 0 0
INVITAE CORP COM 46185L103 11,652 304,946 SH   DFND 1 304,946 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 7,658 241,896 SH   DFND 1 241,896 0 0
IQIYI INC NOTE 4.000%12/1 46267XAE8 1,697 1,619,000 PRN   DFND 1 1,619,000 0 0
IQIYI INC SPONSORED ADS 46267X108 831 50,000 SH   DFND 1 50,000 0 0
IQVIA HLDGS INC COM 46266C105 54,545 282,376 SH   DFND 1 282,376 0 0
IQVIA HLDGS INC PUT 46266C955 0 0 SH Put DFND 1 0 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 6,968 50,181 SH   DFND 1 50,181 0 0
ISHARES INC MSCI BRAZIL ETF 464286400 923 27,600 SH   DFND 1 27,600 0 0
ISHARES INC MSCI EURZONE ETF 464286608 3,116 67,150 SH   DFND 1 67,150 0 0
ISHARES INC MSCI PAC JP ETF 464286665 483 9,605 SH   DFND 1 9,605 0 0
ISHARES INC MSCI WORLD ETF 464286392 829 7,000 SH   DFND 1 7,000 0 0
ISHARES TR 20 YR TR BD ETF 464287432 5,472 40,397 SH   DFND 1 40,397 0 0
ISHARES TR 3 7 YR TREAS BD 464288661 42 325 SH   DFND 1 325 0 0
ISHARES TR GL TIMB FORE ETF 464288174 102 1,200 SH   DFND 1 1,200 0 0
ISHARES TR GLOBAL ENERG ETF 464287341 28 1,125 SH   DFND 1 1,125 0 0
ISHARES TR MSCI AC ASIA ETF 464288182 463 5,000 SH   DFND 1 5,000 0 0
ISHARES TR MSCI ACWI ETF 464288257 1,879 19,750 SH   DFND 1 19,750 0 0
ISHARES TR MSCI CHINA A 46434V514 333 8,100 SH   DFND 1 8,100 0 0
ISHARES TR MSCI CHINA ETF 46429B671 52 631 SH   DFND 1 631 0 0
ISHARES TR MSCI EAFE ETF 464287465 353 4,651 SH   DFND 1 4,651 0 0
ISHARES TR MSCI EMG MKT ETF 464287234 3,870 72,560 SH   DFND 1 72,560 0 0
ISHARES TR NASDAQ BIOTECH 464287556 23 150 SH   DFND 1 150 0 0
ISHARES TR PHLX SEMICND ETF 464287523 93 222 SH   DFND 1 222 0 0
ISHARES TR ROBOTICS ARTIF 46435U556 17 400 SH   DFND 1 400 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 0 0 SH   DFND 1 0 0 0
ISHARES TR US TREAS BD ETF 46429B267 3,036 116,002 SH   DFND 1 116,002 0 0
ITAU UNIBANCO HLDG S A SPON ADR REP PFD 465562106 60 12,168 SH   DFND 1 12,168 0 0
IZEA WORLDWIDE INC COM 46604H105 377 100,000 SH   DFND 1 100,000 0 0
JAZZ INVESTMENTS I LTD NOTE 1.500% 8/1 472145AD3 1,332 1,223,000 PRN   DFND 1 1,223,000 0 0
JD.COM INC SPON ADR CL A 47215P106 849 10,070 SH   DFND 1 10,070 0 0
JETBLUE AWYS CORP COM 477143101 548 26,952 SH   DFND 1 26,952 0 0
JINKOSOLAR HLDG CO LTD SPONSORED ADR 47759T100 10 250 SH   DFND 1 250 0 0
JOHNSON & JOHNSON COM 478160104 13,439 81,776 SH   DFND 1 81,776 0 0
JPMORGAN CHASE & CO CALL 46625H900 0 0 SH Call DFND 1 0 0 0
JPMORGAN CHASE & CO COM 46625H100 85,497 561,583 SH   DFND 1 561,583 0 0
JPMORGAN CHASE & CO PUT 46625H950 10 3,000 SH Put DFND 1 3,000 0 0
JUMIA TECHNOLOGIES AG SPONSORED ADS 48138M105 35 1,000 SH   DFND 1 1,000 0 0
KALA PHARMACEUTICALS INC COM 483119103 135 20,000 SH   DFND 1 20,000 0 0
KALEYRA INC COM 483379103 21 1,500 SH   DFND 1 1,500 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 8,728 829,681 SH   DFND 1 829,681 0 0
KELLOGG CO COM 487836108 1,779 28,110 SH   DFND 1 28,110 0 0
KEYCORP COM 493267108 5 253 SH   DFND 1 253 0 0
KIMBERLY-CLARK CORP COM 494368103 556 4,000 SH   DFND 1 4,000 0 0
KINDER MORGAN INC DEL COM 49456B101 142 8,500 SH   DFND 1 8,500 0 0
KINSALE CAP GROUP INC COM 49714P108 6 35 SH   DFND 1 35 0 0
KONTOOR BRANDS INC COM 50050N103 11 235 SH   DFND 1 235 0 0
KRAFT HEINZ CO COM 500754106 5,036 125,900 SH   DFND 1 125,900 0 0
KRANESHARES TR MSCI CHINA CLEAN 500767850 15 370 SH   DFND 1 370 0 0
KRATOS DEFENSE & SEC SOLUTIO COM NEW 50077B207 3 100 SH   DFND 1 100 0 0
KROGER CO COM 501044101 360 10,000 SH   DFND 1 10,000 0 0
KURA ONCOLOGY INC COM 50127T109 2,948 104,293 SH   DFND 1 104,293 0 0
LAM RESEARCH CORP COM 512807108 9 15 SH   DFND 1 15 0 0
LAS VEGAS SANDS CORP COM 517834107 33 540 SH   DFND 1 540 0 0
LAUDER ESTEE COS INC CL A 518439104 6,443 22,155 SH   DFND 1 22,155 0 0
LEMONADE INC COM 52567D107 49 525 SH   DFND 1 525 0 0
LENDINGTREE INC NEW COM 52603B107 6 30 SH   DFND 1 30 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 23 4,000 SH   DFND 1 4,000 0 0
LILLY ELI & CO COM 532457108 28 150 SH   DFND 1 150 0 0
LINDE PLC PUT G5494J953 0 0 SH Put DFND 1 0 0 0
LINDE PLC SHS G5494J103 99,252 353,512 SH   DFND 1 353,512 0 0
LIVE NATION ENTERTAINMENT IN COM 538034109 2,602 30,739 SH   DFND 1 30,739 0 0
LLOYDS BANKING GROUP PLC SPONSORED ADR 539439109 762 328,433 SH   DFND 1 328,433 0 0
LOCKHEED MARTIN CORP COM 539830109 285 770 SH   DFND 1 770 0 0
LOGITECH INTL S A SHS H50430232 45,829 435,012 SH   DFND 1 435,012 0 0
LORAL SPACE & COM INC COM 543881106 4 100 SH   DFND 1 100 0 0
LOWES COS INC COM 548661107 663 3,487 SH   DFND 1 3,487 0 0
LULULEMON ATHLETICA INC COM 550021109 843 2,750 SH   DFND 1 2,750 0 0
LUMENTUM HLDGS INC COM 55024U109 19 213 SH   DFND 1 213 0 0
LUMENTUM HLDGS INC NOTE 0.500%12/1 55024UAD1 2,834 2,442,000 PRN   DFND 1 2,442,000 0 0
LUMINAR TECHNOLOGIES INC COM CL A 550424105 122 5,000 SH   DFND 1 5,000 0 0
MACERICH CO COM 554382101 8 650 SH   DFND 1 650 0 0
MAGNOLIA OIL & GAS CORP CL A 559663109 391 34,060 SH   DFND 1 34,060 0 0
MARATHON OIL CORP COM 565849106 353 33,043 SH   DFND 1 33,043 0 0
MARATHON PETE CORP COM 56585A102 304 5,691 SH   DFND 1 5,691 0 0
MARCUS CORP DEL COM 566330106 123 6,136 SH   DFND 1 6,136 0 0
MARRIOTT INTL INC NEW CL A 571903202 1,504 10,150 SH   DFND 1 10,150 0 0
MARRIOTT VACTINS WORLDWID CO COM 57164Y107 223 1,281 SH   DFND 1 1,281 0 0
MARSH & MCLENNAN COS INC COM 571748102 6,205 50,954 SH   DFND 1 50,954 0 0
MARVELL TECHNOLOGY GROUP LTD ORD G5876H105 53 1,082 SH   DFND 1 1,082 0 0
MASTERCARD INCORPORATED CL A 57636Q104 1,805 5,070 SH   DFND 1 5,070 0 0
MATCH GROUP INC NEW COM 57667L107 31 230 SH   DFND 1 230 0 0
MATCH GROUP INC NEW PUT 57667L957 0 0 SH Put DFND 1 0 0 0
MAXAR TECHNOLOGIES INC COM 57778K105 4 100 SH   DFND 1 100 0 0
MCDONALDS CORP COM 580135101 11,055 49,313 SH   DFND 1 49,313 0 0
MEDALLIA INC COM 584021109 89 3,200 SH   DFND 1 3,200 0 0
MEDTRONIC PLC SHS G5960L103 12,342 104,492 SH   DFND 1 104,492 0 0
MERCADOLIBRE INC COM 58733R102 258 175 SH   DFND 1 175 0 0
MERCK & CO. INC COM 58933Y105 54,854 711,467 SH   DFND 1 711,467 0 0
MERCURY SYS INC COM 589378108 191 2,700 SH   DFND 1 2,700 0 0
MESOBLAST LTD SPONS ADR 590717104 17 2,000 SH   DFND 1 2,000 0 0
METLIFE INC COM 59156R108 15,232 250,552 SH   DFND 1 250,552 0 0
MGM RESORTS INTERNATIONAL COM 552953101 0 0 SH   DFND 1 0 0 0
MICROCHIP TECHNOLOGY INC. NOTE 1.625% 2/1 595017AF1 799 351,000 PRN   DFND 1 351,000 0 0
MICRON TECHNOLOGY INC COM 595112103 686 7,780 SH   DFND 1 7,780 0 0
MICROSOFT CORP CALL 594918904 461 9,200 SH Call DFND 1 9,200 0 0
MICROSOFT CORP COM 594918104 181,132 768,193 SH   DFND 1 768,193 0 0
MICROSOFT CORP PUT 594918954 0 0 SH Put DFND 1 0 0 0
MICROSTRATEGY INC CL A NEW 594972408 34 50 SH   DFND 1 50 0 0
MICROVISION INC DEL COM NEW 594960304 93 5,000 SH   DFND 1 5,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 7,439 43,428 SH   DFND 1 43,428 0 0
MODERNA INC CALL 60770K907 8 600 SH Call DFND 1 600 0 0
MODERNA INC COM 60770K107 20,931 159,849 SH   DFND 1 159,849 0 0
MODERNA INC PUT 60770K957 0 0 SH Put DFND 1 0 0 0
MOMO INC ADR 60879B107 59 4,000 SH   DFND 1 4,000 0 0
MONDELEZ INTL INC CL A 609207105 29,751 508,307 SH   DFND 1 508,307 0 0
MORGAN STANLEY COM NEW 617446448 62 800 SH   DFND 1 800 0 0
MOTOROLA SOLUTIONS INC COM NEW 620076307 940 5,000 SH   DFND 1 5,000 0 0
MSC INDL DIRECT INC CL A 553530106 167 1,855 SH   DFND 1 1,855 0 0
MTBC INC COM 55378G102 0 0 SH   DFND 1 0 0 0
NANO DIMENSION LTD SPONSORD ADS NEW 63008G203 34 4,000 SH   DFND 1 4,000 0 0
NANOVIRICIDES INC COM 630087302 189 40,000 SH   DFND 1 40,000 0 0
NASDAQ INC COM 631103108 105 717 SH   DFND 1 717 0 0
NATERA INC COM 632307104 16,579 163,278 SH   DFND 1 163,278 0 0
NATWEST GROUP PLC SPONS ADR 2 ORD 639057108 787 146,487 SH   DFND 1 146,487 0 0
NCINO INC COM 63947U107 40 600 SH   DFND 1 600 0 0
NEOGENOMICS INC COM NEW 64049M209 17,411 361,005 SH   DFND 1 361,005 0 0
NEOVASC INC COM 64065J304 0 85 SH   DFND 1 85 0 0
NETEASE INC SPONSORED ADS 64110W102 83 800 SH   DFND 1 800 0 0
NETFLIX INC COM 64110L106 12,965 24,853 SH   DFND 1 24,853 0 0
NETFLIX INC PUT 64110L956 0 0 SH Put DFND 1 0 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 14,574 149,864 SH   DFND 1 149,864 0 0
NEW RELIC INC COM 64829B100 192 3,120 SH   DFND 1 3,120 0 0
NEWMONT CORP COM 651639106 1,846 30,651 SH   DFND 1 30,651 0 0
NEXTCURE INC COM 65343E108 2,789 278,616 SH   DFND 1 278,616 0 0
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NIKE INC CL B 654106103 14,545 109,463 SH   DFND 1 109,463 0 0
NIKOLA CORP COM 654110105 2 110 SH   DFND 1 110 0 0
NIO INC SPON ADS 62914V106 1,220 31,324 SH   DFND 1 31,324 0 0
NOKIA CORP SPONSORED ADR 654902204 0 85 SH   DFND 1 85 0 0
NORTHROP GRUMMAN CORP COM 666807102 0 0 SH   DFND 1 0 0 0
NORWEGIAN CRUISE LINE HLDG L SHS G66721104 609 22,072 SH   DFND 1 22,072 0 0
NOV INC COM 62955J103 432 31,522 SH   DFND 1 31,522 0 0
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NOVARTIS AG SPONSORED ADR 66987V109 26 300 SH   DFND 1 300 0 0
NOVAVAX INC COM NEW 670002401 12,130 66,902 SH   DFND 1 66,902 0 0
NOVOCURE LTD ORD SHS G6674U108 402 3,040 SH   DFND 1 3,040 0 0
NUTANIX INC CL A 67059N108 316 11,900 SH   DFND 1 11,900 0 0
NV5 GLOBAL INC COM 62945V109 8 85 SH   DFND 1 85 0 0
NVIDIA CORPORATION COM 67066G104 10,474 19,615 SH   DFND 1 19,615 0 0
NVIDIA CORPORATION PUT 67066G954 0 0 SH Put DFND 1 0 0 0
NXP SEMICONDUCTORS N V COM N6596X109 805 4,000 SH   DFND 1 4,000 0 0
OBSEVA SA COM H5861P103 12 3,900 SH   DFND 1 3,900 0 0
OCCIDENTAL PETE CORP *W EXP 08/03/202 674599162 15 1,404 SH   DFND 1 1,404 0 0
OCCIDENTAL PETE CORP COM 674599105 266 9,971 SH   DFND 1 9,971 0 0
OCEANEERING INTL INC COM 675232102 387 33,921 SH   DFND 1 33,921 0 0
OI SA SPONSORED ADR NE 670851500 0 2 SH   DFND 1 2 0 0
OMNICOM GROUP INC COM 681919106 219 2,960 SH   DFND 1 2,960 0 0
ONEOK INC NEW COM 682680103 82 1,614 SH   DFND 1 1,614 0 0
ONTRAK INC COM 683373104 9,659 296,641 SH   DFND 1 296,641 0 0
ORACLE CORP COM 68389X105 679 9,687 SH   DFND 1 9,687 0 0
OREILLY AUTOMOTIVE INC COM 67103H107 86 169 SH   DFND 1 169 0 0
OSISKO GOLD ROYALTIES LTD COM 68827L101 44 4,000 SH   DFND 1 4,000 0 0
OTIS WORLDWIDE CORP COM 68902V107 44 645 SH   DFND 1 645 0 0
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PACIFIC BIOSCIENCES CALIF IN COM 69404D108 67 2,000 SH   DFND 1 2,000 0 0
PALANTIR TECHNOLOGIES INC CALL 69608A908 0 0 SH Call DFND 1 0 0 0
PALANTIR TECHNOLOGIES INC CL A 69608A108 1,024 43,900 SH   DFND 1 43,900 0 0
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PALO ALTO NETWORKS INC COM 697435105 67,027 208,099 SH   DFND 1 208,099 0 0
PALO ALTO NETWORKS INC PUT 697435955 0 0 SH Put DFND 1 0 0 0
PAN AMERN SILVER CORP COM 697900108 138 4,600 SH   DFND 1 4,600 0 0
PAR PAC HOLDINGS INC COM NEW 69888T207 258 18,302 SH   DFND 1 18,302 0 0
PARK HOTELS & RESORTS INC COM 700517105 43 2,000 SH   DFND 1 2,000 0 0
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PAYSAFE LIMITED ORD G6964L107 3 250 SH   DFND 1 250 0 0
PDC ENERGY INC COM 69327R101 137 3,983 SH   DFND 1 3,983 0 0
PELOTON INTERACTIVE INC CL A COM 70614W100 1,832 16,291 SH   DFND 1 16,291 0 0
PEPSICO INC COM 713448108 1,069 7,556 SH   DFND 1 7,556 0 0
PERION NETWORK LTD SHS NEW M78673114 9 500 SH   DFND 1 500 0 0
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408 1,081 127,478 SH   DFND 1 127,478 0 0
PFIZER INC COM 717081103 2,994 82,676 SH   DFND 1 82,676 0 0
PG&E CORP COM 69331C108 984 84,000 SH   DFND 1 84,000 0 0
PHARVARIS N V COM N69605108 422 15,030 SH   DFND 1 15,030 0 0
PHENIXFIN CORP COM 71742W103 82 2,500 SH   DFND 1 2,500 0 0
PHILIP MORRIS INTL INC COM 718172109 2,813 31,690 SH   DFND 1 31,690 0 0
PHILLIPS 66 COM 718546104 2,545 31,195 SH   DFND 1 31,195 0 0
PINDUODUO INC NOTE 12/0 722304AC6 2,865 2,707,000 PRN   DFND 1 2,707,000 0 0
PINDUODUO INC SPONSORED ADS 722304102 0 0 SH   DFND 1 0 0 0
PINTEREST INC CALL 72352L906 0 0 SH Call DFND 1 0 0 0
PINTEREST INC CL A 72352L106 33,038 446,271 SH   DFND 1 446,271 0 0
PINTEREST INC PUT 72352L956 0 0 SH Put DFND 1 0 0 0
PJT PARTNERS INC COM CL A 69343T107 6 85 SH   DFND 1 85 0 0
PLUG POWER INC CALL 72919P902 0 0 SH Call DFND 1 0 0 0
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POLARIS INC COM 731068102 12 90 SH   DFND 1 90 0 0
PPG INDS INC COM 693506107 920 6,127 SH   DFND 1 6,127 0 0
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PROSHARES TR S&P 500 DV ARIST 74348A467 105 1,223 SH   DFND 1 1,223 0 0
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PROTO LABS INC COM 743713109 37 300 SH   DFND 1 300 0 0
PTC INC COM 69370C100 925 6,723 SH   DFND 1 6,723 0 0
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PULTE GROUP INC COM 745867101 103 1,959 SH   DFND 1 1,959 0 0
PVH CORPORATION COM 693656100 323 3,052 SH   DFND 1 3,052 0 0
QIAGEN NV DEBT 1.000%11/1 N72482AT4 988 800,000 PRN   DFND 1 800,000 0 0
QIAGEN NV SHS NEW N72482123 2,803 57,777 SH   DFND 1 57,777 0 0
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QUALCOMM INC COM 747525103 655 4,948 SH   DFND 1 4,948 0 0
QUALYS INC COM 74758T303 63 600 SH   DFND 1 600 0 0
QUANTERIX CORP COM 74766Q101 8,119 138,854 SH   DFND 1 138,854 0 0
R1 RCM INC COM 749397105 5,878 238,178 SH   DFND 1 238,178 0 0
RAYTHEON TECHNOLOGIES CORP COM 75513E101 1,091 14,099 SH   DFND 1 14,099 0 0
REDFIN CORP COM 75737F108 20 300 SH   DFND 1 300 0 0
REGENERON PHARMACEUTICALS COM 75886F107 556 1,175 SH   DFND 1 1,175 0 0
REPUBLIC SVCS INC COM 760759100 20 200 SH   DFND 1 200 0 0
RESIDEO TECHNOLOGIES INC COM 76118Y104 5 165 SH   DFND 1 165 0 0
RINGCENTRAL INC NOTE 3/0 76680RAF4 1,635 1,494,000 PRN   DFND 1 1,494,000 0 0
RIO TINTO PLC SPONSORED ADR 767204100 505 6,500 SH   DFND 1 6,500 0 0
RLX TECHNOLOGY INC SPONSORED ADS 74969N103 2 240 SH   DFND 1 240 0 0
ROKU INC COM CL A 77543R102 244 750 SH   DFND 1 750 0 0
ROKU INC PUT 77543R952 0 0 SH Put DFND 1 0 0 0
ROSS STORES INC COM 778296103 703 5,855 SH   DFND 1 5,855 0 0
ROYAL BK CDA COM 780087102 515 5,581 SH   DFND 1 5,581 0 0
ROYAL CARIBBEAN GROUP COM V7780T103 758 8,850 SH   DFND 1 8,850 0 0
ROYAL DUTCH SHELL PLC SPON ADR B 780259107 609 16,531 SH   DFND 1 16,531 0 0
ROYAL DUTCH SHELL PLC SPONS ADR A 780259206 170 4,320 SH   DFND 1 4,320 0 0
ROYAL GOLD INC COM 780287108 269 2,500 SH   DFND 1 2,500 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 4,393 163,172 SH   DFND 1 163,172 0 0
S&P GLOBAL INC COM 78409V104 101,351 287,216 SH   DFND 1 287,216 0 0
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SANDSTORM GOLD LTD COM NEW 80013R206 7 1,000 SH   DFND 1 1,000 0 0
SANGAMO THERAPEUTICS INC COM 800677106 10,756 858,429 SH   DFND 1 858,429 0 0
SC HEALTH CORP UNIT 99/99/9999 G78516302 22 2,000 SH   DFND 1 2,000 0 0
SEA LTD SPONSORD ADS 81141R100 33 150 SH   DFND 1 150 0 0
SEAGATE TECHNOLOGY PLC SHS G7945M107 23 300 SH   DFND 1 300 0 0
SELECT SECTOR SPDR TR ENERGY 81369Y506 108 2,200 SH   DFND 1 2,200 0 0
SELECT SECTOR SPDR TR SBI INT-FINL 81369Y605 34 1,000 SH   DFND 1 1,000 0 0
SEMPRA ENERGY COM 816851109 742 5,590 SH   DFND 1 5,590 0 0
SERVICE CORP INTL COM 817565104 38 750 SH   DFND 1 750 0 0
SERVICENOW INC COM 81762P102 233 465 SH   DFND 1 465 0 0
SHERWIN WILLIAMS CO COM 824348106 1,476 2,000 SH   DFND 1 2,000 0 0
SHOPIFY INC CL A 82509L107 1,257 1,135 SH   DFND 1 1,135 0 0
SHOPIFY INC NOTE 0.125%11/0 82509LAA5 2,291 2,014,000 PRN   DFND 1 2,014,000 0 0
SIFY TECHNOLOGIES LTD SPONSORED ADS 82655M107 0 35 SH   DFND 1 35 0 0
SIGNIFY HEALTH INC CL A COM 82671G100 5,288 180,734 SH   DFND 1 180,734 0 0
SILVERCORP METALS INC COM 82835P103 14 2,790 SH   DFND 1 2,790 0 0
SIMON PPTY GROUP INC NEW COM 828806109 405 3,563 SH   DFND 1 3,563 0 0
SIMPSON MFG INC COM 829073105 539 5,200 SH   DFND 1 5,200 0 0
SKYWEST INC COM 830879102 73 1,331 SH   DFND 1 1,331 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 156 850 SH   DFND 1 850 0 0
SL GREEN RLTY CORP COM 78440X804 84 1,197 SH   DFND 1 1,197 0 0
SLACK TECHNOLOGIES INC COM CL A 83088V102 142 3,500 SH   DFND 1 3,500 0 0
SNAP INC CL A 83304A106 500 9,565 SH   DFND 1 9,565 0 0
SNOWFLAKE INC CL A 833445109 966 4,210 SH   DFND 1 4,210 0 0
SONOS INC COM 83570H108 4,871 130,000 SH   DFND 1 130,000 0 0
SOUTHERN CO COM 842587107 559 9,000 SH   DFND 1 9,000 0 0
SOUTHERN COPPER CORP COM 84265V105 7 100 SH   DFND 1 100 0 0
SOUTHWEST AIRLS CO NOTE 1.250% 5/0 844741BG2 980 564,000 PRN   DFND 1 564,000 0 0
SPDR GOLD TR GOLD SHS 78463V107 344 2,150 SH   DFND 1 2,150 0 0
SPDR INDEX SHS FDS EURO STOXX 50 78463X202 353 7,930 SH   DFND 1 7,930 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 10,680 26,948 SH   DFND 1 26,948 0 0
SPDR SER TR S&P DIVID ETF 78464A763 21 175 SH   DFND 1 175 0 0
SPDR SER TR SSGA GNDER ETF 78468R747 29 310 SH   DFND 1 310 0 0
SPI ENERGY CO LTD SHS NEW G8651P110 18 2,365 SH   DFND 1 2,365 0 0
SPIRIT AEROSYSTEMS HLDGS INC COM CL A 848574109 452 9,299 SH   DFND 1 9,299 0 0
SPIRIT AIRLS INC COM 848577102 159 4,318 SH   DFND 1 4,318 0 0
SPLUNK INC COM 848637104 27 200 SH   DFND 1 200 0 0
SPLUNK INC NOTE 1.125% 9/1 848637AD6 1,065 900,000 PRN   DFND 1 900,000 0 0
SPOTIFY TECHNOLOGY S A PUT L8681T952 0 0 SH Put DFND 1 0 0 0
SPOTIFY TECHNOLOGY S A SHS L8681T102 65,353 243,880 SH   DFND 1 243,880 0 0
SPROUTS FMRS MKT INC COM 85208M102 5,066 190,381 SH   DFND 1 190,381 0 0
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SQUARE INC CL A 852234103 790 3,480 SH   DFND 1 3,480 0 0
STARBUCKS CORP COM 855244109 1,421 13,000 SH   DFND 1 13,000 0 0
STEEL CONNECT INC COM 858098106 2 800 SH   DFND 1 800 0 0
STELLANTIS N.V SHS N82405106 532 30,010 SH   DFND 1 30,010 0 0
STERICYCLE INC COM 858912108 41 600 SH   DFND 1 600 0 0
STERIS PLC SHS USD G8473T100 143 750 SH   DFND 1 750 0 0
STERLING BANCORP DEL COM 85917A100 75 3,263 SH   DFND 1 3,263 0 0
STRYKER CORPORATION COM 863667101 90 370 SH   DFND 1 370 0 0
SUNCOR ENERGY INC NEW COM 867224107 305 14,607 SH   DFND 1 14,607 0 0
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SYNCHRONY FINANCIAL COM 87165B103 5,400 132,723 SH   DFND 1 132,723 0 0
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TABULA RASA HEALTHCARE INC COM 873379101 15,857 344,334 SH   DFND 1 344,334 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 7,489 63,327 SH   DFND 1 63,327 0 0
TAKE-TWO INTERACTIVE SOFTWAR COM 874054109 88 500 SH   DFND 1 500 0 0
TAL EDUCATION GROUP SPONSORED ADS 874080104 21,952 407,650 SH   DFND 1 407,650 0 0
TALEND S A ADS 874224207 88 1,375 SH   DFND 1 1,375 0 0
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TARGET CORP COM 87612E106 139 700 SH   DFND 1 700 0 0
TC ENERGY CORP COM 87807B107 519 11,326 SH   DFND 1 11,326 0 0
TE CONNECTIVITY LTD REG SHS H84989104 3,116 24,144 SH   DFND 1 24,144 0 0
TECHNIPFMC PLC COM G87110105 406 52,954 SH   DFND 1 52,954 0 0
TEEKAY CORPORATION COM Y8564W103 51 15,900 SH   DFND 1 15,900 0 0
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TENCENT MUSIC ENTMT GROUP SPON ADS 88034P109 161 7,835 SH   DFND 1 7,835 0 0
TERADYNE INC COM 880770102 24 200 SH   DFND 1 200 0 0
TESLA INC COM 88160R101 3,831 5,738 SH   DFND 1 5,738 0 0
TESLA INC PUT 88160R951 62 500 SH Put DFND 1 500 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 9 800 SH   DFND 1 800 0 0
TEXAS INSTRS INC COM 882508104 112 595 SH   DFND 1 595 0 0
THE TRADE DESK INC COM CL A 88339J105 33 50 SH   DFND 1 50 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 106,854 234,146 SH   DFND 1 234,146 0 0
THERMO FISHER SCIENTIFIC INC PUT 883556952 0 0 SH Put DFND 1 0 0 0
TIM S A SPONSORED ADR 88706T108 1 45 SH   DFND 1 45 0 0
TJX COS INC NEW COM 872540109 94 1,423 SH   DFND 1 1,423 0 0
TORONTO DOMINION BK ONT COM NEW 891160509 416 6,390 SH   DFND 1 6,390 0 0
TOYOTA MOTOR CORP SP ADR REP2COM 892331307 47 300 SH   DFND 1 300 0 0
TRACTOR SUPPLY CO COM 892356106 131 740 SH   DFND 1 740 0 0
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TRANSOCEAN LTD REG SHS H8817H100 602 169,493 SH   DFND 1 169,493 0 0
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TYSON FOODS INC CL A 902494103 269 3,620 SH   DFND 1 3,620 0 0
UBER TECHNOLOGIES INC COM 90353T100 1,142 20,950 SH   DFND 1 20,950 0 0
UBS GROUP AG SHS H42097107 47,842 3,076,423 SH   DFND 1 3,076,423 0 0
UGI CORP NEW COM 902681105 352 8,576 SH   DFND 1 8,576 0 0
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ULTRA CLEAN HLDGS INC COM 90385V107 406 7,000 SH   DFND 1 7,000 0 0
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UNITED AIRLS HLDGS INC COM 910047109 527 9,173 SH   DFND 1 9,173 0 0
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V F CORP COM 918204108 168 2,100 SH   DFND 1 2,100 0 0
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VANECK VECTORS ETF TR JR GOLD MINERS E 92189F791 270 6,000 SH   DFND 1 6,000 0 0
VANGUARD INTL EQUITY INDEX F FTSE EUROPE ETF 922042874 44 700 SH   DFND 1 700 0 0
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VIATRIS INC COM 92556V106 122 8,665 SH   DFND 1 8,665 0 0
VIPER ENERGY PARTNERS LP COM UNT RP INT 92763M105 284 19,516 SH   DFND 1 19,516 0 0
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VISA INC COM CL A 92826C839 171,869 811,699 SH   DFND 1 811,699 0 0
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VULCAN MATLS CO COM 929160109 337 2,000 SH   DFND 1 2,000 0 0
WABTEC COM 929740108 250 3,156 SH   DFND 1 3,156 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 159 2,900 SH   DFND 1 2,900 0 0
WALMART INC COM 931142103 1,082 7,962 SH   DFND 1 7,962 0 0
WARNER MUSIC GROUP CORP COM CL A 934550203 242 7,060 SH   DFND 1 7,060 0 0
WASTE MGMT INC DEL COM 94106L109 30,820 238,882 SH   DFND 1 238,882 0 0
WEIBO CORP NOTE 1.250%11/1 948596AC5 1,517 1,540,000 PRN   DFND 1 1,540,000 0 0
WELLS FARGO CO NEW CALL 949746901 12 1,000 SH Call DFND 1 1,000 0 0
WELLS FARGO CO NEW COM 949746101 6,322 161,872 SH   DFND 1 161,872 0 0
WESTERN UN CO COM 959802109 984 39,900 SH   DFND 1 39,900 0 0
WHEATON PRECIOUS METALS CORP COM 962879102 259 6,800 SH   DFND 1 6,800 0 0
WILLIAMS COS INC COM 969457100 172 7,245 SH   DFND 1 7,245 0 0
WISDOMTREE TR JAPN HEDGE EQT 97717W851 705 11,500 SH   DFND 1 11,500 0 0
WIX COM LTD SHS M98068105 42 150 SH   DFND 1 150 0 0
WORLD WRESTLING ENTMT INC CL A 98156Q108 1,312 24,200 SH   DFND 1 24,200 0 0
XPENG INC ADS 98422D105 481 13,185 SH   DFND 1 13,185 0 0
YATSEN HLDG LTD ADS 985194109 220 17,800 SH   DFND 1 17,800 0 0
Y-MABS THERAPEUTICS INC COM 984241109 5,488 181,492 SH   DFND 1 181,492 0 0
YOUDAO INC SPONSORED ADS 98741T104 48 2,000 SH   DFND 1 2,000 0 0
YUM CHINA HLDGS INC COM 98850P109 20,604 347,976 SH   DFND 1 347,976 0 0
ZEBRA TECHNOLOGIES CORPORATI CL A 989207105 606 1,250 SH   DFND 1 1,250 0 0
ZIM INTEGRATED SHIPPING SERV SHS M9T951109 5 200 SH   DFND 1 200 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 69 430 SH   DFND 1 430 0 0
ZOETIS INC CL A 98978V103 568 3,602 SH   DFND 1 3,602 0 0
ZOOM VIDEO COMMUNICATIONS IN CALL 98980L901 7 300 SH Call DFND 1 300 0 0
ZOOM VIDEO COMMUNICATIONS IN CL A 98980L101 193 600 SH   DFND 1 600 0 0
ZOOM VIDEO COMMUNICATIONS IN PUT 98980L951 0 0 SH Put DFND 1 0 0 0
ZUORA INC COM CL A 98983V106 104 7,000 SH   DFND 1 7,000 0 0
ZYNGA INC NOTE 0.250% 6/0 98986TAB4 991 723,000 PRN   DFND 1 723,000 0 0
3M CO COM 88579Y101 2,426 12,595 SH   DFND 2 12,595 0 0
ABBOTT LABS COM 002824100 4,510 37,589 SH   DFND 2 37,589 0 0
ABBVIE INC COM 00287Y109 13,339 123,281 SH   DFND 2 123,281 0 0
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ACCENTURE PLC IRELAND SHS CLASS A G1151C101 17 61 SH   DFND 2 61 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 9,195 19,349 SH   DFND 2 19,349 0 0
AGNICO EAGLE MINES LTD COM 008474108 230 3,990 SH   DFND 2 3,990 0 0
AIR PRODS & CHEMS INC COM 009158106 0 0 SH   DFND 2 0 0 0
ALCON AG ORD SHS H01301128 986 14,017 SH   DFND 2 14,017 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 2,363 10,410 SH   DFND 2 10,410 0 0
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AMAZON COM INC COM 023135106 16,559 5,352 SH   DFND 2 5,352 0 0
AMETEK INC COM 031100100 1,284 10,061 SH   DFND 2 10,061 0 0
AMGEN INC COM 031162100 644 2,584 SH   DFND 2 2,584 0 0
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AON PLC SHS CL A G0403H108 271 1,180 SH   DFND 2 1,180 0 0
APPLE INC COM 037833100 9,046 74,043 SH   DFND 2 74,043 0 0
ARISTA NETWORKS INC COM 040413106 2,414 7,998 SH   DFND 2 7,998 0 0
AT&T INC COM 00206R102 61 2,000 SH   DFND 2 2,000 0 0
AXIS CAP HLDGS LTD SHS G0692U109 99 2,000 SH   DFND 2 2,000 0 0
BALL CORP COM 058498106 7,299 86,182 SH   DFND 2 86,182 0 0
BANK NEW YORK MELLON CORP COM 064058100 477 10,093 SH   DFND 2 10,093 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 8 112 SH   DFND 2 112 0 0
BK OF AMERICA CORP COM 060505104 80 2,074 SH   DFND 2 2,074 0 0
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BRISTOL-MYERS SQUIBB CO COM 110122108 76 1,195 SH   DFND 2 1,195 0 0
BROADCOM INC COM 11135F101 14 30 SH   DFND 2 30 0 0
CATERPILLAR INC COM 149123101 116 500 SH   DFND 2 500 0 0
CHUBB LIMITED COM H1467J104 3,408 21,578 SH   DFND 2 21,578 0 0
CISCO SYS INC COM 17275R102 5 100 SH   DFND 2 100 0 0
COCA COLA CO COM 191216100 9,128 173,235 SH   DFND 2 173,235 0 0
COLGATE PALMOLIVE CO COM 194162103 69 876 SH   DFND 2 876 0 0
COMCAST CORP NEW CL A 20030N101 14 266 SH   DFND 2 266 0 0
CSX CORP COM 126408103 3,816 39,577 SH   DFND 2 39,577 0 0
CVS HEALTH CORP COM 126650100 409 5,432 SH   DFND 2 5,432 0 0
DISNEY WALT CO COM 254687106 16,121 87,365 SH   DFND 2 87,365 0 0
DOLLAR GEN CORP NEW COM 256677105 910 4,488 SH   DFND 2 4,488 0 0
EMERSON ELEC CO COM 291011104 20 225 SH   DFND 2 225 0 0
EOG RES INC COM 26875P101 15 200 SH   DFND 2 200 0 0
EXELON CORP COM 30161N101 526 12,030 SH   DFND 2 12,030 0 0
EXPEDIA GROUP INC COM NEW 30212P303 51 300 SH   DFND 2 300 0 0
EXXON MOBIL CORP COM 30231G102 2 37 SH   DFND 2 37 0 0
FACEBOOK INC CL A 30303M102 4,666 15,847 SH   DFND 2 15,847 0 0
FEDEX CORP COM 31428X106 454 1,600 SH   DFND 2 1,600 0 0
FERRARI N V COM N3167Y103 1,147 5,465 SH   DFND 2 5,465 0 0
FRANCO NEV CORP COM 351858105 4 31 SH   DFND 2 31 0 0
FREEPORT-MCMORAN INC CL B 35671D857 1,793 54,431 SH   DFND 2 54,431 0 0
GENERAL ELECTRIC CO COM 369604103 622 47,350 SH   DFND 2 47,350 0 0
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IHS MARKIT LTD SHS G47567105 211 2,174 SH   DFND 2 2,174 0 0
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INTEL CORP COM 458140100 282 4,400 SH   DFND 2 4,400 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 0 0 SH   DFND 2 0 0 0
IQVIA HLDGS INC COM 46266C105 2,209 11,443 SH   DFND 2 11,443 0 0
ISHARES TR MSCI USA MIN VOL 46429B697 3,805 55,000 SH   DFND 2 55,000 0 0
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JPMORGAN CHASE & CO COM 46625H100 13,426 88,209 SH   DFND 2 88,209 0 0
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LAM RESEARCH CORP COM 512807108 10 17 SH   DFND 2 17 0 0
LAUDER ESTEE COS INC CL A 518439104 54 185 SH   DFND 2 185 0 0
LINDE PLC SHS G5494J103 9,139 32,571 SH   DFND 2 32,571 0 0
LIVE NATION ENTERTAINMENT IN COM 538034109 0 0 SH   DFND 2 0 0 0
LOGITECH INTL S A SHS H50430232 890 8,452 SH   DFND 2 8,452 0 0
MARSH & MCLENNAN COS INC COM 571748102 338 2,786 SH   DFND 2 2,786 0 0
MASTERCARD INCORPORATED CL A 57636Q104 4 11 SH   DFND 2 11 0 0
MCDONALDS CORP COM 580135101 1,689 7,546 SH   DFND 2 7,546 0 0
MEDTRONIC PLC SHS G5960L103 175 1,484 SH   DFND 2 1,484 0 0
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METLIFE INC COM 59156R108 3,696 60,769 SH   DFND 2 60,769 0 0
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MICROSOFT CORP COM 594918104 10,001 42,410 SH   DFND 2 42,410 0 0
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MONDELEZ INTL INC CL A 609207105 2,219 37,931 SH   DFND 2 37,931 0 0
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PFIZER INC COM 717081103 139 3,833 SH   DFND 2 3,833 0 0
PHILLIPS 66 COM 718546104 29 360 SH   DFND 2 360 0 0
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PPG INDS INC COM 693506107 49 325 SH   DFND 2 325 0 0
PROCTER AND GAMBLE CO COM 742718109 6,665 49,236 SH   DFND 2 49,236 0 0
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RESMED INC COM 761152107 3 16 SH   DFND 2 16 0 0
S&P GLOBAL INC COM 78409V104 2,281 6,467 SH   DFND 2 6,467 0 0
SELECT SECTOR SPDR TR SBI CONS STPLS 81369Y308 2,049 30,000 SH   DFND 2 30,000 0 0
SEMPRA ENERGY COM 816851109 934 7,050 SH   DFND 2 7,050 0 0
SHERWIN WILLIAMS CO COM 824348106 10 13 SH   DFND 2 13 0 0
SPOTIFY TECHNOLOGY S A SHS L8681T102 8,894 33,198 SH   DFND 2 33,198 0 0
SPROUTS FMRS MKT INC COM 85208M102 340 12,800 SH   DFND 2 12,800 0 0
STELLANTIS N.V SHS N82405106 1,742 98,334 SH   DFND 2 98,334 0 0
STERICYCLE INC COM 858912108 57 850 SH   DFND 2 850 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 1,856 15,690 SH   DFND 2 15,690 0 0
TEXAS INSTRS INC COM 882508104 17 89 SH   DFND 2 89 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 9,705 21,273 SH   DFND 2 21,273 0 0
TRANE TECHNOLOGIES PLC PUT G8994E953 0 0 SH Put DFND 2 0 0 0
TRANE TECHNOLOGIES PLC SHS G8994E103 1,220 7,365 SH   DFND 2 7,365 0 0
UNION PAC CORP COM 907818108 11 48 SH   DFND 2 48 0 0
UNITEDHEALTH GROUP INC COM 91324P102 13 36 SH   DFND 2 36 0 0
VERISIGN INC COM 92343E102 398 2,000 SH   DFND 2 2,000 0 0
VERIZON COMMUNICATIONS INC COM 92343V104 6,333 108,875 SH   DFND 2 108,875 0 0
VIATRIS INC COM 92556V106 5 363 SH   DFND 2 363 0 0
VISA INC COM CL A 92826C839 17,112 80,814 SH   DFND 2 80,814 0 0
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WASTE MGMT INC DEL COM 94106L109 5,279 40,934 SH   DFND 2 40,934 0 0
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