The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101 4,479 3,650 PRN   SOLE   3,650 0 0
3M CO COM 88579Y101 16,788 104,813 SH   SOLE   104,813 0 0
ABBOTT LABS COM 002824100 65,377 600,750 SH   SOLE   600,750 0 0
ABBOTT LABS COM 002824100 2 20 SH   OTR 1 0 0 20
ABBVIE INC COM 00287Y109 58,316 665,808 SH   SOLE   665,808 0 0
ABIOMED INC COM 003654100 647 2,336 SH   SOLE   2,336 0 0
ACACIA COMMUNICATIONS INC COM 00401C108 12,142 180,151 SH   SOLE   180,151 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 12,746 309,000 SH   SOLE   309,000 0 0
ACCELERON PHARMA INC COM 00434H108 56,865 505,357 SH   SOLE   505,357 0 0
ACCELERON PHARMA INC COM 00434H108 3 23 SH   OTR 1 0 0 23
ACCENTURE PLC IRELAND SHS CLASS A G1151C101 2 7 SH   OTR 1 0 0 7
ACCURAY INC COM 004397105 168 70,000 SH   SOLE   70,000 0 0
ACTIVISION BLIZZARD INC COM 00507V109 28,705 354,611 SH   SOLE   354,611 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 2 5 SH   OTR 1 0 0 5
ADOBE SYSTEMS INCORPORATED COM 00724F101 54,970 112,090 SH   SOLE   112,090 0 0
ADVANCE AUTO PARTS INC COM 00751Y106 477 3,105 SH   SOLE   3,105 0 0
ADVANCED DISP SVCS INC DEL COM 00790X101 31,672 1,047,755 SH   SOLE   1,047,755 0 0
ADVANCED DRAIN SYS INC DEL COM 00790R104 17,626 282,305 SH   SOLE   282,305 0 0
ADVANCED DRAIN SYS INC DEL COM 00790R104 3 44 SH   OTR 1 0 0 44
ADVANCED MICRO DEVICES INC COM 007903107 21,022 256,411 SH   SOLE   256,411 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 3,127 303,575 SH   SOLE   303,575 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 6,965 591,800 SH   SOLE   591,800 0 0
AFLAC INC COM 001055102 1,851 50,926 SH   SOLE   50,926 0 0
AFLAC INC COM 001055102 1 39 SH   OTR 1 0 0 39
AFYA LTD CL A COM G01125106 12,437 456,600 SH   SOLE   456,600 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 6,625 65,635 SH   SOLE   65,635 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 2 22 SH   OTR 1 0 0 22
AGIOS PHARMACEUTICALS INC COM 00847X104 1 21 SH   OTR 1 0 0 21
AGIOS PHARMACEUTICALS INC COM 00847X104 13,215 377,584 SH   SOLE   377,584 0 0
AGNICO EAGLE MINES LTD COM 008474108 444 5,593 SH   SOLE   5,593 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 9,053 262,804 SH   SOLE   262,804 0 0
AIR PRODS & CHEMS INC COM 009158106 6 19 SH   OTR 1 0 0 19
AIR PRODS & CHEMS INC COM 009158106 47,241 158,608 SH   SOLE   158,608 0 0
AKAMAI TECHNOLOGIES INC NOTE 0.375% 9/0 00971TAL5 1,849 1,600 PRN   SOLE   1,600 0 0
AKAMAI TECHNOLOGIES INC NOTE 0.125% 5/0 00971TAJ0 8,128 6,300 PRN   SOLE   6,300 0 0
AKAMAI TECHNOLOGIES INC COM 00971T101 10,217 92,434 SH   SOLE   92,434 0 0
AKCEA THERAPEUTICS INC COM 00972L107 4,433 244,395 SH   SOLE   244,395 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 176 70,000 SH   SOLE   70,000 0 0
AKERO THERAPEUTICS INC COM 00973Y108 3,063 99,500 SH   SOLE   99,500 0 0
AKERS BIOSCIENCES INC COM 00973E409 81 36,146 SH   SOLE   36,146 0 0
ALBEMARLE CORP COM 012653101 320 3,585 SH   SOLE   3,585 0 0
ALECTOR INC COM 014442107 1,691 160,474 SH   SOLE   160,474 0 0
ALEXANDRIA REAL ESTATE EQ IN COM 015271109 1,262 7,889 SH   SOLE   7,889 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 64,430 563,072 SH   SOLE   563,072 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 2 7 SH   OTR 1 0 0 7
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 132,198 449,704 SH   SOLE   449,704 0 0
ALIGN TECHNOLOGY INC COM 016255101 1,545 4,720 SH   SOLE   4,720 0 0
ALLAKOS INC COM 01671P100 9,112 111,872 SH   SOLE   111,872 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 2,510 66,555 SH   SOLE   66,555 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 0 6 SH   OTR 1 0 0 6
ALLSCRIPTS HEALTHCARE SOLUTN COM 01988P108 1,384 170,000 SH   SOLE   170,000 0 0
ALLSTATE CORP COM 020002101 33,380 354,590 SH   SOLE   354,590 0 0
ALLSTATE CORP COM 020002101 1 15 SH   OTR 1 0 0 15
ALLY FINL INC COM 02005N100 1,034 41,239 SH   SOLE   41,239 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 24,402 167,600 SH   SOLE   167,600 0 0
ALPHABET INC CAP STK CL A 02079K305 9 6 SH   OTR 1 0 0 6
ALPHABET INC CAP STK CL A 02079K305 253,815 173,189 SH   SOLE   173,189 0 0
ALPHABET INC CAP STK CL C 02079K107 72,570 49,383 SH   SOLE   49,383 0 0
ALTERYX INC COM CL A 02156B103 320 2,820 SH   SOLE   2,820 0 0
ALTRIA GROUP INC COM 02209S103 3,515 2,765 PRN   SOLE   2,765 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 2,551 606,000 SH   SOLE   606,000 0 0
AMAZON COM INC COM 023135106 243,961 77,491 SH   SOLE   77,491 0 0
AMAZON COM INC COM 023135106 3 1 SH   OTR 1 0 0 1
AMBARELLA INC SHS G037AX101 17,171 329,085 SH   SOLE   329,085 0 0
AMERESCO INC CL A 02361E108 1 40 SH   OTR 1 0 0 40
AMERESCO INC CL A 02361E108 7,243 216,864 SH   SOLE   216,864 0 0
AMERICAN AIRLS GROUP INC COM 02376R102 160 13,000 SH   SOLE   13,000 0 0
AMERICAN EXPRESS CO COM 025816109 1 13 SH   OTR 1 0 0 13
AMERICAN EXPRESS CO COM 025816109 15,828 157,892 SH   SOLE   157,892 0 0
AMERICAN INTL GROUP INC COM NEW 026874784 5,939 215,727 SH   SOLE   215,727 0 0
AMERICAN TOWER CORP NEW COM 03027X100 11,996 49,629 SH   SOLE   49,629 0 0
AMERICAN WTR WKS CO INC NEW COM 030420103 33,552 231,594 SH   SOLE   231,594 0 0
AMERICAN WTR WKS CO INC NEW COM 030420103 3 24 SH   OTR 1 0 0 24
AMERIPRISE FINL INC COM 03076C106 5,457 35,409 SH   SOLE   35,409 0 0
AMERIPRISE FINL INC COM 03076C106 1 9 SH   OTR 1 0 0 9
AMERISOURCEBERGEN CORP COM 03073E105 1,069 11,027 SH   SOLE   11,027 0 0
AMERISOURCEBERGEN CORP COM 03073E105 1 11 SH   OTR 1 0 0 11
AMETEK INC COM 031100100 1,841 18,523 SH   SOLE   18,523 0 0
AMGEN INC COM 031162100 320,819 1,262,326 SH   SOLE   1,262,326 0 0
AMGEN INC COM 031162100 8 33 SH   OTR 1 0 0 33
AMICUS THERAPEUTICS INC COM 03152W109 10,894 771,588 SH   SOLE   771,588 0 0
AMPHENOL CORP NEW CL A 032095101 17,557 162,163 SH   SOLE   162,163 0 0
ANALOG DEVICES INC COM 032654105 46,597 399,165 SH   SOLE   399,165 0 0
ANALOG DEVICES INC COM 032654105 2 21 SH   OTR 1 0 0 21
ANGIODYNAMICS INC COM 03475V101 1,507 125,000 SH   SOLE   125,000 0 0
ANNALY CAPITAL MANAGEMENT IN COM 035710409 797 111,974 SH   SOLE   111,974 0 0
ANSYS INC COM 03662Q105 2 7 SH   OTR 1 0 0 7
ANSYS INC COM 03662Q105 31,133 95,146 SH   SOLE   95,146 0 0
ANTHEM INC COM 036752103 15,615 58,139 SH   SOLE   58,139 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 34,660 1,148,865 SH   SOLE   1,148,865 0 0
APOLLO GLOBAL MGMT INC COM CL A 03768E105 1,413 31,575 SH   SOLE   31,575 0 0
APPLE INC COM 037833100 14 122 SH   OTR 1 0 0 122
APPLE INC COM 037833100 232,021 2,003,552 SH   SOLE   2,003,552 0 0
APPLIED MATLS INC COM 038222105 33,928 570,715 SH   SOLE   570,715 0 0
APPLIED MATLS INC COM 038222105 1 19 SH   OTR 1 0 0 19
APREA THERAPEUTICS INC COM 03836J102 5,626 233,828 SH   SOLE   233,828 0 0
APREA THERAPEUTICS INC COM 03836J102 1 22 SH   OTR 1 0 0 22
APTIV PLC SHS G6095L109 4 39 SH   OTR 1 0 0 39
ARCH CAP GROUP LTD ORD G0450A105 637 21,786 SH   SOLE   21,786 0 0
ARCHER DANIELS MIDLAND CO COM 039483102 1,887 40,593 SH   SOLE   40,593 0 0
ARCTURUS THERAPEUTICS HLDGS COM 03969T109 3,420 79,720 SH   SOLE   79,720 0 0
ARCUS BIOSCIENCES INC COM 03969F109 8,375 488,635 SH   SOLE   488,635 0 0
ARCUS BIOSCIENCES INC COM 03969F109 1 35 SH   OTR 1 0 0 35
ARDELYX INC COM 039697107 3,347 637,643 SH   SOLE   637,643 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 27,638 369,556 SH   SOLE   369,556 0 0
ARGENX SE SPONSORED ADR 04016X101 1 4 SH   OTR 1 0 0 4
ARGENX SE SPONSORED ADR 04016X101 10,243 39,019 SH   SOLE   39,019 0 0
ARISTA NETWORKS INC COM 040413106 769 3,714 SH   SOLE   3,714 0 0
ARK ETF TR GENOMIC REV ETF 00214Q302 255 4,000 SH   SOLE   4,000 0 0
ARK ETF TR INNOVATION ETF 00214Q104 239 2,600 SH   SOLE   2,600 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 11,675 271,146 SH   SOLE   271,146 0 0
ARVINAS INC COM 04335A105 0 18 SH   OTR 1 0 0 18
ARVINAS INC COM 04335A105 7,577 320,948 SH   SOLE   320,948 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 41,523 269,079 SH   SOLE   269,079 0 0
ASE TECHNOLOGY HLDG CO LTD SPONSORED ADS 00215W100 110 26,950 SH   SOLE   26,950 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 7,398 450,000 SH   SOLE   450,000 0 0
ASSURANT INC COM 04621X108 845 6,966 SH   SOLE   6,966 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 6,520 118,991 SH   SOLE   118,991 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 6 114 SH   OTR 1 0 0 114
ASURE SOFTWARE INC COM 04649U102 121 16,000 SH   SOLE   16,000 0 0
AT&T INC COM 00206R102 5 192 SH   OTR 1 0 0 192
AT&T INC COM 00206R102 27,439 962,469 SH   SOLE   962,469 0 0
ATMOS ENERGY CORP COM 049560105 3,406 35,630 SH   SOLE   35,630 0 0
ATMOS ENERGY CORP COM 049560105 2 23 SH   OTR 1 0 0 23
AUTODESK INC COM 052769106 67,242 291,089 SH   SOLE   291,089 0 0
AUTODESK INC COM 052769106 2 10 SH   OTR 1 0 0 10
AUTOLIV INC COM 052800109 3,779 51,860 SH   SOLE   51,860 0 0
AUTOMATIC DATA PROCESSING IN COM 053015103 18,500 132,631 SH   SOLE   132,631 0 0
AUTOZONE INC COM 053332102 7,466 6,340 SH   SOLE   6,340 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 428 85,000 SH   SOLE   85,000 0 0
AVALARA INC COM 05338G106 574 4,510 SH   SOLE   4,510 0 0
AVALONBAY CMNTYS INC COM 053484101 1,818 12,176 SH   SOLE   12,176 0 0
AVANTOR INC COM 05352A100 3,552 157,963 SH   SOLE   157,963 0 0
AVERY DENNISON CORP COM 053611109 2,701 21,131 SH   SOLE   21,131 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 563 20,000 SH   SOLE   20,000 0 0
AXSOME THERAPEUTICS INC COM 05464T104 7,157 100,455 SH   SOLE   100,455 0 0
BADGER METER INC COM 056525108 1,106 16,920 SH   SOLE   16,920 0 0
BAIDU INC SPON ADR REP A 056752108 16,242 128,312 SH   SOLE   128,312 0 0
BAKER HUGHES COMPANY CL A 05722G100 4,842 364,360 SH   SOLE   364,360 0 0
BALL CORP COM 058498106 4 43 SH   OTR 1 0 0 43
BALL CORP COM 058498106 29,051 349,525 SH   SOLE   349,525 0 0
BALLARD PWR SYS INC NEW COM 058586108 2,247 148,795 SH   SOLE   148,795 0 0
BANCO BRADESCO S A SP ADR PFD NEW 059460303 714 208,172 SH   SOLE   208,172 0 0
BANCO SANTANDER BRASIL S A ADS REP 1 UNIT 05967A107 59 11,920 SH   SOLE   11,920 0 0
BANCOLOMBIA S A SPON ADR PREF 05968L102 210 8,210 SH   SOLE   8,210 0 0
BANK MONTREAL QUE COM 063671101 1,337 22,950 SH   SOLE   22,950 0 0
BANK NEW YORK MELLON CORP COM 064058100 7,224 210,381 SH   SOLE   210,381 0 0
BANK NEW YORK MELLON CORP COM 064058100 1 26 SH   OTR 1 0 0 26
BANK NOVA SCOTIA B C COM 064149107 2,061 49,773 SH   SOLE   49,773 0 0
BAOZUN INC SPONSORED ADR 06684L103 11,631 358,000 SH   SOLE   358,000 0 0
BARRICK GOLD CORP COM 067901108 2,723 97,243 SH   SOLE   97,243 0 0
BAXTER INTL INC COM 071813109 3,985 49,559 SH   SOLE   49,559 0 0
BCE INC COM NEW 05534B760 2,806 67,874 SH   SOLE   67,874 0 0
BECTON DICKINSON & CO COM 075887109 11,636 50,010 SH   SOLE   50,010 0 0
BEIGENE LTD SPONSORED ADR 07725L102 2 6 SH   OTR 1 0 0 6
BEIGENE LTD SPONSORED ADR 07725L102 47,029 164,191 SH   SOLE   164,191 0 0
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 23,084 108,411 SH   SOLE   108,411 0 0
BEST BUY INC COM 086516101 27,678 248,715 SH   SOLE   248,715 0 0
BEYOND MEAT INC COM 08862E109 1,995 12,013 SH   SOLE   12,013 0 0
BHP GROUP LTD SPONSORED ADS 088606108 4 73 SH   OTR 1 0 0 73
BILIBILI INC SPONS ADS REP Z 090040106 10,529 253,100 SH   SOLE   253,100 0 0
BIO RAD LABS INC CL A 090572207 63,526 123,246 SH   SOLE   123,246 0 0
BIO RAD LABS INC CL A 090572207 3 6 SH   OTR 1 0 0 6
BIOGEN INC COM 09062X103 104,273 367,589 SH   SOLE   367,589 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 10,199 156,887 SH   SOLE   156,887 0 0
BIOLIFE SOLUTIONS INC COM NEW 09062W204 1,302 45,000 SH   SOLE   45,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 27,982 367,819 SH   SOLE   367,819 0 0
BIONTECH SE SPONSORED ADS 09075V102 24,058 347,521 SH   SOLE   347,521 0 0
BIONTECH SE SPONSORED ADS 09075V102 1 16 SH   OTR 1 0 0 16
BIO-TECHNE CORP COM 09073M104 2 10 SH   OTR 1 0 0 10
BIO-TECHNE CORP COM 09073M104 27,274 110,100 SH   SOLE   110,100 0 0
BK OF AMERICA CORP COM 060505104 21,137 877,440 SH   SOLE   877,440 0 0
BLACKROCK INC COM 09247X101 10,436 18,519 SH   SOLE   18,519 0 0
BLACKSTONE GROUP INC COM CL A 09260D107 1,514 29,012 SH   SOLE   29,012 0 0
BLOOM ENERGY CORP COM CL A 093712107 1 76 SH   OTR 1 0 0 76
BLOOM ENERGY CORP COM CL A 093712107 7,018 390,539 SH   SOLE   390,539 0 0
BLUEBIRD BIO INC COM 09609G100 17,783 329,634 SH   SOLE   329,634 0 0
BLUEBIRD BIO INC COM 09609G100 1 12 SH   OTR 1 0 0 12
BLUEPRINT MEDICINES CORP COM 09627Y109 49,499 533,989 SH   SOLE   533,989 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 2 26 SH   OTR 1 0 0 26
BMC STK HLDGS INC COM 05591B109 14,844 346,601 SH   SOLE   346,601 0 0
BOEING CO COM 097023105 1,503 8,987 SH   SOLE   8,987 0 0
BOOKING HOLDINGS INC COM 09857L108 7,443 4,351 SH   SOLE   4,351 0 0
BOSTON PROPERTIES INC COM 101121101 1,029 12,810 SH   SOLE   12,810 0 0
BOSTON SCIENTIFIC CORP COM 101137107 2,873 75,200 SH   SOLE   75,200 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 6 95 SH   OTR 1 0 0 95
BRISTOL-MYERS SQUIBB CO RIGHT 99/99/9999 110122157 438 194,693 SH   SOLE   194,693 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 102,153 1,694,431 SH   SOLE   1,694,431 0 0
BROADCOM INC COM 11135F101 45,593 125,152 SH   SOLE   125,152 0 0
BROADRIDGE FINL SOLUTIONS IN COM 11133T103 2,267 17,173 SH   SOLE   17,173 0 0
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104 1,350 40,939 SH   SOLE   40,939 0 0
BROOKFIELD RENEWABLE PARTNER PARTNERSHIP UNIT G16258108 1,399 26,629 SH   SOLE   26,629 0 0
BROOKS AUTOMATION INC NEW COM 114340102 12,514 270,525 SH   SOLE   270,525 0 0
BROWN FORMAN CORP CL B 115637209 1,611 21,388 SH   SOLE   21,388 0 0
BUNGE LIMITED COM G16962105 832 18,201 SH   SOLE   18,201 0 0
BURLINGTON STORES INC COM 122017106 671 3,256 SH   SOLE   3,256 0 0
CABOT OIL & GAS CORP COM 127097103 2,774 159,798 SH   SOLE   159,798 0 0
CADENCE DESIGN SYSTEM INC COM 127387108 5 51 SH   OTR 1 0 0 51
CADENCE DESIGN SYSTEM INC COM 127387108 23,497 220,374 SH   SOLE   220,374 0 0
CAMECO CORP COM 13321L108 197 19,546 SH   SOLE   19,546 0 0
CAMPBELL SOUP CO COM 134429109 15,267 315,636 SH   SOLE   315,636 0 0
CANADIAN IMP BK COMM COM 136069101 877 11,775 SH   SOLE   11,775 0 0
CANADIAN NAT RES LTD COM 136385101 421 26,368 SH   SOLE   26,368 0 0
CANADIAN NATL RY CO COM 136375102 4,639 43,702 SH   SOLE   43,702 0 0
CANADIAN PAC RY LTD COM 13645T100 1,274 4,201 SH   SOLE   4,201 0 0
CANON INC SPONSORED ADR 138006309 1 50 SH   OTR 1 0 0 50
CAPITAL ONE FINL CORP COM 14040H105 2 25 SH   OTR 1 0 0 25
CAPITAL ONE FINL CORP COM 14040H105 3,260 45,369 SH   SOLE   45,369 0 0
CARDINAL HEALTH INC COM 14149Y108 1 24 SH   OTR 1 0 0 24
CARDINAL HEALTH INC COM 14149Y108 2,963 63,113 SH   SOLE   63,113 0 0
CAREDX INC COM 14167L103 1,518 40,000 SH   SOLE   40,000 0 0
CARMAX INC COM 143130102 687 7,478 SH   SOLE   7,478 0 0
CARNIVAL CORP UNIT 99/99/9999 143658300 550 36,248 SH   SOLE   36,248 0 0
CARRIER GLOBAL CORPORATION COM 14448C104 1,503 49,224 SH   SOLE   49,224 0 0
CATALENT INC COM 148806102 800 9,344 SH   SOLE   9,344 0 0
CATERPILLAR INC DEL COM 149123101 22,622 151,677 SH   SOLE   151,677 0 0
CATERPILLAR INC DEL COM 149123101 2 11 SH   OTR 1 0 0 11
CBOE GLOBAL MARKETS INC COM 12503M108 681 7,763 SH   SOLE   7,763 0 0
CBRE GROUP INC CL A 12504L109 13,270 282,537 SH   SOLE   282,537 0 0
CDW CORP COM 12514G108 4,403 36,840 SH   SOLE   36,840 0 0
CELLULAR BIOMEDICINE GROUP I COM NEW 15117P102 4,316 235,317 SH   SOLE   235,317 0 0
CEMEX SAB DE CV SPON ADR NEW 151290889 308 81,075 SH   SOLE   81,075 0 0
CENOVUS ENERGY INC COM 15135U109 72 18,527 SH   SOLE   18,527 0 0
CENTENE CORP DEL COM 15135B101 2,052 35,183 SH   SOLE   35,183 0 0
CENTERPOINT ENERGY INC COM 15189T107 2,086 107,807 SH   SOLE   107,807 0 0
CENTRAL EUROPEAN MEDIA ENTRP CL A NEW G20045202 6,077 1,450,357 SH   SOLE   1,450,357 0 0
CERNER CORP COM 156782104 13,719 189,779 SH   SOLE   189,779 0 0
CEVA INC COM 157210105 12,101 307,386 SH   SOLE   307,386 0 0
CF INDS HLDGS INC COM 125269100 4,461 145,257 SH   SOLE   145,257 0 0
CGI INC CL A SUB VTG 12532H104 402 5,939 SH   SOLE   5,939 0 0
CHARLES RIV LABS INTL INC COM 159864107 9,929 43,846 SH   SOLE   43,846 0 0
CHARTER COMMUNICATIONS INC N CL A 16119P108 13,918 22,294 SH   SOLE   22,294 0 0
CHECK POINT SOFTWARE TECH LT ORD M22465104 0 4 SH   OTR 1 0 0 4
CHEGG INC NOTE 0.125% 3/1 163092AD1 2,526 1,664 PRN   SOLE   1,664 0 0
CHEGG INC COM 163092109 221 3,100 SH   SOLE   3,100 0 0
CHENIERE ENERGY INC COM NEW 16411R208 5,578 120,565 SH   SOLE   120,565 0 0
CHEVRON CORP NEW COM 166764100 2,103 29,212 SH   SOLE   29,212 0 0
CHIASMA INC COM 16706W102 101 23,500 SH   SOLE   23,500 0 0
CHIPOTLE MEXICAN GRILL INC COM 169656105 6,305 5,070 SH   SOLE   5,070 0 0
CHURCH & DWIGHT INC COM 171340102 15,042 160,521 SH   SOLE   160,521 0 0
CIA ENERGETICA DE MINAS GERA SP ADR N-V PFD 204409601 151 81,718 SH   SOLE   81,718 0 0
CIGNA CORP NEW COM 125523100 1 7 SH   OTR 1 0 0 7
CIGNA CORP NEW COM 125523100 16,456 97,144 SH   SOLE   97,144 0 0
CINCINNATI FINL CORP COM 172062101 643 8,251 SH   SOLE   8,251 0 0
CINTAS CORP COM 172908105 2,191 6,582 SH   SOLE   6,582 0 0
CISCO SYS INC COM 17275R102 2 59 SH   OTR 1 0 0 59
CISCO SYS INC COM 17275R102 39,442 1,001,363 SH   SOLE   1,001,363 0 0
CITIGROUP INC COM NEW 172967424 22,864 530,357 SH   SOLE   530,357 0 0
CITIGROUP INC COM NEW 172967424 1 33 SH   OTR 1 0 0 33
CITIZENS FINL GROUP INC COM 174610105 1,488 58,882 SH   SOLE   58,882 0 0
CITRIX SYS INC COM 177376100 2 11 SH   OTR 1 0 0 11
CITRIX SYS INC COM 177376100 18,716 135,914 SH   SOLE   135,914 0 0
CLOROX CO DEL COM 189054109 5,381 25,604 SH   SOLE   25,604 0 0
CLOVIS ONCOLOGY INC COM 189464100 8,077 1,385,558 SH   SOLE   1,385,558 0 0
CLOVIS ONCOLOGY INC COM 189464100 0 77 SH   OTR 1 0 0 77
CME GROUP INC COM 12572Q105 3,753 22,430 SH   SOLE   22,430 0 0
CNX RES CORP COM 12653C108 4,581 485,285 SH   SOLE   485,285 0 0
COCA COLA CO COM 191216100 24,164 489,475 SH   SOLE   489,475 0 0
COCA COLA CO COM 191216100 1 17 SH   OTR 1 0 0 17
COGNEX CORP COM 192422103 528 8,108 SH   SOLE   8,108 0 0
COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102 7,814 112,570 SH   SOLE   112,570 0 0
COHERUS BIOSCIENCES INC COM 19249H103 12,984 707,990 SH   SOLE   707,990 0 0
COHERUS BIOSCIENCES INC COM 19249H103 1 60 SH   OTR 1 0 0 60
COLGATE PALMOLIVE CO COM 194162103 1 17 SH   OTR 1 0 0 17
COLGATE PALMOLIVE CO COM 194162103 9,805 127,098 SH   SOLE   127,098 0 0
COMCAST CORP NEW CL A 20030N101 18,973 410,150 SH   SOLE   410,150 0 0
COMCAST CORP NEW CL A 20030N101 4 95 SH   OTR 1 0 0 95
COMERICA INC COM 200340107 1,244 32,527 SH   SOLE   32,527 0 0
CONAGRA BRANDS INC COM 205887102 1,127 31,560 SH   SOLE   31,560 0 0
CONCHO RES INC COM 20605P101 493 11,168 SH   SOLE   11,168 0 0
CONOCOPHILLIPS COM 20825C104 3,664 111,575 SH   SOLE   111,575 0 0
CONSOLIDATED EDISON INC COM 209115104 5,039 64,767 SH   SOLE   64,767 0 0
CONSTELLATION BRANDS INC CL A 21036P108 2,178 11,493 SH   SOLE   11,493 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 7,887 389,302 SH   SOLE   389,302 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 0 18 SH   OTR 1 0 0 18
COPART INC COM 217204106 3,333 31,695 SH   SOLE   31,695 0 0
COPART INC COM 217204106 400 400 PRN   SOLE   400 0 0
CORNING INC COM 219350105 3,658 112,870 SH   SOLE   112,870 0 0
CORTEVA INC COM 22052L104 1,805 62,643 SH   SOLE   62,643 0 0
COSTAR GROUP INC COM 22160N109 1,505 1,774 SH   SOLE   1,774 0 0
COSTCO WHSL CORP NEW COM 22160K105 9,986 28,130 SH   SOLE   28,130 0 0
CRH PLC ADR 12626K203 1 38 SH   OTR 1 0 0 38
CROWN CASTLE INTL CORP NEW COM 22822V101 12,570 75,499 SH   SOLE   75,499 0 0
CRYOLIFE INC COM 228903100 525 28,403 SH   SOLE   28,403 0 0
CSX CORP COM 126408103 4,188 53,922 SH   SOLE   53,922 0 0
CSX CORP COM 126408103 1 15 SH   OTR 1 0 0 15
CUMMINS INC COM 231021106 3 14 SH   OTR 1 0 0 14
CUMMINS INC COM 231021106 16,993 80,478 SH   SOLE   80,478 0 0
CVS HEALTH CORP COM 126650100 12,030 206,010 SH   SOLE   206,010 0 0
CVS HEALTH CORP COM 126650100 3 48 SH   OTR 1 0 0 48
CYTOKINETICS INC COM NEW 23282W605 3,036 140,225 SH   SOLE   140,225 0 0
D R HORTON INC COM 23331A109 6,417 84,857 SH   SOLE   84,857 0 0
DANAHER CORPORATION COM 235851102 164,263 762,875 SH   SOLE   762,875 0 0
DANAHER CORPORATION COM 235851102 14 67 SH   OTR 1 0 0 67
DARDEN RESTAURANTS INC COM 237194105 717 7,115 SH   SOLE   7,115 0 0
DATADOG INC CL A COM 23804L103 681 6,670 SH   SOLE   6,670 0 0
DAVITA INC COM 23918K108 3,691 43,101 SH   SOLE   43,101 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 1 10 SH   OTR 1 0 0 10
DECIPHERA PHARMACEUTICALS IN COM 24344T101 12,799 249,509 SH   SOLE   249,509 0 0
DEERE & CO COM 244199105 10,307 46,509 SH   SOLE   46,509 0 0
DELL TECHNOLOGIES INC CL C 24703L202 5,545 81,917 SH   SOLE   81,917 0 0
DENTSPLY SIRONA INC COM 24906P109 862 19,715 SH   SOLE   19,715 0 0
DEVON ENERGY CORP NEW COM 25179M103 343 36,238 SH   SOLE   36,238 0 0
DEXCOM INC COM 252131107 6,375 15,465 SH   SOLE   15,465 0 0
DIAMONDBACK ENERGY INC COM 25278X109 486 16,145 SH   SOLE   16,145 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 21,753 1,209,206 SH   SOLE   1,209,206 0 0
DIGITAL RLTY TR INC COM 253868103 1,919 13,078 SH   SOLE   13,078 0 0
DIGITAL TURBINE INC COM NEW 25400W102 1,360 1,150 PRN   SOLE   1,150 0 0
DIGITAL TURBINE INC COM NEW 25400W102 894 27,300 SH   SOLE   27,300 0 0
DISCOVER FINL SVCS COM 254709108 4,162 72,033 SH   SOLE   72,033 0 0
DISCOVERY INC COM SER C 25470F302 901 45,954 SH   SOLE   45,954 0 0
DISNEY WALT CO COM DISNEY 254687106 70,081 564,792 SH   SOLE   564,792 0 0
DISNEY WALT CO COM DISNEY 254687106 5 40 SH   OTR 1 0 0 40
DOCUSIGN INC COM 256163106 2,440 11,335 SH   SOLE   11,335 0 0
DOLLAR GEN CORP NEW COM 256677105 37,180 177,378 SH   SOLE   177,378 0 0
DOLLAR TREE INC COM 256746108 1,032 11,294 SH   SOLE   11,294 0 0
DOMINION ENERGY INC COM 25746U109 4,438 56,229 SH   SOLE   56,229 0 0
DOMINOS PIZZA INC COM 25754A201 5,511 12,960 SH   SOLE   12,960 0 0
DOVER CORP COM 260003108 1,602 14,791 SH   SOLE   14,791 0 0
DOW INC COM 260557103 3,037 64,559 SH   SOLE   64,559 0 0
DUKE REALTY CORP COM NEW 264411505 235 6,362 SH   SOLE   6,362 0 0
DUPONT DE NEMOURS INC COM 26614N102 6,066 109,335 SH   SOLE   109,335 0 0
E TRADE FINANCIAL CORP COM NEW 269246401 1 28 SH   OTR 1 0 0 28
E TRADE FINANCIAL CORP COM NEW 269246401 9,849 196,801 SH   SOLE   196,801 0 0
EATON CORP PLC SHS G29183103 2 20 SH   OTR 1 0 0 20
EBAY INC. COM 278642103 14,799 284,058 SH   SOLE   284,058 0 0
ECOLAB INC COM 278865100 2 12 SH   OTR 1 0 0 12
ECOLAB INC COM 278865100 23,470 117,450 SH   SOLE   117,450 0 0
EDISON INTL COM 281020107 1,853 36,448 SH   SOLE   36,448 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 6,965 87,263 SH   SOLE   87,263 0 0
EIDOS THERAPEUTICS INC COM 28249H104 9,384 185,721 SH   SOLE   185,721 0 0
ELANCO ANIMAL HEALTH INC COM 28414H103 610 21,840 SH   SOLE   21,840 0 0
ELECTRONIC ARTS INC COM 285512109 30,715 235,538 SH   SOLE   235,538 0 0
EMERSON ELEC CO COM 291011104 33,477 510,570 SH   SOLE   510,570 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106 2,931 64,034 SH   SOLE   64,034 0 0
ENBRIDGE INC COM 29250N105 1,197 41,092 SH   SOLE   41,092 0 0
ENPHASE ENERGY INC COM 29355A107 3 39 SH   OTR 1 0 0 39
ENPHASE ENERGY INC COM 29355A107 13,041 157,906 SH   SOLE   157,906 0 0
ENTERGY CORP NEW COM 29364G103 2,601 26,403 SH   SOLE   26,403 0 0
ENVIVA PARTNERS LP COM UNIT 29414J107 754 18,718 SH   SOLE   18,718 0 0
EOG RES INC COM 26875P101 1,234 34,327 SH   SOLE   34,327 0 0
EPAM SYS INC COM 29414B104 9,148 28,300 SH   SOLE   28,300 0 0
EPIZYME INC COM 29428V104 0 25 SH   OTR 1 0 0 25
EPIZYME INC COM 29428V104 4,308 361,127 SH   SOLE   361,127 0 0
EQUIFAX INC COM 294429105 1,141 7,275 SH   SOLE   7,275 0 0
EQUINIX INC COM 29444U700 3 4 SH   OTR 1 0 0 4
EQUINIX INC COM 29444U700 30,589 40,244 SH   SOLE   40,244 0 0
EQUINOR ASA SPONSORED ADR 29446M102 1 82 SH   OTR 1 0 0 82
EQUITABLE HLDGS INC COM 29452E101 5,906 323,835 SH   SOLE   323,835 0 0
EQUITY LIFESTYLE PPTYS INC COM 29472R108 685 11,175 SH   SOLE   11,175 0 0
EQUITY RESIDENTIAL SH BEN INT 29476L107 2,041 39,772 SH   SOLE   39,772 0 0
ERICSSON ADR B SEK 10 294821608 1 103 SH   OTR 1 0 0 103
ERICSSON ADR B SEK 10 294821608 1,172 107,629 SH   SOLE   107,629 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 3,566 95,955 SH   SOLE   95,955 0 0
ESSENTIAL UTILS INC COM 29670G102 1,326 32,941 SH   SOLE   32,941 0 0
ESSEX PPTY TR INC COM 297178105 930 4,633 SH   SOLE   4,633 0 0
ETF MANAGERS TR PRIME CYBR SCRTY 26924G201 1,869 40,150 SH   SOLE   40,150 0 0
ETSY INC COM 29786A106 708 5,823 SH   SOLE   5,823 0 0
EVERSOURCE ENERGY COM 30040W108 5,425 64,936 SH   SOLE   64,936 0 0
EXACT SCIENCES CORP NOTE 0.375% 3/1 30063PAB1 3,134 2,650 PRN   SOLE   2,650 0 0
EXACT SCIENCES CORP NOTE 0.375% 3/0 30063PAC9 2,334 2,150 PRN   SOLE   2,150 0 0
EXACT SCIENCES CORP COM 30063P105 2 19 SH   OTR 1 0 0 19
EXACT SCIENCES CORP COM 30063P105 24,728 242,561 SH   SOLE   242,561 0 0
EXCHANGE TRADED CONCEPTS TR EMQQ EM INTERN 301505889 764 14,620 SH   SOLE   14,620 0 0
EXELIXIS INC COM 30161Q104 29,954 1,225,179 SH   SOLE   1,225,179 0 0
EXELIXIS INC COM 30161Q104 2 72 SH   OTR 1 0 0 72
EXELON CORP COM 30161N101 3,975 111,167 SH   SOLE   111,167 0 0
EXPEDIA GROUP INC COM NEW 30212P303 744 8,110 SH   SOLE   8,110 0 0
EXPEDITORS INTL WASH INC COM 302130109 7,349 81,187 SH   SOLE   81,187 0 0
EXTRA SPACE STORAGE INC COM 30225T102 726 6,788 SH   SOLE   6,788 0 0
EXXON MOBIL CORP COM 30231G102 10,013 291,691 SH   SOLE   291,691 0 0
F M C CORP COM NEW 302491303 966 9,126 SH   SOLE   9,126 0 0
F5 NETWORKS INC COM 315616102 6,765 55,104 SH   SOLE   55,104 0 0
FACEBOOK INC CL A 30303M102 3 12 SH   OTR 1 0 0 12
FACEBOOK INC CL A 30303M102 143,113 546,398 SH   SOLE   546,398 0 0
FASTENAL CO COM 311900104 8,294 183,960 SH   SOLE   183,960 0 0
FEDERAL RLTY INVT TR SH BEN INT NEW 313747206 268 3,647 SH   SOLE   3,647 0 0
FEDEX CORP COM 31428X106 4,926 19,586 SH   SOLE   19,586 0 0
FIBROGEN INC COM 31572Q808 10,405 253,041 SH   SOLE   253,041 0 0
FIDELITY NATIONAL FINANCIAL FNF GROUP COM 31620R303 471 15,041 SH   SOLE   15,041 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 7,777 52,829 SH   SOLE   52,829 0 0
FIFTH THIRD BANCORP COM 316773100 2,125 99,668 SH   SOLE   99,668 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 6,903 63,300 SH   SOLE   63,300 0 0
FISERV INC COM 337738108 3,202 31,073 SH   SOLE   31,073 0 0
FLEETCOR TECHNOLOGIES INC COM 339041105 979 4,113 SH   SOLE   4,113 0 0
FLIR SYS INC COM 302445101 293 8,171 SH   SOLE   8,171 0 0
FLUIDIGM CORP DEL COM 34385P108 2,117 285,000 SH   SOLE   285,000 0 0
FORD MTR CO DEL COM 345370860 2 280 SH   OTR 1 0 0 280
FORD MTR CO DEL COM 345370860 6,792 1,019,828 SH   SOLE   1,019,828 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 12,090 242,582 SH   SOLE   242,582 0 0
FORTINET INC COM 34959E109 12,929 109,751 SH   SOLE   109,751 0 0
FORTIVE CORP NOTE 0.875% 2/1 34959JAK4 7,138 7,100 PRN   SOLE   7,100 0 0
FORTIVE CORP COM 34959J108 2,350 30,835 SH   SOLE   30,835 0 0
FORTRESS BIOTECH INC COM 34960Q109 91 22,500 SH   SOLE   22,500 0 0
FORTUNE BRANDS HOME & SEC IN COM 34964C106 346 4,000 SH   SOLE   4,000 0 0
FOX CORP CL A COM 35137L105 273 9,798 SH   SOLE   9,798 0 0
FOX CORP CL B COM 35137L204 804 28,735 SH   SOLE   28,735 0 0
FRANCO NEV CORP COM 351858105 685 4,917 SH   SOLE   4,917 0 0
FRANKLIN RESOURCES INC COM 354613101 962 47,296 SH   SOLE   47,296 0 0
FREEPORT-MCMORAN INC CL B 35671D857 3,387 216,549 SH   SOLE   216,549 0 0
GALLAGHER ARTHUR J & CO COM 363576109 1,068 10,118 SH   SOLE   10,118 0 0
GAP INC COM 364760108 283 16,601 SH   SOLE   16,601 0 0
GCI LIBERTY INC COM CLASS A 36164V305 22,513 274,689 SH   SOLE   274,689 0 0
GENERAL ELECTRIC CO COM 369604103 3,989 640,395 SH   SOLE   640,395 0 0
GENERAL MLS INC COM 370334104 1 16 SH   OTR 1 0 0 16
GENERAL MLS INC COM 370334104 17,868 289,696 SH   SOLE   289,696 0 0
GENERAL MTRS CO COM 37045V100 3,024 102,207 SH   SOLE   102,207 0 0
GENMAB A/S SPONSORED ADS 372303206 5,616 153,401 SH   SOLE   153,401 0 0
GENMAB A/S SPONSORED ADS 372303206 6 162 SH   OTR 1 0 0 162
GENUINE PARTS CO COM 372460105 873 9,172 SH   SOLE   9,172 0 0
GILDAN ACTIVEWEAR INC COM 375916103 907 46,197 SH   SOLE   46,197 0 0
GILEAD SCIENCES INC COM 375558103 121,683 1,925,752 SH   SOLE   1,925,752 0 0
GILEAD SCIENCES INC COM 375558103 2 38 SH   OTR 1 0 0 38
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 1 17 SH   OTR 1 0 0 17
GLOBAL PMTS INC COM 37940X102 3,320 18,697 SH   SOLE   18,697 0 0
GODADDY INC CL A 380237107 539 7,089 SH   SOLE   7,089 0 0
GOLD FIELDS LTD SPONSORED ADR 38059T106 359 29,200 SH   SOLE   29,200 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 9,048 45,025 SH   SOLE   45,025 0 0
GOODYEAR TIRE & RUBR CO COM 382550101 100 13,031 SH   SOLE   13,031 0 0
GRAINGER W W INC COM 384802104 2,644 7,411 SH   SOLE   7,411 0 0
GREAT PANTHER MNG LTD COM 39115V101 12 14,000 SH   SOLE   14,000 0 0
GRUBHUB INC COM 400110102 17,570 242,931 SH   SOLE   242,931 0 0
GRUPO FINANCIERO GALICIA S.A SPONSORED ADR 399909100 1,057 146,000 SH   SOLE   146,000 0 0
GUARDANT HEALTH INC COM 40131M109 1 7 SH   OTR 1 0 0 7
GUARDANT HEALTH INC COM 40131M109 10,320 92,331 SH   SOLE   92,331 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 10,555 108,427 SH   SOLE   108,427 0 0
HALLIBURTON CO COM 406216101 1,203 99,867 SH   SOLE   99,867 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 27,499 1,046,433 SH   SOLE   1,046,433 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 1 39 SH   OTR 1 0 0 39
HANNON ARMSTRONG SUST INFR C COM 41068X100 10,094 238,797 SH   SOLE   238,797 0 0
HANNON ARMSTRONG SUST INFR C COM 41068X100 2 47 SH   OTR 1 0 0 47
HARTFORD FINL SVCS GROUP INC COM 416515104 6,155 166,990 SH   SOLE   166,990 0 0
HCA HEALTHCARE INC COM 40412C101 6,440 51,655 SH   SOLE   51,655 0 0
HD SUPPLY HLDGS INC COM 40416M105 685 16,616 SH   SOLE   16,616 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 7,476 149,652 SH   SOLE   149,652 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 1 13 SH   OTR 1 0 0 13
HEALTHPEAK PROPERTIES INC COM 42250P103 1,210 44,568 SH   SOLE   44,568 0 0
HEICO CORP NEW CL A 422806208 581 6,549 SH   SOLE   6,549 0 0
HENRY JACK & ASSOC INC COM 426281101 583 3,587 SH   SOLE   3,587 0 0
HENRY SCHEIN INC COM 806407102 652 11,095 SH   SOLE   11,095 0 0
HERON THERAPEUTICS INC COM 427746102 19,546 1,318,972 SH   SOLE   1,318,972 0 0
HERSHEY CO COM 427866108 4,003 27,925 SH   SOLE   27,925 0 0
HERSHEY CO COM 427866108 3 21 SH   OTR 1 0 0 21
HESS CORP COM 42809H107 1 21 SH   OTR 1 0 0 21
HESS CORP COM 42809H107 9,730 237,727 SH   SOLE   237,727 0 0
HEWLETT PACKARD ENTERPRISE C COM 42824C109 1,291 137,747 SH   SOLE   137,747 0 0
HILL ROM HLDGS INC COM 431475102 1 14 SH   OTR 1 0 0 14
HILL ROM HLDGS INC COM 431475102 15,734 188,414 SH   SOLE   188,414 0 0
HILTON WORLDWIDE HLDGS INC COM 43300A203 2,118 24,829 SH   SOLE   24,829 0 0
HOLLYSYS AUTOMATION TCHNGY L SHS G45667105 9,726 880,226 SH   SOLE   880,226 0 0
HOLOGIC INC COM 436440101 55,212 830,668 SH   SOLE   830,668 0 0
HOLOGIC INC COM 436440101 4 67 SH   OTR 1 0 0 67
HOME DEPOT INC COM 437076102 44,000 158,446 SH   SOLE   158,446 0 0
HOME DEPOT INC COM 437076102 4 16 SH   OTR 1 0 0 16
HONDA MOTOR LTD AMERN SHS 438128308 3 115 SH   OTR 1 0 0 115
HONEYWELL INTL INC COM 438516106 9,477 57,576 SH   SOLE   57,576 0 0
HORMEL FOODS CORP COM 440452100 1,403 28,707 SH   SOLE   28,707 0 0
HOST HOTELS & RESORTS INC COM 44107P104 2,032 188,337 SH   SOLE   188,337 0 0
HOWMET AEROSPACE INC COM 443201108 438 26,195 SH   SOLE   26,195 0 0
HP INC COM 40434L105 7,134 375,689 SH   SOLE   375,689 0 0
HP INC COM 40434L105 1 59 SH   OTR 1 0 0 59
HSBC HLDGS PLC SPON ADR NEW 404280406 2 108 SH   OTR 1 0 0 108
HUBSPOT INC COM 443573100 935 3,200 SH   SOLE   3,200 0 0
HUDSON LTD COM CL A G46408103 18,290 2,406,686 SH   SOLE   2,406,686 0 0
HUMANA INC COM 444859102 16,966 40,994 SH   SOLE   40,994 0 0
HUNTINGTON BANCSHARES INC COM 446150104 1,784 194,537 SH   SOLE   194,537 0 0
HUNTINGTON INGALLS INDS INC COM 446413106 303 2,155 SH   SOLE   2,155 0 0
ICICI BANK LIMITED ADR 45104G104 4,588 466,777 SH   SOLE   466,777 0 0
IDEX CORP COM 45167R104 1,487 8,150 SH   SOLE   8,150 0 0
IDEXX LABS INC COM 45168D104 7,845 19,956 SH   SOLE   19,956 0 0
IGM BIOSCIENCES INC COM 449585108 9,616 130,280 SH   SOLE   130,280 0 0
IGM BIOSCIENCES INC COM 449585108 1 7 SH   OTR 1 0 0 7
IHS MARKIT LTD SHS G47567105 2,318 29,521 SH   SOLE   29,521 0 0
ILLINOIS TOOL WKS INC COM 452308109 4,548 23,540 SH   SOLE   23,540 0 0
ILLUMINA INC COM 452327109 91,971 297,575 SH   SOLE   297,575 0 0
ILLUMINA INC COM 452327109 2 7 SH   OTR 1 0 0 7
ILLUMINA INC NOTE 8/1 452327AK5 2,235 2,100 PRN   SOLE   2,100 0 0
ILLUMINA INC NOTE 0.500% 6/1 452327AH2 3,094 2,400 PRN   SOLE   2,400 0 0
IMMUNOMEDICS INC COM 452907108 9,044 106,369 SH   SOLE   106,369 0 0
IMMUNOVANT INC COM 45258J102 7,741 220,000 SH   SOLE   220,000 0 0
INCYTE CORP COM 45337C102 28,956 322,681 SH   SOLE   322,681 0 0
INCYTE CORP COM 45337C102 1 11 SH   OTR 1 0 0 11
INFOSYS LTD SPONSORED ADR 456788108 3,424 247,978 SH   SOLE   247,978 0 0
ING GROEP N.V. SPONSORED ADR 456837103 1 80 SH   OTR 1 0 0 80
INGERSOLL RAND INC COM 45687V106 797 22,401 SH   SOLE   22,401 0 0
INGREDION INC COM 457187102 2 30 SH   OTR 1 0 0 30
INGREDION INC COM 457187102 230 3,043 SH   SOLE   3,043 0 0
INSMED INC COM PAR $.01 457669307 9,384 292,000 SH   SOLE   292,000 0 0
INSULET CORP COM 45784P101 828 3,498 SH   SOLE   3,498 0 0
INTEL CORP COM 458140100 38,061 735,019 SH   SOLE   735,019 0 0
INTEL CORP COM 458140100 3 63 SH   OTR 1 0 0 63
INTERCONTINENTAL EXCHANGE IN COM 45866F104 1 10 SH   OTR 1 0 0 10
INTERCONTINENTAL EXCHANGE IN COM 45866F104 3,244 32,422 SH   SOLE   32,422 0 0
INTERNATIONAL BUSINESS MACHS COM 459200101 2 13 SH   OTR 1 0 0 13
INTERNATIONAL BUSINESS MACHS COM 459200101 16,396 134,767 SH   SOLE   134,767 0 0
INTERNATIONAL FLAVORS&FRAGRA COM 459506101 926 7,565 SH   SOLE   7,565 0 0
INTERNATIONAL PAPER CO COM 460146103 3,864 95,326 SH   SOLE   95,326 0 0
INTERPUBLIC GROUP COS INC COM 460690100 923 55,379 SH   SOLE   55,379 0 0
INTERPUBLIC GROUP COS INC COM 460690100 2 91 SH   OTR 1 0 0 91
INTRA CELLULAR THERAPIES INC COM 46116X101 11,033 430,000 SH   SOLE   430,000 0 0
INTUIT COM 461202103 19,973 61,230 SH   SOLE   61,230 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 29,148 41,082 SH   SOLE   41,082 0 0
INVITATION HOMES INC COM 46187W107 722 25,784 SH   SOLE   25,784 0 0
IONIS PHARMACEUTICALS INC COM 462222100 12,038 253,700 SH   SOLE   253,700 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 22,551 685,051 SH   SOLE   685,051 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 1 30 SH   OTR 1 0 0 30
IQVIA HLDGS INC COM 46266C105 2,007 12,733 SH   SOLE   12,733 0 0
IRON MTN INC NEW COM 46284V101 760 28,364 SH   SOLE   28,364 0 0
ISHARES INC MSCI CDA ETF 464286509 1,952 71,200 SH   SOLE   71,200 0 0
ISHARES TR MSCI CHINA ETF 46429B671 816 11,000 SH   SOLE   11,000 0 0
ISHARES TR U.S. PHARMA ETF 464288836 294 1,800 SH   SOLE   1,800 0 0
ISIS PHARMACEUTICALS INC DEL NOTE 1.000%11/1 464337AJ3 2,167 2,100 PRN   SOLE   2,100 0 0
ITAU UNIBANCO HLDG S A SPON ADR REP PFD 465562106 724 181,920 SH   SOLE   181,920 0 0
ITRON INC COM 465741106 1,067 17,562 SH   SOLE   17,562 0 0
JD.COM INC SPON ADR CL A 47215P106 48,453 624,344 SH   SOLE   624,344 0 0
JOHNSON & JOHNSON COM 478160104 5 34 SH   OTR 1 0 0 34
JOHNSON & JOHNSON COM 478160104 61,950 416,127 SH   SOLE   416,127 0 0
JONES LANG LASALLE INC COM 48020Q107 1,399 14,627 SH   SOLE   14,627 0 0
JOUNCE THERAPEUTICS INC COM 481116101 0 35 SH   OTR 1 0 0 35
JOUNCE THERAPEUTICS INC COM 481116101 2,878 352,725 SH   SOLE   352,725 0 0
JPMORGAN CHASE & CO COM 46625H100 47,398 492,363 SH   SOLE   492,363 0 0
JPMORGAN CHASE & CO COM 46625H100 3 28 SH   OTR 1 0 0 28
KANSAS CITY SOUTHERN COM NEW 485170302 8,549 47,278 SH   SOLE   47,278 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 1 36 SH   OTR 1 0 0 36
KARYOPHARM THERAPEUTICS INC COM 48576U106 7,640 523,334 SH   SOLE   523,334 0 0
KB FINL GROUP INC SPONSORED ADR 48241A105 315 9,792 SH   SOLE   9,792 0 0
KELLOGG CO COM 487836108 4,172 64,594 SH   SOLE   64,594 0 0
KEURIG DR PEPPER INC COM 49271V100 1 34 SH   OTR 1 0 0 34
KEURIG DR PEPPER INC COM 49271V100 2,011 72,856 SH   SOLE   72,856 0 0
KEYCORP COM 493267108 2,559 214,510 SH   SOLE   214,510 0 0
KEYSIGHT TECHNOLOGIES INC COM 49338L103 27,035 273,701 SH   SOLE   273,701 0 0
KEYSIGHT TECHNOLOGIES INC COM 49338L103 1 11 SH   OTR 1 0 0 11
KEZAR LIFE SCIENCES INC COM 49372L100 2,904 600,000 SH   SOLE   600,000 0 0
KIMBERLY CLARK CORP COM 494368103 10,962 74,243 SH   SOLE   74,243 0 0
KIMBERLY CLARK CORP COM 494368103 1 7 SH   OTR 1 0 0 7
KIMCO RLTY CORP COM 49446R109 113 10,029 SH   SOLE   10,029 0 0
KINDER MORGAN INC DEL COM 49456B101 6,685 542,169 SH   SOLE   542,169 0 0
KINROSS GOLD CORP COM 496902404 1,455 1,150 PRN   SOLE   1,150 0 0
KINROSS GOLD CORP COM 496902404 3,986 453,153 SH   SOLE   453,153 0 0
KLA CORP COM NEW 482480100 5,701 29,426 SH   SOLE   29,426 0 0
KODIAK SCIENCES INC COM 50015M109 21,691 366,348 SH   SOLE   366,348 0 0
KRAFT HEINZ CO COM 500754106 1,350 45,084 SH   SOLE   45,084 0 0
KROGER CO COM 501044101 6,035 177,967 SH   SOLE   177,967 0 0
KROGER CO COM 501044101 2 66 SH   OTR 1 0 0 66
KURA ONCOLOGY INC COM 50127T109 1 22 SH   OTR 1 0 0 22
KURA ONCOLOGY INC COM 50127T109 16,520 539,174 SH   SOLE   539,174 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 41,067 218,139 SH   SOLE   218,139 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 3 17 SH   OTR 1 0 0 17
LAM RESEARCH CORP COM 512807108 4,758 14,342 SH   SOLE   14,342 0 0
LAMB WESTON HLDGS INC COM 513272104 646 9,746 SH   SOLE   9,746 0 0
LAS VEGAS SANDS CORP COM 517834107 876 18,785 SH   SOLE   18,785 0 0
LAUDER ESTEE COS INC CL A 518439104 10,769 49,343 SH   SOLE   49,343 0 0
LEAR CORP COM NEW 521865204 240 2,205 SH   SOLE   2,205 0 0
LENNAR CORP CL A 526057104 997 12,204 SH   SOLE   12,204 0 0
LIBERTY BROADBAND CORP COM SER C 530307305 806 5,645 SH   SOLE   5,645 0 0
LIBERTY MEDIA CORP DEL COM C SIRIUSXM 531229607 538 16,259 SH   SOLE   16,259 0 0
LILLY ELI & CO COM 532457108 37,122 250,802 SH   SOLE   250,802 0 0
LINCOLN NATL CORP IND COM 534187109 2,686 85,721 SH   SOLE   85,721 0 0
LIVE NATION ENTERTAINMENT IN COM 538034109 402 7,465 SH   SOLE   7,465 0 0
LOEWS CORP COM 540424108 1,062 30,566 SH   SOLE   30,566 0 0
LOOP INDS INC COM 543518104 1,487 108,895 SH   SOLE   108,895 0 0
LOWES COS INC COM 548661107 36,621 220,804 SH   SOLE   220,804 0 0
LULULEMON ATHLETICA INC COM 550021109 15,132 45,943 SH   SOLE   45,943 0 0
LUMEN TECHNOLOGIES INC COM 156700106 705 69,841 SH   SOLE   69,841 0 0
M & T BK CORP COM 55261F104 1,176 12,774 SH   SOLE   12,774 0 0
MACROGENICS INC COM 556099109 14,656 581,828 SH   SOLE   581,828 0 0
MACROGENICS INC COM 556099109 1 26 SH   OTR 1 0 0 26
MACYS INC COM 55616P104 142 25,000 SH   SOLE   25,000 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 11,229 94,584 SH   SOLE   94,584 0 0
MAGNA INTL INC COM 559222401 1,299 28,472 SH   SOLE   28,472 0 0
MANULIFE FINL CORP COM 56501R106 4,924 355,119 SH   SOLE   355,119 0 0
MARATHON OIL CORP COM 565849106 1,746 426,838 SH   SOLE   426,838 0 0
MARATHON PETE CORP COM 56585A102 1,087 37,036 SH   SOLE   37,036 0 0
MARKEL CORP COM 570535104 654 672 SH   SOLE   672 0 0
MARKETAXESS HLDGS INC COM 57060D108 915 1,901 SH   SOLE   1,901 0 0
MARRIOTT INTL INC NEW CL A 571903202 1,838 19,853 SH   SOLE   19,853 0 0
MARSH & MCLENNAN COS INC COM 571748102 5,716 49,834 SH   SOLE   49,834 0 0
MARTIN MARIETTA MATLS INC COM 573284106 1,242 5,279 SH   SOLE   5,279 0 0
MARVELL TECHNOLOGY GROUP LTD ORD G5876H105 3,535 89,050 SH   SOLE   89,050 0 0
MASCO CORP COM 574599106 2 30 SH   OTR 1 0 0 30
MASCO CORP COM 574599106 18,057 327,546 SH   SOLE   327,546 0 0
MASIMO CORP COM 574795100 2,597 11,000 SH   SOLE   11,000 0 0
MASTERCARD INCORPORATED CL A 57636Q104 36,911 109,153 SH   SOLE   109,153 0 0
MATCH GROUP INC NEW COM 57667L107 1,290 11,663 SH   SOLE   11,663 0 0
MAXIM INTEGRATED PRODS INC COM 57772K101 9,480 140,220 SH   SOLE   140,220 0 0
MCCORMICK & CO INC COM NON VTG 579780206 8,444 43,503 SH   SOLE   43,503 0 0
MCDONALDS CORP COM 580135101 1 5 SH   OTR 1 0 0 5
MCDONALDS CORP COM 580135101 12,020 54,766 SH   SOLE   54,766 0 0
MCKESSON CORP COM 58155Q103 5,994 40,247 SH   SOLE   40,247 0 0
MEDTRONIC PLC SHS G5960L103 5 44 SH   OTR 1 0 0 44
MERCADOLIBRE INC COM 58733R102 24,161 22,321 SH   SOLE   22,321 0 0
MERCK & CO. INC COM 58933Y105 16 189 SH   OTR 1 0 0 189
MERCK & CO. INC COM 58933Y105 243,366 2,934,013 SH   SOLE   2,934,013 0 0
MERSANA THERAPEUTICS INC COM 59045L106 1 27 SH   OTR 1 0 0 27
MERSANA THERAPEUTICS INC COM 59045L106 10,942 587,681 SH   SOLE   587,681 0 0
MESA LABS INC COM 59064R109 359 250 PRN   SOLE   250 0 0
MESA LABS INC COM 59064R109 2,089 8,200 SH   SOLE   8,200 0 0
METLIFE INC COM 59156R108 2 48 SH   OTR 1 0 0 48
METLIFE INC COM 59156R108 9,729 261,743 SH   SOLE   261,743 0 0
METTLER TOLEDO INTERNATIONAL COM 592688105 1,832 1,897 SH   SOLE   1,897 0 0
MGM RESORTS INTERNATIONAL COM 552953101 858 39,429 SH   SOLE   39,429 0 0
MICROCHIP TECHNOLOGY INC. COM 595017104 3,616 35,187 SH   SOLE   35,187 0 0
MICRON TECHNOLOGY INC COM 595112103 4,912 104,614 SH   SOLE   104,614 0 0
MICRON TECHNOLOGY INC COM 595112103 1 25 SH   OTR 1 0 0 25
MICROSOFT CORP COM 594918104 428,272 2,036,277 SH   SOLE   2,036,277 0 0
MICROSOFT CORP COM 594918104 18 84 SH   OTR 1 0 0 84
MID-AMER APT CMNTYS INC COM 59522J103 797 6,870 SH   SOLE   6,870 0 0
MIRATI THERAPEUTICS INC COM 60468T105 1 5 SH   OTR 1 0 0 5
MIRATI THERAPEUTICS INC COM 60468T105 22,106 133,132 SH   SOLE   133,132 0 0
MITSUBISHI UFJ FINL GROUP IN SPONSORED ADS 606822104 1 294 SH   OTR 1 0 0 294
MITSUBISHI UFJ FINL GROUP IN SPONSORED ADS 606822104 1,258 313,714 SH   SOLE   313,714 0 0
MODERNA INC COM 60770K107 27,071 38,214,700 SH Call SOLE   38,214,700 0 0
MOHAWK INDS INC COM 608190104 247 2,536 SH   SOLE   2,536 0 0
MOLINA HEALTHCARE INC COM 60855R100 482 2,636 SH   SOLE   2,636 0 0
MOLSON COORS BEVERAGE CO CL B 60871R209 637 18,989 SH   SOLE   18,989 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 11,527 219,575 SH   SOLE   219,575 0 0
MOMO INC NOTE 1.250% 7/0 60879BAB3 2,142 1,835 PRN   SOLE   1,835 0 0
MONDELEZ INTL INC CL A 609207105 8,457 147,205 SH   SOLE   147,205 0 0
MONDELEZ INTL INC CL A 609207105 2 31 SH   OTR 1 0 0 31
MONGODB INC CL A 60937P106 714 3,086 SH   SOLE   3,086 0 0
MONSTER BEVERAGE CORP NEW COM 61174X109 7,548 94,124 SH   SOLE   94,124 0 0
MONTAGE RES CORP COM 61179L100 1,306 297,448 SH   SOLE   297,448 0 0
MOODYS CORP COM 615369105 15,229 52,542 SH   SOLE   52,542 0 0
MORGAN STANLEY COM NEW 617446448 20,389 421,707 SH   SOLE   421,707 0 0
MORGAN STANLEY COM NEW 617446448 3 70 SH   OTR 1 0 0 70
MORPHOSYS AG SPONSORED ADS 617760202 9,530 303,607 SH   SOLE   303,607 0 0
MORPHOSYS AG SPONSORED ADS 617760202 2 75 SH   OTR 1 0 0 75
MOSAIC CO NEW COM 61945C103 2,753 150,682 SH   SOLE   150,682 0 0
MOTOROLA SOLUTIONS INC COM NEW 620076307 4,682 29,860 SH   SOLE   29,860 0 0
MSCI INC COM 55354G100 1,785 5,002 SH   SOLE   5,002 0 0
MYOKARDIA INC COM 62857M105 21,263 155,972 SH   SOLE   155,972 0 0
MYOVANT SCIENCES LTD COM G637AM102 0 26 SH   OTR 1 0 0 26
MYOVANT SCIENCES LTD COM G637AM102 6,840 486,838 SH   SOLE   486,838 0 0
NATIONAL FUEL GAS CO N J COM 636180101 433 10,674 SH   SOLE   10,674 0 0
NATIONAL RETAIL PROPERTIES I COM 637417106 471 13,658 SH   SOLE   13,658 0 0
NEKTAR THERAPEUTICS COM 640268108 5,241 315,929 SH   SOLE   315,929 0 0
NEOGENOMICS INC COM NEW 64049M209 1,289 34,949 SH   SOLE   34,949 0 0
NEOGENOMICS INC COM NEW 64049M209 1 34 SH   OTR 1 0 0 34
NETAPP INC COM 64110D104 771 17,590 SH   SOLE   17,590 0 0
NETEASE INC SPONSORED ADS 64110W102 18,977 41,740 SH   SOLE   41,740 0 0
NETFLIX INC COM 64110L106 35,284 70,567 SH   SOLE   70,567 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 15,027 156,282 SH   SOLE   156,282 0 0
NEW ORIENTAL ED & TECHNOLOGY SPON ADR 647581107 25,222 168,716 SH   SOLE   168,716 0 0
NEWMONT CORP COM 651639106 14,116 222,488 SH   SOLE   222,488 0 0
NEXTERA ENERGY INC COM 65339F101 35,743 128,783 SH   SOLE   128,783 0 0
NEXTERA ENERGY PARTNERS LP COM UNIT PART IN 65341B106 11,920 198,816 SH   SOLE   198,816 0 0
NEXTERA ENERGY PARTNERS LP COM UNIT PART IN 65341B106 2 27 SH   OTR 1 0 0 27
NGM BIOPHARMACEUTICALS INC COM 62921N105 3,639 228,764 SH   SOLE   228,764 0 0
NIKE INC CL B 654106103 62,813 500,365 SH   SOLE   500,365 0 0
NIKE INC CL B 654106103 2 19 SH   OTR 1 0 0 19
NIO INC SPON ADS 62914V106 3,126 2,950 PRN   SOLE   2,950 0 0
NOBLE ENERGY INC COM 655044105 3,941 460,929 SH   SOLE   460,929 0 0
NORFOLK SOUTHN CORP COM 655844108 4,244 19,833 SH   SOLE   19,833 0 0
NORTHERN TR CORP COM 665859104 1,376 17,651 SH   SOLE   17,651 0 0
NORTONLIFELOCK INC COM 668771108 6,571 315,324 SH   SOLE   315,324 0 0
NOVAVAX INC COM NEW 670002401 5,263 48,575 SH   SOLE   48,575 0 0
NOVOCURE LTD ORD SHS G6674U108 1 10 SH   OTR 1 0 0 10
NOVO-NORDISK A S ADR 670100205 2 22 SH   OTR 1 0 0 22
NUANCE COMMUNICATIONS INC COM 67020Y100 3,916 118,000 SH   SOLE   118,000 0 0
NUCOR CORP COM 670346105 1 17 SH   OTR 1 0 0 17
NUCOR CORP COM 670346105 2,236 49,844 SH   SOLE   49,844 0 0
NUTRIEN LTD COM 67077M108 723 18,489 SH   SOLE   18,489 0 0
NVIDIA CORPORATION COM 67066G104 75,094 138,755 SH   SOLE   138,755 0 0
NVR INC COM 62944T105 866 212 SH   SOLE   212 0 0
OCCIDENTAL PETE CORP *W EXP 08/03/202 674599162 44 1,473,200 SH Call SOLE   1,473,200 0 0
OCCIDENTAL PETE CORP COM 674599105 623 62,197 SH   SOLE   62,197 0 0
OKTA INC NOTE 0.125% 9/0 679295AD7 2,857 2,260 PRN   SOLE   2,260 0 0
OKTA INC CL A 679295105 15,805 73,910 SH   SOLE   73,910 0 0
OLD DOMINION FREIGHT LINE IN COM 679580100 6,764 37,389 SH   SOLE   37,389 0 0
OMNICOM GROUP INC COM 681919106 1,917 38,721 SH   SOLE   38,721 0 0
OMNICOM GROUP INC COM 681919106 1 29 SH   OTR 1 0 0 29
ON SEMICONDUCTOR CORP NOTE 1.000%12/0 682189AK1 3,376 2,800 PRN   SOLE   2,800 0 0
ON SEMICONDUCTOR CORP COM 682189105 2 96 SH   OTR 1 0 0 96
ON SEMICONDUCTOR CORP NOTE 1.625%10/1 682189AP0 3,062 2,300 PRN   SOLE   2,300 0 0
ON SEMICONDUCTOR CORP COM 682189105 33,890 1,562,522 SH   SOLE   1,562,522 0 0
ONE GAS INC COM 68235P108 884 12,810 SH   SOLE   12,810 0 0
ONEOK INC NEW COM 682680103 4,034 155,294 SH   SOLE   155,294 0 0
ORACLE CORP COM 68389X105 3 51 SH   OTR 1 0 0 51
ORACLE CORP COM 68389X105 35,373 592,530 SH   SOLE   592,530 0 0
OREILLY AUTOMOTIVE INC COM 67103H107 1,616 3,504 SH   SOLE   3,504 0 0
ORMAT TECHNOLOGIES INC COM 686688102 1 14 SH   OTR 1 0 0 14
ORMAT TECHNOLOGIES INC COM 686688102 5,315 89,920 SH   SOLE   89,920 0 0
OTIS WORLDWIDE CORP COM 68902V107 5,368 86,002 SH   SOLE   86,002 0 0
OWENS CORNING NEW COM 690742101 2,486 36,134 SH   SOLE   36,134 0 0
PACCAR INC COM 693718108 3,080 36,121 SH   SOLE   36,121 0 0
PACKAGING CORP AMER COM 695156109 995 9,125 SH   SOLE   9,125 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 428 11,350 SH   SOLE   11,350 0 0
PALO ALTO NETWORKS INC COM 697435105 49,133 200,756 SH   SOLE   200,756 0 0
PALO ALTO NETWORKS INC NOTE 0.750% 7/0 697435AD7 6,322 5,678 PRN   SOLE   5,678 0 0
PALO ALTO NETWORKS INC COM 697435105 1 5 SH   OTR 1 0 0 5
PAN AMERN SILVER CORP COM 697900108 9,130 284,000 SH   SOLE   284,000 0 0
PARKER-HANNIFIN CORP COM 701094104 7,697 38,041 SH   SOLE   38,041 0 0
PAYCHEX INC COM 704326107 1,592 19,960 SH   SOLE   19,960 0 0
PAYCOM SOFTWARE INC COM 70432V102 733 2,356 SH   SOLE   2,356 0 0
PAYPAL HLDGS INC COM 70450Y103 1 6 SH   OTR 1 0 0 6
PAYPAL HLDGS INC COM 70450Y103 105,255 534,231 SH   SOLE   534,231 0 0
PEMBINA PIPELINE CORP COM 706327103 4,480 211,773 SH   SOLE   211,773 0 0
PENUMBRA INC COM 70975L107 972 5,000 SH   SOLE   5,000 0 0
PEOPLES UNITED FINANCIAL INC COM 712704105 799 77,477 SH   SOLE   77,477 0 0
PEPSICO INC COM 713448108 5 38 SH   OTR 1 0 0 38
PEPSICO INC COM 713448108 67,090 484,073 SH   SOLE   484,073 0 0
PERKINELMER INC COM 714046109 2,391 19,053 SH   SOLE   19,053 0 0
PERSONALIS INC COM 71535D106 10,998 507,559 SH   SOLE   507,559 0 0
PERSONALIS INC COM 71535D106 1 46 SH   OTR 1 0 0 46
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408 172 24,100 SH   SOLE   24,100 0 0
PFIZER INC COM 717081103 6,515 177,525 SH   SOLE   177,525 0 0
PHILLIPS 66 COM 718546104 1,722 33,228 SH   SOLE   33,228 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 0 103 SH   OTR 1 0 0 103
PIERIS PHARMACEUTICALS INC COM 720795103 4,777 2,307,711 SH   SOLE   2,307,711 0 0
PINDUODUO INC SPONSORED ADS 722304102 24,646 332,400 SH   SOLE   332,400 0 0
PINTEREST INC CL A 72352L106 759 18,278 SH   SOLE   18,278 0 0
PIONEER NAT RES CO COM 723787107 957 11,131 SH   SOLE   11,131 0 0
PLANET FITNESS INC CL A 72703H101 4,629 75,133 SH   SOLE   75,133 0 0
PNC FINL SVCS GROUP INC COM 693475105 5,023 45,707 SH   SOLE   45,707 0 0
POWER INTEGRATIONS INC COM 739276103 2 30 SH   OTR 1 0 0 30
POWER INTEGRATIONS INC COM 739276103 8,208 148,168 SH   SOLE   148,168 0 0
PPG INDS INC COM 693506107 2 20 SH   OTR 1 0 0 20
PPG INDS INC COM 693506107 2,161 17,705 SH   SOLE   17,705 0 0
PRICE T ROWE GROUP INC COM 74144T108 10,095 78,736 SH   SOLE   78,736 0 0
PRICELINE GRP INC NOTE 0.900% 9/1 741503AX4 18,009 15,422 PRN   SOLE   15,422 0 0
PRINCIPAL FINANCIAL GROUP IN COM 74251V102 8,045 199,784 SH   SOLE   199,784 0 0
PROCTER AND GAMBLE CO COM 742718109 7 51 SH   OTR 1 0 0 51
PROCTER AND GAMBLE CO COM 742718109 137,021 985,875 SH   SOLE   985,875 0 0
PROGRESSIVE CORP COM 743315103 6,866 72,529 SH   SOLE   72,529 0 0
PROLOGIS INC. COM 74340W103 29,610 294,292 SH   SOLE   294,292 0 0
PROOFPOINT INC NOTE 0.250% 8/1 743424AF0 12,066 11,170 PRN   SOLE   11,170 0 0
PRUDENTIAL FINL INC COM 744320102 12,881 202,802 SH   SOLE   202,802 0 0
PRUDENTIAL FINL INC COM 744320102 2 36 SH   OTR 1 0 0 36
PTC INC COM 69370C100 24,394 294,912 SH   SOLE   294,912 0 0
PTC THERAPEUTICS INC COM 69366J200 35,059 749,960 SH   SOLE   749,960 0 0
PUBLIC STORAGE COM 74460D109 2,458 11,038 SH   SOLE   11,038 0 0
PUBLIC SVC ENTERPRISE GRP IN COM 744573106 2,364 43,049 SH   SOLE   43,049 0 0
PULTE GROUP INC COM 745867101 3,178 68,662 SH   SOLE   68,662 0 0
PVH CORPORATION COM 693656100 5,397 90,497 SH   SOLE   90,497 0 0
QIWI PLC SPON ADR REP B 74735M108 6,832 393,800 SH   SOLE   393,800 0 0
QORVO INC COM 74736K101 15,087 116,949 SH   SOLE   116,949 0 0
QUALCOMM INC COM 747525103 77,712 660,397 SH   SOLE   660,397 0 0
QUALCOMM INC COM 747525103 1 10 SH   OTR 1 0 0 10
QUEST DIAGNOSTICS INC COM 74834L100 4,445 38,825 SH   SOLE   38,825 0 0
RADIUS HEALTH INC COM NEW 750469207 3,538 312,025 SH   SOLE   312,025 0 0
RAYTHEON TECHNOLOGIES CORP COM 75513E101 201 3,500 SH   SOLE   3,500 0 0
REALTY INCOME CORP COM 756109104 1,219 20,060 SH   SOLE   20,060 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 15,254 156,584 SH   SOLE   156,584 0 0
REDHILL BIOPHARMA LTD SPONSORED ADS 757468103 843 82,523 SH   SOLE   82,523 0 0
REGENERON PHARMACEUTICALS COM 75886F107 180,817 323,029 SH   SOLE   323,029 0 0
REGENERON PHARMACEUTICALS COM 75886F107 4 7 SH   OTR 1 0 0 7
REGIONS FINANCIAL CORP NEW COM 7591EP100 3,706 321,420 SH   SOLE   321,420 0 0
REINSURANCE GRP OF AMERICA I COM NEW 759351604 1,371 14,404 SH   SOLE   14,404 0 0
RENEWABLE ENERGY GROUP INC COM NEW 75972A301 2,189 40,983 SH   SOLE   40,983 0 0
REPUBLIC SVCS INC COM 760759100 2,150 23,030 SH   SOLE   23,030 0 0
REPUBLIC SVCS INC COM 760759100 3 32 SH   OTR 1 0 0 32
RESMED INC COM 761152107 2,807 16,375 SH   SOLE   16,375 0 0
RESTAURANT BRANDS INTL INC COM 76131D103 8,853 154,631 SH   SOLE   154,631 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 672 280,000 SH   SOLE   280,000 0 0
RINGCENTRAL INC CL A 76680R206 1,080 3,933 SH   SOLE   3,933 0 0
ROBERT HALF INTL INC COM 770323103 2,469 46,646 SH   SOLE   46,646 0 0
ROCKWELL AUTOMATION INC COM 773903109 51,673 234,164 SH   SOLE   234,164 0 0
ROCKWELL AUTOMATION INC COM 773903109 2 11 SH   OTR 1 0 0 11
ROGERS COMMUNICATIONS INC CL B 775109200 650 16,431 SH   SOLE   16,431 0 0
ROKU INC COM CL A 77543R102 960 5,086 SH   SOLE   5,086 0 0
ROPER TECHNOLOGIES INC COM 776696106 5,382 13,623 SH   SOLE   13,623 0 0
ROSS STORES INC COM 778296103 2,033 21,787 SH   SOLE   21,787 0 0
ROYAL BK CDA COM 780087102 5,430 77,588 SH   SOLE   77,588 0 0
S&P GLOBAL INC COM 78409V104 42,459 117,750 SH   SOLE   117,750 0 0
S&P GLOBAL INC COM 78409V104 4 11 SH   OTR 1 0 0 11
SAGE THERAPEUTICS INC COM 78667J108 9,125 149,300 SH   SOLE   149,300 0 0
SALESFORCE COM INC COM 79466L302 1,957 1,900 PRN   SOLE   1,900 0 0
SANGAMO THERAPEUTICS INC COM 800677106 3,496 370,000 SH   SOLE   370,000 0 0
SANOFI SPONSORED ADR 80105N105 3 58 SH   OTR 1 0 0 58
SANOFI SPONSORED ADR 80105N105 3,015 60,090 SH   SOLE   60,090 0 0
SAREPTA THERAPEUTICS INC COM 803607100 24,550 174,829 SH   SOLE   174,829 0 0
SBA COMMUNICATIONS CORP NEW CL A 78410G104 4,162 13,069 SH   SOLE   13,069 0 0
SCHLUMBERGER LTD COM 806857108 6,685 429,665 SH   SOLE   429,665 0 0
SCHWAB CHARLES CORP COM 808513105 2,564 70,778 SH   SOLE   70,778 0 0
SEATTLE GENETICS INC COM 812578102 4 20 SH   OTR 1 0 0 20
SEATTLE GENETICS INC COM 812578102 101,183 517,079 SH   SOLE   517,079 0 0
SEMPRA ENERGY COM 816851109 11,018 93,089 SH   SOLE   93,089 0 0
SERVICENOW INC COM 81762P102 15,017 30,965 SH   SOLE   30,965 0 0
SHAW COMMUNICATIONS INC CL B CONV 82028K200 6,384 350,925 SH   SOLE   350,925 0 0
SHERWIN WILLIAMS CO COM 824348106 11,501 16,508 SH   SOLE   16,508 0 0
SHINHAN FINANCIAL GROUP CO L SPN ADR RESTRD 824596100 240 10,460 SH   SOLE   10,460 0 0
SHOPIFY INC CL A 82509L107 1,406 1,378 SH   SOLE   1,378 0 0
SILICON LABORATORIES INC COM 826919102 16,533 168,967 SH   SOLE   168,967 0 0
SIMON PPTY GROUP INC NEW COM 828806109 1,507 23,299 SH   SOLE   23,299 0 0
SIRIUS XM HOLDINGS INC COM 82968B103 84 15,754 SH   SOLE   15,754 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 1,496 10,285 SH   SOLE   10,285 0 0
SMUCKER J M CO COM NEW 832696405 1,212 10,488 SH   SOLE   10,488 0 0
SNAP INC NOTE 0.750% 8/0 83304AAB2 3,336 2,400 PRN   SOLE   2,400 0 0
SNAP INC CL A 83304A106 1,081 41,415 SH   SOLE   41,415 0 0
SNAP ON INC COM 833034101 1,082 7,355 SH   SOLE   7,355 0 0
SOCIEDAD QUIMICA Y MINERA DE SPON ADR SER B 833635105 20,164 622,000 SH   SOLE   622,000 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104 4 15 SH   OTR 1 0 0 15
SOLAREDGE TECHNOLOGIES INC COM 83417M104 23,189 97,293 SH   SOLE   97,293 0 0
SONY CORP SPONSORED ADR 835699307 2 32 SH   OTR 1 0 0 32
SONY CORP SPONSORED ADR 835699307 1,253 16,324 SH   SOLE   16,324 0 0
SOUTHERN COPPER CORP COM 84265V105 19,266 425,600 SH   SOLE   425,600 0 0
SOUTHWEST AIRLS CO COM 844741108 6,824 181,978 SH   SOLE   181,978 0 0
SOUTHWEST AIRLS CO NOTE 1.250% 5/0 844741BG2 28,829 22,000 PRN   SOLE   22,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 12,264 2,809,600 SH Put SOLE   2,809,600 0 0
SPDR SER TR S&P BIOTECH 78464A870 252 2,265 SH   SOLE   2,265 0 0
SPLUNK INC COM 848637104 40,779 216,767 SH   SOLE   216,767 0 0
SQUARE INC CL A 852234103 2,977 18,318 SH   SOLE   18,318 0 0
SSR MNG INC COM 784730103 3,332 179,086 SH   SOLE   179,086 0 0
STANLEY BLACK & DECKER INC COM 854502101 1 4 SH   OTR 1 0 0 4
STANLEY BLACK & DECKER INC COM 854502101 8,395 51,762 SH   SOLE   51,762 0 0
STARBUCKS CORP COM 855244109 2 21 SH   OTR 1 0 0 21
STARBUCKS CORP COM 855244109 42,458 494,180 SH   SOLE   494,180 0 0
STATE STR CORP COM 857477103 7,179 121,014 SH   SOLE   121,014 0 0
STEEL DYNAMICS INC COM 858119100 620 21,672 SH   SOLE   21,672 0 0
STRYKER CORPORATION COM 863667101 9,134 43,839 SH   SOLE   43,839 0 0
SUN CMNTYS INC COM 866674104 698 4,963 SH   SOLE   4,963 0 0
SUN LIFE FINANCIAL INC. COM 866796105 3,251 80,032 SH   SOLE   80,032 0 0
SUNCOR ENERGY INC NEW COM 867224107 752 61,772 SH   SOLE   61,772 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 417 20,000 SH   SOLE   20,000 0 0
SVB FINANCIAL GROUP COM 78486Q101 773 3,214 SH   SOLE   3,214 0 0
SYNCHRONY FINANCIAL COM 87165B103 1,366 52,207 SH   SOLE   52,207 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 0 30 SH   OTR 1 0 0 30
SYNDAX PHARMACEUTICALS INC COM 87164F105 5,289 358,342 SH   SOLE   358,342 0 0
SYNOPSYS INC COM 871607107 19,599 91,596 SH   SOLE   91,596 0 0
SYNOPSYS INC COM 871607107 3 16 SH   OTR 1 0 0 16
SYSCO CORP COM 871829107 2,165 34,796 SH   SOLE   34,796 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 73,106 901,797 SH   SOLE   901,797 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 2 24 SH   OTR 1 0 0 24
TAKE-TWO INTERACTIVE SOFTWAR COM 874054109 3,099 18,758 SH   SOLE   18,758 0 0
TAL EDUCATION GROUP SPONSORED ADS 874080104 23,099 303,793 SH   SOLE   303,793 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 3,632 32,000 SH   SOLE   32,000 0 0
TANGER FACTORY OUTLET CTRS I COM 875465106 84 14,000 SH   SOLE   14,000 0 0
TARGET CORP COM 87612E106 1 8 SH   OTR 1 0 0 8
TARGET CORP COM 87612E106 5,511 35,010 SH   SOLE   35,010 0 0
TC ENERGY CORP COM 87807B107 920 21,980 SH   SOLE   21,980 0 0
TD AMERITRADE HLDG CORP COM 87236Y108 23,112 590,377 SH   SOLE   590,377 0 0
TE CONNECTIVITY LTD REG SHS H84989104 4 36 SH   OTR 1 0 0 36
TEAM INC NOTE 5.000% 8/0 878155AE0 171 200,000 PRN   SOLE   200,000 0 0
TECK RESOURCES LTD CL B 878742204 513 36,970 SH   SOLE   36,970 0 0
TELADOC HEALTH INC COM 87918A105 2,811 12,822 SH   SOLE   12,822 0 0
TELEDYNE TECHNOLOGIES INC COM 879360105 879 2,834 SH   SOLE   2,834 0 0
TELEFLEX INCORPORATED COM 879369106 672 1,975 SH   SOLE   1,975 0 0
TELEFONICA S A SPONSORED ADR 879382208 2 627 SH   OTR 1 0 0 627
TELUS CORPORATION COM 87971M103 4,842 276,066 SH   SOLE   276,066 0 0
TENABLE HLDGS INC COM 88025T102 24,269 642,910 SH   SOLE   642,910 0 0
TERADYNE INC COM 880770102 343 4,313 SH   SOLE   4,313 0 0
TESLA INC COM 88160R101 66,039 153,943 SH   SOLE   153,943 0 0
TETRA TECH INC NEW COM 88162G103 10,230 107,122 SH   SOLE   107,122 0 0
TETRA TECH INC NEW COM 88162G103 2 18 SH   OTR 1 0 0 18
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 2,323 2,150 PRN   SOLE   2,150 0 0
TEXAS INSTRS INC COM 882508104 30,505 213,646 SH   SOLE   213,646 0 0
TEXAS INSTRS INC COM 882508104 1 10 SH   OTR 1 0 0 10
TG THERAPEUTICS INC COM 88322Q108 2 68 SH   OTR 1 0 0 68
TG THERAPEUTICS INC COM 88322Q108 40,176 1,501,421 SH   SOLE   1,501,421 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 11 26 SH   OTR 1 0 0 26
THERMO FISHER SCIENTIFIC INC COM 883556102 154,178 349,212 SH   SOLE   349,212 0 0
THOMSON REUTERS CORP. COM NEW 884903709 2,909 36,574 SH   SOLE   36,574 0 0
TIFFANY & CO NEW COM 886547108 22,528 194,464 SH   SOLE   194,464 0 0
TILLYS INC CL A 886885102 724 120,000 SH   SOLE   120,000 0 0
TJX COS INC NEW COM 872540109 11,850 212,953 SH   SOLE   212,953 0 0
T-MOBILE US INC COM 872590104 3,685 32,228 SH   SOLE   32,228 0 0
TOPBUILD CORP COM 89055F103 15,040 88,114 SH   SOLE   88,114 0 0
TOPBUILD CORP COM 89055F103 3 17 SH   OTR 1 0 0 17
TORONTO DOMINION BK ONT COM NEW 891160509 5,833 126,380 SH   SOLE   126,380 0 0
TOTAL SE SPONSORED ADS 89151E109 1,461 42,583 SH   SOLE   42,583 0 0
TOTAL SE SPONSORED ADS 89151E109 5 157 SH   OTR 1 0 0 157
TOYOTA MOTOR CORP SP ADR REP2COM 892331307 5 41 SH   OTR 1 0 0 41
TPI COMPOSITES INC COM 87266J104 1,180 40,736 SH   SOLE   40,736 0 0
TRACTOR SUPPLY CO COM 892356106 4,059 28,318 SH   SOLE   28,318 0 0
TRANE TECHNOLOGIES PLC SHS G8994E103 3 22 SH   OTR 1 0 0 22
TRANSUNION COM 89400J107 769 9,146 SH   SOLE   9,146 0 0
TRAVELERS COMPANIES INC COM 89417E109 1 9 SH   OTR 1 0 0 9
TRAVELERS COMPANIES INC COM 89417E109 11,203 103,554 SH   SOLE   103,554 0 0
TREX CO INC COM 89531P105 2 22 SH   OTR 1 0 0 22
TREX CO INC COM 89531P105 10,210 142,607 SH   SOLE   142,607 0 0
TRIMBLE INC COM 896239100 3 62 SH   OTR 1 0 0 62
TRIMBLE INC COM 896239100 34,987 718,459 SH   SOLE   718,459 0 0
TRUIST FINL CORP COM 89832Q109 3,257 85,598 SH   SOLE   85,598 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 20,542 235,150 SH   SOLE   235,150 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 1 13 SH   OTR 1 0 0 13
TWILIO INC CL A 90138F102 2,375 9,612 SH   SOLE   9,612 0 0
TWITTER INC COM 90184L102 2,015 1,450 PRN   SOLE   1,450 0 0
TWITTER INC NOTE 1.000% 9/1 90184LAD4 10,163 210,000 PRN   SOLE   210,000 0 0
TWITTER INC NOTE 0.250% 6/1 90184LAF9 2,446 2,200 PRN   SOLE   2,200 0 0
TWITTER INC COM 90184L102 7,768 174,127 SH   SOLE   174,127 0 0
TYLER TECHNOLOGIES INC COM 902252105 909 2,608 SH   SOLE   2,608 0 0
UBER TECHNOLOGIES INC COM 90353T100 1,291 35,381 SH   SOLE   35,381 0 0
UGI CORP NEW COM 902681105 1,323 40,124 SH   SOLE   40,124 0 0
ULTA BEAUTY INC COM 90384S303 575 2,569 SH   SOLE   2,569 0 0
UNILEVER N V N Y SHS NEW 904784709 2 29 SH   OTR 1 0 0 29
UNILEVER N V N Y SHS NEW 904784709 1,776 29,405 SH   SOLE   29,405 0 0
UNION PAC CORP COM 907818108 2 9 SH   OTR 1 0 0 9
UNION PAC CORP COM 907818108 46,578 236,605 SH   SOLE   236,605 0 0
UNITED MICROELECTRONICS CORP SPON ADR NEW 910873405 252 52,694 SH   SOLE   52,694 0 0
UNITED PARCEL SERVICE INC CL B 911312106 14,212 85,292 SH   SOLE   85,292 0 0
UNITED RENTALS INC COM 911363109 7,082 40,584 SH   SOLE   40,584 0 0
UNITEDHEALTH GROUP INC COM 91324P102 862 740 PRN   SOLE   740 0 0
UNITEDHEALTH GROUP INC COM 91324P102 49,201 157,818 SH   SOLE   157,818 0 0
UNIVERSAL DISPLAY CORP COM 91347P105 2 9 SH   OTR 1 0 0 9
UNIVERSAL DISPLAY CORP COM 91347P105 26,708 147,774 SH   SOLE   147,774 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100 4,660 43,546 SH   SOLE   43,546 0 0
US BANCORP DEL COM NEW 902973304 3,452 96,286 SH   SOLE   96,286 0 0
V F CORP COM 918204108 7,226 102,871 SH   SOLE   102,871 0 0
VAIL RESORTS INC COM 91879Q109 1,254 1,000 PRN   SOLE   1,000 0 0
VALE S A SPONSORED ADS 91912E105 129 12,210 SH   SOLE   12,210 0 0
VALERO ENERGY CORP COM 91913Y100 1,238 28,588 SH   SOLE   28,588 0 0
VARIAN MED SYS INC COM 92220P105 28,427 165,279 SH   SOLE   165,279 0 0
VARONIS SYS INC COM 922280102 23,806 206,266 SH   SOLE   206,266 0 0
VEEVA SYS INC CL A COM 922475108 4,209 14,969 SH   SOLE   14,969 0 0
VENTAS INC COM 92276F100 1,339 31,917 SH   SOLE   31,917 0 0
VERACYTE INC COM 92337F107 1 20 SH   OTR 1 0 0 20
VERACYTE INC COM 92337F107 6,581 202,575 SH   SOLE   202,575 0 0
VEREIT INC COM 92339V100 532 81,895 SH   SOLE   81,895 0 0
VERISIGN INC COM 92343E102 2 8 SH   OTR 1 0 0 8
VERISIGN INC COM 92343E102 1,508 7,364 SH   SOLE   7,364 0 0
VERISK ANALYTICS INC COM 92345Y106 2 9 SH   OTR 1 0 0 9
VERISK ANALYTICS INC COM 92345Y106 9,991 53,919 SH   SOLE   53,919 0 0
VERIZON COMMUNICATIONS INC COM 92343V104 5 77 SH   OTR 1 0 0 77
VERIZON COMMUNICATIONS INC COM 92343V104 32,619 548,327 SH   SOLE   548,327 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 2 9 SH   OTR 1 0 0 9
VERTEX PHARMACEUTICALS INC COM 92532F100 151,870 558,122 SH   SOLE   558,122 0 0
VIACOMCBS INC CL B 92556H206 1,234 44,054 SH   SOLE   44,054 0 0
VIAVI SOLUTIONS INC NOTE 1.000% 3/0 925550AB1 1,785 1,570 PRN   SOLE   1,570 0 0
VIEWRAY INC COM 92672L107 0 82 SH   OTR 1 0 0 82
VIEWRAY INC COM 92672L107 3,086 881,623 SH   SOLE   881,623 0 0
VIPSHOP HOLDINGS LIMITED SPONSORED ADS A 92763W103 27,784 1,776,558 SH   SOLE   1,776,558 0 0
VIR BIOTECHNOLOGY INC COM 92764N102 7,059 205,622 SH   SOLE   205,622 0 0
VISA INC COM CL A 92826C839 69,509 347,611 SH   SOLE   347,611 0 0
VISA INC COM CL A 92826C839 4 21 SH   OTR 1 0 0 21
VIVINT SOLAR INC COM 92854Q106 35,612 840,936 SH   SOLE   840,936 0 0
VMWARE INC CL A COM 928563402 33,747 234,901 SH   SOLE   234,901 0 0
VMWARE INC CL A COM 928563402 2 14 SH   OTR 1 0 0 14
VODAFONE GROUP PLC NEW SPONSORED ADR 92857W308 1 41 SH   OTR 1 0 0 41
VONAGE HLDGS CORP NOTE 1.750% 6/0 92886TAJ1 197 200,000 PRN   SOLE   200,000 0 0
VONAGE HLDGS CORP COM 92886T201 655 30,490 SH   SOLE   30,490 0 0
VORNADO RLTY TR SH BEN INT 929042109 1,118 33,158 SH   SOLE   33,158 0 0
VORNADO RLTY TR SH BEN INT 929042109 1 41 SH   OTR 1 0 0 41
VOYA FINANCIAL INC COM 929089100 396 8,265 SH   SOLE   8,265 0 0
VULCAN MATLS CO COM 929160109 12,868 94,940 SH   SOLE   94,940 0 0
VULCAN MATLS CO COM 929160109 1 10 SH   OTR 1 0 0 10
WABTEC COM 929740108 1,020 16,484 SH   SOLE   16,484 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 2,587 72,033 SH   SOLE   72,033 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 1 31 SH   OTR 1 0 0 31
WALMART INC COM 931142103 2,360 16,872 SH   SOLE   16,872 0 0
WASTE CONNECTIONS INC COM 94106B101 13,292 128,060 SH   SOLE   128,060 0 0
WASTE CONNECTIONS INC COM 94106B101 2 16 SH   OTR 1 0 0 16
WASTE MGMT INC DEL COM 94106L109 64,542 570,331 SH   SOLE   570,331 0 0
WASTE MGMT INC DEL COM 94106L109 9 80 SH   OTR 1 0 0 80
WATERS CORP COM 941848103 1,325 6,769 SH   SOLE   6,769 0 0
WAYFAIR INC CL A 94419L101 1,020 3,506 SH   SOLE   3,506 0 0
WAYFAIR INC CL A 94419L101 1,025 1,000 PRN   SOLE   1,000 0 0
WEC ENERGY GROUP INC COM 92939U106 212 2,189 SH   SOLE   2,189 0 0
WEIBO CORP NOTE 1.250%11/1 948596AC5 3,831 4,000 PRN   SOLE   4,000 0 0
WELLS FARGO CO NEW COM 949746101 6,044 257,077 SH   SOLE   257,077 0 0
WELLTOWER INC COM 95040Q104 2,175 39,489 SH   SOLE   39,489 0 0
WEST PHARMACEUTICAL SVSC INC COM 955306105 1 4 SH   OTR 1 0 0 4
WEST PHARMACEUTICAL SVSC INC COM 955306105 7,052 25,653 SH   SOLE   25,653 0 0
WESTERN DIGITAL CORP. NOTE 1.500% 2/0 958102AP0 3,830 4,000 PRN   SOLE   4,000 0 0
WESTERN DIGITAL CORP. COM 958102105 661 18,076 SH   SOLE   18,076 0 0
WESTERN UN CO COM 959802109 526 24,563 SH   SOLE   24,563 0 0
WESTPAC BANKING CORP SPONSORED ADR 961214301 2 185 SH   OTR 1 0 0 185
WESTROCK CO COM 96145D105 601 17,310 SH   SOLE   17,310 0 0
WEYERHAEUSER CO MTN BE COM NEW 962166104 1,502 52,652 SH   SOLE   52,652 0 0
WHIRLPOOL CORP COM 963320106 537 2,920 SH   SOLE   2,920 0 0
WILLIAMS COS INC COM 969457100 6,753 343,663 SH   SOLE   343,663 0 0
WIPRO LTD SPON ADR 1 SH 97651M109 1,182 1,000 PRN   SOLE   1,000 0 0
WIPRO LTD SPON ADR 1 SH 97651M109 59 12,607 SH   SOLE   12,607 0 0
WORKDAY INC NOTE 0.250%10/0 98138HAF8 1,172 760 PRN   SOLE   760 0 0
WORKDAY INC CL A 98138H101 9,959 46,293 SH   SOLE   46,293 0 0
WORKIVA INC COM CL A 98139A105 500 8,970 SH   SOLE   8,970 0 0
WP CAREY INC COM 92936U109 712 10,933 SH   SOLE   10,933 0 0
WYNN RESORTS LTD COM 983134107 539 7,513 SH   SOLE   7,513 0 0
XENCOR INC COM 98401F105 2 40 SH   OTR 1 0 0 40
XENCOR INC COM 98401F105 28,379 731,647 SH   SOLE   731,647 0 0
XILINX INC COM 983919101 1,560 14,967 SH   SOLE   14,967 0 0
XP INC CL A G98239109 12,456 298,800 SH   SOLE   298,800 0 0
XPO LOGISTICS INC COM 983793100 429 5,068 SH   SOLE   5,068 0 0
XYLEM INC COM 98419M100 3 36 SH   OTR 1 0 0 36
XYLEM INC COM 98419M100 24,390 289,959 SH   SOLE   289,959 0 0
YAMANA GOLD INC COM 98462Y100 73 12,940 SH   SOLE   12,940 0 0
Y-MABS THERAPEUTICS INC COM 984241109 7,013 182,687 SH   SOLE   182,687 0 0
Y-MABS THERAPEUTICS INC COM 984241109 1 17 SH   OTR 1 0 0 17
YUM BRANDS INC COM 988498101 1,502 16,452 SH   SOLE   16,452 0 0
YUM CHINA HLDGS INC COM 98850P109 2,118 40,000 SH   SOLE   40,000 0 0
ZEBRA TECHNOLOGIES CORPORATI CL A 989207105 19,205 76,076 SH   SOLE   76,076 0 0
ZEBRA TECHNOLOGIES CORPORATI CL A 989207105 2 6 SH   OTR 1 0 0 6
ZENDESK INC COM 98936J101 254 2,470 SH   SOLE   2,470 0 0
ZILLOW GROUP INC CL C CAP STK 98954M200 506 4,984 SH   SOLE   4,984 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 1,488 10,931 SH   SOLE   10,931 0 0
ZIONS BANCORPORATION N A COM 989701107 5,278 180,645 SH   SOLE   180,645 0 0
ZOETIS INC CL A 98978V103 4,993 30,192 SH   SOLE   30,192 0 0
ZOGENIX INC COM NEW 98978L204 16,985 947,329 SH   SOLE   947,329 0 0
ZOOM VIDEO COMMUNICATIONS IN CL A 98980L101 3,706 7,883 SH   SOLE   7,883 0 0
ZSCALER INC COM 98980G102 401 2,850 SH   SOLE   2,850 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADS A 98980A105 6,020 201,199 SH   SOLE   201,199 0 0
ZYMEWORKS INC COM 98985W102 28,973 622,032 SH   SOLE   622,032 0 0
ZYMEWORKS INC COM 98985W102 1 28 SH   OTR 1 0 0 28
ZYNGA INC NOTE 0.250% 6/0 98986TAB4 1,171 920 PRN   SOLE   920 0 0