The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Adobe Inc Common Stock 00724F101 17,616 40,468 SH   SOLE   40,468 0 0
Aerojet Rocketdyne Holdings In Common Stock 007800105 254 6,415 SH   SOLE   6,415 0 0
AeroVironment Inc Common Stock 008073108 11,125 139,712 SH   SOLE   123,626 16,086 0
Alibaba Group Holding Ltd ADR 01609W102 33,122 153,558 SH   SOLE   139,532 13,275 751
Align Technology Inc Common Stock 016255101 585 2,133 SH   SOLE   2,133 0 0
Allegheny Technologies Inc Common Stock 01741R102 52 5,084 SH   SOLE   5,084 0 0
Alphabet Inc Common Stock 02079K107 4,333 3,065 SH   SOLE   3,065 0 0
Altair Engineering Inc Common Stock 021369103 1,811 45,555 SH   SOLE   45,555 0 0
Amazon.com Inc Common Stock 023135106 49,002 17,762 SH   SOLE   17,762 0 0
AMETEK Inc Common Stock 031100100 453 5,073 SH   SOLE   5,073 0 0
ANSYS Inc Common Stock 03662Q105 5,260 18,032 SH   SOLE   18,032 0 0
Apple Inc Common Stock 037833100 37,804 103,630 SH   SOLE   103,630 0 0
AquaBounty Technologies Inc Common Stock 03842K200 3,616 1,122,985 SH   SOLE   1,122,985 0 0
Arcturus Therapeutics Holdings Common Stock 03969T109 89,686 1,918,835 SH   SOLE   1,918,835 0 0
Autodesk Inc Common Stock 052769106 81,293 339,868 SH   SOLE   250,903 60,932 28,033
Baidu Inc ADR 056752108 5,188 43,272 SH   SOLE   43,272 0 0
Renishaw PLC Common Stock G75006117 1,981 39,764 SH   SOLE   39,764 0 0
CareDx Inc Common Stock 14167L103 45,191 1,275,502 SH   SOLE   1,275,502 0 0
Carpenter Technology Corp Common Stock 144285103 51 2,085 SH   SOLE   2,085 0 0
Castle Biosciences Inc Common Stock 14843C105 17,856 473,770 SH   SOLE   473,770 0 0
Cellectis SA ADR 15117K103 49,472 2,779,327 SH   SOLE   2,440,665 321,127 17,535
Cellular Biomedicine Group Inc Common Stock 15117P102 9,007 601,653 SH   SOLE   601,653 0 0
Cerus Corp Common Stock 157085101 143,606 21,758,435 SH   SOLE   19,144,634 616,222 1,997,579
Codexis Inc Common Stock 192005106 11,402 1,000,168 SH   SOLE   1,000,168 0 0
Deere & Co Common Stock 244199105 6,973 44,373 SH   SOLE   44,373 0 0
DuPont de Nemours Inc Common Stock 26614N102 56 1,060 SH   SOLE   1,060 0 0
Eastman Chemical Co Common Stock 277432100 51 734 SH   SOLE   734 0 0
Eastman Kodak Co Common Stock 277461406 41 18,332 SH   SOLE   18,332 0 0
Editas Medicine Inc Common Stock 28106W103 223,215 7,546,146 SH   SOLE   6,255,748 667,480 622,918
Eventbrite Inc Common Stock 29975E109 133 15,493 SH   SOLE   5,726 9,767 0
ExOne Co/The Common Stock 302104104 27,596 3,227,654 SH   SOLE   2,846,835 0 380,819
FLIR Systems Inc Common Stock 302445101 8,363 206,137 SH   SOLE   206,137 0 0
Facebook Inc Common Stock 30303M102 38,695 170,411 SH   SOLE   170,411 0 0
FARO Technologies Inc Common Stock 311642102 459 8,567 SH   SOLE   8,567 0 0
Fate Therapeutics Inc Common Stock 31189P102 34,990 1,019,830 SH   SOLE   1,019,830 0 0
General Electric Co Common Stock 369604103 289 42,321 SH   SOLE   42,321 0 0
Grayscale Bitcoin Trust BTC Open-End Fund 389637109 35,467 3,692,595 SH   SOLE   2,590,094 594,812 507,689
Guardant Health Inc Common Stock 40131M109 37,202 458,552 SH   SOLE   458,552 0 0
Guidewire Software Inc Common Stock 40171V100 3,061 27,612 SH   SOLE   27,612 0 0
HDFC Bank Ltd ADR 40415F101 3,684 81,049 SH   SOLE   81,049 0 0
HP Inc Common Stock 40434L105 1,773 101,724 SH   SOLE   101,724 0 0
Hexcel Corp Common Stock 428291108 59 1,300 SH   SOLE   1,300 0 0
HubSpot Inc Common Stock 443573100 19,516 86,989 SH   SOLE   86,989 0 0
Illumina Inc Common Stock 452327109 343,884 928,537 SH   SOLE   776,289 87,509 64,739
Incyte Corp Common Stock 45337C102 34,599 332,778 SH   SOLE   332,778 0 0
Inovio Pharmaceuticals Inc Common Stock 45773H201 20,790 771,427 SH   SOLE   771,427 0 0
Intellia Therapeutics Inc Common Stock 45826J105 239,699 11,403,379 SH   SOLE   9,619,242 909,016 875,121
Interactive Brokers Group Inc Common Stock 45841N107 4,238 101,466 SH   SOLE   101,466 0 0
Intercontinental Exchange Inc Common Stock 45866F104 5,510 60,152 SH   SOLE   60,152 0 0
Intuit Inc Common Stock 461202103 2,660 8,980 SH   SOLE   8,980 0 0
Intuitive Surgical Inc Common Stock 46120E602 5,499 9,650 SH   SOLE   9,650 0 0
OC Oerlikon Corp AG Common Stock H59187106 305 37,406 SH   SOLE   37,406 0 0
Invitae Corp Common Stock 46185L103 721,529 23,820,712 SH   SOLE   20,060,537 1,756,839 2,003,336
Ionis Pharmaceuticals Inc Common Stock 462222100 20,290 344,131 SH   SOLE   344,131 0 0
Iovance Biotherapeutics Inc Common Stock 462260100 116,258 4,235,273 SH   SOLE   3,909,687 142,293 183,293
Iridium Communications Inc Common Stock 46269C102 83,219 3,271,191 SH   SOLE   2,708,955 260,717 301,519
JD.com Inc ADR 47215P106 9,178 152,516 SH   SOLE   152,516 0 0
SGL Carbon SE Common Stock D6949M108 49 13,659 SH   SOLE   13,659 0 0
Kaiser Aluminum Corp Common Stock 483007704 270 3,662 SH   SOLE   3,662 0 0
Komatsu Ltd ADR 500458401 7,794 381,311 SH   SOLE   381,311 0 0
Kratos Defense & Security Solu Common Stock 50077B207 8,733 558,726 SH   SOLE   558,726 0 0
Henkel AG & Co KGaA Preference D3207M110 43 464 SH   SOLE   464 0 0
Bertrandt AG Common Stock D1014N107 288 7,304 SH   SOLE   7,304 0 0
LendingClub Corp Common Stock 52603A208 16,963 3,728,033 SH   SOLE   2,847,835 183,369 696,829
LendingTree Inc Common Stock 52603B107 272,359 940,694 SH   SOLE   771,294 81,503 87,897
Dassault Systemes SE Common Stock F2457H472 1,535 8,886 SH   SOLE   8,886 0 0
Lincoln Electric Holdings Inc Common Stock 533900106 304 3,606 SH   SOLE   3,606 0 0
Siemens AG Common Stock D69671218 372 3,158 SH   SOLE   3,158 0 0
Materialise NV ADR 57667T100 107,405 4,760,879 SH   SOLE   4,454,434 75,126 231,319
MercadoLibre Inc Common Stock 58733R102 48,621 49,323 SH   SOLE   40,268 8,872 183
Microsoft Corp Common Stock 594918104 1,533 7,532 SH   SOLE   7,532 0 0
Bezeq The Israeli Telecommunic Common Stock M2012Q100 1,375 1,515,960 SH   SOLE   1,515,960 0 0
Bet Shemesh Engines Holdings 1 Common Stock M20119109 757 44,459 SH   SOLE   44,459 0 0
Moog Inc Common Stock 615394202 274 5,164 SH   SOLE   5,164 0 0
Rakuten Inc Common Stock J64264104 2,098 238,613 SH   SOLE   238,613 0 0
Danel Adir Yeoshua Ltd Common Stock M27013107 1,332 14,270 SH   SOLE   14,270 0 0
Hilan Ltd Common Stock M5299H123 1,186 29,467 SH   SOLE   29,467 0 0
Nano Dimension Ltd ADR 63008G203 230 104,711 SH   SOLE   104,711 0 0
NanoString Technologies Inc Common Stock 63009R109 102,279 3,484,811 SH   SOLE   3,101,731 376,277 6,803
Elbit Systems Ltd Common Stock M3760D101 4,977 36,316 SH   SOLE   36,316 0 0
SBI Holdings Inc/Japan Common Stock J6991H100 4,307 199,500 SH   SOLE   199,500 0 0
Partner Communications Co Ltd Common Stock M78465107 1,149 258,813 SH   SOLE   258,813 0 0
Netflix Inc Common Stock 64110L106 15,560 34,195 SH   SOLE   32,301 1,894 0
Nice Ltd ADR 653656108 1,192 6,299 SH   SOLE   6,299 0 0
FirstRand Ltd Common Stock S5202Z131 30 13,580 SH   SOLE   13,580 0 0
NVIDIA Corp Common Stock 67066G104 22,907 60,297 SH   SOLE   53,045 6,949 303
NuVasive Inc Common Stock 670704105 278 4,991 SH   SOLE   4,991 0 0
Matrix IT Ltd Common Stock M6859E153 1,240 58,408 SH   SOLE   58,408 0 0
Organovo Holdings Inc Common Stock 68620A104 14,929 27,138,427 SH   SOLE   27,067,858 70,569 0
Toray Industries Inc Common Stock J89494116 40 8,508 SH   SOLE   8,508 0 0
PTC Inc Common Stock 69370C100 1,578 20,280 SH   SOLE   20,280 0 0
Pacific Biosciences of Califor Common Stock 69404D108 28,399 8,231,492 SH   SOLE   8,231,492 0 0
One Software Technologies Ltd Common Stock M9866H102 1,083 15,170 SH   SOLE   15,170 0 0
PayPal Holdings Inc Common Stock 70450Y103 28,614 164,229 SH   SOLE   159,679 4,550 0
Personalis Inc Common Stock 71535D106 26,831 2,068,683 SH   SOLE   2,068,683 0 0
Straumann Holding AG Common Stock H8300N119 1,743 2,028 SH   SOLE   2,028 0 0
Pinduoduo Inc ADR 722304102 22,019 256,510 SH   SOLE   256,510 0 0
Pinterest Inc Common Stock 72352L106 167,671 7,562,955 SH   SOLE   6,216,024 770,649 576,282
Pluristem Therapeutics Inc Common Stock 72940R300 10,331 1,168,616 SH   SOLE   1,168,616 0 0
PolyOne Corp Common Stock 73179P106 52 1,991 SH   SOLE   1,991 0 0
Proto Labs Inc Common Stock 743713109 249,279 2,216,406 SH   SOLE   1,767,664 241,365 207,377
Wirecard AG Common Stock D22359133 10 1,324 SH   SOLE   1,324 0 0
Rakuten Inc ADR 75102W108 119 13,623 SH   SOLE   13,623 0 0
Redhill Biopharma Ltd ADR 757468103 979 146,162 SH   SOLE   146,162 0 0
Roku Inc Common Stock 77543R102 387,227 3,322,980 SH   SOLE   2,779,786 302,273 240,921
salesforce.com Inc Common Stock 79466L302 25,081 133,887 SH   SOLE   84,751 46,520 2,616
Charles Schwab Corp/The Common Stock 808513105 1,133 33,589 SH   SOLE   33,589 0 0
Seres Therapeutics Inc Common Stock 81750R102 59,400 12,478,934 SH   SOLE   10,675,801 991,437 811,696
Shopify Inc Common Stock 82509L107 500 527 SH   SOLE   527 0 0
Snap Inc Common Stock 83304A106 44,851 1,909,364 SH   SOLE   1,909,364 0 0
SolarEdge Technologies Inc Common Stock 83417M104 1,515 10,918 SH   SOLE   10,918 0 0
Splunk Inc Common Stock 848637104 194,850 980,624 SH   SOLE   798,690 105,192 76,742
Square Inc Common Stock 852234103 633,392 6,035,756 SH   SOLE   4,963,263 591,304 481,189
Stryker Corp Common Stock 863667101 274 1,523 SH   SOLE   1,523 0 0
Syros Pharmaceuticals Inc Common Stock 87184Q107 90,750 8,513,133 SH   SOLE   7,708,929 186,593 617,611
Taiwan Semiconductor Manufactu ADR 874039100 5,958 104,955 SH   SOLE   104,955 0 0
Teladoc Health Inc Common Stock 87918A105 25,330 132,729 SH   SOLE   105,460 26,160 1,109
Tencent Holdings Ltd ADR 88032Q109 56,025 875,394 SH   SOLE   822,135 50,523 2,736
Teradyne Inc Common Stock 880770102 148,179 1,753,395 SH   SOLE   1,335,974 250,058 167,363
Tesla Inc Common Stock 88160R101 769,200 712,348 SH   SOLE   643,119 67,350 1,879
Teva Pharmaceutical Industries ADR 881624209 1,233 99,992 SH   SOLE   99,992 0 0
Trade Desk Inc/The Common Stock 88339J105 14,893 36,637 SH   SOLE   36,637 0 0
3D Systems Corp Common Stock 88554D205 1,502 214,934 SH   SOLE   214,934 0 0
3M Co Common Stock 88579Y101 43 274 SH   SOLE   274 0 0
TransUnion Common Stock 89400J107 2,130 24,473 SH   SOLE   24,473 0 0
Trimble Inc Common Stock 896239100 11,000 254,688 SH   SOLE   254,688 0 0
Twilio Inc Common Stock 90138F102 28,194 128,495 SH   SOLE   128,495 0 0
Twist Bioscience Corp Common Stock 90184D100 74,450 1,643,490 SH   SOLE   1,541,161 34,419 67,910
Twitter Inc Common Stock 90184L102 12,669 425,282 SH   SOLE   347,957 76,382 943
2U Inc Common Stock 90214J101 365,328 9,624,014 SH   SOLE   8,007,787 820,504 795,723
Ultra Clean Holdings Inc Common Stock 90385V107 376 16,612 SH   SOLE   16,612 0 0
United Parcel Service Inc Common Stock 911312106 294 2,646 SH   SOLE   2,646 0 0
Veracyte Inc Common Stock 92337F107 131,152 5,063,793 SH   SOLE   4,867,208 196,585 0
Verisk Analytics Inc Common Stock 92345Y106 2,177 12,790 SH   SOLE   12,790 0 0
Workday Inc Common Stock 98138H101 19,818 105,776 SH   SOLE   105,776 0 0
Xilinx Inc Common Stock 983919101 205,579 2,089,426 SH   SOLE   1,709,493 202,517 177,416
Xerox Holdings Corp Common Stock 98421M106 35 2,275 SH   SOLE   2,275 0 0
Zillow Group Inc Common Stock 98954M101 289,300 5,033,059 SH   SOLE   4,059,715 510,735 462,609
Koninklijke DSM NV Common Stock N5017D122 45 323 SH   SOLE   323 0 0
Arkema SA Common Stock F0392W125 49 509 SH   SOLE   509 0 0
MGI Digital Graphic Technology Common Stock F4090S113 1,551 35,557 SH   SOLE   35,557 0 0
Sandvik AB Common Stock W74857165 54 2,866 SH   SOLE   2,866 0 0
Hexagon AB Common Stock W40063104 514 8,790 SH   SOLE   8,790 0 0
Cellcom Israel Ltd Common Stock M2196U109 1,203 306,060 SH   SOLE   306,060 0 0
Evonik Industries AG Common Stock D2R90Y117 44 1,718 SH   SOLE   1,718 0 0
Fattal Holdings 1998 Ltd Common Stock M4148G105 875 20,511 SH   SOLE   20,511 0 0
Meituan Dianping Common Stock G59669104 6,986 314,967 SH   SOLE   314,967 0 0
SLM Solutions Group AG Common Stock D6T690109 1,450 198,354 SH   SOLE   198,354 0 0
ZhongAn Online P&C Insurance C Common Stock Y989DF109 5,605 1,132,800 SH   SOLE   1,132,800 0 0
Adyen NV Common Stock N3501V104 6,563 4,506 SH   SOLE   4,506 0 0
Atlassian Corp PLC Common Stock G06242104 13,505 74,915 SH   SOLE   74,915 0 0
Medtronic PLC Common Stock G5960L103 256 2,789 SH   SOLE   2,789 0 0
Aptiv PLC Common Stock G6095L109 148 1,901 SH   SOLE   0 1,901 0
Sapiens International Corp NV Common Stock G7T16G103 1,382 49,375 SH   SOLE   49,375 0 0
CRISPR Therapeutics AG Common Stock H17182108 476,454 6,483,251 SH   SOLE   5,442,693 545,280 495,278
Spotify Technology SA Common Stock L8681T102 104,606 405,152 SH   SOLE   336,513 42,500 26,139
Allot Ltd Common Stock M0854Q105 1,080 103,176 SH   SOLE   103,176 0 0
AudioCodes Ltd Common Stock M15342104 1,408 44,296 SH   SOLE   44,296 0 0
Camtek Ltd/Israel Common Stock M20791105 1,310 104,165 SH   SOLE   104,165 0 0
Ceragon Networks Ltd Common Stock M22013102 1,115 518,434 SH   SOLE   518,434 0 0
Check Point Software Technolog Common Stock M22465104 1,058 9,851 SH   SOLE   9,851 0 0
Compugen Ltd Common Stock M25722105 211,758 14,098,423 SH   SOLE   13,729,669 219,844 148,910
CyberArk Software Ltd Common Stock M2682V108 1,157 11,658 SH   SOLE   11,658 0 0
Evogene Ltd Common Stock M4119S104 395 395,241 SH   SOLE   395,241 0 0
Galmed Pharmaceuticals Ltd Common Stock M47238106 1,110 232,172 SH   SOLE   232,172 0 0
Fiverr International Ltd Common Stock M4R82T106 2,508 33,969 SH   SOLE   33,969 0 0
Ituran Location and Control Lt Common Stock M6158M104 1,038 64,764 SH   SOLE   64,764 0 0
Nova Measuring Instruments Ltd Common Stock M7516K103 1,376 28,555 SH   SOLE   28,555 0 0
Radware Ltd Common Stock M81873107 1,134 48,063 SH   SOLE   48,063 0 0
Stratasys Ltd Common Stock M85548101 179,060 11,290,045 SH   SOLE   8,962,625 894,489 1,432,931
Taro Pharmaceutical Industries Common Stock M8737E108 1,005 15,114 SH   SOLE   15,114 0 0
Tower Semiconductor Ltd Common Stock M87915274 1,092 57,213 SH   SOLE   57,213 0 0
UroGen Pharma Ltd Common Stock M96088105 1,233 47,208 SH   SOLE   47,208 0 0
Wix.com Ltd Common Stock M98068105 2,161 8,434 SH   SOLE   8,434 0 0
NXP Semiconductors NV Common Stock N6596X109 6,233 54,655 SH   SOLE   54,655 0 0
DocuSign Inc Common Stock 256163106 2,866 16,642 SH   SOLE   16,642 0 0
Zscaler Inc Common Stock 98980G102 85,535 781,139 SH   SOLE   648,444 82,459 50,236
GMO internet Inc Common Stock J1822R104 75 2,700 SH   SOLE   2,700 0 0
Discovery Ltd Common Stock S2192Y109 1,823 303,034 SH   SOLE   303,034 0 0
Inmode Ltd Common Stock M5425M103 1,289 45,530 SH   SOLE   45,530 0 0
Perion Network Ltd Common Stock M78673114 1,131 216,292 SH   SOLE   216,292 0 0
Silvergate Capital Corp Common Stock 82837P408 1,439 102,820 SH   SOLE   102,820 0 0
Alteryx Inc Common Stock 02156B103 17,748 108,037 SH   SOLE   108,037 0 0
Meituan Dianping ADR 58533E103 554 12,424 SH   SOLE   12,424 0 0
Z Holdings Corp Common Stock J9894K105 7,018 1,438,620 SH   SOLE   1,438,620 0 0
Sea Ltd ADR 81141R100 25,999 242,436 SH   SOLE   242,436 0 0
Z Holdings Corp ADR 98877X101 646 66,488 SH   SOLE   66,488 0 0
Pure Storage Inc Common Stock 74624M102 192,589 11,113,032 SH   SOLE   9,703,514 796,964 612,554
Synopsys Inc Common Stock 871607107 18,417 94,448 SH   SOLE   94,448 0 0
HUYA Inc ADR 44852D108 33,710 1,805,554 SH   SOLE   1,805,554 0 0
RADA Electronic Industries Ltd Common Stock M81863124 1,525 233,138 SH   SOLE   233,138 0 0
Sol-Gel Technologies Ltd Common Stock M8694L103 1,138 127,152 SH   SOLE   127,152 0 0
PagerDuty Inc Common Stock 69553P100 148,780 5,198,461 SH   SOLE   4,275,469 508,897 414,095
Bellicum Pharmaceuticals Inc Common Stock 079481404 1 94 SH   SOLE   94 0 0
Precigen Inc Common Stock 74017N105 2 474 SH   SOLE   474 0 0
Caterpillar Inc Common Stock 149123101 8,032 63,497 SH   SOLE   63,497 0 0
Rockwell Automation Inc Common Stock 773903109 2,872 13,484 SH   SOLE   13,484 0 0
Arconic Corp Common Stock 03966V107 434 31,162 SH   SOLE   31,162 0 0
Howmet Aerospace Inc Common Stock 443201108 390 24,629 SH   SOLE   24,629 0 0
Lightspeed POS Inc Common Stock 53227R106 1,181 49,601 SH   SOLE   49,601 0 0
Adaptive Biotechnologies Corp Common Stock 00650F109 14,956 309,138 SH   SOLE   309,138 0 0
10X Genomics Inc Common Stock 88025U109 30,058 336,553 SH   SOLE   336,553 0 0
Crowdstrike Holdings Inc Common Stock 22788C105 13,381 133,427 SH   SOLE   133,427 0 0
Okta Inc Common Stock 679295105 12,330 61,577 SH   SOLE   61,577 0 0
Bitcoin Fund/The Closed-End Fund 09175G104 3,185 313,436 SH   SOLE   0 0 313,436
Schrodinger Inc/United States Common Stock 80810D103 14,241 155,516 SH   SOLE   155,516 0 0
Slack Technologies Inc Common Stock 83088V102 146,997 4,728,097 SH   SOLE   4,060,331 440,768 226,998
TCS Group Holding PLC GDR 87238U203 1,049 51,660 SH   SOLE   51,660 0 0
Phreesia Inc Common Stock 71944F106 637 22,536 SH   SOLE   22,536 0 0
Virgin Galactic Holdings Inc Common Stock 92766K106 3,113 190,514 SH   SOLE   190,514 0 0
Workhorse Group Inc Common Stock 98138J206 1,798 103,400 SH   SOLE   103,400 0 0
Adyen NV ADR 00783V104 1,229 42,000 SH   SOLE   42,000 0 0
VMware Inc Common Stock 928563402 6,791 43,850 SH   SOLE   43,850 0 0