The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 36,012 366,800 SH Call DFND   0 366,800 0
ABBVIE INC COM 00287Y109 63,286 644,588 SH   DFND   0 644,588 0
ACORDA THERAPEUTICS INC NOTE 1.750% 6/1 00484MAA4 1,713 2,000,000 PRN   DFND   0 2,000,000 0
AERIE PHARMACEUTICALS INC COM 00771V108 33,567 2,274,220 SH   DFND   0 2,274,220 0
ALEXION PHARMACEUTICALS INC COM 015351109 76,198 678,884 SH   DFND   0 678,884 0
ALLENA PHARMACEUTICALS INC COM 018119107 449 284,285 SH   DFND 1 0 284,285 0
AMAZON COM INC COM 023135106 14,738 5,342 SH   DFND   0 5,342 0
ANTHEM INC COM 036752103 26,298 100,000 SH   DFND   0 100,000 0
APTIV PLC SHS G6095L109 10,734 137,757 SH   DFND   0 137,757 0
ARCUS BIOSCIENCES INC COM 03969F109 42,938 1,735,581 SH   DFND   0 1,735,581 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 16,481 261,808 SH   DFND   0 261,808 0
ASTRAZENECA PLC SPONSORED ADR 046353108 33,617 635,600 SH   DFND   0 635,600 0
BAXTER INTL INC COM 071813109 25,419 295,222 SH   DFND   0 295,222 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 59,583 483,079 SH   DFND   0 483,079 0
BIOMARIN PHARMACEUTICAL INC NOTE 0.599% 8/0 09061GAH4 51,199 41,600,000 PRN   DFND   0 41,600,000 0
CARDINAL HEALTH INC COM 14149Y108 26,095 500,000 SH Call DFND   0 500,000 0
CARDINAL HEALTH INC COM 14149Y108 45,193 865,933 SH   DFND   0 865,933 0
COHERUS BIOSCIENCES INC COM 19249H103 7,353 411,727 SH   DFND   0 411,727 0
CONSTELLATION PHARMCETICLS I COM 210373106 31,594 1,051,390 SH   DFND   0 1,051,390 0
DANAHER CORPORATION COM 235851102 30,472 172,321 SH   DFND   0 172,321 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 14,938 250,133 SH   DFND   0 250,133 0
DEERE & CO COM 244199105 11,996 76,336 SH   DFND   0 76,336 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 10,143 1,143,526 SH   DFND   0 1,143,526 0
EDWARDS LIFESCIENCES CORP COM 28176E108 27,190 393,435 SH   DFND   0 393,435 0
EXACT SCIENCES CORP COM 30063P105 14,056 161,679 SH   DFND   0 161,679 0
EXACT SCIENCES CORP NOTE 0.375% 3/0 30063PAC9 8,620 9,000,000 PRN   DFND   0 9,000,000 0
FLUIDIGM CORP DEL COM 34385P108 7,716 1,924,072 SH   DFND   0 1,924,072 0
GILEAD SCIENCES INC COM 375558103 51,812 673,412 SH   DFND   0 673,412 0
HALOZYME THERAPEUTICS INC COM 40637H109 16,020 597,545 SH   DFND   0 597,545 0
HCA HEALTHCARE INC COM 40412C101 17,432 179,600 SH Call DFND   0 179,600 0
HCA HEALTHCARE INC COM 40412C101 31,967 329,357 SH   DFND   0 329,357 0
HERON THERAPEUTICS INC COM 427746102 32,824 2,231,402 SH   DFND   0 2,231,402 0
HOLOGIC INC COM 436440101 34,985 613,776 SH   DFND   0 613,776 0
HORIZON THERAPEUTICS PUB LTD SHS G46188101 63,499 1,142,478 SH   DFND   0 1,142,478 0
HUMANA INC COM 444859102 33,354 86,020 SH   DFND   0 86,020 0
ICON PLC SHS G4705A100 17,346 102,966 SH   DFND   0 102,966 0
ICU MED INC COM 44930G107 19,758 107,200 SH Call DFND   0 107,200 0
ICU MED INC COM 44930G107 41,571 225,551 SH   DFND   0 225,551 0
IGM BIOSCIENCES INC COM 449585108 8,467 115,988 SH   DFND   0 115,988 0
IMMUNOMEDICS INC COM 452907108 12,758 360,000 SH Call DFND   0 360,000 0
IMMUNOMEDICS INC COM 452907108 112,663 3,178,974 SH   DFND   0 3,178,974 0
IMMUNOVANT INC COM 45258J102 1,635 67,163 SH   DFND   0 67,163 0
INVESCO QQQ TR UNIT SER 1 46090E103 69,179 279,400 SH Put DFND   0 279,400 0
IQVIA HLDGS INC COM 46266C105 40,796 287,538 SH   DFND   0 287,538 0
IRHYTHM TECHNOLOGIES INC COM 450056106 28,805 248,558 SH   DFND   0 248,558 0
ISHARES TR CHINA LG-CAP ETF 464287184 26,329 663,200 SH Put DFND   0 663,200 0
ISHARES TR RUSSELL 2000 ETF 464287655 12,199 85,200 SH Call DFND   0 85,200 0
JOHNSON & JOHNSON COM 478160104 10,852 77,167 SH   DFND   0 77,167 0
KARUNA THERAPEUTICS INC COM 48576A100 39,295 352,545 SH   DFND   0 352,545 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 51,549 310,330 SH   DFND   0 310,330 0
MCKESSON CORP COM 58155Q103 50,502 329,175 SH   DFND   0 329,175 0
MICROSOFT CORP COM 594918104 19,369 95,177 SH   DFND   0 95,177 0
MOLINA HEALTHCARE INC COM 60855R100 16,582 93,168 SH   DFND   0 93,168 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 19,296 579,994 SH   DFND   0 579,994 0
NEVRO CORP COM 64157F103 12,446 104,180 SH   DFND   0 104,180 0
NEVRO CORP NOTE 2.750% 4/0 64157FAC7 2,733 2,000,000 PRN   DFND   0 2,000,000 0
NEXTERA ENERGY INC COM 65339F101 4,940 20,570 SH   DFND   0 20,570 0
NVIDIA CORPORATION COM 67066G104 14,480 38,113 SH   DFND   0 38,113 0
NXP SEMICONDUCTORS N V COM N6596X109 14,582 127,871 SH   DFND   0 127,871 0
PACIRA BIOSCIENCES COM 695127100 3,148 60,000 SH Put DFND   0 60,000 0
PENUMBRA INC COM 70975L107 19,903 111,302 SH   DFND   0 111,302 0
PPD INC COM 69355F102 28,770 1,073,491 SH   DFND   0 1,073,491 0
QUEST DIAGNOSTICS INC COM 74834L100 10,135 88,933 SH   DFND   0 88,933 0
SELECT SECTOR SPDR TR SBI INT-FINL 81369Y605 10,034 433,600 SH Call DFND   0 433,600 0
SELECT SECTOR SPDR TR SBI INT-INDS 81369Y704 9,350 136,100 SH Call DFND   0 136,100 0
SHOPIFY INC CL A 82509L107 8,974 9,454 SH   DFND   0 9,454 0
SPDR SER TR S&P BIOTECH 78464A870 49,045 438,100 SH Put DFND   0 438,100 0
SQUARE INC CL A 852234103 19,048 181,509 SH   DFND   0 181,509 0
TENET HEALTHCARE CORP COM NEW 88033G407 10,479 578,625 SH   DFND   0 578,625 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 25,083 2,034,296 SH   DFND   0 2,034,296 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 6,919 855,270 SH   DFND   0 855,270 0
UNITEDHEALTH GROUP INC COM 91324P102 16,491 55,910 SH   DFND   0 55,910 0
VERTEX PHARMACEUTICALS INC COM 92532F100 17,138 59,035 SH   DFND   0 59,035 0
VISA INC COM CL A 92826C839 8,397 43,468 SH   DFND   0 43,468 0
ZENDESK INC COM 98936J101 5,935 67,034 SH   DFND   0 67,034 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 21,472 179,891 SH   DFND   0 179,891 0