The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AES CORP COM 00130H105 326,310 22,523,198 SH   DFND 1, 2 22,258,045 0 265,153
ASGN INC COM 00191U102 65,128 976,725 SH   DFND 1, 2 976,725 0 0
ABBOTT LABS COM 002824100 5,184,913 56,714,070 SH   DFND 1, 2 56,562,244 0 151,826
ABBVIE INC COM 00287Y109 1,128,034 11,489,450 SH   DFND 1, 2 11,489,450 0 0
ACTIVISION BLIZZARD INC COM 00507V109 3,439,821 45,322,139 SH   DFND 1, 2 45,056,212 0 265,927
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 78,468 1,621,904 SH   DFND 1, 2 1,621,904 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 13,225 1,321,200 SH   DFND 1, 2 1,321,200 0 0
ADOBE INC COM 00724F101 1,055,402 2,424,969 SH   DFND 1, 2 2,408,625 0 16,344
AGNICO EAGLE MINES LTD COM 008474108 277 4,325 SH   DFND 1, 2 4,325 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 206,156 3,854,832 SH   DFND 1, 2 3,854,832 0 0
AIR LEASE CORP CL A 00912X302 384,752 13,135,952 SH   DFND 1, 2 13,135,952 0 0
AIR PRODS & CHEMS INC COM 009158106 1,366,575 5,659,830 SH   DFND 1, 2 5,654,222 0 5,608
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 41,192 190,975 SH   DFND 1, 2 189,311 0 1,664
ALLAKOS INC COM 01671P100 247,415 3,443,010 SH   DFND 1, 2 3,443,010 0 0
ALLEGHENY TECHNOLOGIES INC COM 01741R102 107,864 10,585,255 SH   DFND 1, 2 10,585,255 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 308,943 7,214,913 SH   DFND 1, 2 7,214,748 0 165
ALPHABET INC CAP STK CL C 02079K107 6,167,754 4,363,371 SH   DFND 1, 2 4,346,314 0 17,057
ALPHABET INC CAP STK CL A 02079K305 2,515,337 1,773,806 SH   DFND 1, 2 1,773,770 0 36
ALTERYX INC COM CL A 02156B103 91,588 557,513 SH   DFND 1, 2 557,513 0 0
ALTRIA GROUP INC COM 02209S103 922,733 23,509,202 SH   DFND 1, 2 23,449,666 0 59,536
AMAZON COM INC COM 023135106 11,891,333 4,310,865 SH   DFND 1, 2 4,292,974 0 17,891
AMBEV SA SPONSORED ADR 02319V103 2,978 1,128,200 SH   DFND 1, 2 1,128,200 0 0
AMERICA MOVIL SAB DE CV SPON ADR L SHS 02364W105 763,291 60,132,288 SH   DFND 1, 2 59,414,719 0 717,569
AMERICAN TOWER CORP NEW COM 03027X100 1,291,800 4,999,729 SH   DFND 1, 2 4,894,207 0 105,522
AMERISOURCEBERGEN CORP COM 03073E105 174,170 1,728,389 SH   DFND 1, 2 1,728,389 0 0
AMETEK INC COM 031100100 157,360 1,762,909 SH   DFND 1, 2 1,640,900 0 122,009
AMGEN INC COM 031162100 969,481 4,110,420 SH   DFND 1, 2 4,110,169 0 251
AMPHENOL CORP NEW CL A 032095101 259,531 2,708,813 SH   DFND 1, 2 2,708,458 0 355
ANALOG DEVICES INC COM 032654105 205,992 1,679,649 SH   DFND 1, 2 1,679,649 0 0
ANGLOGOLD ASHANTI LIMITED SPONSORED ADR 035128206 255,379 8,659,846 SH   DFND 1, 2 8,659,846 0 0
ANHEUSER BUSCH INBEV SA/NV SPONSORED ADR 03524A108 195,038 3,956,141 SH   DFND 1, 2 3,760,229 0 195,912
ANTHEM INC COM 036752103 1,978,450 7,523,953 SH   DFND 1, 2 7,478,790 0 45,163
APOLLO GLOBAL MGMT INC COM CL A 03768E105 275,043 5,509,672 SH   DFND 1, 2 5,509,672 0 0
APPLE INC COM 037833100 1,028,598 2,820,345 SH   DFND 1, 2 2,748,495 0 71,850
APPLIED MATLS INC COM 038222105 1,162,631 19,233,070 SH   DFND 1, 2 19,227,739 0 5,331
APPLIED MOLECULAR TRANS INC COM 03824M109 16,474 655,300 SH   DFND 1, 2 655,300 0 0
ARAMARK COM 03852U106 180,560 8,000,000 SH   DFND 1, 2 8,000,000 0 0
ARCOSA INC COM 039653100 55,780 1,321,800 SH   DFND 1, 2 1,321,800 0 0
ARES MANAGEMENT CORPORATION CL A COM STK 03990B101 261,502 6,586,942 SH   DFND 1, 2 6,586,942 0 0
ARMSTRONG WORLD INDS INC COM 04247X102 395,431 5,072,223 SH   DFND 1, 2 5,072,223 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 1,578,231 29,838,626 SH   DFND 1, 2 28,345,547 0 1,493,079
AUTODESK INC COM 052769106 57,080 238,637 SH   DFND 1, 2 238,637 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 19,600 1,222,688 SH   DFND 1, 2 1,222,688 0 0
AVALARA INC COM 05338G106 2,553 19,183 SH   DFND 1, 2 19,183 0 0
AZUL S A SPONSR ADR PFD 05501U106 4,854 434,140 SH   DFND 1, 2 434,140 0 0
BCE INC COM NEW 05534B760 41,850 1,001,925 SH   DFND 1, 2 1,001,925 0 0
BWX TECHNOLOGIES INC COM 05605H100 355,973 6,285,317 SH   DFND 1, 2 6,241,094 0 44,223
BAKER HUGHES COMPANY CL A 05722G100 33,828 2,198,035 SH   DFND 1, 2 2,198,035 0 0
BK OF AMERICA CORP COM 060505104 355,406 14,964,453 SH   DFND 1, 2 14,964,453 0 0
BANK NEW YORK MELLON CORP COM 064058100 719,808 18,631,390 SH   DFND 1, 2 18,481,801 0 149,589
BARRICK GOLD CORPORATION COM 067901108 219,143 8,139,000 SH   DFND 1, 2 8,010,248 0 128,752
BAXTER INTL INC COM 071813109 780,440 9,065,473 SH   DFND 1, 2 9,020,840 0 44,633
BEIGENE LTD SPONSORED ADR 07725L102 1,121,742 5,953,435 SH   DFND 1, 2 5,895,587 0 57,848
BERKSHIRE HATHAWAY INC DEL CL A 084670108 129,908 486 SH   DFND 1, 2 486 0 0
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 861,654 4,826,942 SH   DFND 1, 2 4,825,002 0 1,940
BIOMARIN PHARMACEUTICAL INC COM 09061G101 120,294 975,326 SH   DFND 1, 2 973,337 0 1,989
BLACKROCK INC COM 09247X101 1,573,119 2,891,344 SH   DFND 1, 2 2,888,441 0 2,903
BLACKSTONE GROUP INC COM CL A 09260D107 946,010 16,696,256 SH   DFND 1, 2 16,696,256 0 0
BLUEBIRD BIO INC COM 09609G100 68,816 1,127,386 SH   DFND 1, 2 1,127,386 0 0
BOEING CO COM 097023105 639,020 3,486,026 SH   DFND 1, 2 3,483,210 0 2,816
BOOKING HOLDINGS INC COM 09857L108 1,034,946 649,953 SH   DFND 1, 2 649,953 0 0
BRIGHT HORIZONS FAM SOL IN D COM 109194100 25,585 218,300 SH   DFND 1, 2 218,300 0 0
BRITISH AMERN TOB PLC SPONSORED ADR 110448107 396,983 10,206,999 SH   DFND 1, 2 9,245,935 0 961,064
BROADCOM INC COM 11135F101 11,049,664 35,013,371 SH   DFND 1, 2 34,911,116 0 102,255
CDK GLOBAL INC COM 12508E101 269,901 6,516,201 SH   DFND 1, 2 6,516,201 0 0
CIGNA CORP NEW COM 125523100 980,874 5,227,158 SH   DFND 1, 2 5,205,638 0 21,520
CME GROUP INC COM 12572Q105 1,819,394 11,193,902 SH   DFND 1, 2 11,116,160 0 77,742
CMS ENERGY CORP COM 125896100 384,207 6,578,658 SH   DFND 1, 2 6,490,074 0 88,584
CSX CORP COM 126408103 869,143 12,467,593 SH   DFND 1, 2 12,234,683 0 232,910
CVS HEALTH CORP COM 126650100 1,610,106 24,782,448 SH   DFND 1, 2 24,764,353 0 18,095
CABLE ONE INC COM 12685J105 281,101 158,484 SH   DFND 1, 2 149,092 0 9,392
CABOT MICROELECTRONICS CORP COM 12709P103 69,317 496,751 SH   DFND 1, 2 496,751 0 0
CACTUS INC CL A 127203107 25,785 1,249,900 SH   DFND 1, 2 1,249,900 0 0
CANADIAN NATL RY CO COM 136375102 63,831 726,108 SH   DFND 1, 2 617,117 0 108,991
CANADIAN NAT RES LTD COM 136385101 360,754 20,793,560 SH   DFND 1, 2 20,793,560 0 0
CANNAE HLDGS INC COM 13765N107 14,549 353,987 SH   DFND 1, 2 353,987 0 0
CARDINAL HEALTH INC COM 14149Y108 41,596 797,019 SH   DFND 1, 2 797,019 0 0
CARNIVAL CORP UNIT 99/99/9999 143658300 51,227 3,119,809 SH   DFND 1, 2 3,119,809 0 0
CARRIER GLOBAL CORPORATION COM 14448C104 49,972 2,248,977 SH   DFND 1, 2 2,248,977 0 0
CATERPILLAR INC DEL COM 149123101 955,664 7,554,656 SH   DFND 1, 2 7,554,656 0 0
CELANESE CORP DEL COM 150870103 740,182 8,572,917 SH   DFND 1, 2 8,569,549 0 3,368
CELLECTIS S A SPON ADS 15117K103 23,840 1,339,336 SH   DFND 1, 2 1,339,336 0 0
CENTENE CORP DEL COM 15135B101 883,378 13,900,530 SH   DFND 1, 2 13,899,458 0 1,072
CENTENNIAL RESOURCE DEV INC CL A 15136A102 553 621,700 SH   DFND 1, 2 621,700 0 0
CENTERPOINT ENERGY INC COM 15189T107 106,476 5,703,069 SH   DFND 1, 2 5,703,069 0 0
CHARTER COMMUNICATIONS INC N CL A 16119P108 5,266,434 10,325,595 SH   DFND 1, 2 10,292,869 0 32,726
CHEVRON CORP NEW COM 166764100 3,222,772 36,123,709 SH   DFND 1, 2 35,881,728 0 241,981
CHIPOTLE MEXICAN GRILL INC COM 169656105 1,056,270 1,003,792 SH   DFND 1, 2 993,026 0 10,766
CHURCH & DWIGHT INC COM 171340102 1,190,382 15,399,511 SH   DFND 1, 2 15,399,426 0 85
CISCO SYS INC COM 17275R102 308,027 6,604,351 SH   DFND 1, 2 6,604,351 0 0
CITIGROUP INC COM NEW 172967424 44,900 878,665 SH   DFND 1, 2 878,665 0 0
CLOROX CO DEL COM 189054109 6,061 27,856 SH   DFND 1, 2 18,194 0 9,662
CLOUDERA INC COM 18914U100 3,770 296,400 SH   DFND 1, 2 296,400 0 0
CLOVIS ONCOLOGY INC COM 189464100 803 119,000 SH   DFND 1, 2 119,000 0 0
COCA COLA CO COM 191216100 640,812 14,343,845 SH   DFND 1, 2 14,242,318 0 101,527
COLGATE PALMOLIVE CO COM 194162103 72,973 996,081 SH   DFND 1, 2 996,081 0 0
COMCAST CORP NEW CL A 20030N101 7,246,730 185,909,690 SH   DFND 1, 2 185,332,708 0 576,982
CONCHO RES INC COM 20605P101 534,281 10,374,571 SH   DFND 1, 2 10,368,525 0 6,046
CONOCOPHILLIPS COM 20825C104 1,133,379 26,973,826 SH   DFND 1, 2 26,900,896 0 72,930
CONSTELLATION BRANDS INC CL A 21036P108 142,012 811,729 SH   DFND 1, 2 811,729 0 0
CORTEXYME INC COM 22053A107 82,531 1,782,519 SH   DFND 1, 2 1,782,519 0 0
COSTCO WHSL CORP NEW COM 22160K105 1,518,508 5,008,518 SH   DFND 1, 2 4,944,316 0 64,202
COUSINS PPTYS INC COM NEW 222795502 14,597 489,353 SH   DFND 1, 2 489,353 0 0
COVANTA HLDG CORP COM 22282E102 19,370 2,019,800 SH   DFND 1, 2 2,019,800 0 0
CREE INC COM 225447101 210,959 3,564,098 SH   DFND 1, 2 3,564,098 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 2,426,184 14,506,966 SH   DFND 1, 2 14,325,618 0 181,348
CROWN CASTLE INTL CORP NEW 6.875% CON PFD A 22822V309 99,694 67,121 SH   DFND 1, 2 67,121 0 0
CRYOLIFE INC COM 228903100 4,451 232,174 SH   DFND 1, 2 232,174 0 0
CUMMINS INC COM 231021106 72,301 417,298 SH   DFND 1, 2 417,298 0 0
DANAHER CORPORATION COM 235851102 1,169,598 6,616,796 SH   DFND 1, 2 6,534,102 0 82,694
DARDEN RESTAURANTS INC COM 237194105 367,556 4,850,944 SH   DFND 1, 2 4,850,879 0 65
DEERE & CO COM 244199105 1,230,085 7,828,685 SH   DFND 1, 2 7,783,415 0 45,270
DEL TACO RESTAURANTS INC NEW COM 245496104 8,529 1,438,200 SH   DFND 1, 2 1,438,200 0 0
DEXCOM INC COM 252131107 67,324 166,067 SH   DFND 1, 2 166,067 0 0
DIAGEO P L C SPON ADR NEW 25243Q205 76,902 573,640 SH   DFND 1, 2 319,621 0 254,019
DIGITAL RLTY TR INC COM 253868103 795,481 5,598,529 SH   DFND 1, 2 5,574,553 0 23,976
DOMINOS PIZZA INC COM 25754A201 7,241 19,600 SH   DFND 1, 2 19,600 0 0
DOW INC COM 260557103 1,548,253 37,984,011 SH   DFND 1, 2 37,927,657 0 56,354
DUPONT DE NEMOURS INC COM 26614N102 210,806 3,967,735 SH   DFND 1, 2 3,967,735 0 0
EOG RES INC COM 26875P101 2,630,253 51,921,884 SH   DFND 1, 2 51,828,786 0 93,098
EAST WEST BANCORP INC COM 27579R104 410,850 11,342,022 SH   DFND 1, 2 11,276,531 0 65,491
EATON VANCE CORP COM NON VTG 278265103 42,072 1,089,955 SH   DFND 1, 2 1,089,955 0 0
EDISON INTL COM 281020107 847,152 15,596,241 SH   DFND 1, 2 15,554,682 0 41,559
EDWARDS LIFESCIENCES CORP COM 28176E108 1,123,589 16,259,416 SH   DFND 1, 2 16,190,053 0 69,363
ELECTRONIC ARTS INC COM 285512109 79,500 602,089 SH   DFND 1, 2 601,678 0 411
ENBRIDGE INC COM 29250N105 2,988,626 98,269,285 SH   DFND 1, 2 97,573,706 0 695,579
ENDAVA PLC ADS 29260V105 15,562 322,200 SH   DFND 1, 2 322,200 0 0
EPAM SYS INC COM 29414B104 81,112 321,860 SH   DFND 1, 2 321,860 0 0
EQUIFAX INC COM 294429105 1,462,144 8,506,874 SH   DFND 1, 2 8,502,768 0 4,106
EQUINIX INC COM 29444U700 1,615,906 2,301,630 SH   DFND 1, 2 2,273,157 0 28,473
EQUITRANS MIDSTREAM CORP COM 294600101 304,010 36,585,360 SH   DFND 1, 2 36,422,847 0 162,513
EURONET WORLDWIDE INC COM 298736109 81,312 848,590 SH   DFND 1, 2 848,590 0 0
EVERTEC INC COM 30040P103 20,848 741,912 SH   DFND 1, 2 741,912 0 0
EXELON CORP COM 30161N101 1,064,583 29,337,367 SH   DFND 1, 2 29,196,696 0 140,671
EXTRA SPACE STORAGE INC COM 30225T102 151,185 1,636,734 SH   DFND 1, 2 1,636,734 0 0
FTI CONSULTING INC COM 302941109 45,236 394,900 SH   DFND 1, 2 394,900 0 0
FACEBOOK INC CL A 30303M102 11,735,331 51,683,693 SH   DFND 1, 2 51,620,543 0 63,150
FAIR ISAAC CORP COM 303250104 12,165 29,100 SH   DFND 1, 2 29,100 0 0
FEDEX CORP COM 31428X106 106,613 760,329 SH   DFND 1, 2 760,329 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 862,131 8,134,084 SH   DFND 1, 2 8,132,862 0 1,222
FISERV INC COM 337738108 240,543 2,464,097 SH   DFND 1, 2 2,460,894 0 3,203
FLEETCOR TECHNOLOGIES INC COM 339041105 785,155 3,121,516 SH   DFND 1, 2 3,121,516 0 0
FORTIS INC COM 349553107 357 9,400 SH   DFND 1, 2 9,400 0 0
FOX CORP CL A COM 35137L105 12,704 473,666 SH   DFND 1, 2 473,666 0 0
FRANCO NEV CORP COM 351858105 44,837 321,091 SH   DFND 1, 2 321,091 0 0
GCI LIBERTY INC COM CLASS A 36164V305 59,165 831,901 SH   DFND 1, 2 831,901 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 4,136 33,700 SH   DFND 1, 2 33,700 0 0
GALAPAGOS NV SPON ADR 36315X101 43,304 220,321 SH   DFND 1, 2 134,779 0 85,542
GALLAGHER ARTHUR J & CO COM 363576109 369,317 3,788,254 SH   DFND 1, 2 3,788,124 0 130
GAMING & LEISURE PPTYS INC COM 36467J108 250,059 7,227,495 SH   DFND 1, 2 7,156,603 0 70,892
GENERAC HLDGS INC COM 368736104 98,909 811,197 SH   DFND 1, 2 811,197 0 0
GENERAL DYNAMICS CORP COM 369550108 185,246 1,239,434 SH   DFND 1, 2 1,239,434 0 0
GENERAL MLS INC COM 370334104 715,779 11,610,366 SH   DFND 1, 2 11,610,366 0 0
GENMAB A/S SPONSORED ADS 372303206 84,887 2,599,924 SH   DFND 1, 2 1,508,798 0 1,091,126
GERDAU SA SPON ADR REP PFD 373737105 377,021 127,372,056 SH   DFND 1, 2 127,372,056 0 0
GILEAD SCIENCES INC COM 375558103 4,395,771 57,143,147 SH   DFND 1, 2 56,902,066 0 241,081
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 768,009 18,828,643 SH   DFND 1, 2 18,726,506 0 102,137
GLOBAL PMTS INC COM 37940X102 1,019,142 6,009,943 SH   DFND 1, 2 5,938,816 0 71,127
GODADDY INC CL A 380237107 665,872 9,082,621 SH   DFND 1, 2 8,913,646 0 168,975
GOL LINHAS AEREAS INTELIGENT SPON ADR PFD NEW 38045R206 7,093 1,046,096 SH   DFND 1, 2 1,046,096 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 899,535 4,551,841 SH   DFND 1, 2 4,551,841 0 0
GOSSAMER BIO INC COM 38341P102 67,053 5,157,951 SH   DFND 1, 2 5,157,951 0 0
GRACO INC COM 384109104 20,156 420,000 SH   DFND 1, 2 420,000 0 0
GRIFOLS S A SP ADR REP B NVT 398438408 24,761 1,337,790 SH   DFND 1, 2 975,390 0 362,400
GROCERY OUTLET HLDG CORP COM 39874R101 126,104 3,090,776 SH   DFND 1, 2 3,090,776 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 25,555 560,584 SH   DFND 1, 2 384,614 0 175,970
HALLIBURTON CO COM 406216101 11,945 920,282 SH   DFND 1, 2 920,282 0 0
HASBRO INC COM 418056107 84,361 1,125,565 SH   DFND 1, 2 1,125,439 0 126
HEALTH CATALYST INC COM 42225T107 35,698 1,223,800 SH   DFND 1, 2 1,223,800 0 0
HEICO CORP NEW COM 422806109 107,254 1,076,303 SH   DFND 1, 2 1,075,993 0 310
HEICO CORP NEW CL A 422806208 57,470 706,819 SH   DFND 1, 2 668,761 0 38,058
HENRY JACK & ASSOC INC COM 426281101 136,501 743,901 SH   DFND 1, 2 611,671 0 132,230
HESS CORP COM 42809H107 456,032 8,802,001 SH   DFND 1, 2 8,802,001 0 0
HILTON GRAND VACATIONS INC COM 43283X105 131,528 6,727,775 SH   DFND 1, 2 6,727,775 0 0
HILTON WORLDWIDE HLDGS INC COM 43300A203 324,594 4,419,170 SH   DFND 1, 2 4,412,896 0 6,274
HOME DEPOT INC COM 437076102 68,023 271,537 SH   DFND 1, 2 271,537 0 0
HONEYWELL INTL INC COM 438516106 2,517 17,407 SH   DFND 1, 2 17,220 0 187
HORMEL FOODS CORP COM 440452100 590,367 12,230,375 SH   DFND 1, 2 12,141,268 0 89,107
HUAZHU GROUP LTD SPONSORED ADS 44332N106 26,644 760,158 SH   DFND 1, 2 760,158 0 0
HUBSPOT INC COM 443573100 320,804 1,429,925 SH   DFND 1, 2 1,429,925 0 0
HUMANA INC COM 444859102 2,506,875 6,465,741 SH   DFND 1, 2 6,442,628 0 23,113
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 115,238 4,167,563 SH   DFND 1, 2 3,865,287 0 302,276
HUYA INC ADS REP SHS A 44852D108 48,107 2,576,716 SH   DFND 1, 2 2,576,716 0 0
ICICI BANK LIMITED ADR 45104G104 263,544 28,371,464 SH   DFND 1, 2 28,214,899 0 156,565
IDEXX LABS INC COM 45168D104 63,396 192,015 SH   DFND 1, 2 192,015 0 0
INARI MED INC COM 45332Y109 21,798 450,000 SH   DFND 1, 2 450,000 0 0
INCYTE CORP COM 45337C102 936,702 9,009,420 SH   DFND 1, 2 9,004,423 0 4,997
INFOSYS LTD SPONSORED ADR 456788108 159,826 16,546,241 SH   DFND 1, 2 16,429,757 0 116,484
INSULET CORP COM 45784P101 57,960 298,361 SH   DFND 1, 2 298,361 0 0
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 9,078 193,200 SH   DFND 1, 2 193,200 0 0
INTEL CORP COM 458140100 6,621,501 110,686,080 SH   DFND 1, 2 110,322,894 0 363,186
INTERCONTINENTAL EXCHANGE IN COM 45866F104 2,055,010 22,437,383 SH   DFND 1, 2 22,263,160 0 174,223
INTERNATIONAL FLAVORS&FRAGRA COM 459506101 464,654 3,794,334 SH   DFND 1, 2 3,793,977 0 357
INTUIT COM 461202103 32,673 110,312 SH   DFND 1, 2 110,312 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 38,018 66,719 SH   DFND 1, 2 66,719 0 0
IRIDIUM COMMUNICATIONS INC COM 46269C102 121,988 4,795,145 SH   DFND 1, 2 4,795,145 0 0
ISHARES TR MSCI EAFE ETF 464287465 1,970 32,304 SH   DFND 1, 2 32,304 0 0
JPMORGAN CHASE & CO COM 46625H100 2,976,875 31,651,662 SH   DFND 1, 2 31,444,995 0 206,667
JOHNSON & JOHNSON COM 478160104 2,565,496 18,243,094 SH   DFND 1, 2 18,227,015 0 16,079
KLA CORP COM NEW 482480100 1,691,700 8,699,303 SH   DFND 1, 2 8,669,906 0 29,397
KKR & CO INC COM 48251W104 703,112 22,769,159 SH   DFND 1, 2 22,769,159 0 0
KT CORP SPONSORED ADR 48268K101 99,238 10,190,241 SH   DFND 1, 2 10,016,396 0 173,845
KARUNA THERAPEUTICS INC COM 48576A100 52,899 474,600 SH   DFND 1, 2 474,600 0 0
KEURIG DR PEPPER INC COM 49271V100 1,030,648 36,290,424 SH   DFND 1, 2 36,289,175 0 1,249
KEYCORP COM 493267108 429,409 35,255,226 SH   DFND 1, 2 35,255,226 0 0
KONINKLIJKE PHILIPS N V NY REG SH NEW 500472303 57,598 1,231,438 SH   DFND 1, 2 667,997 0 563,441
KRAFT HEINZ CO COM 500754106 225,564 7,073,200 SH   DFND 1, 2 7,073,200 0 0
KRATOS DEFENSE & SEC SOLUTIO COM NEW 50077B207 48,710 3,116,442 SH   DFND 1, 2 3,116,442 0 0
L3HARRIS TECHNOLOGIES INC COM 502431109 867,643 5,113,693 SH   DFND 1, 2 5,113,439 0 254
LAMAR ADVERTISING CO NEW CL A 512816109 107,747 1,613,949 SH   DFND 1, 2 1,613,949 0 0
LAMB WESTON HLDGS INC COM 513272104 236,261 3,695,627 SH   DFND 1, 2 3,695,226 0 401
LAS VEGAS SANDS CORP COM 517834107 161,759 3,556,227 SH   DFND 1, 2 3,425,073 0 131,154
LAUDER ESTEE COS INC CL A 518439104 327,681 1,737,416 SH   DFND 1, 2 1,699,369 0 38,047
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 29,519 693,588 SH   DFND 1, 2 693,588 0 0
LIBERTY BROADBAND CORP COM SER C 530307305 29,339 236,682 SH   DFND 1, 2 236,682 0 0
LILLY ELI & CO COM 532457108 3,477,370 21,181,307 SH   DFND 1, 2 21,107,662 0 73,645
LIVERAMP HLDGS INC COM 53815P108 144,039 3,391,541 SH   DFND 1, 2 3,391,541 0 0
LIVONGO HEALTH INC COM 539183103 12,985 172,700 SH   DFND 1, 2 172,700 0 0
LOCKHEED MARTIN CORP COM 539830109 893,845 2,449,353 SH   DFND 1, 2 2,445,979 0 3,374
LOMA NEGRA CORP SPONSORED ADS 54150E104 35,674 8,374,187 SH   DFND 1, 2 8,374,187 0 0
MKS INSTRS INC COM 55306N104 428,533 3,784,288 SH   DFND 1, 2 3,784,288 0 0
MSCI INC COM 55354G100 331,411 993,219 SH   DFND 1, 2 978,422 0 14,797
MANULIFE FINL CORP COM 56501R106 151 11,100 SH   DFND 1, 2 11,100 0 0
MARKETAXESS HLDGS INC COM 57060D108 89,114 177,900 SH   DFND 1, 2 177,900 0 0
MARSH & MCLENNAN COS INC COM 571748102 2,333,954 21,742,620 SH   DFND 1, 2 21,516,028 0 226,592
MARRIOTT INTL INC NEW CL A 571903202 169,990 1,982,854 SH   DFND 1, 2 1,982,854 0 0
MASTERCARD INCORPORATED CL A 57636Q104 1,037,351 3,508,121 SH   DFND 1, 2 3,507,999 0 122
MATTEL INC COM 577081102 38,111 3,941,175 SH   DFND 1, 2 3,941,175 0 0
MAXIM INTEGRATED PRODS INC COM 57772K101 223,250 3,683,390 SH   DFND 1, 2 3,683,390 0 0
MERCADOLIBRE INC COM 58733R102 630,754 640,084 SH   DFND 1, 2 616,849 0 23,235
MERCK & CO. INC COM 58933Y105 2,787,262 36,046,496 SH   DFND 1, 2 35,923,805 0 122,691
METTLER TOLEDO INTERNATIONAL COM 592688105 265,827 329,995 SH   DFND 1, 2 329,995 0 0
MICROSOFT CORP COM 594918104 19,984,854 98,209,725 SH   DFND 1, 2 97,938,056 0 271,669
MICRON TECHNOLOGY INC COM 595112103 927,037 17,994,036 SH   DFND 1, 2 17,987,823 0 6,213
MOLINA HEALTHCARE INC COM 60855R100 120,753 678,462 SH   DFND 1, 2 678,462 0 0
MOLSON COORS BEVERAGE CO CL B 60871R209 99,847 2,905,904 SH   DFND 1, 2 2,905,904 0 0
MONDELEZ INTL INC CL A 609207105 1,144,931 22,393,662 SH   DFND 1, 2 22,309,853 0 83,809
MONGODB INC CL A 60937P106 237,557 1,049,560 SH   DFND 1, 2 1,049,560 0 0
MOODYS CORP COM 615369105 1,460,118 5,316,086 SH   DFND 1, 2 5,262,006 0 54,080
MOSAIC CO NEW COM 61945C103 61,644 4,927,562 SH   DFND 1, 2 4,927,562 0 0
MURPHY OIL CORP COM 626717102 281,548 20,402,044 SH   DFND 1, 2 20,402,044 0 0
NASDAQ INC COM 631103108 239,471 2,004,441 SH   DFND 1, 2 2,004,373 0 68
NETAPP INC COM 64110D104 1,191,622 26,857,101 SH   DFND 1, 2 26,829,979 0 27,122
NETFLIX INC COM 64110L106 6,887,840 15,137,030 SH   DFND 1, 2 15,124,240 0 12,790
NEUROCRINE BIOSCIENCES INC COM 64125C109 743,924 6,096,396 SH   DFND 1, 2 6,056,033 0 40,363
NEWELL BRANDS INC COM 651229106 18,068 1,137,800 SH   DFND 1, 2 1,137,800 0 0
NEWMONT CORP COM 651639106 71,943 1,165,254 SH   DFND 1, 2 1,165,254 0 0
NEXTERA ENERGY INC COM 65339F101 321,670 1,339,352 SH   DFND 1, 2 1,338,201 0 1,151
NEXTERA ENERGY INC UNIT 09/01/2022S 65339F796 59,474 1,225,266 SH   DFND 1, 2 1,225,266 0 0
NIKE INC CL B 654106103 712,620 7,270,310 SH   DFND 1, 2 7,177,332 0 92,978
NOBLE ENERGY INC COM 655044105 370,951 41,400,793 SH   DFND 1, 2 41,400,793 0 0
NORFOLK SOUTHERN CORP COM 655844108 1,071,617 6,103,741 SH   DFND 1, 2 6,097,850 0 5,891
NORTHROP GRUMMAN CORP COM 666807102 5,012,761 16,304,392 SH   DFND 1, 2 16,230,921 0 73,471
NOVARTIS AG SPONSORED ADR 66987V109 65,270 747,346 SH   DFND 1, 2 630,637 0 116,709
NOVANTA INC COM 67000B104 35,800 335,300 SH   DFND 1, 2 335,300 0 0
NOVO-NORDISK A S ADR 670100205 313,055 4,777,814 SH   DFND 1, 2 3,638,548 0 1,139,266
NUCANA PLC SPONSORED ADR 67022C106 18,210 3,372,153 SH   DFND 1, 2 3,372,153 0 0
NUCOR CORP COM 670346105 75,983 1,834,901 SH   DFND 1, 2 1,834,901 0 0
NUTRIEN LTD COM 67077M108 104,746 3,257,263 SH   DFND 1, 2 3,112,908 0 144,355
OKTA INC CL A 679295105 1,101 5,500 SH   DFND 1, 2 5,500 0 0
OLD DOMINION FREIGHT LINE IN COM 679580100 452,819 2,670,080 SH   DFND 1, 2 2,670,080 0 0
ON SEMICONDUCTOR CORP COM 682189105 371,123 18,724,687 SH   DFND 1, 2 18,724,687 0 0
ONECONNECT FINL TECHNOLOGY C SPONSORED ADS 68248T105 27,130 1,485,734 SH   DFND 1, 2 1,485,734 0 0
OTIS WORLDWIDE CORP COM 68902V107 63,934 1,124,416 SH   DFND 1, 2 1,124,416 0 0
PG&E CORP COM 69331C108 147,214 16,596,801 SH   DFND 1, 2 16,596,801 0 0
PNC FINL SVCS GROUP INC COM 693475105 1,592,614 15,139,015 SH   DFND 1, 2 15,108,357 0 30,658
PPG INDS INC COM 693506107 485,641 4,578,927 SH   DFND 1, 2 4,578,927 0 0
PPL CORP COM 69351T106 13,518 523,133 SH   DFND 1, 2 523,133 0 0
PACCAR INC COM 693718108 195,442 2,611,114 SH   DFND 1, 2 2,611,114 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 23,447 6,796,300 SH   DFND 1, 2 6,796,300 0 0
PARK HOTELS RESORTS INC COM 700517105 8,518 861,300 SH   DFND 1, 2 861,300 0 0
PAYCHEX INC COM 704326107 722,094 9,533,899 SH   DFND 1, 2 9,517,215 0 16,684
PAYCOM SOFTWARE INC COM 70432V102 98,896 319,297 SH   DFND 1, 2 319,297 0 0
PAYPAL HLDGS INC COM 70450Y103 119,218 684,259 SH   DFND 1, 2 684,259 0 0
PEBBLEBROOK HOTEL TR COM 70509V100 8,652 633,400 SH   DFND 1, 2 633,400 0 0
PEMBINA PIPELINE CORP COM 706327103 208 8,317 SH   DFND 1, 2 8,317 0 0
PEPSICO INC COM 713448108 377,808 2,856,896 SH   DFND 1, 2 2,824,387 0 32,509
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408 78,908 9,541,437 SH   DFND 1, 2 9,541,437 0 0
PFIZER INC COM 717081103 208,312 6,370,407 SH   DFND 1, 2 6,370,407 0 0
PHILIP MORRIS INTL INC COM 718172109 3,586,235 51,185,974 SH   DFND 1, 2 50,978,616 0 207,358
PHREESIA INC COM 71944F106 26,743 945,659 SH   DFND 1, 2 945,659 0 0
PINTEREST INC CL A 72352L106 298,641 13,470,519 SH   DFND 1, 2 13,470,519 0 0
PIONEER NAT RES CO COM 723787107 698,588 7,150,731 SH   DFND 1, 2 7,138,908 0 11,823
POOL CORPORATION COM 73278L105 18,732 68,900 SH   DFND 1, 2 68,900 0 0
PROCTER AND GAMBLE CO COM 742718109 519,776 4,348,057 SH   DFND 1, 2 4,293,063 0 54,994
PUBLIC SVC ENTERPRISE GRP IN COM 744573106 226,226 4,601,832 SH   DFND 1, 2 4,601,832 0 0
PUBLIC STORAGE COM 74460D109 476,442 2,483,028 SH   DFND 1, 2 2,471,538 0 11,490
QUALCOMM INC COM 747525103 625,405 6,860,131 SH   DFND 1, 2 6,811,242 0 48,889
RAYTHEON TECHNOLOGIES CORP COM 75513E101 1,787,715 29,011,767 SH   DFND 1, 2 29,000,366 0 11,401
REALPAGE INC COM 75606N109 92,934 1,429,530 SH   DFND 1, 2 1,429,530 0 0
REGENERON PHARMACEUTICALS COM 75886F107 979,426 1,570,474 SH   DFND 1, 2 1,570,474 0 0
RELX PLC SPONSORED ADR 759530108 289,968 12,299,776 SH   DFND 1, 2 11,089,009 0 1,210,767
REVANCE THERAPEUTICS INC COM 761330109 28,374 1,161,900 SH   DFND 1, 2 1,161,900 0 0
RINGCENTRAL INC CL A 76680R206 831,937 2,918,976 SH   DFND 1, 2 2,918,976 0 0
ROSS STORES INC COM 778296103 20,140 236,279 SH   DFND 1, 2 236,279 0 0
ROYAL DUTCH SHELL PLC SPON ADR B 780259107 143,214 4,702,358 SH   DFND 1, 2 4,672,153 0 30,205
ROYAL DUTCH SHELL PLC SPONS ADR A 780259206 1,024 31,328 SH   DFND 1, 2 31,328 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 2,490 416,396 SH   DFND 1, 2 416,396 0 0
RYANAIR HOLDINGS PLC SPONSORED ADS 783513203 340,491 5,131,108 SH   DFND 1, 2 5,070,313 0 60,795
S&P GLOBAL INC COM 78409V104 1,264,114 3,836,707 SH   DFND 1, 2 3,836,461 0 246
SVB FINANCIAL GROUP COM 78486Q101 391,967 1,818,618 SH   DFND 1, 2 1,818,618 0 0
SVMK INC COM 78489X103 269,141 11,433,351 SH   DFND 1, 2 11,433,351 0 0
SABRE CORP COM 78573M104 2,993 371,400 SH   DFND 1, 2 371,400 0 0
SAGE THERAPEUTICS INC COM 78667J108 18,100 435,311 SH   DFND 1, 2 435,311 0 0
SAIA INC COM 78709Y105 41,715 375,200 SH   DFND 1, 2 375,200 0 0
SANDSTORM GOLD LTD COM NEW 80013R206 13,096 1,361,300 SH   DFND 1, 2 1,361,300 0 0
SAP SE SPON ADR 803054204 218,666 1,570,719 SH   DFND 1, 2 1,241,090 0 329,629
SAREPTA THERAPEUTICS INC COM 803607100 24,311 151,623 SH   DFND 1, 2 151,623 0 0
SCHLUMBERGER LTD COM 806857108 531,488 28,901,373 SH   DFND 1, 2 28,880,664 0 20,709
SCHRODINGER INC COM 80810D103 28,432 310,500 SH   DFND 1, 2 310,500 0 0
SEATTLE GENETICS INC COM 812578102 3,175,849 18,697,224 SH   DFND 1, 2 18,521,118 0 176,106
SEMPRA ENERGY COM 816851109 2,131,761 18,183,736 SH   DFND 1, 2 18,119,988 0 63,748
SEMPRA ENERGY 6% PFD CONV A 816851406 277,166 2,836,033 SH   DFND 1, 2 2,836,033 0 0
SERVICENOW INC COM 81762P102 1,474,792 3,641,245 SH   DFND 1, 2 3,629,474 0 11,771
SHERWIN WILLIAMS CO COM 824348106 375,108 649,144 SH   DFND 1, 2 649,115 0 29
SHOPIFY INC CL A 82509L107 213,236 224,648 SH   DFND 1, 2 224,648 0 0
SILK RD MED INC COM 82710M100 13,430 320,600 SH   DFND 1, 2 320,600 0 0
SMARTSHEET INC COM CL A 83200N103 127,662 2,507,111 SH   DFND 1, 2 2,507,111 0 0
SOUTH ST CORP COM 840441109 11,289 236,866 SH   DFND 1, 2 236,866 0 0
STAAR SURGICAL CO COM PAR $0.01 852312305 118,058 1,918,400 SH   DFND 1, 2 1,918,400 0 0
STATE STR CORP COM 857477103 839,651 13,214,062 SH   DFND 1, 2 13,169,671 0 44,391
STERICYCLE INC COM 858912108 5,766 103,000 SH   DFND 1, 2 103,000 0 0
STMICROELECTRONICS N V NY REGISTRY 861012102 3,384 126,521 SH   DFND 1, 2 586 0 125,935
STURM RUGER & CO INC COM 864159108 27,192 357,788 SH   DFND 1, 2 357,788 0 0
SUN LIFE FINANCIAL INC. COM 866796105 283 7,700 SH   DFND 1, 2 7,700 0 0
SUNCOR ENERGY INC NEW COM 867224107 603,250 35,778,586 SH   DFND 1, 2 35,778,586 0 0
SYNNEX CORP COM 87162W100 150,866 1,259,631 SH   DFND 1, 2 1,259,631 0 0
SYSCO CORP COM 871829107 194,233 3,553,470 SH   DFND 1, 2 3,553,470 0 0
TFI INTL INC COM 87241L109 468 13,300 SH   DFND 1, 2 13,300 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 2,069,105 36,464,609 SH   DFND 1, 2 35,404,602 0 1,060,007
TC ENERGY CORP COM 87807B107 1,166,217 27,258,974 SH   DFND 1, 2 27,188,371 0 70,603
TELADOC HEALTH INC COM 87918A105 103,054 540,000 SH   DFND 1, 2 540,000 0 0
TELUS CORPORATION COM 87971M103 401 23,908 SH   DFND 1, 2 23,908 0 0
TERADATA CORP DEL COM 88076W103 25,974 1,248,757 SH   DFND 1, 2 1,248,757 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 252,875 20,508,958 SH   DFND 1, 2 20,508,958 0 0
TEXAS INSTRS INC COM 882508104 98,433 775,722 SH   DFND 1, 2 765,676 0 10,046
THERMO FISHER SCIENTIFIC INC COM 883556102 694,424 1,916,532 SH   DFND 1, 2 1,915,566 0 966
TORONTO DOMINION BK ONT COM NEW 891160509 104,674 2,346,426 SH   DFND 1, 2 2,346,426 0 0
TOTAL S.A. SPONSORED ADS 89151E109 19,253 494,946 SH   DFND 1, 2 308,504 0 186,442
TRADEWEB MKTS INC CL A 892672106 9,093 156,400 SH   DFND 1, 2 156,400 0 0
TRANSDIGM GROUP INC COM 893641100 2,299,521 5,201,854 SH   DFND 1, 2 5,181,527 0 20,327
TRAVELERS COMPANIES INC COM 89417E109 1,428,213 12,522,696 SH   DFND 1, 2 12,522,696 0 0
TRIMBLE INC COM 896239100 1,028,635 23,816,678 SH   DFND 1, 2 23,802,208 0 14,470
TRINITY INDS INC COM 896522109 186,774 8,774,802 SH   DFND 1, 2 8,712,974 0 61,828
TRIP COM GROUP LTD ADS 89677Q107 226,626 8,743,223 SH   DFND 1, 2 8,733,489 0 9,734
TRUIST FINL CORP COM 89832Q109 3,086,813 82,214,580 SH   DFND 1, 2 81,976,214 0 238,366
TWILIO INC CL A 90138F102 128,647 586,306 SH   DFND 1, 2 586,306 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 475,979 6,085,132 SH   DFND 1, 2 6,085,074 0 58
UNILEVER PLC SPON ADR NEW 904767704 125,194 2,280,992 SH   DFND 1, 2 2,269,088 0 11,904
UNION PAC CORP COM 907818108 1,298,057 7,678,310 SH   DFND 1, 2 7,660,166 0 18,144
UNITEDHEALTH GROUP INC COM 91324P102 5,494,045 18,629,123 SH   DFND 1, 2 18,529,650 0 99,473
UPWORK INC COM 91688F104 91,632 6,345,736 SH   DFND 1, 2 6,345,736 0 0
VAIL RESORTS INC COM 91879Q109 347,898 1,909,951 SH   DFND 1, 2 1,909,951 0 0
VALE S A SPONSORED ADS 91912E105 781,276 75,778,972 SH   DFND 1, 2 75,729,590 0 49,382
VENTAS INC COM 92276F100 95,784 2,615,616 SH   DFND 1, 2 2,615,616 0 0
VERISIGN INC COM 92343E102 774,962 3,746,856 SH   DFND 1, 2 3,746,856 0 0
VERIZON COMMUNICATIONS INC COM 92343V104 2,126,254 38,568,476 SH   DFND 1, 2 38,531,868 0 36,608
VERTEX PHARMACEUTICALS INC COM 92532F100 1,668,456 5,747,509 SH   DFND 1, 2 5,729,851 0 17,658
VIACOMCBS INC CL B 92556H206 70,853 3,038,310 SH   DFND 1, 2 3,038,310 0 0
VICI PPTYS INC COM 925652109 242,665 12,019,072 SH   DFND 1, 2 12,019,072 0 0
VIOMI TECHNOLOGY CO LTD SPONSORED ADS 92762J103 1,988 375,000 SH   DFND 1, 2 375,000 0 0
VIR BIOTECHNOLOGY INC COM 92764N102 44,834 1,094,305 SH   DFND 1, 2 1,094,305 0 0
VISA INC COM CL A 92826C839 4,324,819 22,391,135 SH   DFND 1, 2 22,167,340 0 223,795
VODAFONE GROUP PLC NEW SPONSORED ADR 92857W308 19,561 1,242,355 SH   DFND 1, 2 786,954 0 455,401
WABTEC COM 929740108 554,887 9,638,898 SH   DFND 1, 2 9,550,986 0 87,912
WALGREENS BOOTS ALLIANCE INC COM 931427108 61,120 1,441,847 SH   DFND 1, 2 1,441,847 0 0
WASTE CONNECTIONS INC COM 94106B101 901,113 9,611,852 SH   DFND 1, 2 9,434,696 0 177,156
WASTE MGMT INC DEL COM 94106L109 222,426 2,101,156 SH   DFND 1, 2 2,061,750 0 39,406
WEBSTER FINL CORP CONN COM 947890109 24,364 851,600 SH   DFND 1, 2 851,600 0 0
WELLS FARGO CO NEW COM 949746101 466,008 18,203,446 SH   DFND 1, 2 18,203,446 0 0
WHEATON PRECIOUS METALS CORP COM 962879102 187,660 4,266,743 SH   DFND 1, 2 4,266,743 0 0
WYNDHAM HOTELS & RESORTS INC COM 98311A105 16,622 390,000 SH   DFND 1, 2 390,000 0 0
WYNN RESORTS LTD COM 983134107 321,695 4,318,629 SH   DFND 1, 2 4,318,629 0 0
XCEL ENERGY INC COM 98389B100 760,814 12,173,028 SH   DFND 1, 2 12,167,033 0 5,995
XENON PHARMACEUTICALS INC COM 98420N105 13,239 1,055,726 SH   DFND 1, 2 1,055,726 0 0
YEXT INC COM 98585N106 24,158 1,454,400 SH   DFND 1, 2 1,454,400 0 0
YETI HLDGS INC COM 98585X104 33,359 780,700 SH   DFND 1, 2 780,700 0 0
YUM BRANDS INC COM 988498101 196,594 2,261,988 SH   DFND 1, 2 2,209,455 0 52,533
YUM CHINA HLDGS INC COM 98850P109 83,324 1,733,145 SH   DFND 1, 2 1,719,575 0 13,570
ZEBRA TECHNOLOGIES CORPORATI CL A 989207105 9,291 36,300 SH   DFND 1, 2 36,300 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 174,390 1,461,041 SH   DFND 1, 2 1,461,041 0 0
ZOETIS INC CL A 98978V103 453,097 3,306,339 SH   DFND 1, 2 3,305,963 0 376
AON PLC SHS CL A G0403H108 1,919,850 9,973,278 SH   DFND 1, 2 9,838,866 0 134,412
ARCH CAP GROUP LTD ORD G0450A105 263,715 9,204,707 SH   DFND 1, 2 9,204,707 0 0
AXALTA COATING SYS LTD COM G0750C108 31,561 1,399,600 SH   DFND 1, 2 1,399,600 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 439,392 6,010,015 SH   DFND 1, 2 6,009,935 0 80
ACCENTURE PLC IRELAND SHS CLASS A G1151C101 89,801 418,223 SH   DFND 1, 2 418,180 0 43
BROOKFIELD PROPERTY PARTRS L UNIT LTD PARTN G16249107 28,192 2,850,550 SH   DFND 1, 2 2,850,550 0 0
CREDICORP LTD COM G2519Y108 85,981 643,235 SH   DFND 1, 2 643,235 0 0
COSAN LTD SHS A G25343107 5,437 361,000 SH   DFND 1, 2 361,000 0 0
DESPEGAR COM CORP ORD SHS G27358103 4,176 581,609 SH   DFND 1, 2 581,609 0 0
EVEREST RE GROUP LTD COM G3223R108 353,159 1,712,988 SH   DFND 1, 2 1,707,533 0 5,455
FABRINET SHS G3323L100 13,613 218,080 SH   DFND 1, 2 218,080 0 0
FRESH DEL MONTE PRODUCE INC ORD G36738105 8,166 331,700 SH   DFND 1, 2 331,700 0 0
JOHNSON CTLS INTL PLC SHS G51502105 771,173 22,588,879 SH   DFND 1, 2 22,553,407 0 35,472
LINDE PLC SHS G5494J103 751,156 3,541,457 SH   DFND 1, 2 3,518,324 0 23,133
NEW FRONTIER HEALTH CORP ORD SHS G6461G106 18,145 2,191,400 SH   DFND 1, 2 2,191,400 0 0
NIELSEN HLDGS PLC SHS EUR G6518L108 12,726 856,400 SH   DFND 1, 2 856,400 0 0
NOVOCURE LTD ORD SHS G6674U108 206,820 3,487,688 SH   DFND 1, 2 3,487,688 0 0
RENAISSANCERE HOLDINGS LTD COM G7496G103 196,976 1,151,756 SH   DFND 1, 2 1,151,559 0 197
ROYALTY PHARMA PLC SHS CL A G7709Q104 395,054 8,137,055 SH   DFND 1, 2 8,137,055 0 0
VALARIS PLC SHS CLASS A G9402V109 28 42,745 SH   DFND 1, 2 42,745 0 0
CHUBB LIMITED COM H1467J104 2,832,108 22,367,823 SH   DFND 1, 2 22,271,125 0 96,698
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 40,648 553,115 SH   DFND 1, 2 553,115 0 0
UBS GROUP AG SHS H42097107 337,306 29,358,016 SH   DFND 1, 2 29,355,907 0 2,109
GLOBANT S A COM L44385109 58,821 392,531 SH   DFND 1, 2 392,531 0 0
NEXA RES S A COM L67359106 45,748 6,889,813 SH   DFND 1, 2 6,889,813 0 0
ASML HOLDING N V N Y REGISTRY SHS N07059210 2,688,334 7,307,973 SH   DFND 1, 2 7,119,903 0 188,070
ELASTIC N V ORD SHS N14506104 200,747 2,177,058 SH   DFND 1, 2 2,176,988 0 70
LYONDELLBASELL INDUSTRIES N SHS - A - N53745100 2,010,308 30,589,121 SH   DFND 1, 2 30,577,333 0 11,788
YANDEX N V SHS CLASS A N97284108 301,784 6,033,415 SH   DFND 1, 2 6,023,656 0 9,759
ROYAL CARIBBEAN CRUISES LTD COM V7780T103 237,740 4,726,437 SH   DFND 1, 2 4,656,346 0 70,091
FLEX LTD ORD Y2573F102 179,015 17,464,922 SH   DFND 1, 2 17,464,922 0 0