The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERON PHARMA INC COM 00434H108 1,561 13,872 SH   SOLE   13,872 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 1,460 30,028 SH   SOLE   30,028 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 2,406 68,752 SH   SOLE   68,752 0 0
ALECTOR INC COM 014442107 592 56,240 SH   SOLE   56,240 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 74 646 SH   SOLE   646 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 247,544 842,043 SH   SOLE   792,642 0 49,401
ALKERMES PLC SHS G01767105 2,696 162,716 SH   SOLE   162,716 0 0
ALLY FINL INC COM 02005N100 171,571 6,843,680 SH   SOLE   6,206,016 0 637,664
ALPHABET INC CAP STK CL A 02079K305 49,970 34,095 SH   SOLE   25,016 0 9,079
ALPHABET INC CAP STK CL C 02079K107 125,254 85,230 SH   SOLE   80,289 0 4,941
AMBARELLA INC SHS G037AX101 20,097 385,148 SH   SOLE   314,657 0 70,491
AMERICAN EAGLE OUTFITTERS IN COM 02553E106 47,341 3,196,559 SH   SOLE   2,700,385 0 496,174
AMERIPRISE FINL INC COM 03076C106 72 470 SH   SOLE   470 0 0
AMERISOURCEBERGEN CORP COM 03073E105 74 760 SH   SOLE   760 0 0
ANALOG DEVICES INC COM 032654105 2,004 17,168 SH   SOLE   17,168 0 0
APPIAN CORP CL A 03782L101 692 10,693 SH   SOLE   10,693 0 0
APPLE INC COM 037833100 1,481 12,788 SH   SOLE   12,788 0 0
ARCUS BIOSCIENCES INC COM 03969F109 1,492 87,058 SH   SOLE   87,058 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 812 427,141 SH   SOLE   427,141 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 3,697 224,892 SH   SOLE   224,892 0 0
ATRECA INC CL A COM 04965G109 1,673 119,751 SH   SOLE   119,751 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 422 15,000 SH   SOLE   15,000 0 0
BARRICK GOLD CORP COM 067901108 169,101 6,015,689 SH   SOLE   5,181,885 0 833,804
BERKELEY LTS INC COM 084310101 153 2,000 SH   SOLE   2,000 0 0
BIO RAD LABS INC CL A 090572207 1,218 2,362 SH   SOLE   2,362 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 1,588 462,402 SH   SOLE   462,402 0 0
BIONTECH SE SPONSORED ADS 09075V102 21,267 307,197 SH   SOLE   307,197 0 0
BITAUTO HLDGS LTD SPONSORED ADS 091727107 0 9 SH   SOLE   9 0 0
BLUEBIRD BIO INC COM 09609G100 27,395 507,784 SH   SOLE   443,094 0 64,690
BLUEPRINT MEDICINES CORP COM 09627Y109 3,663 39,511 SH   SOLE   39,511 0 0
BOINGO WIRELESS INC COM 09739C102 1,097 107,613 SH   SOLE   107,613 0 0
BOOKING HOLDINGS INC COM 09857L108 254,368 148,694 SH   SOLE   130,274 0 18,420
CANADA GOOSE HLDGS INC SHS SUB VTG 135086106 10,546 327,836 SH   SOLE   327,836 0 0
CARDINAL HEALTH INC COM 14149Y108 2,097 44,670 SH   SOLE   44,670 0 0
CARRIER GLOBAL CORPORATION COM 14448C104 79,772 2,612,050 SH   SOLE   2,382,386 0 229,664
CARVANA CO CL A 146869102 15,891 71,241 SH   SOLE   71,241 0 0
CEDAR FAIR L P DEPOSITRY UNIT 150185106 7,269 258,951 SH   SOLE   258,951 0 0
CENTOGENE N V COM N1976T109 3,545 374,695 SH   SOLE   374,695 0 0
CGI INC CL A SUB VTG 12532H104 71 1,050 SH   SOLE   1,050 0 0
CISCO SYS INC COM 17275R102 1,406 35,700 SH   SOLE   35,700 0 0
COHERUS BIOSCIENCES INC COM 19249H103 2,605 142,034 SH   SOLE   142,034 0 0
CUREVAC N V COM N2451R105 3,220 69,176 SH   SOLE   69,176 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 1,331 200,224 SH   SOLE   200,224 0 0
DENALI THERAPEUTICS INC COM 24823R105 2,537 70,793 SH   SOLE   70,793 0 0
DISCOVERY INC COM SER A 25470F104 73 3,343 SH   SOLE   3,343 0 0
EBAY INC. COM 278642103 1,182 22,679 SH   SOLE   22,679 0 0
EQUIFAX INC COM 294429105 28,816 183,659 SH   SOLE   183,659 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 32,215 866,681 SH   SOLE   764,462 0 102,219
FACEBOOK INC CL A 30303M102 175,472 669,998 SH   SOLE   591,786 0 78,212
FEDEX CORP COM 31428X106 181,674 722,306 SH   SOLE   617,942 0 104,364
FIVE PRIME THERAPEUTICS INC COM 33830X104 1,539 327,414 SH   SOLE   327,414 0 0
FOOT LOCKER INC COM 344849104 4,408 133,456 SH   SOLE   133,456 0 0
FOX CORP CL A COM 35137L105 37 1,324 SH   SOLE   1,324 0 0
FREEPORT-MCMORAN INC CL B 35671D857 72,886 4,660,219 SH   SOLE   3,778,645 0 881,574
FULCRUM THERAPEUTICS INC COM 359616109 663 83,550 SH   SOLE   83,550 0 0
GENERAL ELECTRIC CO COM 369604103 215,198 34,542,199 SH   SOLE   30,006,202 0 4,535,997
GENETRON HLDGS LTD ADS 37186H100 4,482 375,359 SH   SOLE   375,359 0 0
GILEAD SCIENCES INC COM 375558103 102,858 1,627,758 SH   SOLE   1,427,303 0 200,455
GOLDEN OCEAN GROUP LTD SHS NEW G39637205 45,760 1,300,000 SH   SOLE   1,300,000 0 0
HANESBRANDS INC COM 410345102 76 4,824 SH   SOLE   4,824 0 0
HCA HEALTHCARE INC COM 40412C101 68 544 SH   SOLE   544 0 0
HUAZHU GROUP LTD SPONSORED ADS 44332N106 138,089 3,193,544 SH   SOLE   3,193,544 0 0
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 2,747 85,055 SH   SOLE   85,055 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 2,426 193,123 SH   SOLE   193,123 0 0
IHS MARKIT LTD SHS G47567105 9,787 124,660 SH   SOLE   124,660 0 0
IMMATICS N.V SHS N44445109 2,429 228,960 SH   SOLE   228,960 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 1,077 920,294 SH   SOLE   920,294 0 0
INHIBRX INC COM 45720L107 1,350 75,000 SH   SOLE   75,000 0 0
INTEL CORP COM 458140100 14,830 286,395 SH   SOLE   286,395 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 1,293 65,031 SH   SOLE   65,031 0 0
INTERNATIONAL BUSINESS MACHS COM 459200101 146 1,196 SH   SOLE   1,196 0 0
ITAU UNIBANCO HLDG S A SPON ADR REP PFD 465562106 34 8,658 SH   SOLE   8,658 0 0
JD.COM INC SPON ADR CL A 47215P106 36,564 471,127 SH   SOLE   471,127 0 0
JOHNSON & JOHNSON COM 478160104 3,796 25,495 SH   SOLE   25,495 0 0
JOYY INC ADS REPSTG COM A 46591M109 35 432 SH   SOLE   432 0 0
KOHLS CORP COM 500255104 6,743 363,883 SH   SOLE   363,883 0 0
KONTOOR BRANDS INC COM 50050N103 6,307 260,600 SH   SOLE   260,600 0 0
LAM RESEARCH CORP COM 512807108 68,665 206,977 SH   SOLE   180,210 0 26,767
LEAP THERAPEUTICS INC COM 52187K101 833 420,471 SH   SOLE   420,471 0 0
LIBERTY GLOBAL PLC SHS CL A G5480U104 311 14,800 SH   SOLE   14,800 0 0
LIVANOVA PLC SHS G5509L101 1,881 41,603 SH   SOLE   41,603 0 0
LIVERAMP HLDGS INC COM 53815P108 173 3,347 SH   SOLE   3,347 0 0
LOUISIANA PAC CORP COM 546347105 7,870 266,673 SH   SOLE   266,673 0 0
LUMEN TECHNOLOGIES INC COM 156700106 615 60,907 SH   SOLE   60,907 0 0
LYONDELLBASELL INDUSTRIES N SHS - A - N53745100 69 979 SH   SOLE   979 0 0
MAGELLAN MIDSTREAM PRTNRS LP COM UNIT RP LP 559080106 66 1,941 SH   SOLE   1,941 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 1,642 241,463 SH   SOLE   241,463 0 0
MANULIFE FINL CORP COM 56501R106 70 4,999 SH   SOLE   4,999 0 0
MEDALLIA INC COM 584021109 55,652 2,029,605 SH   SOLE   1,748,732 0 280,873
MELCO RESORTS AND ENTMNT LTD ADR 585464100 57,747 3,468,287 SH   SOLE   3,468,287 0 0
MERCK & CO. INC COM 58933Y105 108 1,298 SH   SOLE   1,298 0 0
MERSANA THERAPEUTICS INC COM 59045L106 2,065 110,906 SH   SOLE   110,906 0 0
MERUS N V COM N5749R100 2,285 190,408 SH   SOLE   190,408 0 0
MICROCHIP TECHNOLOGY INC. COM 595017104 232,021 2,257,889 SH   SOLE   2,016,164 0 241,725
MICRON TECHNOLOGY INC COM 595112103 214,652 4,570,945 SH   SOLE   4,064,833 0 506,112
MICROSOFT CORP COM 594918104 5,258 24,998 SH   SOLE   24,998 0 0
MODERNA INC COM 60770K107 1,311 18,528 SH   SOLE   18,528 0 0
MOMO INC ADR 60879B107 34,463 2,504,587 SH   SOLE   2,169,882 0 334,705
MOTOROLA SOLUTIONS INC COM NEW 620076307 252 1,606 SH   SOLE   1,606 0 0
MYOVANT SCIENCES LTD COM G637AM102 3,536 251,639 SH   SOLE   251,639 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 3,053 68,289 SH   SOLE   68,289 0 0
NIELSEN HLDGS PLC SHS EUR G6518L108 241 17,000 SH   SOLE   17,000 0 0
NOAH HLDGS LTD SPON ADS CL A 65487X102 49,163 1,885,812 SH   SOLE   1,885,812 0 0
NUVASIVE INC COM 670704105 909 18,705 SH   SOLE   18,705 0 0
OMNICOM GROUP INC COM 681919106 68 1,364 SH   SOLE   1,364 0 0
ONECONNECT FINL TECHNOLOGY C SPONSORED ADS 68248T105 27,195 1,276,742 SH   SOLE   1,276,742 0 0
ORACLE CORP COM 68389X105 1,910 31,996 SH   SOLE   31,996 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 1,693 411,977 SH   SOLE   411,977 0 0
OVID THERAPEUTICS INC COM 690469101 1,340 233,413 SH   SOLE   233,413 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 6,888 697,913 SH   SOLE   697,913 0 0
PAYPAL HLDGS INC COM 70450Y103 2,581 13,099 SH   SOLE   13,099 0 0
PERKINELMER INC COM 714046109 2,517 20,053 SH   SOLE   20,053 0 0
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408 64 9,029 SH   SOLE   9,029 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 1,053 508,768 SH   SOLE   508,768 0 0
PLANET FITNESS INC CL A 72703H101 12,504 202,922 SH   SOLE   202,922 0 0
PROTHENA CORP PLC SHS G72800108 1,281 128,223 SH   SOLE   128,223 0 0
PRUDENTIAL FINL INC COM 744320102 69 1,088 SH   SOLE   1,088 0 0
QIWI PLC SPON ADR REP B 74735M108 6,073 350,000 SH   SOLE   350,000 0 0
QUANTERIX CORP COM 74766Q101 11,449 339,323 SH   SOLE   315,832 0 23,491
RELAY THERAPEUTICS INC COM 75943R102 85 2,000 SH   SOLE   2,000 0 0
ROKU INC COM CL A 77543R102 1,397 7,398 SH   SOLE   7,398 0 0
SANGAMO THERAPEUTICS INC COM 800677106 2,063 218,336 SH   SOLE   218,336 0 0
SCHLUMBERGER LTD COM 806857108 91 5,820 SH   SOLE   5,820 0 0
SEAWORLD ENTMT INC COM 81282V100 5,868 297,573 SH   SOLE   297,573 0 0
SIGNET JEWELERS LIMITED SHS G81276100 6,594 352,634 SH   SOLE   352,634 0 0
SIX FLAGS ENTMT CORP NEW COM 83001A102 7,233 356,326 SH   SOLE   356,326 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 123,603 849,503 SH   SOLE   727,119 0 122,384
STEEL DYNAMICS INC COM 858119100 25,358 885,714 SH   SOLE   885,714 0 0
STORE CAP CORP COM 862121100 75 2,728 SH   SOLE   2,728 0 0
SYNCHRONY FINANCIAL COM 87165B103 39 1,487 SH   SOLE   1,487 0 0
TECHNIPFMC PLC COM G87110105 35,944 5,696,387 SH   SOLE   5,031,634 0 664,753
TRIP COM GROUP LTD ADS 89677Q107 228,209 7,328,470 SH   SOLE   6,649,812 0 678,658
TWILIO INC CL A 90138F102 787 3,184 SH   SOLE   3,184 0 0
ULTA BEAUTY INC COM 90384S303 11,966 53,426 SH   SOLE   53,426 0 0
UNITED STATES STL CORP NEW COM 912909108 328 44,623 SH   SOLE   44,623 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100 71 668 SH   SOLE   668 0 0
VAIL RESORTS INC COM 91879Q109 44,712 208,964 SH   SOLE   178,231 0 30,733
WABTEC COM 929740108 16,108 260,317 SH   SOLE   255,503 0 4,814
WARRIOR MET COAL INC COM 93627C101 13,837 810,120 SH   SOLE   676,820 0 133,300
WAVE LIFE SCIENCES LTD SHS Y95308105 1,752 206,384 SH   SOLE   206,384 0 0
WYNDHAM HOTELS & RESORTS INC COM 98311A105 5,373 106,399 SH   SOLE   106,399 0 0
XILINX INC COM 983919101 960 9,209 SH   SOLE   9,209 0 0
YUM CHINA HLDGS INC COM 98850P109 85,360 1,621,152 SH   SOLE   1,621,152 0 0
ZAI LAB LTD ADR 98887Q104 5,684 68,337 SH   SOLE   68,337 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 1,022 7,510 SH   SOLE   7,510 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADS A 98980A105 204,768 6,843,849 SH   SOLE   5,859,586 0 984,263
ZYMEWORKS INC COM 98985W102 2,437 52,327 SH   SOLE   52,327 0 0