The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 46,367 519,168 SH   DFND   0 0 519,168
1LIFE HEALTHCARE INC COM 68269G107 88,132 2,426,548 SH   DFND   0 0 2,426,548
2U INC COM 90214J101 2,147 56,564 SH   DFND   0 0 56,564
ABIOMED INC COM 003654100 31,425 130,093 SH   DFND   0 0 130,093
ACCEL ENTERTAINMENT INC COM CL A1 00436Q106 23 2,400 SH   DFND   0 0 2,400
ACTIVISION BLIZZARD INC COM 00507V109 1,563 20,598 SH   DFND   0 0 20,598
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 118,786 2,455,269 SH   DFND   0 0 2,455,269
ADOBE INC COM 00724F101 54,449 125,082 SH   DFND   0 0 125,082
ADYEN NV 144A COM N3501V104 48,658 33,441 SH   DFND   0 0 33,441
AFYA LTD CL A COM G01125106 6,101 260,294 SH   DFND   0 0 260,294
AGORA INC ADS 00851L103 441 9,991 SH   DFND   0 0 9,991
ALAMOS GOLD INC NEW COM CL A 011532108 4,933 525,922 SH   DFND   0 0 525,922
ALASKA COMMUNICATIONS SYS GR COM 01167P101 2,639 946,041 SH   DFND   0 0 946,041
ALECTOR INC COM 014442107 62,504 2,557,462 SH   DFND   0 0 2,557,462
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 83,015 384,862 SH   DFND   0 0 384,862
ALLAKOS INC COM 01671P100 3,218 44,781 SH   DFND   0 0 44,781
ALLOGENE THERAPEUTICS INC COM 019770106 6,873 160,520 SH   DFND   0 0 160,520
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 130,895 883,768 SH   DFND   0 0 883,768
ALPHABET INC CAP STK CL A 02079K305 58,197 41,040 SH   DFND   0 0 41,040
ALPHABET INC CAP STK CL C 02079K107 66,557 47,083 SH   DFND   0 0 47,083
ALTERYX INC COM CL A 02156B103 14,303 87,065 SH   DFND   0 0 87,065
ALTUS MIDSTREAM CO CL A 02215L100 755 1,191,925 SH   DFND   0 0 1,191,925
AMAZON COM INC COM 023135106 452,024 163,847 SH   DFND   0 0 163,847
AMERICAN TOWER CORP NEW COM 03027X100 19,979 77,276 SH   DFND   0 0 77,276
AMICUS THERAPEUTICS INC COM 03152W109 32,068 2,126,511 SH   DFND   0 0 2,126,511
AMYRIS INC COM NEW 03236M200 217 50,718 SH   DFND   0 0 50,718
ANAPLAN INC COM 03272L108 8,668 191,315 SH   DFND   0 0 191,315
ANTERIX INC COM 03676C100 2,745 60,532 SH   DFND   0 0 60,532
APACHE CORP COM 037411105 3,180 235,533 SH   DFND   0 0 235,533
APPFOLIO INC COM CL A 03783C100 74,555 458,205 SH   DFND   0 0 458,205
APPIAN CORP CL A 03782L101 1,275 24,873 SH   DFND   0 0 24,873
APPLE INC COM 037833100 8,726 23,919 SH   DFND   0 0 23,919
APPLIED OPTOELECTRONICS INC COM 03823U102 77 7,050 SH   DFND   0 0 7,050
APTOSE BIOSCIENCES INC COM NEW 03835T200 1 125 SH   DFND   0 0 125
ARCO PLATFORM LTD COM CL A G04553106 12 286 SH   DFND   0 0 286
ARCUS BIOSCIENCES INC COM 03969F109 19,918 805,074 SH   DFND   0 0 805,074
ARENA PHARMACEUTICALS INC COM NEW 040047607 19,829 314,998 SH   DFND   0 0 314,998
ARGENX SE SPONSORED ADR 04016X101 31,602 140,308 SH   DFND   0 0 140,308
ARISTA NETWORKS INC COM 040413106 81,200 386,612 SH   DFND   0 0 386,612
ARITZIA INC SUB VTG SHS ISIN CA04045U1021 SEDOL BDCG2C2 COM 04045U102 9,291 665,699 SH   DFND   0 0 665,699
ARVINAS INC COM 04335A105 48,184 1,436,604 SH   DFND   0 0 1,436,604
ASHTEAD GROUP ORD GBP010 ISIN GB0000536739 SEDOL 0053673 COM G05320109 88,231 2,626,245 SH   DFND   0 0 2,626,245
ATLASSIAN CORP PLC CL A G06242104 34,342 190,505 SH   DFND   0 0 190,505
ATRICURE INC COM 04963C209 46,449 1,033,350 SH   DFND   0 0 1,033,350
AUTO TRADER GROUP PLC ORD GBP001 ISIN GB00BVYVFW23 SEDOL BVYV COM G06708104 2,045 314,377 SH   DFND   0 0 314,377
AUTODESK INC COM 052769106 136,927 572,462 SH   DFND   0 0 572,462
AVIDITY BIOSCIENCES INC COM 05370A108 283 10,000 SH   DFND   0 0 10,000
AXIS BANK GDR EACH REPR 1 INR10 REG S ISIN US05462W1099 SEDOL COM 05462W109 1,792 66,979 SH   DFND   0 0 66,979
AXOGEN INC COM 05463X106 249 26,940 SH   DFND   0 0 26,940
AZEK CO INC CL A 05478C105 8,430 264,601 SH   DFND   0 0 264,601
AZUL S A SPONSR ADR PFD 05501U106 32,065 2,868,072 SH   DFND   0 0 2,868,072
BARCLAYS BK PLC IPTH SR B S&P 06746P621 9,301 273,958 SH   DFND   0 0 273,958
BASICFIT NV 144A REG S ISIN NL0011872650 SEDOL BD9Y9B7 COM N10058100 12 457 SH   DFND   0 0 457
BEAM THERAPEUTICS INC COM 07373V105 2,551 91,105 SH   DFND   0 0 91,105
BENEFYTT TECHNOLOGIES INC COM CL A 08182C106 266 13,010 SH   DFND   0 0 13,010
BERKLEY W R CORP COM 084423102 4,620 80,646 SH   DFND   0 0 80,646
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 569 3,190 SH   DFND   0 0 3,190
BEYOND MEAT INC COM 08862E109 54,560 407,228 SH   DFND   0 0 407,228
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 7,483 102,352 SH   DFND   0 0 102,352
BK OF AMERICA CORP COM 060505104 1 35 SH   DFND   0 0 35
BLUEBIRD BIO INC COM 09609G100 37,385 612,464 SH   DFND   0 0 612,464
BOSTON SCIENTIFIC CORP COM 101137107 778 22,173 SH   DFND   0 0 22,173
BRP GROUP INC COM CL A 05589G102 7,329 424,384 SH   DFND   0 0 424,384
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 58 2,132 SH   DFND   0 0 2,132
CALIX INC COM 13100M509 33,176 2,226,569 SH   DFND   0 0 2,226,569
CARL ZEISS MEDITEC AG NPV ISIN DE0005313704 SEDOL 5922961 COM D14895102 1,135 11,647 SH   DFND   0 0 11,647
CARVANA CO CL A 146869102 178,616 1,485,987 SH   DFND   0 0 1,485,987
CASPER SLEEP INC COM 147626105 102 11,357 SH   DFND   0 0 11,357
CATAPULT GROUP INTERNATIONAL ISIN AU000000CAT9 SEDOL BTL0Y76 COM Q2159P101 145 186,684 SH   DFND   0 0 186,684
CELLNEX TELECOM SAU EUR025 144A REG S ISIN ES0105066007 SEDOL COM E2R41M104 10,264 168,483 SH   DFND   0 0 168,483
CHARLES RIV LABS INTL INC COM 159864107 4,399 25,232 SH   DFND   0 0 25,232
CHART INDS INC COM PAR $0.01 16115Q308 29 607 SH   DFND   0 0 607
CHEGG INC COM 163092109 103,258 1,535,205 SH   DFND   0 0 1,535,205
CHEWY INC CL A 16679L109 12,433 278,205 SH   DFND   0 0 278,205
CHIPOTLE MEXICAN GRILL INC COM 169656105 1 1 SH   DFND   0 0 1
CHUBB LIMITED COM H1467J104 11,285 89,124 SH   DFND   0 0 89,124
CITIGROUP INC COM NEW 172967424 2 35 SH   DFND   0 0 35
CLOUDFLARE INC CL A COM 18915M107 183,365 5,100,558 SH   DFND   0 0 5,100,558
CODEXIS INC COM 192005106 29,054 2,548,574 SH   DFND   0 0 2,548,574
CONTROLADORA VUELA COMP DE A SPON ADR RP 10 21240E105 14,011 2,653,543 SH   DFND   0 0 2,653,543
CORECIVIC INC COM 21871N101 76 8,079 SH   DFND   0 0 8,079
COUPA SOFTWARE INC COM 22266L106 116,850 421,780 SH   DFND   0 0 421,780
COVETRUS INC COM 22304C100 0 8 SH   DFND   0 0 8
CREE INC COM 225447101 897 15,158 SH   DFND   0 0 15,158
CRIMSON WINE GROUP COM USD001 COM 22662X100 370 68,496 SH   DFND   0 0 68,496
CROWDSTRIKE HLDGS INC CL A 22788C105 62,864 626,824 SH   DFND   0 0 626,824
D R HORTON INC COM 23331A109 3,312 59,728 SH   DFND   0 0 59,728
DATADOG INC CL A COM 23804L103 32,663 375,647 SH   DFND   0 0 375,647
DELTA AIR LINES INC DEL COM NEW 247361702 231 8,247 SH   DFND   0 0 8,247
DENALI THERAPEUTICS INC COM 24823R105 81,855 3,385,233 SH   DFND   0 0 3,385,233
DEXCOM INC COM 252131107 204,268 503,868 SH   DFND   0 0 503,868
DIAMONDBACK ENERGY INC COM 25278X109 2,011 48,096 SH   DFND   0 0 48,096
DINE BRANDS GLOBAL INC COM 254423106 982 23,329 SH   DFND   0 0 23,329
DISH NETWORK CORPORATION CL A 25470M109 40,635 1,177,497 SH   DFND   0 0 1,177,497
DISNEY WALT CO COM DISNEY 254687106 3,965 35,553 SH   DFND   0 0 35,553
DOCUSIGN INC COM 256163106 257,997 1,498,153 SH   DFND   0 0 1,498,153
DOWNEY FINL CORP COM 261018105 0 200 SH   DFND   0 0 200
DRAFTKINGS INC COM CL A 26142R104 801 24,070 SH   DFND   0 0 24,070
EHEALTH INC COM 28238P109 24,614 250,549 SH   DFND   0 0 250,549
EIDOS THERAPEUTICS INC COM 28249H104 16,398 343,989 SH   DFND   0 0 343,989
ELASTIC N V ORD SHS N14506104 4,077 44,214 SH   DFND   0 0 44,214
ENPHASE ENERGY INC COM 29355A107 118,548 2,492,066 SH   DFND   0 0 2,492,066
ENTERCOM COMMUNICATIONS CORP CL A 293639100 36 26,326 SH   DFND   0 0 26,326
EPAM SYS INC COM 29414B104 94,527 375,094 SH   DFND   0 0 375,094
EQUATOR EXPLORATION COM STK NPV COM G3084F128 0 215,000 SH   DFND   0 0 215,000
EROS INTL PLC SHS NEW G3788M114 82 25,828 SH   DFND   0 0 25,828
ESPERION THERAPEUTICS INC NE COM 29664W105 58 1,128 SH   DFND   0 0 1,128
ETSY INC COM 29786A106 40,620 382,378 SH   DFND   0 0 382,378
EVEREST RE GROUP LTD COM G3223R108 3,702 17,955 SH   DFND   0 0 17,955
EXACT SCIENCES CORP COM 30063P105 122,153 1,405,026 SH   DFND   0 0 1,405,026
FACEBOOK INC CL A 30303M102 81,849 360,458 SH   DFND   0 0 360,458
FASTLY INC CL A 31188V100 48,095 564,954 SH   DFND   0 0 564,954
FERGUSON PLC ORD GBP010 ISIN JE00BJVNSS43 SEDOL BJVNSS4 COM G3421J106 9,427 115,391 SH   DFND   0 0 115,391
FLEX LNG LTD BM USD010 ISIN BMG359472021 SEDOL BJJMGB2 COM ZZCKKNHC2 365 79,541 SH   DFND   0 0 79,541
FLOOR & DECOR HLDGS INC CL A 339750101 8,804 152,717 SH   DFND   0 0 152,717
FOUR SEAS MERCANTILE HLDGS HKD010 ISIN KYG365451049 SEDOL 634 COM G36545104 79 270,000 SH   DFND   0 0 270,000
FRANCO NEV CORP COM 351858105 10,264 73,501 SH   DFND   0 0 73,501
FRESHPET INC COM 358039105 178,337 2,131,693 SH   DFND   0 0 2,131,693
FRIENDLY ENERGY EXPLORATION COM NPV COM 35846A200 0 690 SH   DFND   0 0 690
GALAPAGOS NV NPV ISIN BE0003818359 SEDOL B07Q2V5 COM B44170106 56,333 286,526 SH   DFND   0 0 286,526
GENERATION BIO CO COM 37148K100 1,486 70,741 SH   DFND   0 0 70,741
GEOPARK LTD USD SHS G38327105 3,696 377,556 SH   DFND   0 0 377,556
GILEAD SCIENCES INC COM 375558103 1,323 17,199 SH   DFND   0 0 17,199
GLAUKOS CORP COM 377322102 34,505 898,094 SH   DFND   0 0 898,094
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 445 7,050 SH   DFND   0 0 7,050
GLOBANT S A COM L44385109 94,891 633,241 SH   DFND   0 0 633,241
GOLDEN MINERALS CO COM 381119106 20 47,017 SH   DFND   0 0 47,017
GOLDMAN SACHS GROUP INC COM 38141G104 78,632 397,897 SH   DFND   0 0 397,897
GRID DYNAMICS HLDGS INC CL A 39813G109 174 25,234 SH   DFND   0 0 25,234
GROCERY OUTLET HLDG CORP COM 39874R101 4,066 99,661 SH   DFND   0 0 99,661
GTT COMMUNICATIONS INC COM 362393100 9,491 1,163,131 SH   DFND   0 0 1,163,131
GUARDANT HEALTH INC COM 40131M109 729 8,988 SH   DFND   0 0 8,988
H & E EQUIPMENT SERVICES INC COM 404030108 2,500 135,303 SH   DFND   0 0 135,303
HDFC BANK LTD SPONSORED ADS 40415F101 6,600 145,186 SH   DFND   0 0 145,186
HEALTHEQUITY INC COM 42226A107 3,824 65,180 SH   DFND   0 0 65,180
HEARUSA INC NEW COM 422360305 0 375 SH   DFND   0 0 375
HEICO CORP NEW CL A 422806208 4,459 54,885 SH   DFND   0 0 54,885
HEICO CORP NEW COM 422806109 2,764 27,735 SH   DFND   0 0 27,735
HELLOFRESH SE SHS ISIN DE000A161408 SEDOL BYWH8S0 COM D3R2MA100 86,078 1,616,870 SH   DFND   0 0 1,616,870
HUBSPOT INC COM 443573100 144,059 642,115 SH   DFND   0 0 642,115
ICICI BANK LIMITED ADR 45104G104 2,980 320,773 SH   DFND   0 0 320,773
IDEXX LABS INC COM 45168D104 3,248 9,838 SH   DFND   0 0 9,838
ILLUMINA INC COM 452327109 6,490 17,524 SH   DFND   0 0 17,524
IMPINJ INC COM 453204109 1,610 58,607 SH   DFND   0 0 58,607
INARI MED INC COM 45332Y109 9,839 203,123 SH   DFND   0 0 203,123
INPHI CORP COM 45772F107 9,436 80,306 SH   DFND   0 0 80,306
INSPIRE MED SYS INC COM 457730109 96,013 1,103,349 SH   DFND   0 0 1,103,349
INSULET CORP COM 45784P101 3,499 18,014 SH   DFND   0 0 18,014
INTERBREW PLC GDREACH REPR 1 A SH REG S COM 45845T308 0 200 SH   DFND   0 0 200
INTL GNRL INSURANCE HLDNGS L SHS G4809J106 13,899 2,014,315 SH   DFND   0 0 2,014,315
INTUITIVE SURGICAL INC COM NEW 46120E602 101,288 177,752 SH   DFND   0 0 177,752
INVITAE CORP COM 46185L103 220,795 7,289,360 SH   DFND   0 0 7,289,360
IRHYTHM TECHNOLOGIES INC COM 450056106 39,865 343,990 SH   DFND   0 0 343,990
JPMORGAN CHASE & CO COM 46625H100 1,594 16,951 SH   DFND   0 0 16,951
KAMBI GROUP PLC EUR0003 ISIN MT0000780107 SEDOL BMNQDC1 COM X4170A107 25 1,118 SH   DFND   0 0 1,118
KB HOME COM 48666K109 263 8,563 SH   DFND   0 0 8,563
KIRKLAND LAKE GOLD LTD COM 49741E100 14,593 353,857 SH   DFND   0 0 353,857
KORNIT DIGITAL LTD SHS M6372Q113 52,218 978,238 SH   DFND   0 0 978,238
KRYSTAL BIOTECH INC COM 501147102 307 7,421 SH   DFND   0 0 7,421
KURA SUSHI USA INC CL A COM 501270102 408 28,562 SH   DFND   0 0 28,562
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 848 19,927 SH   DFND   0 0 19,927
LGI HOMES INC COM 50187T106 98,695 1,121,153 SH   DFND   0 0 1,121,153
LI NING CO LTD HKD01 ISIN KYG5496K1242 SEDOL B01JCK9 COM G5496K124 15 4,621 SH   DFND   0 0 4,621
LIBERTY MEDIA CORP DEL COM A BRAVES GRP 531229706 2,632 131,054 SH   DFND   0 0 131,054
LIBERTY MEDIA CORP DEL COM C BRAVES GRP 531229888 7,107 360,018 SH   DFND   0 0 360,018
LIBERTY MEDIA CORP DEL COM SER C FRMLA 531229854 1,915 60,394 SH   DFND   0 0 60,394
LIVE NATION ENTERTAINMENT IN COM 538034109 12 278 SH   DFND   0 0 278
LIVEPERSON INC COM 538146101 5,310 128,168 SH   DFND   0 0 128,168
LIVONGO HEALTH INC COM 539183103 126,071 1,676,694 SH   DFND   0 0 1,676,694
LOVESAC COMPANY COM 54738L109 746 28,423 SH   DFND   0 0 28,423
LULULEMON ATHLETICA INC COM 550021109 32,648 104,638 SH   DFND   0 0 104,638
LUMENTUM HLDGS INC COM 55024U109 813 9,986 SH   DFND   0 0 9,986
LYFT INC CL A COM 55087P104 1,958 59,321 SH   DFND   0 0 59,321
MAG SILVER CORP COM 55903Q104 20,105 1,425,868 SH   DFND   0 0 1,425,868
MAGENTA THERAPEUTICS INC COM 55910K108 32,546 4,333,703 SH   DFND   0 0 4,333,703
MAGNOLIA OIL & GAS CORP CL A 559663109 3,417 563,884 SH   DFND   0 0 563,884
MARINEMAX INC COM 567908108 2,011 89,824 SH   DFND   0 0 89,824
MARTIN MARIETTA MATLS INC COM 573284106 23,568 114,091 SH   DFND   0 0 114,091
MASTERCARD INCORPORATED CL A 57636Q104 23,803 80,496 SH   DFND   0 0 80,496
MATCH GROUP INC COM 57665R106 94,906 886,562 SH   DFND   0 0 886,562
MAXAR TECHNOLOGIES INC COM 57778K105 18,541 1,032,342 SH   DFND   0 0 1,032,342
MAYVILLE ENGINEERING CO INC COM 578605107 973 123,214 SH   DFND   0 0 123,214
MERCADOLIBRE INC COM 58733R102 146,207 148,318 SH   DFND   0 0 148,318
MGP INGREDIENTS INC NEW COM 55303J106 772 21,030 SH   DFND   0 0 21,030
MICROSOFT CORP COM 594918104 52,210 256,547 SH   DFND   0 0 256,547
MOLECULAR TEMPLATES INC COM 608550109 7,146 518,174 SH   DFND   0 0 518,174
MONGODB INC CL A 60937P106 178,199 787,306 SH   DFND   0 0 787,306
MONOLITHIC PWR SYS INC COM 609839105 10,593 44,695 SH   DFND   0 0 44,695
MYOKARDIA INC COM 62857M105 731 7,562 SH   DFND   0 0 7,562
MYOVANT SCIENCES LTD COM G637AM102 3,786 183,597 SH   DFND   0 0 183,597
NATERA INC COM 632307104 59,248 1,188,281 SH   DFND   0 0 1,188,281
NATIONAL VISION HLDGS INC COM 63845R107 18 603 SH   DFND   0 0 603
NEOPHOTONICS CORP COM 64051T100 604 67,979 SH   DFND   0 0 67,979
NETCOMPANY GROUP AS DKK1 144A ISIN DK0060952919 SEDOL BFYDWS1 COM K7020C102 1,254 19,124 SH   DFND   0 0 19,124
NETFLIX INC COM 64110L106 525,736 1,155,363 SH   DFND   0 0 1,155,363
NEW PACIFIC METALS CORP COM NPV ISIN CA6478241012 SEDOL BF4CP8 COM 647824101 8,747 2,154,287 SH   DFND   0 0 2,154,287
NEW YORK TIMES CO CL A 650111107 121,818 2,898,349 SH   DFND   0 0 2,898,349
NIKE INC CL B 654106103 13,593 138,634 SH   DFND   0 0 138,634
NINTENDO CO LTD ADR8 CNV INTO 1 ORDNPV COM 654445303 262 4,713 SH   DFND   0 0 4,713
NOBLE MIDSTREAM PARTNERS LP COM UNIT REPST 65506L105 8 945 SH   DFND   0 0 945
NORDSTROM INC COM 655664100 19,256 1,243,139 SH   DFND   0 0 1,243,139
NV5 GLOBAL INC COM 62945V109 33 644 SH   DFND   0 0 644
NVIDIA CORPORATION COM 67066G104 67,929 178,804 SH   DFND   0 0 178,804
OCADO GROUP PLC ORD GBP002 ISIN GB00B3MBS747 SEDOL B3MBS74 COM G6718L106 275,000 10,974,557 SH   DFND   0 0 10,974,557
OKTA INC CL A 679295105 323,266 1,614,474 SH   DFND   0 0 1,614,474
ONEWATER MARINE INC CL A COM 68280L101 17,000 700,148 SH   DFND   0 0 700,148
OPTION CARE HEALTH INC COM NEW 68404L201 46,772 3,369,762 SH   DFND   0 0 3,369,762
PAGERDUTY INC COM 69553P100 2,443 85,343 SH   DFND   0 0 85,343
PALOMAR HLDGS INC COM 69753M105 12,566 146,528 SH   DFND   0 0 146,528
PARAMOUNT RESOURCES LIMITED COM NPV CLASS A ISIN CA6993202069 S COM 699320206 118 101,091 SH   DFND   0 0 101,091
PASSAGE BIO INC COM 702712100 1,134 41,487 SH   DFND   0 0 41,487
PAYPAL HLDGS INC COM 70450Y103 29,274 168,017 SH   DFND   0 0 168,017
PDF SOLUTIONS INC COM 693282105 538 27,528 SH   DFND   0 0 27,528
PELOTON INTERACTIVE INC CL A COM 70614W100 213,113 3,688,984 SH   DFND   0 0 3,688,984
PENN NATL GAMING INC COM 707569109 13,694 448,410 SH   DFND   0 0 448,410
PENN TREATY AMERN CORP COM NEW COM 707874400 0 125 SH   DFND   0 0 125
PENSKE AUTOMOTIVE GRP INC COM 70959W103 2,423 62,590 SH   DFND   0 0 62,590
PENUMBRA INC COM 70975L107 344 1,923 SH   DFND   0 0 1,923
PINDUODUO INC SPONSORED ADS 722304102 13,494 157,205 SH   DFND   0 0 157,205
PINTEREST INC CL A 72352L106 302 13,618 SH   DFND   0 0 13,618
POOL CORPORATION COM 73278L105 91,279 335,745 SH   DFND   0 0 335,745
PREVAIL THERAPEUTICS INC COM 74140Y101 0 5 SH   DFND   0 0 5
PROOFPOINT INC COM 743424103 5,145 46,299 SH   DFND   0 0 46,299
PROVENTION BIO INC COM 74374N102 17,655 1,251,260 SH   DFND   0 0 1,251,260
PURPLE INNOVATION INC COM 74640Y106 17,371 965,043 SH   DFND   0 0 965,043
Q2 HLDGS INC COM 74736L109 55,685 649,088 SH   DFND   0 0 649,088
QUANTERIX CORP COM 74766Q101 74,847 2,732,633 SH   DFND   0 0 2,732,633
QUIDEL CORP COM 74838J101 8,527 38,113 SH   DFND   0 0 38,113
QUOTIENT LTD SHS G73268107 3,052 412,415 SH   DFND   0 0 412,415
REDFIN CORP COM 75737F108 3,358 80,117 SH   DFND   0 0 80,117
REECE LIMITED NPV ISIN AU000000REH4 SEDOL 6728801 COM Q80528138 3,253 514,098 SH   DFND   0 0 514,098
REGENERON PHARMACEUTICALS COM 75886F107 4,356 6,985 SH   DFND   0 0 6,985
RENAISSANCERE HOLDINGS LTD COM G7496G103 3,446 20,147 SH   DFND   0 0 20,147
RENALYTIX AI PLC ORD GBP00025 ISIN GB00BYWL4Y04 SEDOL BYWL4Y0 COM G7489R108 1,615 246,582 SH   DFND   0 0 246,582
REPARE THERAPEUTICS INC COM 760273102 115 3,711 SH   DFND   0 0 3,711
REPLIGEN CORP COM 759916109 61,181 494,952 SH   DFND   0 0 494,952
RIGHTMOVE ORD GBP0001 ISIN GB00BGDT3G23 SEDOL BGDT3G2 COM G7565D106 5,871 870,172 SH   DFND   0 0 870,172
RINGCENTRAL INC CL A 76680R206 299,126 1,049,529 SH   DFND   0 0 1,049,529
ROKU INC COM CL A 77543R102 283,087 2,429,306 SH   DFND   0 0 2,429,306
ROYALTY PHARMA PLC SHS CL A G7709Q104 1,460 30,069 SH   DFND   0 0 30,069
SAFARICOM PLC KES005 ISIN KE1000001402 SEDOL B2QN3J6 COM V74587102 25,803 95,960,324 SH   DFND   0 0 95,960,324
SAFETY INS GROUP INC COM 78648T100 354 4,645 SH   DFND   0 0 4,645
SALESFORCE COM INC COM 79466L302 40,179 214,481 SH   DFND   0 0 214,481
SAREPTA THERAPEUTICS INC COM 803607100 144,253 899,671 SH   DFND   0 0 899,671
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TESLA INC COM 88160R101 561,335 519,846 SH   DFND   0 0 519,846
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WORKDAY INC CL A 98138H101 29,850 159,320 SH   DFND   0 0 159,320
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XP INC CL A G98239109 26,955 641,626 SH   DFND   0 0 641,626
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