The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101 42,047 262,500 SH   DFND 1 262,500 0 0
ABBVIE INC COM 00287Y109 796 9,093 SH   DFND 1 9,093 0 0
ADMA BIOLOGICS INC COM 000899104 72 30,075 SH   DFND 1 30,075 0 0
AKARI THERAPEUTICS PLC SPONSORED ADR 00972G108 156 89,815 SH   DFND 1 89,815 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 148 20,020 SH   DFND 1 20,020 0 0
ALPHABET INC CLASS A CL A 38259P508 339 231 SH   DFND 1 231 0 0
ALPHABET INC CLASS C CL C 38259P706 10,287 7,000 SH   DFND 1 0 0 7,000
ALPINE IMMUNE SCIENCES INC COM 02083G100 92 10,445 SH   DFND 1 10,445 0 0
ALTRIA GROUP INC COM 02209S103 12,361 319,890 SH   DFND 1 319,890 0 0
AMARIN CORP PLC-ADR SPONSORED ADR 023111206 63 15,000 SH   DFND 1 15,000 0 0
AMGEN INC COM 031162100 8,291 32,620 SH   DFND 1 32,620 0 0
ANAVEX LIFE SCIENCES CORP COM 032797300 389 85,585 SH   DFND 1 85,585 0 0
ANHEUSER-BUSCH INBEV NV SPONSORED ADR 03524A108 6,086 112,960 SH   DFND 1 112,960 0 0
BANK OF NEW YORK MELLON CORP COM 064058100 19,358 563,710 SH   DFND 1 563,710 0 0
BECTON DICKINSON & CO COM 075887109 5,577 23,970 SH   DFND 1 23,970 0 0
BERKSHIRE HATHAWAY INC CLASS A CL A 084670108 250,561 783 SH   DFND 1 783 0 0
BERKSHIRE HATHAWAY INC CLASS B CL B 084670702 1,574 7,390 SH   DFND 1 7,390 0 0
BHP BILLITON PLC SPONSORED ADR 05545E209 6,915 162,100 SH   DFND 1 162,100 0 0
BIODELIVERY SCIENCES INTERNATIONAL INC COM 09060J106 93 25,000 SH   DFND 1 25,000 0 0
BOEING CO COM 097023105 5,536 33,500 SH   DFND 1 33,500 0 0
BRITISH AMERICAN TOBACCO PLC SPONSORED ADR 110448107 855 23,650 SH   DFND 1 23,650 0 0
CHINA MOBILE LIMITED SPONSORED ADR 16941M109 1,553 48,300 SH   DFND 1 48,300 0 0
CIGNA CORPORATION COM 125509109 3,879 22,899 SH   DFND 1 22,899 0 0
CISCO SYSTEMS INC COM 17275R102 1,753 44,500 SH   DFND 1 44,500 0 0
COCA COLA CO COM 191216100 2,390 48,400 SH   DFND 1 48,400 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 80 19,959 SH   DFND 1 19,959 0 0
DANAHER CORP COM 235851102 40,620 188,640 SH   DFND 1 188,640 0 0
ECOLAB INC COM 278865100 420 2,100 SH   DFND 1 2,100 0 0
EXXON MOBIL CORPORATION COM 30231G102 9,281 270,350 SH   DFND 1 270,350 0 0
FORTIVE CORP COM 34959J108 4,896 64,240 SH   DFND 1 64,240 0 0
GENERAL ELECTRIC COMPANY COM 369604103 313 50,280 SH   DFND 1 50,280 0 0
GILEAD SCIENCES INC COM 375558103 1,177 18,630 SH   DFND 1 18,630 0 0
HONEYWELL INTERNATIONAL INC COM 438516106 2,667 16,200 SH   DFND 1 16,200 0 0
INTUITIVE SURGICAL INC COM 46120E602 13,233 18,650 SH   DFND 1 18,650 0 0
JACK HENRY & ASSOCIATES INC COM 426281101 2,227 13,700 SH   DFND 1 13,700 0 0
JOHNSON & JOHNSON COM 478160104 50,049 336,170 SH   DFND 1 336,170 0 0
THE KRAFT HEINZ COMPANY COM 500754106 933 31,150 SH   DFND 1 31,150 0 0
LINDE PUBLIC LIMITED COMPANY COM G5494J103 37,310 156,680 SH   DFND 1 156,680 0 0
LOCKHEED MARTIN CORP COM 539830109 2,373 6,190 SH   DFND 1 6,190 0 0
MASTERCARD INC CL A 57636Q104 3,382 10,000 SH   DFND 1 10,000 0 0
MEDTRONIC INC COM 585055106 9,058 87,160 SH   DFND 1 87,160 0 0
MOODYS CORPORATION COM 20775CZK3 15,058 51,950 SH   DFND 1 51,950 0 0
NASDAQ INC COM 631103108 4,111 33,500 SH   DFND 1 33,500 0 0
NESTLE SA SPONSORED ADR 641069406 28,279 237,130 SH   DFND 1 237,130 0 0
NOVO NORDISK A/S SPONSORED ADR 670100205 8,116 116,900 SH   DFND 1 116,900 0 0
NUTRIEN LTD COM 67077M108 14,127 360,110 SH   DFND 1 360,110 0 0
OMNICOM GROUP INC COM 681919106 272 5,500 SH   DFND 1 5,500 0 0
PHILLIPS 66 COM 718546104 8,563 165,190 SH   DFND 1 165,190 0 0
ROCHE HOLDING AG SPONSORED ADR 771195104 9,518 222,320 SH   DFND 1 222,320 0 0
ROPER TECHNOLOGIES INC COM 776696106 27,895 70,600 SH   DFND 1 70,600 0 0
ROYAL DUTCH SHELL PLC CLASS B CL B 780259107 7,224 298,280 SH   DFND 1 298,280 0 0
STORE CAPITAL CORPORATION REIT 862121100 1,007 36,700 SH   DFND 1 36,700 0 0
UNION PACIFIC CORP COM 907818108 803 4,080 SH   DFND 1 4,080 0 0
US BANCORP COM 902973304 6,586 183,720 SH   DFND 1 183,720 0 0
VANGUARD FTSE EMERGING MARKETS ETF ETF 922042858 2,543 58,810 SH   DFND 1 58,810 0 0
VANGUARD S&P 500 ETF ETF 922908363 5,907 19,200 SH   DFND 1 19,200 0 0
VISA INC CLASS A CL A 92826C839 30,655 153,300 SH   DFND 1 153,300 0 0
WABTEC CORPORATION COM 929740108 4,576 73,943 SH   DFND 1 73,943 0 0
WATERS CORPORATION COM 941848103 9,123 46,620 SH   DFND 1 46,620 0 0
WELLS FARGO & CO COM 949746101 43,005 1,829,230 SH   DFND 1 1,829,230 0 0
VEEVA SYSTEMS INC-CLASS A CL A 922475108 562 2,000 SH   DFND 1 2,000 0 0