The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AES CORP COM 00130H105 1,881,636 80,069,614 SH   DFND 1, 2 80,069,614 0 0
ABBOTT LABS COM 002824100 306,549 2,799,876 SH   DFND 1, 2 2,790,899 0 8,977
ABCELLERA BIOLOGICS INC COM 00288U106 146,450 3,639,423 SH   DFND 1, 2 3,639,423 0 0
ACACIA COMMUNICATIONS INC COM 00401C108 27,725 380,000 SH   DFND 1, 2 380,000 0 0
ACTIVISION BLIZZARD INC COM 00507V109 2,663,406 28,685,107 SH   DFND 1, 2 28,680,532 0 4,575
ACUTUS MED INC COM 005111109 36,104 1,253,167 SH   DFND 1, 2 1,253,167 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 43,135 8,002,700 SH   DFND 1, 2 8,002,700 0 0
ADDUS HOMECARE CORP COM 006739106 84,480 721,500 SH   DFND 1, 2 721,500 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 1,259,645 2,518,700 SH   DFND 1, 2 2,515,901 0 2,799
ADVANCED MICRO DEVICES INC COM 007903107 4,241,460 46,248,550 SH   DFND 1, 2 46,239,004 0 9,546
AGORA INC ADS 00851L103 58,549 1,480,000 SH   DFND 1, 2 1,480,000 0 0
AIRBNB INC COM CL A 009066101 369,147 2,514,628 SH   DFND 1, 2 2,514,628 0 0
AIR PRODS & CHEMS INC COM 009158106 287,340 1,051,710 SH   DFND 1, 2 1,047,791 0 3,919
ALARM COM HLDGS INC COM 011642105 157,968 1,527,000 SH   DFND 1, 2 1,527,000 0 0
ALCOA CORP COM 013872106 20,976 910,000 SH   DFND 1, 2 910,000 0 0
ALEXANDRIA REAL ESTATE EQ IN COM 015271109 609,515 3,420,014 SH   DFND 1, 2 3,420,014 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 2,277 9,551 SH   DFND 1, 2 6 0 9,545
ALIGN TECHNOLOGY INC COM 016255101 11,910 22,288 SH   DFND 1, 2 22,288 0 0
ALLAKOS INC COM 01671P100 900,429 6,431,639 SH   DFND 1, 2 6,431,639 0 0
ALLEGHENY TECHNOLOGIES INC COM 01741R102 43,425 2,589,437 SH   DFND 1, 2 2,589,437 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 59,865 2,371,817 SH   DFND 1, 2 2,371,817 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 45,820 352,546 SH   DFND 1, 2 352,546 0 0
ALPHABET INC CAP STK CL C 02079K107 4,011,271 2,289,705 SH   DFND 1, 2 2,288,291 0 1,414
ALPHABET INC CAP STK CL A 02079K305 3,082,173 1,758,630 SH   DFND 1, 2 1,754,225 0 4,405
ALTIMMUNE INC COM NEW 02155H200 15,837 1,404,000 SH   DFND 1, 2 1,404,000 0 0
ALTERYX INC COM CL A 02156B103 562,250 4,616,549 SH   DFND 1, 2 4,616,547 0 2
ALTICE USA INC CL A 02156K103 38,768 1,023,700 SH   DFND 1, 2 1,023,700 0 0
ALTRIA GROUP INC COM 02209S103 4,647,408 113,351,403 SH   DFND 1, 2 113,351,403 0 0
AMAZON COM INC COM 023135106 10,245,653 3,145,786 SH   DFND 1, 2 3,144,122 0 1,664
AMERICA MOVIL SAB DE CV SPON ADR L SHS 02364W105 113,024 7,773,167 SH   DFND 1, 2 7,760,239 0 12,928
AMERICAN AIRLS GROUP INC NOTE 6.500% 7/0 02376RAF9 4,572 3,633,000 PRN   DFND 1, 2 3,633,000 0 0
AMERICAN ELEC PWR CO INC COM 025537101 1,188,982 14,278,635 SH   DFND 1, 2 14,278,635 0 0
AMERICAN ELEC PWR CO INC UNIT 08/01/2021 025537127 122,039 2,435,904 SH   DFND 1, 2 2,435,904 0 0
AMERICAN ELEC PWR CO INC UNIT 08/15/2025 02557T307 90,104 1,779,651 SH   DFND 1, 2 1,779,651 0 0
AMERICAN TOWER CORP NEW COM 03027X100 1,911,352 8,515,360 SH   DFND 1, 2 8,513,996 0 1,364
AMERICAN WELL CORP CL A 03044L105 36,194 1,428,900 SH   DFND 1, 2 1,428,900 0 0
AMPHENOL CORP NEW CL A 032095101 60,504 462,672 SH   DFND 1, 2 462,672 0 0
ANALOG DEVICES INC COM 032654105 348,990 2,362,347 SH   DFND 1, 2 2,362,345 0 2
APACHE CORP COM 037411105 35,170 2,478,500 SH   DFND 1, 2 2,478,500 0 0
APOLLO GLOBAL MGMT INC COM CL A 03768E105 583,924 11,921,674 SH   DFND 1, 2 11,921,674 0 0
APPLE INC COM 037833100 3,143,247 23,688,472 SH   DFND 1, 2 23,665,180 0 23,292
APPFOLIO INC COM CL A 03783C100 27,189 151,018 SH   DFND 1, 2 151,018 0 0
APPLIED MATLS INC COM 038222105 1,105,272 12,807,324 SH   DFND 1, 2 12,807,324 0 0
APPLIED MOLECULAR TRANS INC COM 03824M109 78,954 2,565,932 SH   DFND 1, 2 2,565,932 0 0
ARAMARK COM 03852U106 196,974 5,118,862 SH   DFND 1, 2 5,118,862 0 0
ARCHER DANIELS MIDLAND CO COM 039483102 1,056,853 20,965,148 SH   DFND 1, 2 20,965,148 0 0
ARCOSA INC COM 039653100 51,469 937,000 SH   DFND 1, 2 937,000 0 0
ARES MANAGEMENT CORPORATION CL A COM STK 03990B101 480,603 10,214,738 SH   DFND 1, 2 10,214,738 0 0
ARGENX SE SPONSORED ADR 04016X101 194,581 661,639 SH   DFND 1, 2 661,639 0 0
ARISTA NETWORKS INC COM 040413106 871,759 3,000,168 SH   DFND 1, 2 3,000,168 0 0
ARTISAN PARTNERS ASSET MGMT CL A 04316A108 35,490 705,000 SH   DFND 1, 2 705,000 0 0
ASSETMARK FINL HLDGS INC COM 04546L106 54,450 2,250,000 SH   DFND 1, 2 2,250,000 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 231,456 4,629,747 SH   DFND 1, 2 4,550,242 0 79,505
AUTODESK INC COM 052769106 2,318,691 7,593,856 SH   DFND 1, 2 7,590,936 0 2,920
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 26,425 2,955,806 SH   DFND 1, 2 2,955,806 0 0
AUTOMATIC DATA PROCESSING IN COM 053015103 765,508 4,344,541 SH   DFND 1, 2 4,344,541 0 0
BCE INC COM NEW 05534B760 321 7,500 SH   DFND 1, 2 7,500 0 0
BP PLC SPONSORED ADR 055622104 35,212 1,715,969 SH   DFND 1, 2 1,715,969 0 0
BMC STK HLDGS INC COM 05591B109 31,093 579,222 SH   DFND 1, 2 579,222 0 0
BAKER HUGHES COMPANY CL A 05722G100 1,718,737 82,431,759 SH   DFND 1, 2 82,335,893 0 95,866
BANDWIDTH INC COM CL A 05988J103 111,103 723,000 SH   DFND 1, 2 723,000 0 0
BK OF AMERICA CORP COM 060505104 3,406,395 112,385,201 SH   DFND 1, 2 112,385,201 0 0
BANK NOVA SCOTIA B C COM 064149107 1,092,293 20,210,560 SH   DFND 1, 2 20,210,560 0 0
BARRICK GOLD CORP COM 067901108 978,841 42,968,542 SH   DFND 1, 2 42,968,542 0 0
BARRETT BUSINESS SVCS INC COM 068463108 41,660 610,765 SH   DFND 1, 2 610,765 0 0
BAUSCH HEALTH COS INC COM 071734107 19,790 951,447 SH   DFND 1, 2 951,447 0 0
BAXTER INTL INC COM 071813109 747,519 9,316,035 SH   DFND 1, 2 9,316,035 0 0
BEAZER HOMES USA INC COM NEW 07556Q881 25,146 1,659,813 SH   DFND 1, 2 1,659,813 0 0
BENTLEY SYS INC COM CL B 08265T208 24,306 600,000 SH   DFND 1, 2 600,000 0 0
BERKSHIRE HATHAWAY INC DEL CL A 084670108 190,255 547 SH   DFND 1, 2 547 0 0
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 837,521 3,612,030 SH   DFND 1, 2 3,612,030 0 0
BEYOND MEAT INC COM 08862E109 11,862 94,895 SH   DFND 1, 2 94,895 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 16,826 525,000 SH   DFND 1, 2 525,000 0 0
BLACK KNIGHT INC COM 09215C105 10,425 118,000 SH   DFND 1, 2 118,000 0 0
BLACKLINE INC COM 09239B109 79,361 595,000 SH   DFND 1, 2 595,000 0 0
BLACKROCK INC COM 09247X101 5,339,805 7,400,696 SH   DFND 1, 2 7,393,312 0 7,384
BLACKSTONE GROUP INC COM CL A 09260D107 1,178,676 18,186,643 SH   DFND 1, 2 18,186,643 0 0
BLUEBIRD BIO INC COM 09609G100 135,312 3,127,163 SH   DFND 1, 2 3,127,163 0 0
BOEING CO COM 097023105 1,542,602 7,206,398 SH   DFND 1, 2 7,206,363 0 35
BOOKING HOLDINGS INC COM 09857L108 1,382,923 620,905 SH   DFND 1, 2 620,905 0 0
BOOT BARN HLDGS INC COM 099406100 8,745 201,673 SH   DFND 1, 2 201,673 0 0
BOSTON SCIENTIFIC CORP COM 101137107 259,331 7,214,234 SH   DFND 1, 2 7,162,661 0 51,573
BOTTOMLINE TECH DEL INC COM 101388106 246,962 4,682,629 SH   DFND 1, 2 4,682,629 0 0
BRIGHT HORIZONS FAM SOL IN D COM 109194100 555,822 3,213,031 SH   DFND 1, 2 3,213,031 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 626,348 10,097,496 SH   DFND 1, 2 10,097,496 0 0
BRITISH AMERN TOB PLC SPONSORED ADR 110448107 205,211 5,473,375 SH   DFND 1, 2 5,412,246 0 61,129
BROADCOM INC COM 11135F101 17,026,112 38,885,917 SH   DFND 1, 2 38,857,365 0 28,552
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104 542,881 13,152,349 SH   DFND 1, 2 13,106,310 0 46,039
BROOKFIELD INFRASTRUCTURE CO COM SB VTG SHS A 11275Q107 5,766 79,616 SH   DFND 1, 2 79,616 0 0
BURLINGTON STORES INC COM 122017106 482,622 1,845,238 SH   DFND 1, 2 1,845,238 0 0
C3 AI INC CL A 12468P104 4,690 33,800 SH   DFND 1, 2 33,800 0 0
CDW CORP COM 12514G108 85,664 650,000 SH   DFND 1, 2 650,000 0 0
CF INDS HLDGS INC COM 125269100 216,557 5,594,335 SH   DFND 1, 2 5,594,335 0 0
CIGNA CORP NEW COM 125523100 3,153,997 15,150,606 SH   DFND 1, 2 15,136,973 0 13,633
CME GROUP INC COM 12572Q105 6,160,000 33,836,999 SH   DFND 1, 2 33,830,545 0 6,454
CMS ENERGY CORP COM 125896100 440,620 7,223,147 SH   DFND 1, 2 7,164,920 0 58,227
CSX CORP COM 126408103 6,352,937 70,004,980 SH   DFND 1, 2 69,968,544 0 36,436
CVS HEALTH CORP COM 126650100 2,367,477 34,663,171 SH   DFND 1, 2 34,631,020 0 32,151
CABOT OIL & GAS CORP COM 127097103 449,609 27,617,280 SH   DFND 1, 2 27,617,280 0 0
CAESARS ENTERTAINMENT INC NE COM 12769G100 825,744 11,118,142 SH   DFND 1, 2 11,118,142 0 0
CALIFORNIA RES CORP COMMON STOCK 13057Q305 7,196 305,059 SH   DFND 1, 2 305,059 0 0
CAMDEN PPTY TR SH BEN INT 133131102 257,822 2,580,285 SH   DFND 1, 2 2,580,285 0 0
CANADIAN NAT RES LTD COM 136385101 1,257,127 52,311,018 SH   DFND 1, 2 52,303,040 0 7,978
CANNAE HLDGS INC COM 13765N107 293,004 6,618,574 SH   DFND 1, 2 6,618,574 0 0
CAPITAL ONE FINL CORP COM 14040H105 2,140,440 21,653,857 SH   DFND 1, 2 21,608,437 0 45,420
CARGURUS INC COM CL A 141788109 25,701 810,000 SH   DFND 1, 2 810,000 0 0
CARLYLE GROUP INC COM 14316J108 285,735 9,088,274 SH   DFND 1, 2 9,088,274 0 0
CARRIER GLOBAL CORPORATION COM 14448C104 517,743 13,725,966 SH   DFND 1, 2 13,725,966 0 0
CARVANA CO CL A 146869102 124,616 520,231 SH   DFND 1, 2 520,231 0 0
CATALENT INC COM 148806102 562,740 5,407,323 SH   DFND 1, 2 5,407,323 0 0
CATERPILLAR INC COM 149123101 598,178 3,286,527 SH   DFND 1, 2 3,268,559 0 17,968
CAVCO INDS INC DEL COM 149568107 29,979 170,870 SH   DFND 1, 2 170,870 0 0
CELLECTIS S A SPON ADS 15117K103 23,678 875,000 SH   DFND 1, 2 875,000 0 0
CENTENE CORP DEL COM 15135B101 2,273,616 37,874,670 SH   DFND 1, 2 37,874,670 0 0
CENOVUS ENERGY INC COM 15135U109 77,924 12,798,618 SH   DFND 1, 2 12,798,618 0 0
CENTURY CMNTYS INC COM 156504300 39,884 911,000 SH   DFND 1, 2 911,000 0 0
CERIDIAN HCM HLDG INC COM 15677J108 1,061,461 9,961,158 SH   DFND 1, 2 9,961,158 0 0
CERTARA INC COM 15687V109 45,479 1,348,727 SH   DFND 1, 2 1,348,727 0 0
CHARTER COMMUNICATIONS INC N CL A 16119P108 1,417,798 2,143,145 SH   DFND 1, 2 2,143,145 0 0
CHEMED CORP NEW COM 16359R103 135,057 253,575 SH   DFND 1, 2 253,575 0 0
CHEVRON CORP NEW COM 166764100 1,176,709 13,933,606 SH   DFND 1, 2 13,915,851 0 17,755
CHEWY INC CL A 16679L109 4,968 55,270 SH   DFND 1, 2 55,270 0 0
CHINDATA GROUP HLDGS LTD ADS 16955F107 172,879 7,215,310 SH   DFND 1, 2 7,215,310 0 0
CHIPOTLE MEXICAN GRILL INC COM 169656105 373,625 269,433 SH   DFND 1, 2 269,433 0 0
CIMAREX ENERGY CO COM 171798101 202,108 5,388,122 SH   DFND 1, 2 5,388,122 0 0
CINTAS CORP COM 172908105 212,937 602,435 SH   DFND 1, 2 602,435 0 0
CITIGROUP INC COM NEW 172967424 2,693,246 43,679,604 SH   DFND 1, 2 43,631,843 0 47,761
CLEAR CHANNEL OUTDOOR HLDGS COM 18453H106 1,722 1,043,695 SH   DFND 1, 2 1,043,695 0 0
CLOUDFLARE INC CL A COM 18915M107 51,305 675,155 SH   DFND 1, 2 675,155 0 0
COCA COLA CO COM 191216100 983,613 17,936,177 SH   DFND 1, 2 17,917,833 0 18,344
COLGATE PALMOLIVE CO COM 194162103 2,092,741 24,473,635 SH   DFND 1, 2 24,473,635 0 0
COMCAST CORP NEW CL A 20030N101 5,313,598 101,407,187 SH   DFND 1, 2 101,291,368 0 115,819
CONAGRA BRANDS INC COM 205887102 2,171,152 59,877,551 SH   DFND 1, 2 59,819,725 0 57,826
CONOCOPHILLIPS COM 20825C104 581,165 14,532,761 SH   DFND 1, 2 14,532,761 0 0
CONSTELLATION BRANDS INC CL A 21036P108 914,344 4,174,135 SH   DFND 1, 2 4,174,135 0 0
COOPER TIRE & RUBR CO COM 216831107 24,948 616,000 SH   DFND 1, 2 616,000 0 0
COPART INC COM 217204106 633,087 4,975,140 SH   DFND 1, 2 4,975,140 0 0
CORTEVA INC COM 22052L104 384,274 9,924,439 SH   DFND 1, 2 9,924,439 0 0
CORTEXYME INC COM 22053A107 72,512 2,610,237 SH   DFND 1, 2 2,610,237 0 0
COSTCO WHSL CORP NEW COM 22160K105 1,484,495 3,939,997 SH   DFND 1, 2 3,932,573 0 7,424
COSTAR GROUP INC COM 22160N109 46,214 50,000 SH   DFND 1, 2 50,000 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 3,192,167 20,052,561 SH   DFND 1, 2 20,052,561 0 0
CUMULUS MEDIA INC COM CL A 231082801 6,794 779,084 SH   DFND 1, 2 779,084 0 0
D R HORTON INC COM 23331A109 444,791 6,453,727 SH   DFND 1, 2 6,453,727 0 0
DTE ENERGY CO COM 233331107 2,567,467 21,147,082 SH   DFND 1, 2 21,147,082 0 0
DTE ENERGY CO UNIT 11/01/2022S 233331842 175,851 3,652,915 SH   DFND 1, 2 3,652,915 0 0
DADA NEXUS LTD ADS 23344D108 12,775 350,000 SH   DFND 1, 2 350,000 0 0
DANAHER CORPORATION COM 235851102 656,316 2,954,517 SH   DFND 1, 2 2,954,517 0 0
DARDEN RESTAURANTS INC COM 237194105 1,405,844 11,801,911 SH   DFND 1, 2 11,801,911 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 15,409 270,000 SH   DFND 1, 2 270,000 0 0
DEERE & CO COM 244199105 882,273 3,279,216 SH   DFND 1, 2 3,279,216 0 0
DELL TECHNOLOGIES INC CL C 24703L202 743,542 10,145,200 SH   DFND 1, 2 10,145,200 0 0
DELTA AIR LINES INC DEL COM NEW 247361702 1,129,924 28,100,560 SH   DFND 1, 2 28,100,560 0 0
DENBURY INC COM 24790A101 89,178 3,471,305 SH   DFND 1, 2 3,471,305 0 0
DEXCOM INC COM 252131107 485,462 1,313,054 SH   DFND 1, 2 1,313,054 0 0
DIAMONDBACK ENERGY INC COM 25278X109 139,527 2,882,791 SH   DFND 1, 2 2,882,791 0 0
DIEBOLD NXDF INC COM 253651103 7,302 685,000 SH   DFND 1, 2 685,000 0 0
DIGITAL RLTY TR INC COM 253868103 2,413,697 17,301,391 SH   DFND 1, 2 17,284,363 0 17,028
DISNEY WALT CO COM 254687106 648,069 3,576,937 SH   DFND 1, 2 3,576,937 0 0
DISCOVER FINL SVCS COM 254709108 763,575 8,434,930 SH   DFND 1, 2 8,403,281 0 31,649
DISH NETWORK CORPORATION NOTE 3.375% 8/1 25470MAB5 41,727 43,660,000 PRN   DFND 1, 2 43,660,000 0 0
DOCUSIGN INC COM 256163106 552,867 2,487,029 SH   DFND 1, 2 2,487,029 0 0
DOLBY LABORATORIES INC COM CL A 25659T107 63,228 650,963 SH   DFND 1, 2 650,963 0 0
DOLLAR GEN CORP NEW COM 256677105 2,371,647 11,277,447 SH   DFND 1, 2 11,277,447 0 0
DOMINION ENERGY INC COM 25746U109 150,952 2,007,346 SH   DFND 1, 2 2,007,346 0 0
DOMINION ENERGY INC UNIT 99/99/9999 25746U133 227,250 2,265,028 SH   DFND 1, 2 2,265,028 0 0
DOMINOS PIZZA INC COM 25754A201 1,500,012 3,911,781 SH   DFND 1, 2 3,911,781 0 0
DOW INC COM 260557103 2,977,417 53,647,177 SH   DFND 1, 2 53,610,778 0 36,399
DRAFTKINGS INC COM CL A 26142R104 79,478 1,707,000 SH   DFND 1, 2 1,707,000 0 0
DUKE ENERGY CORP NEW COM NEW 26441C204 274,680 3,000,000 SH   DFND 1, 2 3,000,000 0 0
DUN & BRADSTREET HLDGS INC COM 26484T106 343,027 13,776,184 SH   DFND 1, 2 13,776,184 0 0
EOG RES INC COM 26875P101 214,343 4,298,027 SH   DFND 1, 2 4,298,027 0 0
EASTMAN CHEM CO COM 277432100 1,019,620 10,167,734 SH   DFND 1, 2 10,167,734 0 0
EDITAS MEDICINE INC COM 28106W103 98,154 1,400,000 SH   DFND 1, 2 1,400,000 0 0
EHEALTH INC COM 28238P109 37,889 536,600 SH   DFND 1, 2 536,600 0 0
EMERSON ELEC CO COM 291011104 1,531,490 19,055,495 SH   DFND 1, 2 19,055,495 0 0
ENBRIDGE INC COM 29250N105 224,739 7,025,301 SH   DFND 1, 2 7,016,087 0 9,214
ENDAVA PLC ADS 29260V105 89,475 1,165,798 SH   DFND 1, 2 1,165,798 0 0
EPAM SYS INC COM 29414B104 945,218 2,637,694 SH   DFND 1, 2 2,637,694 0 0
EQUIFAX INC COM 294429105 33,474 173,582 SH   DFND 1, 2 173,582 0 0
EQUINIX INC COM 29444U700 1,625,735 2,276,366 SH   DFND 1, 2 2,276,366 0 0
ESSENTIAL UTILS INC UNIT 04/30/2022 29670G201 2,208 35,600 SH   DFND 1, 2 35,600 0 0
ETSY INC COM 29786A106 67,232 377,900 SH   DFND 1, 2 377,900 0 0
EXACT SCIENCES CORP COM 30063P105 1,364,434 10,298,396 SH   DFND 1, 2 10,298,396 0 0
EXTRA SPACE STORAGE INC COM 30225T102 162,308 1,400,895 SH   DFND 1, 2 1,400,895 0 0
EXXON MOBIL CORP COM 30231G102 583,733 14,161,390 SH   DFND 1, 2 14,161,096 0 294
FLIR SYS INC COM 302445101 120,146 2,741,185 SH   DFND 1, 2 2,741,185 0 0
FACEBOOK INC CL A 30303M102 11,072,000 40,533,105 SH   DFND 1, 2 40,515,591 0 17,514
FEDEX CORP COM 31428X106 144,555 556,794 SH   DFND 1, 2 556,794 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 79,103 559,192 SH   DFND 1, 2 559,192 0 0
FIFTH THIRD BANCORP COM 316773100 15,421 559,335 SH   DFND 1, 2 559,335 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 797,602 5,428,448 SH   DFND 1, 2 5,428,448 0 0
FIRSTSERVICE CORP NEW COM 33767E202 27,374 200,000 SH   DFND 1, 2 200,000 0 0
FISERV INC COM 337738108 629,421 5,528,026 SH   DFND 1, 2 5,528,026 0 0
FIVE BELOW INC COM 33829M101 621,521 3,551,956 SH   DFND 1, 2 3,551,956 0 0
FLEETCOR TECHNOLOGIES INC COM 339041105 984,879 3,609,864 SH   DFND 1, 2 3,609,864 0 0
FLEXION THERAPEUTICS INC COM 33938J106 44,117 3,823,000 SH   DFND 1, 2 3,823,000 0 0
FLOOR & DECOR HLDGS INC CL A 339750101 1,054,024 11,351,906 SH   DFND 1, 2 11,351,906 0 0
FOCUS FINL PARTNERS INC COM CL A 34417P100 104,209 2,395,600 SH   DFND 1, 2 2,395,600 0 0
FRANCO NEV CORP COM 351858105 817,575 6,520,618 SH   DFND 1, 2 6,520,618 0 0
FRONTDOOR INC COM 35905A109 28,519 568,000 SH   DFND 1, 2 568,000 0 0
FULLER H B CO COM 359694106 22,308 430,000 SH   DFND 1, 2 430,000 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 318,187 2,757,013 SH   DFND 1, 2 2,757,013 0 0
GALAPAGOS NV SPON ADR 36315X101 451 4,520 SH   DFND 1, 2 2 0 4,518
GAMING & LEISURE PPTYS INC COM 36467J108 830,116 19,578,207 SH   DFND 1, 2 19,578,207 0 0
GENERAL ELECTRIC CO COM 369604103 62,559 5,792,461 SH   DFND 1, 2 5,792,461 0 0
GENERAL MLS INC COM 370334104 957,563 16,285,079 SH   DFND 1, 2 16,285,079 0 0
GENERAL MTRS CO COM 37045V100 3,364,766 80,805,672 SH   DFND 1, 2 80,714,685 0 90,987
GENETRON HLDGS LTD ADS 37186H100 34,611 2,472,191 SH   DFND 1, 2 2,472,191 0 0
GENTEX CORP COM 371901109 48,147 1,419,000 SH   DFND 1, 2 1,419,000 0 0
GILEAD SCIENCES INC COM 375558103 2,244,985 38,534,588 SH   DFND 1, 2 38,510,036 0 24,552
GLAUKOS CORP COM 377322102 71,521 950,322 SH   DFND 1, 2 950,322 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 14,741 400,580 SH   DFND 1, 2 400,580 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 62,999 1,454,609 SH   DFND 1, 2 1,454,609 0 0
GODADDY INC CL A 380237107 11,779 142,000 SH   DFND 1, 2 142,000 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 214,744 814,365 SH   DFND 1, 2 811,514 0 2,851
GOSSAMER BIO INC COM 38341P102 966 99,858 SH   DFND 1, 2 99,858 0 0
GRACO INC COM 384109104 69,022 954,000 SH   DFND 1, 2 954,000 0 0
GRAND CANYON ED INC COM 38526M106 181,409 1,948,333 SH   DFND 1, 2 1,948,333 0 0
GREENHILL & CO INC COM 395259104 14,200 1,169,700 SH   DFND 1, 2 1,169,700 0 0
GRIFOLS S A SP ADR REP B NVT 398438408 213,778 11,593,149 SH   DFND 1, 2 11,593,149 0 0
GROCERY OUTLET HLDG CORP COM 39874R101 61,426 1,565,000 SH   DFND 1, 2 1,565,000 0 0
GUIDEWIRE SOFTWARE INC COM 40171V100 456,835 3,548,782 SH   DFND 1, 2 3,548,782 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 75,060 1,039,031 SH   DFND 1, 2 961,301 0 77,730
HAEMONETICS CORP COM 405024100 140,434 1,182,600 SH   DFND 1, 2 1,182,600 0 0
HALLIBURTON CO COM 406216101 1,217,399 64,412,667 SH   DFND 1, 2 64,412,667 0 0
HARLEY DAVIDSON INC COM 412822108 21,726 592,000 SH   DFND 1, 2 592,000 0 0
HEICO CORP NEW COM 422806109 376,530 2,843,885 SH   DFND 1, 2 2,843,885 0 0
HELMERICH & PAYNE INC COM 423452101 31,498 1,360,000 SH   DFND 1, 2 1,360,000 0 0
HENRY JACK & ASSOC INC COM 426281101 236,300 1,458,735 SH   DFND 1, 2 1,458,735 0 0
HESS CORP COM 42809H107 211,507 4,006,572 SH   DFND 1, 2 4,006,572 0 0
HOME DEPOT INC COM 437076102 8,991,059 33,849,372 SH   DFND 1, 2 33,819,376 0 29,996
HONEYWELL INTL INC COM 438516106 6,188,088 29,093,275 SH   DFND 1, 2 29,064,049 0 29,226
HUBBELL INC COM 443510607 287,710 1,835,000 SH   DFND 1, 2 1,835,000 0 0
HUBSPOT INC COM 443573100 790,424 1,993,804 SH   DFND 1, 2 1,993,804 0 0
HUMANA INC COM 444859102 1,955,510 4,766,445 SH   DFND 1, 2 4,761,893 0 4,552
HUNTSMAN CORP COM 447011107 566,928 22,550,824 SH   DFND 1, 2 22,550,824 0 0
HUYA INC ADS REP SHS A 44852D108 90,935 4,562,740 SH   DFND 1, 2 4,562,740 0 0
ICICI BANK LIMITED ADR 45104G104 1,301 88,731 SH   DFND 1, 2 43 0 88,688
IDEX CORP COM 45167R104 405,727 2,036,875 SH   DFND 1, 2 2,029,764 0 7,111
IDEXX LABS INC COM 45168D104 482,704 965,676 SH   DFND 1, 2 962,926 0 2,750
IHEARTMEDIA INC COM CL A 45174J509 5,209 401,284 SH   DFND 1, 2 401,284 0 0
ILLINOIS TOOL WKS INC COM 452308109 346,340 1,698,744 SH   DFND 1, 2 1,698,744 0 0
ILLUMINA INC COM 452327109 560,582 1,515,087 SH   DFND 1, 2 1,515,087 0 0
INCYTE CORP COM 45337C102 34,444 396,000 SH   DFND 1, 2 396,000 0 0
INHIBRX INC COM 45720L107 39,564 1,200,000 SH   DFND 1, 2 1,200,000 0 0
INPHI CORP COM 45772F107 41,401 258,000 SH   DFND 1, 2 258,000 0 0
INSULET CORP COM 45784P101 1,778,210 6,956,101 SH   DFND 1, 2 6,951,550 0 4,551
INTEL CORP COM 458140100 813,517 16,329,967 SH   DFND 1, 2 16,290,963 0 39,004
INTERCONTINENTAL HOTELS GROU SPONSORED ADS 45857P806 867 13,479 SH   DFND 1, 2 9 0 13,470
INTERFACE INC COM 458665304 26,687 2,541,658 SH   DFND 1, 2 2,541,658 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 2,221,409 19,268,235 SH   DFND 1, 2 19,256,227 0 12,008
INTUITIVE SURGICAL INC COM NEW 46120E602 3,119,593 3,813,232 SH   DFND 1, 2 3,808,907 0 4,325
IRIDIUM COMMUNICATIONS INC COM 46269C102 152,340 3,873,868 SH   DFND 1, 2 3,873,868 0 0
IRON MTN INC NEW COM 46284V101 858,256 29,113,163 SH   DFND 1, 2 29,113,163 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 23,122 2,030,000 SH   DFND 1, 2 2,030,000 0 0
ISHARES TR CORE S&P500 ETF 464287200 2,681 7,183 SH   DFND 1, 2 41 0 7,142
ISHARES TR MSCI ACWI ETF 464288257 352 3,881 SH   DFND 1, 2 0 0 3,881
JOYY INC ADS REPSTG COM A 46591M109 213,443 2,668,699 SH   DFND 1, 2 2,668,699 0 0
JPMORGAN CHASE & CO COM 46625H100 10,271,175 80,831,721 SH   DFND 1, 2 80,766,496 0 65,225
JACOBS ENGR GROUP INC COM 469814107 641,005 5,882,943 SH   DFND 1, 2 5,882,943 0 0
JAMF HLDG CORP COM 47074L105 57,147 1,910,000 SH   DFND 1, 2 1,910,000 0 0
JELD-WEN HLDG INC COM 47580P103 10,524 415,000 SH   DFND 1, 2 415,000 0 0
JOHN BEAN TECHNOLOGIES CORP COM 477839104 31,745 278,785 SH   DFND 1, 2 278,785 0 0
JOHNSON & JOHNSON COM 478160104 3,682,187 23,396,982 SH   DFND 1, 2 23,374,099 0 22,883
KE HLDGS INC SPONSORED ADS 482497104 446,353 7,252,537 SH   DFND 1, 2 7,238,634 0 13,903
KB HOME COM 48666K109 99,149 2,957,918 SH   DFND 1, 2 2,957,918 0 0
KELLOGG CO COM 487836108 905,819 14,555,981 SH   DFND 1, 2 14,555,981 0 0
KEURIG DR PEPPER INC COM 49271V100 1,338,783 41,836,980 SH   DFND 1, 2 41,836,980 0 0
KEYCORP COM 493267108 362,431 22,086,000 SH   DFND 1, 2 22,086,000 0 0
KINSALE CAP GROUP INC COM 49714P108 17,415 87,020 SH   DFND 1, 2 87,020 0 0
KONINKLIJKE PHILIPS N V NY REG SH NEW 500472303 1,379 25,328 SH   DFND 1, 2 12 0 25,316
KONTOOR BRANDS INC COM 50050N103 227,749 5,615,120 SH   DFND 1, 2 5,615,120 0 0
KROGER CO COM 501044101 256,144 8,065,000 SH   DFND 1, 2 8,065,000 0 0
L3HARRIS TECHNOLOGIES INC COM 502431109 760,720 4,024,547 SH   DFND 1, 2 4,024,547 0 0
LAM RESEARCH CORP COM 512807108 101,080 214,031 SH   DFND 1, 2 214,031 0 0
LAMAR ADVERTISING CO NEW CL A 512816109 195,843 2,353,322 SH   DFND 1, 2 2,353,322 0 0
LAS VEGAS SANDS CORP COM 517834107 278,875 4,679,104 SH   DFND 1, 2 4,679,104 0 0
LAUDER ESTEE COS INC CL A 518439104 113,574 426,664 SH   DFND 1, 2 426,664 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 33,608 1,193,479 SH   DFND 1, 2 1,193,479 0 0
LEMONADE INC COM 52567D107 30,870 252,000 SH   DFND 1, 2 252,000 0 0
LENNAR CORP CL A 526057104 280,286 3,676,840 SH   DFND 1, 2 3,676,840 0 0
LENNAR CORP CL B 526057302 1,296 21,169 SH   DFND 1, 2 21,169 0 0
LENNOX INTL INC COM 526107107 421,746 1,539,388 SH   DFND 1, 2 1,539,388 0 0
LEVI STRAUSS & CO NEW CL A COM STK 52736R102 12,561 625,548 SH   DFND 1, 2 625,548 0 0
LILLY ELI & CO COM 532457108 481,861 2,853,951 SH   DFND 1, 2 2,853,951 0 0
LIVE NATION ENTERTAINMENT IN COM 538034109 261,586 3,559,968 SH   DFND 1, 2 3,559,968 0 0
LOCKHEED MARTIN CORP COM 539830109 5,746,291 16,187,677 SH   DFND 1, 2 16,174,893 0 12,784
LUFAX HOLDING LTD ADS REP SHS CL A 54975P102 375,883 26,470,653 SH   DFND 1, 2 26,470,653 0 0
LULULEMON ATHLETICA INC COM 550021109 60,748 174,547 SH   DFND 1, 2 174,547 0 0
M D C HLDGS INC COM 552676108 47,022 967,528 SH   DFND 1, 2 967,528 0 0
MGM GROWTH PPTYS LLC CL A COM 55303A105 139,066 4,443,000 SH   DFND 1, 2 4,443,000 0 0
MACYS INC COM 55616P104 21,375 1,900,000 SH   DFND 1, 2 1,900,000 0 0
MAGNA INTL INC COM 559222401 807 11,400 SH   DFND 1, 2 11,400 0 0
MAGNOLIA OIL & GAS CORP CL A 559663109 14,120 2,000,000 SH   DFND 1, 2 2,000,000 0 0
MANPOWERGROUP INC COM 56418H100 428,380 4,750,272 SH   DFND 1, 2 4,750,272 0 0
MANULIFE FINL CORP COM 56501R106 197,201 11,082,459 SH   DFND 1, 2 11,082,459 0 0
MARKETAXESS HLDGS INC COM 57060D108 86,383 151,400 SH   DFND 1, 2 151,400 0 0
MARSH & MCLENNAN COS INC COM 571748102 1,919,877 16,409,747 SH   DFND 1, 2 16,377,972 0 31,775
MARRIOTT INTL INC NEW CL A 571903202 729,767 5,531,888 SH   DFND 1, 2 5,531,888 0 0
MASCO CORP COM 574599106 89,261 1,625,000 SH   DFND 1, 2 1,625,000 0 0
MASTERCARD INCORPORATED CL A 57636Q104 4,743,169 13,288,461 SH   DFND 1, 2 13,278,500 0 9,961
MATCH GROUP INC NEW COM 57667L107 312,812 2,069,001 SH   DFND 1, 2 2,069,001 0 0
MELCO RESORTS AND ENTMNT LTD ADR 585464100 393,059 21,189,225 SH   DFND 1, 2 21,164,839 0 24,386
MERCADOLIBRE INC COM 58733R102 3,907,320 2,332,336 SH   DFND 1, 2 2,328,526 0 3,810
MERCK & CO. INC COM 58933Y105 1,670,836 20,426,403 SH   DFND 1, 2 20,390,015 0 36,388
METTLER TOLEDO INTERNATIONAL COM 592688105 378,734 332,316 SH   DFND 1, 2 332,316 0 0
MICROSOFT CORP COM 594918104 24,564,294 110,441,260 SH   DFND 1, 2 110,372,606 0 68,654
MICRON TECHNOLOGY INC COM 595112103 110,001 1,463,163 SH   DFND 1, 2 1,463,163 0 0
MID-AMER APT CMNTYS INC COM 59522J103 237,422 1,874,040 SH   DFND 1, 2 1,874,040 0 0
MIDDLEBY CORP COM 596278101 90,502 702,000 SH   DFND 1, 2 702,000 0 0
MOELIS & CO CL A 60786M105 33,620 719,000 SH   DFND 1, 2 719,000 0 0
MOLINA HEALTHCARE INC COM 60855R100 1,229,419 5,780,605 SH   DFND 1, 2 5,780,605 0 0
MONDELEZ INTL INC CL A 609207105 2,091,714 35,774,136 SH   DFND 1, 2 35,774,136 0 0
MONEYGRAM INTL INC COM NEW 60935Y208 8,869 1,622,886 SH   DFND 1, 2 1,622,886 0 0
MONGODB INC CL A 60937P106 2,650,046 7,380,921 SH   DFND 1, 2 7,380,921 0 0
MONSTER BEVERAGE CORP NEW COM 61174X109 70,629 763,719 SH   DFND 1, 2 763,719 0 0
MOODYS CORP COM 615369105 494,878 1,705,113 SH   DFND 1, 2 1,702,239 0 2,874
MORGAN STANLEY COM NEW 617446448 404,176 5,897,798 SH   DFND 1, 2 5,897,798 0 0
MOTOROLA SOLUTIONS INC COM NEW 620076307 1,111,456 6,535,671 SH   DFND 1, 2 6,535,671 0 0
NMI HLDGS INC CL A 629209305 16,648 735,000 SH   DFND 1, 2 735,000 0 0
NVR INC COM 62944T105 215,588 52,842 SH   DFND 1, 2 52,842 0 0
NASDAQ INC COM 631103108 1,224,476 9,224,616 SH   DFND 1, 2 9,224,616 0 0
NATERA INC COM 632307104 86,980 874,000 SH   DFND 1, 2 874,000 0 0
NAVIENT CORPORATION COM 63938C108 12,471 1,270,000 SH   DFND 1, 2 1,270,000 0 0
NETFLIX INC COM 64110L106 7,407,250 13,698,696 SH   DFND 1, 2 13,695,851 0 2,845
NEVRO CORP COM 64157F103 27,696 160,000 SH   DFND 1, 2 160,000 0 0
NEW FORTRESS ENERGY INC COM CL A 644393100 197,763 3,690,306 SH   DFND 1, 2 3,690,306 0 0
NEW YORK TIMES CO CL A 650111107 520,418 10,052,497 SH   DFND 1, 2 10,052,497 0 0
NEXSTAR MEDIA GROUP INC CL A 65336K103 122,340 1,120,432 SH   DFND 1, 2 1,120,432 0 0
NEXTERA ENERGY INC UNIT 99/99/9999 65339F739 31,515 613,500 SH   DFND 1, 2 613,500 0 0
NEXTERA ENERGY INC UNIT 99/99/9999 65339F770 254,102 4,998,064 SH   DFND 1, 2 4,998,064 0 0
NIKE INC CL B 654106103 2,246,768 15,881,575 SH   DFND 1, 2 15,868,602 0 12,973
908 DEVICES INC COM 65443P102 24,204 425,000 SH   DFND 1, 2 425,000 0 0
NORDSTROM INC COM 655664100 23,720 760,000 SH   DFND 1, 2 760,000 0 0
NORFOLK SOUTHN CORP COM 655844108 1,940,605 8,167,216 SH   DFND 1, 2 8,162,711 0 4,505
NORTHROP GRUMMAN CORP COM 666807102 1,607,448 5,275,222 SH   DFND 1, 2 5,266,948 0 8,274
NORTONLIFELOCK INC COM 668771108 1,303,002 62,704,639 SH   DFND 1, 2 62,704,639 0 0
NOVARTIS AG SPONSORED ADR 66987V109 44,850 474,983 SH   DFND 1, 2 440,868 0 34,115
NOVAVAX INC COM NEW 670002401 132,222 1,185,742 SH   DFND 1, 2 1,185,742 0 0
NOVO-NORDISK A S ADR 670100205 1,629 23,207 SH   DFND 1, 2 11 0 23,196
NU SKIN ENTERPRISES INC CL A 67018T105 43,704 800,000 SH   DFND 1, 2 800,000 0 0
NUCOR CORP COM 670346105 961,589 18,078,560 SH   DFND 1, 2 18,042,137 0 36,423
NUVASIVE INC COM 670704105 43,149 766,000 SH   DFND 1, 2 766,000 0 0
NUTRIEN LTD COM 67077M108 288 5,992 SH   DFND 1, 2 5,992 0 0
OAK STR HEALTH INC COM 67181A107 242,996 3,973,113 SH   DFND 1, 2 3,973,113 0 0
OASIS PETROLEUM INC COM NEW 674215207 77,641 2,094,997 SH   DFND 1, 2 2,094,997 0 0
OKTA INC CL A 679295105 127,130 500,000 SH   DFND 1, 2 500,000 0 0
OSHKOSH CORP COM 688239201 65,431 760,207 SH   DFND 1, 2 760,207 0 0
PG&E CORP UNIT 99/99/9999 69331C140 7,413 60,350 SH   DFND 1, 2 60,350 0 0
PGT INNOVATIONS INC COM 69336V101 23,045 1,133,000 SH   DFND 1, 2 1,133,000 0 0
PNC FINL SVCS GROUP INC COM 693475105 2,331,761 15,649,853 SH   DFND 1, 2 15,618,130 0 31,723
PPD INC COM 69355F102 55,849 1,632,071 SH   DFND 1, 2 1,632,071 0 0
PACCAR INC COM 693718108 1,953,248 22,638,476 SH   DFND 1, 2 22,638,476 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 141,269 5,446,000 SH   DFND 1, 2 5,446,000 0 0
PACKAGING CORP AMER COM 695156109 859,041 6,228,996 SH   DFND 1, 2 6,228,996 0 0
PARKER-HANNIFIN CORP COM 701094104 1,381,142 5,070,084 SH   DFND 1, 2 5,070,084 0 0
PARSLEY ENERGY INC CL A 701877102 30,402 2,141,000 SH   DFND 1, 2 2,141,000 0 0
PAYCHEX INC COM 704326107 209,414 2,247,413 SH   DFND 1, 2 2,247,413 0 0
PAYCOM SOFTWARE INC COM 70432V102 480,208 1,061,819 SH   DFND 1, 2 1,061,819 0 0
PAYLOCITY HLDG CORP COM 70438V106 30,887 150,000 SH   DFND 1, 2 150,000 0 0
PAYPAL HLDGS INC COM 70450Y103 5,352,324 22,853,795 SH   DFND 1, 2 22,840,892 0 12,903
PELOTON INTERACTIVE INC CL A COM 70614W100 1,256,273 8,280,205 SH   DFND 1, 2 8,280,205 0 0
PEMBINA PIPELINE CORP COM 706327103 516 21,827 SH   DFND 1, 2 21,827 0 0
PENN NATL GAMING INC NOTE 2.750% 5/1 707569AU3 329 87,000 PRN   DFND 1, 2 87,000 0 0
PENUMBRA INC COM 70975L107 156,312 893,209 SH   DFND 1, 2 893,209 0 0
PETROLEO BRASILEIRO SA PETRO SP ADR NON VTG 71654V101 339,794 30,722,806 SH   DFND 1, 2 30,722,806 0 0
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408 618,235 55,052,224 SH   DFND 1, 2 54,978,451 0 73,773
PFIZER INC COM 717081103 9,815,286 266,647,618 SH   DFND 1, 2 266,466,799 0 180,819
PHILIP MORRIS INTL INC COM 718172109 6,815,317 82,320,538 SH   DFND 1, 2 82,320,538 0 0
PIONEER NAT RES CO COM 723787107 638,265 5,604,174 SH   DFND 1, 2 5,595,496 0 8,678
POLARIS INC COM 731068102 46,211 485,000 SH   DFND 1, 2 485,000 0 0
POOL CORP COM 73278L105 152,613 409,700 SH   DFND 1, 2 409,700 0 0
PRECISION BIOSCIENCES INC COM 74019P108 33,877 4,062,000 SH   DFND 1, 2 4,062,000 0 0
PROCTER AND GAMBLE CO COM 742718109 1,086,542 7,808,982 SH   DFND 1, 2 7,808,982 0 0
PROGRESSIVE CORP COM 743315103 794,305 8,033,024 SH   DFND 1, 2 8,033,024 0 0
PROLOGIS INC. COM 74340W103 252,439 2,533,000 SH   DFND 1, 2 2,533,000 0 0
PUBLIC SVC ENTERPRISE GRP IN COM 744573106 477,955 8,198,192 SH   DFND 1, 2 8,198,192 0 0
PUBLIC STORAGE COM 74460D109 170,426 738,000 SH   DFND 1, 2 738,000 0 0
PULMONX CORP COM 745848101 46,894 679,430 SH   DFND 1, 2 679,430 0 0
QUALCOMM INC COM 747525103 690,009 4,529,400 SH   DFND 1, 2 4,529,400 0 0
RADIAN GROUP INC COM 750236101 33,251 1,642,000 SH   DFND 1, 2 1,642,000 0 0
RATTLER MIDSTREAM LP COM UNITS 75419T103 27,110 2,859,750 SH   DFND 1, 2 2,859,750 0 0
RAYTHEON TECHNOLOGIES CORP COM 75513E101 933,113 13,048,711 SH   DFND 1, 2 13,048,711 0 0
RED ROCK RESORTS INC CL A 75700L108 63,400 2,531,956 SH   DFND 1, 2 2,531,956 0 0
REDWOOD TR INC COM 758075402 22,494 2,562,000 SH   DFND 1, 2 2,562,000 0 0
REGENERON PHARMACEUTICALS COM 75886F107 3,355,556 6,945,768 SH   DFND 1, 2 6,942,919 0 2,849
REGIONS FINANCIAL CORP NEW COM 7591EP100 482,246 29,916,013 SH   DFND 1, 2 29,916,013 0 0
REPAY HLDGS CORP COM CL A 76029L100 67,308 2,470,000 SH   DFND 1, 2 2,470,000 0 0
REPUBLIC SVCS INC COM 760759100 135,016 1,402,038 SH   DFND 1, 2 1,402,038 0 0
RESMED INC COM 761152107 1,134,988 5,339,610 SH   DFND 1, 2 5,339,610 0 0
RESTAURANT BRANDS INTL INC COM 76131D103 2,208,766 36,141,836 SH   DFND 1, 2 36,123,056 0 18,780
REVANCE THERAPEUTICS INC COM 761330109 60,364 2,130,000 SH   DFND 1, 2 2,130,000 0 0
REVOLUTION MEDICINES INC COM 76155X100 48,617 1,228,000 SH   DFND 1, 2 1,228,000 0 0
REXNORD CORP COM 76169B102 242,107 6,130,855 SH   DFND 1, 2 6,130,855 0 0
RINGCENTRAL INC CL A 76680R206 4,160,869 10,979,414 SH   DFND 1, 2 10,979,414 0 0
RIO TINTO PLC SPONSORED ADR 767204100 124,160 1,650,442 SH   DFND 1, 2 1,632,929 0 17,513
ROYAL DUTCH SHELL PLC SPON ADR B 780259107 6,077 180,820 SH   DFND 1, 2 180,820 0 0
ROYAL GOLD INC COM 780287108 828,652 7,791,013 SH   DFND 1, 2 7,791,013 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 8,478 1,117,000 SH   DFND 1, 2 1,117,000 0 0
S&P GLOBAL INC COM 78409V104 1,366,822 4,157,886 SH   DFND 1, 2 4,157,886 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 2,079 5,590 SH   DFND 1, 2 0 0 5,590
SVB FINANCIAL GROUP COM 78486Q101 380,541 981,205 SH   DFND 1, 2 981,205 0 0
SAIA INC COM 78709Y105 124,752 690,000 SH   DFND 1, 2 690,000 0 0
SAILPOINT TECHNOLOGIES HLDGS COM 78781P105 118,623 2,228,072 SH   DFND 1, 2 2,228,072 0 0
SAP SE SPON ADR 803054204 1,642 12,569 SH   DFND 1, 2 6 0 12,563
SCHOLAR ROCK HLDG CORP COM 80706P103 13,346 275,000 SH   DFND 1, 2 275,000 0 0
SCIENTIFIC GAMES CORP COM 80874P109 4,605 111,000 SH   DFND 1, 2 111,000 0 0
SEA LTD SPONSORD ADS 81141R100 3,927,602 19,732,002 SH   DFND 1, 2 19,708,957 0 23,045
SEACOAST BKG CORP FLA COM NEW 811707801 111,377 3,781,901 SH   DFND 1, 2 3,781,901 0 0
SEAGEN INC COM 81181C104 31,458 179,616 SH   DFND 1, 2 179,616 0 0
SEER INC COM CL A 81578P106 46,035 820,000 SH   DFND 1, 2 820,000 0 0
SERVICENOW INC COM 81762P102 145,653 264,625 SH   DFND 1, 2 263,205 0 1,420
SHAW COMMUNICATIONS INC CL B CONV 82028K200 91,264 5,200,066 SH   DFND 1, 2 5,200,066 0 0
SHERWIN WILLIAMS CO COM 824348106 1,717,823 2,337,477 SH   DFND 1, 2 2,335,910 0 1,567
SHOCKWAVE MED INC COM 82489T104 60,676 585,000 SH   DFND 1, 2 585,000 0 0
SHOPIFY INC CL A 82509L107 6,454,237 5,701,828 SH   DFND 1, 2 5,696,022 0 5,806
SILK RD MED INC COM 82710M100 136,226 2,163,000 SH   DFND 1, 2 2,163,000 0 0
SIMON PPTY GROUP INC NEW COM 828806109 478,976 5,616,508 SH   DFND 1, 2 5,616,492 0 16
SIMPLY GOOD FOODS CO COM 82900L102 155,263 4,951,000 SH   DFND 1, 2 4,951,000 0 0
SIX FLAGS ENTMT CORP NEW COM 83001A102 51,627 1,514,000 SH   DFND 1, 2 1,514,000 0 0
SMARTSHEET INC COM CL A 83200N103 968,559 13,978,147 SH   DFND 1, 2 13,965,919 0 12,228
SNAP INC CL A 83304A106 1,802,769 36,004,979 SH   DFND 1, 2 36,004,979 0 0
SNOWFLAKE INC CL A 833445109 104,354 370,837 SH   DFND 1, 2 370,837 0 0
SOUTH ST CORP COM 840441109 34,036 470,765 SH   DFND 1, 2 470,765 0 0
SOUTHWEST AIRLS CO COM 844741108 154,507 3,314,896 SH   DFND 1, 2 3,314,896 0 0
SOUTHWEST AIRLS CO NOTE 1.250% 5/0 844741BG2 6,148 4,218,000 PRN   DFND 1, 2 4,218,000 0 0
SOUTHWESTERN ENERGY CO COM 845467109 684 229,524 SH   DFND 1, 2 229,524 0 0
SQUARE INC CL A 852234103 1,194,761 5,489,620 SH   DFND 1, 2 5,489,620 0 0
STARBUCKS CORP COM 855244109 92,852 867,936 SH   DFND 1, 2 867,936 0 0
STERICYCLE INC COM 858912108 29,812 430,000 SH   DFND 1, 2 430,000 0 0
STEPSTONE GROUP INC COM CL A 85914M107 27,860 700,000 SH   DFND 1, 2 700,000 0 0
STMICROELECTRONICS N V NY REGISTRY 861012102 251 6,678 SH   DFND 1, 2 3 0 6,675
STRATEGIC ED INC COM 86272C103 126,217 1,324,000 SH   DFND 1, 2 1,324,000 0 0
SUN CMNTYS INC COM 866674104 741,993 4,883,141 SH   DFND 1, 2 4,883,141 0 0
SUNCOR ENERGY INC NEW COM 867224107 159,690 9,520,787 SH   DFND 1, 2 9,520,787 0 0
SYNCHRONY FINANCIAL COM 87165B103 1,760,628 50,723,927 SH   DFND 1, 2 50,723,927 0 0
SYNEOS HEALTH INC CL A 87166B102 47,549 697,910 SH   DFND 1, 2 697,910 0 0
TJX COS INC NEW COM 872540109 109,570 1,604,483 SH   DFND 1, 2 1,604,483 0 0
T-MOBILE US INC COM 872590104 2,601,167 19,289,338 SH   DFND 1, 2 19,289,338 0 0
TTM TECHNOLOGIES INC COM 87305R109 16,099 1,167,000 SH   DFND 1, 2 1,167,000 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 4,213,569 38,642,566 SH   DFND 1, 2 38,524,001 0 118,565
TANDEM DIABETES CARE INC COM NEW 875372203 294,021 3,072,964 SH   DFND 1, 2 3,072,964 0 0
TARGET CORP COM 87612E106 1,474,550 8,352,970 SH   DFND 1, 2 8,352,970 0 0
TC ENERGY CORP COM 87807B107 724,661 17,822,296 SH   DFND 1, 2 17,787,102 0 35,194
TELADOC HEALTH INC COM 87918A105 847,023 4,235,962 SH   DFND 1, 2 4,235,962 0 0
TELUS CORPORATION COM 87971M103 68,717 3,469,648 SH   DFND 1, 2 3,469,648 0 0
TERMINIX GLOBAL HOLDINGS INC COM 88087E100 34,177 670,000 SH   DFND 1, 2 670,000 0 0
TESLA INC COM 88160R101 32,636,772 46,249,648 SH   DFND 1, 2 46,229,682 0 19,966
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 510,283 52,879,377 SH   DFND 1, 2 52,818,672 0 60,705
TEXAS INSTRS INC COM 882508104 1,309,974 7,981,318 SH   DFND 1, 2 7,981,265 0 53
TEXTRON INC COM 883203101 37,697 780,000 SH   DFND 1, 2 780,000 0 0
TG THERAPEUTICS INC COM 88322Q108 44,217 850,000 SH   DFND 1, 2 850,000 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 7,443,849 15,981,520 SH   DFND 1, 2 15,975,716 0 5,804
TOLL BROTHERS INC COM 889478103 545,218 12,542,404 SH   DFND 1, 2 12,542,404 0 0
TOPBUILD CORP COM 89055F103 260,197 1,413,500 SH   DFND 1, 2 1,413,500 0 0
TORONTO DOMINION BK ONT COM NEW 891160509 1,087,832 19,253,401 SH   DFND 1, 2 19,219,324 0 34,077
TRADEWEB MKTS INC CL A 892672106 265,734 4,255,150 SH   DFND 1, 2 4,255,150 0 0
TRANSDIGM GROUP INC COM 893641100 525,696 849,472 SH   DFND 1, 2 849,472 0 0
TRUPANION INC COM 898202106 203,866 1,703,000 SH   DFND 1, 2 1,703,000 0 0
TRUIST FINL CORP COM 89832Q109 68,763 1,434,646 SH   DFND 1, 2 1,434,646 0 0
TURQUOISE HILL RES LTD COM 900435207 35,805 2,881,983 SH   DFND 1, 2 2,881,983 0 0
TWIST BIOSCIENCE CORP COM 90184D100 416,703 2,949,272 SH   DFND 1, 2 2,949,272 0 0
TWITTER INC COM 90184L102 626,989 11,578,740 SH   DFND 1, 2 11,578,740 0 0
TWITTER INC NOTE 0.250% 6/1 90184LAF9 1,635 1,350,000 PRN   DFND 1, 2 1,350,000 0 0
TYLER TECHNOLOGIES INC COM 902252105 451,112 1,033,428 SH   DFND 1, 2 1,033,428 0 0
UBER TECHNOLOGIES INC COM 90353T100 1,208,923 23,704,367 SH   DFND 1, 2 23,704,367 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 433,248 3,129,724 SH   DFND 1, 2 3,129,724 0 0
UMPQUA HLDGS CORP COM 904214103 27,032 1,785,500 SH   DFND 1, 2 1,785,500 0 0
UNILEVER PLC SPON ADR NEW 904767704 81,872 1,356,390 SH   DFND 1, 2 1,356,390 0 0
UNION PAC CORP COM 907818108 1,489,044 7,151,350 SH   DFND 1, 2 7,146,865 0 4,485
UNITED AIRLS HLDGS INC COM 910047109 92,330 2,134,796 SH   DFND 1, 2 2,134,796 0 0
UNITED PARCEL SERVICE INC CL B 911312106 571,570 3,394,121 SH   DFND 1, 2 3,394,121 0 0
UNITED RENTALS INC COM 911363109 171,896 741,217 SH   DFND 1, 2 741,217 0 0
UNITEDHEALTH GROUP INC COM 91324P102 12,338,609 35,185,176 SH   DFND 1, 2 35,162,620 0 22,556
UPSTART HLDGS INC COM 91680M107 48,900 1,200,000 SH   DFND 1, 2 1,200,000 0 0
V F CORP COM 918204108 807,119 9,449,735 SH   DFND 1, 2 9,427,038 0 22,697
VAIL RESORTS INC COM 91879Q109 19,806 71,000 SH   DFND 1, 2 71,000 0 0
VALE S A SPONSORED ADS 91912E105 1,878,795 112,098,170 SH   DFND 1, 2 111,941,657 0 156,513
VALERO ENERGY CORP COM 91913Y100 1,045,819 18,487,164 SH   DFND 1, 2 18,487,164 0 0
VANGUARD INTL EQUITY INDEX F TT WRLD ST ETF 922042742 550 5,949 SH   DFND 1, 2 0 0 5,949
VERISIGN INC COM 92343E102 118,754 548,769 SH   DFND 1, 2 548,769 0 0
VERIZON COMMUNICATIONS INC COM 92343V104 2,975,416 50,645,912 SH   DFND 1, 2 50,595,560 0 50,352
VERTEX PHARMACEUTICALS INC COM 92532F100 2,281,653 9,654,155 SH   DFND 1, 2 9,651,331 0 2,824
VIAVI SOLUTIONS INC COM 925550105 85,837 5,732,000 SH   DFND 1, 2 5,732,000 0 0
VIACOMCBS INC CL B 92556H206 193,143 5,183,657 SH   DFND 1, 2 5,183,657 0 0
VIATRIS INC COM 92556V106 623,428 33,267,251 SH   DFND 1, 2 33,267,156 0 95
VICI PPTYS INC COM 925652109 71,978 2,822,686 SH   DFND 1, 2 2,822,686 0 0
VICTORY CAP HLDGS INC COM CL A 92645B103 20,146 812,000 SH   DFND 1, 2 812,000 0 0
VIPER ENERGY PARTNERS LP COM UNT RP INT 92763M105 16,907 1,455,000 SH   DFND 1, 2 1,455,000 0 0
VISA INC COM CL A 92826C839 2,699,103 12,339,912 SH   DFND 1, 2 12,323,516 0 16,396
VISTRA CORP COM 92840M102 7,263 369,425 SH   DFND 1, 2 369,425 0 0
VULCAN MATLS CO COM 929160109 966,794 6,518,736 SH   DFND 1, 2 6,518,736 0 0
VROOM INC COM 92918V109 17,588 429,300 SH   DFND 1, 2 429,300 0 0
WADDELL & REED FINL INC CL A 930059100 47,120 1,850,000 SH   DFND 1, 2 1,850,000 0 0
WALMART INC COM 931142103 342,229 2,374,114 SH   DFND 1, 2 2,374,114 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 676,739 16,969,393 SH   DFND 1, 2 16,969,393 0 0
WARNER MUSIC GROUP CORP COM CL A 934550203 87,551 2,304,570 SH   DFND 1, 2 2,304,570 0 0
WASTE CONNECTIONS INC COM 94106B101 86,159 840,000 SH   DFND 1, 2 840,000 0 0
WASTE MGMT INC DEL COM 94106L109 315,049 2,671,491 SH   DFND 1, 2 2,671,491 0 0
WATSCO INC COM 942622200 233,628 1,031,244 SH   DFND 1, 2 1,031,244 0 0
WAYFAIR INC CL A 94419L101 163,318 723,253 SH   DFND 1, 2 723,253 0 0
WESTLAKE CHEM CORP COM 960413102 450,484 5,520,640 SH   DFND 1, 2 5,520,640 0 0
WHEATON PRECIOUS METALS CORP COM 962879102 643,461 15,415,932 SH   DFND 1, 2 15,415,932 0 0
WHITING PETE CORP NEW COM NEW 966387508 5,462 218,460 SH   DFND 1, 2 218,460 0 0
WILLSCOT MOBIL MINI HLDNG CO COM CL A 971378104 88,736 3,829,760 SH   DFND 1, 2 3,829,760 0 0
WINNEBAGO INDS INC COM 974637100 7,152 119,320 SH   DFND 1, 2 119,320 0 0
WORKDAY INC CL A 98138H101 95,062 396,735 SH   DFND 1, 2 396,735 0 0
WORLD WRESTLING ENTMT INC CL A 98156Q108 32,290 672,000 SH   DFND 1, 2 672,000 0 0
WYNN RESORTS LTD COM 983134107 196,944 1,745,493 SH   DFND 1, 2 1,745,487 0 6
XCEL ENERGY INC COM 98389B100 1,348,476 20,226,677 SH   DFND 1, 2 20,190,891 0 35,786
XENON PHARMACEUTICALS INC COM 98420N105 14,819 963,500 SH   DFND 1, 2 963,500 0 0
XPENG INC ADS 98422D105 379,202 8,853,662 SH   DFND 1, 2 8,853,662 0 0
YETI HLDGS INC COM 98585X104 110,743 1,617,400 SH   DFND 1, 2 1,617,400 0 0
YUM BRANDS INC COM 988498101 340,596 3,137,402 SH   DFND 1, 2 3,137,402 0 0
ZAI LAB LTD ADR 98887Q104 1,157,352 8,551,442 SH   DFND 1, 2 8,551,442 0 0
ZENDESK INC COM 98936J101 714,185 4,990,112 SH   DFND 1, 2 4,990,112 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 44,149 850,000 SH   DFND 1, 2 850,000 0 0
ZILLOW GROUP INC CL A 98954M101 177,178 1,303,357 SH   DFND 1, 2 1,303,357 0 0
ZILLOW GROUP INC CL C CAP STK 98954M200 390,523 3,008,653 SH   DFND 1, 2 3,008,653 0 0
ZILLOW GROUP INC NOTE 1.500% 7/0 98954MAC5 5,840 3,430,000 PRN   DFND 1, 2 3,430,000 0 0
ZOETIS INC CL A 98978V103 1,484,278 8,968,525 SH   DFND 1, 2 8,958,342 0 10,183
ZOOMINFO TECHNOLOGIES INC COM CL A 98980F104 288,525 5,982,269 SH   DFND 1, 2 5,982,269 0 0
EURONAV NV SHS B38564108 6,000 750,000 SH   DFND 1, 2 750,000 0 0
ADIENT PLC ORD SHS G0084W101 35,639 1,025,000 SH   DFND 1, 2 1,025,000 0 0
AON PLC SHS CL A G0403H108 1,484,166 7,024,973 SH   DFND 1, 2 7,024,973 0 0
ARCH CAP GROUP LTD ORD G0450A105 682,772 18,929,088 SH   DFND 1, 2 18,929,088 0 0
ARCO PLATFORM LTD COM CL A G04553106 55,453 1,562,501 SH   DFND 1, 2 1,562,501 0 0
ATLASSIAN CORP PLC CL A G06242104 4,490 19,200 SH   DFND 1, 2 19,200 0 0
BANK OF NT BUTTERFIELD&SON L SHS NEW G0772R208 60,762 1,950,000 SH   DFND 1, 2 1,950,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 398,504 4,649,448 SH   DFND 1, 2 4,649,448 0 0
BROOKFIELD PROPERTY PARTRS L UNIT LTD PARTN G16249107 41,549 2,871,366 SH   DFND 1, 2 2,871,366 0 0
BROOKFIELD INFRAST PARTNERS LP INT UNIT G16252101 941,759 19,034,056 SH   DFND 1, 2 19,034,056 0 0
BUNGE LIMITED COM G16962105 94,435 1,440,000 SH   DFND 1, 2 1,440,000 0 0
CLARIVATE PLC ORD SHS G21810109 72,119 2,427,423 SH   DFND 1, 2 2,427,423 0 0
CREDICORP LTD COM G2519Y108 11,385 69,415 SH   DFND 1, 2 69,415 0 0
COCA COLA EUROPEAN PARTNERS SHS G25839104 178,319 3,578,549 SH   DFND 1, 2 3,578,549 0 0
EATON CORP PLC SHS G29183103 6,379 53,100 SH   DFND 1, 2 53,100 0 0
ENSTAR GROUP LIMITED SHS G3075P101 111,563 544,500 SH   DFND 1, 2 544,500 0 0
ESSENT GROUP LTD COM G3198U102 149,623 3,463,500 SH   DFND 1, 2 3,463,500 0 0
FRESH DEL MONTE PRODUCE INC ORD G36738105 24,744 1,028,000 SH   DFND 1, 2 1,028,000 0 0
HELEN OF TROY LTD COM G4388N106 71,656 322,500 SH   DFND 1, 2 322,500 0 0
JANUS HENDERSON GROUP PLC ORD SHS G4474Y214 39,013 1,200,041 SH   DFND 1, 2 1,200,041 0 0
JOHNSON CTLS INTL PLC SHS G51502105 60,903 1,307,204 SH   DFND 1, 2 1,306,844 0 360
LINDE PLC SHS G5494J103 2,952,463 11,216,225 SH   DFND 1, 2 11,196,162 0 20,063
MEDTRONIC PLC SHS G5960L103 129,481 1,105,349 SH   DFND 1, 2 1,105,349 0 0
NOMAD FOODS LTD USD ORD SHS G6564A105 12,710 500,000 SH   DFND 1, 2 500,000 0 0
NORWEGIAN CRUISE LINE HLDG L SHS G66721104 27,973 1,100,000 SH   DFND 1, 2 1,100,000 0 0
NOVOCURE LTD ORD SHS G6674U108 1,340,201 7,745,038 SH   DFND 1, 2 7,745,038 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 1,156,251 20,328,177 SH   DFND 1, 2 20,311,962 0 16,215
RENAISSANCERE HLDGS LTD COM G7496G103 400,410 2,414,728 SH   DFND 1, 2 2,414,728 0 0
VENATOR MATLS PLC SHS G9329Z100 28,264 8,538,871 SH   DFND 1, 2 8,538,871 0 0
WILLIS TOWERS WATSON PLC LTD SHS G96629103 424,315 2,014,026 SH   DFND 1, 2 2,014,026 0 0
CHUBB LIMITED COM H1467J104 1,806,180 11,734,918 SH   DFND 1, 2 11,705,374 0 29,544
LOGITECH INTL S A SHS H50430232 592,939 6,113,466 SH   DFND 1, 2 6,113,466 0 0
TE CONNECTIVITY LTD REG SHS H84989104 2,201,813 18,186,279 SH   DFND 1, 2 18,186,279 0 0
GLOBANT S A COM L44385109 133,932 615,466 SH   DFND 1, 2 615,466 0 0
SPOTIFY TECHNOLOGY S A SHS L8681T102 49,201 156,364 SH   DFND 1, 2 156,364 0 0
JFROG LTD ORD SHS M6191J100 31,415 500,000 SH   DFND 1, 2 500,000 0 0
ASML HOLDING N V N Y REGISTRY SHS N07059210 3,873,827 7,942,592 SH   DFND 1, 2 7,912,619 0 29,973
FERRARI N V COM N3167Y103 261,831 1,132,370 SH   DFND 1, 2 1,126,129 0 6,241
LYONDELLBASELL INDUSTRIES N SHS - A - N53745100 2,365,852 25,811,260 SH   DFND 1, 2 25,797,732 0 13,528
YANDEX N V SHS CLASS A N97284108 733,181 10,537,243 SH   DFND 1, 2 10,537,243 0 0
COPA HOLDINGS SA CL A P31076105 52,839 684,183 SH   DFND 1, 2 684,183 0 0
SCORPIO TANKERS INC SHS Y7542C130 3,861 345,000 SH   DFND 1, 2 345,000 0 0