The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABORATORIES COMMON STOCK 002824100 45,202 572,829 SH   DFND 1,2 572,829 0 0
ABBVIE INC COMMON STOCK 00287Y109 6,337 83,169 SH   DFND 1,2 83,169 0 0
ACCENTURE PLC CL A COMMON STOCK G1151C101 133 817 SH   DFND 1,2 817 0 0
ACTIVISION BLIZZARD INC COMMON STOCK 00507V109 104,514 1,757,132 SH   DFND 1,2 1,757,132 0 0
ADOBE INC COMMON STOCK 00724F101 52,995 166,525 SH   DFND 1,2 166,525 0 0
ADVANCED MICRO DEVICES INC COMMON STOCK 007903107 4,072 89,527 SH   DFND 1,2 89,527 0 0
AES CORP (THE) COMMON STOCK 00130H105 42,949 3,158,047 SH   DFND 1,2 3,158,047 0 0
AGIOS PHARMACEUTICALS INC COMMON STOCK 00847X104 2,355 66,379 SH   DFND 1,2 66,379 0 0
AIR PRODUCTS AND CHEMICALS INC COMMON STOCK 009158106 32,639 163,512 SH   DFND 1,2 163,512 0 0
ALIBABA GROUP HOLDING LTD ADR COMMON STOCK 01609W102 149,302 767,701 SH   DFND 1,2 767,701 0 0
ALLAKOS INC COMMON STOCK 01671P100 7,849 176,422 SH   DFND 1,2 176,422 0 0
ALLEGHENY TECHNOLOGIES INC COMMON STOCK 01741R102 27,473 3,232,117 SH   DFND 1,2 3,232,117 0 0
ALPHABET INC CL A COMMON STOCK 02079K305 34,433 29,634 SH   DFND 1,2 29,634 0 0
ALPHABET INC CL C COMMON STOCK 02079K107 103,212 88,761 SH   DFND 1,2 88,761 0 0
ALTERYX INC CL A COMMON STOCK 02156B103 2,902 30,497 SH   DFND 1,2 30,497 0 0
ALTICE USA INC CL A COMMON STOCK 02156K103 712 31,954 SH   DFND 1,2 31,954 0 0
ALTRIA GROUP INC COMMON STOCK 02209S103 693 17,910 SH   DFND 1,2 17,910 0 0
AMAZON.COM INC COMMON STOCK 023135106 136,685 70,105 SH   DFND 1,2 70,105 0 0
AMERICA MOVIL SAB DE CV L ADR COMMON STOCK 02364W105 51,201 4,346,405 SH   DFND 1,2 4,346,405 0 0
AMERICAN TOWER CORP (REIT) COMMON STOCK 03027X100 51,739 237,607 SH   DFND 1,2 237,607 0 0
ANALOG DEVICES INC COMMON STOCK 032654105 111 1,233 SH   DFND 1,2 1,233 0 0
ANTHEM INC COMMON STOCK 036752103 33,159 146,051 SH   DFND 1,2 146,051 0 0
AON PLC CL A COMMON STOCK G0403H108 73,170 443,348 SH   DFND 1,2 443,348 0 0
APPLE INC COMMON STOCK 037833100 53,581 210,708 SH   DFND 1,2 210,708 0 0
APPLIED MATERIALS INC COMMON STOCK 038222105 844 18,423 SH   DFND 1,2 18,423 0 0
ARCH CAPITAL GROUP LTD COMMON STOCK G0450A105 2,405 84,501 SH   DFND 1,2 84,501 0 0
ARES MANAGEMENT CORP CL A COMMON STOCK 03990B101 2,015 65,145 SH   DFND 1,2 65,145 0 0
ARMSTRONG WORLD INDUSTRIES INC COMMON STOCK 04247X102 2,199 27,687 SH   DFND 1,2 27,687 0 0
ASML HOLDING NV (USD) COMMON STOCK N07059210 123,488 471,977 SH   DFND 1,2 471,977 0 0
ASTRAZENECA PLC ADR COMMON STOCK 046353108 2,358 52,788 SH   DFND 1,2 52,788 0 0
AUTODESK INC COMMON STOCK 052769106 4,276 27,395 SH   DFND 1,2 27,395 0 0
AZUL SA PN ADR COMMON STOCK 05501U106 1,076 105,600 SH   DFND 1,2 105,600 0 0
BAKER HUGHES CO CL A COMMON STOCK 05722G100 1,891 180,063 SH   DFND 1,2 180,063 0 0
BANK OF AMERICA CORP COMMON STOCK 060505104 10,464 492,874 SH   DFND 1,2 492,874 0 0
BANK OF NEW YORK MELLON CORP COMMON STOCK 064058100 1,372 40,729 SH   DFND 1,2 40,729 0 0
BARRICK GOLD CORP (USD) COMMON STOCK 067901108 7,265 396,555 SH   DFND 1,2 396,555 0 0
BAXTER INTERNATIONAL INC COMMON STOCK 071813109 218 2,680 SH   DFND 1,2 2,680 0 0
BEIGENE LTD ADR COMMON STOCK 07725L102 127,699 1,037,272 SH   DFND 1,2 1,037,272 0 0
BERKSHIRE HATHAWAY INC CL A COMMON STOCK 084670108 4,080 15 SH   DFND 1,2 15 0 0
BERKSHIRE HATHAWAY INC CL B COMMON STOCK 084670702 3,609 19,739 SH   DFND 1,2 19,739 0 0
BIOHAVEN PHARMACEUTICAL HOLDING CO LTD COMMON STOCK G11196105 36,068 1,059,893 SH   DFND 1,2 1,059,893 0 0
BLACKROCK INC COMMON STOCK 09247X101 7,025 15,966 SH   DFND 1,2 15,966 0 0
BLACKSTONE GROUP INC (THE) CL A COMMON STOCK 09260D107 3,475 76,255 SH   DFND 1,2 76,255 0 0
BLUEBIRD BIO INC COMMON STOCK 09609G100 63 1,364 SH   DFND 1,2 1,364 0 0
BOEING CO COMMON STOCK 097023105 13,661 91,597 SH   DFND 1,2 91,597 0 0
BOOKING HOLDINGS INC COMMON STOCK 09857L108 33,198 24,677 SH   DFND 1,2 24,677 0 0
BOSTON SCIENTIFIC CORP COMMON STOCK 101137107 12,603 386,234 SH   DFND 1,2 386,234 0 0
BRITISH AMERICAN TOBACCO PLC ADR COMMON STOCK 110448107 114 3,340 SH   DFND 1,2 3,340 0 0
BROADCOM INC COMMON STOCK 11135F101 85,976 362,615 SH   DFND 1,2 362,615 0 0
BROADCOM INC SER A CV PFD 8.000 PERCENT CUM 09-30-22 CONV PREFRD STCK 11135F200 305 326 SH   DFND 1,2 326 0 0
BWX TECHNOLOGIES INC COMMON STOCK 05605H100 162 3,322 SH   DFND 1,2 3,322 0 0
CABLE ONE INC COMMON STOCK 12685J105 41,255 25,094 SH   DFND 1,2 25,094 0 0
CANADA GOOSE HOLDINGS INC S/V (USD) COMMON STOCK 135086106 1,450 72,900 SH   DFND 1,2 72,900 0 0
CANADIAN NATIONAL RAILWAY CO COMMON STOCK 136375102 26,580 340,030 SH   DFND 1,2 340,030 0 0
CANADIAN NATURAL RESOURCES LTD COMMON STOCK 136385101 1,517 111,056 SH   DFND 1,2 111,056 0 0
CATERPILLAR INC COMMON STOCK 149123101 11,672 100,584 SH   DFND 1,2 100,584 0 0
CDK GLOBAL INC COMMON STOCK 12508E101 29,456 896,694 SH   DFND 1,2 896,694 0 0
CELANESE CORP COMMON STOCK 150870103 743 10,123 SH   DFND 1,2 10,123 0 0
CELLECTIS SA ADR COMMON STOCK 15117K103 9,086 987,600 SH   DFND 1,2 987,600 0 0
CENTENNIAL RESOURCE DEVELOPMENT INC CL A COMMON STOCK 15136A102 0 575 SH   DFND 1,2 575 0 0
CF INDUSTRIES HOLDINGS INC COMMON STOCK 125269100 285 10,472 SH   DFND 1,2 10,472 0 0
CHARTER COMMUNICATIONS INC CL A COMMON STOCK 16119P108 98,851 226,561 SH   DFND 1,2 226,561 0 0
CHEVRON CORP COMMON STOCK 166764100 27,499 379,504 SH   DFND 1,2 379,504 0 0
CHIPOTLE MEXICAN GRILL INC COMMON STOCK 169656105 58,368 89,193 SH   DFND 1,2 89,193 0 0
CHUBB LTD COMMON STOCK H1467J104 44,265 396,317 SH   DFND 1,2 396,317 0 0
CHURCH AND DWIGHT CO INC COMMON STOCK 171340102 39,569 616,527 SH   DFND 1,2 616,527 0 0
CIGNA CORP COMMON STOCK 125523100 156 880 SH   DFND 1,2 880 0 0
CLOROX CO (THE) COMMON STOCK 189054109 374 2,160 SH   DFND 1,2 2,160 0 0
CME GROUP INC CL A COMMON STOCK 12572Q105 49,433 285,891 SH   DFND 1,2 285,891 0 0
CMS ENERGY CORP COMMON STOCK 125896100 666 11,340 SH   DFND 1,2 11,340 0 0
COCA-COLA CO COMMON STOCK 191216100 2,047 46,271 SH   DFND 1,2 46,271 0 0
COCA-COLA EUROPEAN PARTNERS PLC COMMON STOCK G25839104 2,507 66,812 SH   DFND 1,2 66,812 0 0
COMCAST CORP CL A COMMON STOCK 20030N101 43,574 1,267,423 SH   DFND 1,2 1,267,423 0 0
CONCHO RESOURCES INC COMMON STOCK 20605P101 17,337 404,606 SH   DFND 1,2 404,606 0 0
CONOCOPHILLIPS COMMON STOCK 20825C104 24,676 801,171 SH   DFND 1,2 801,171 0 0
COSTCO WHOLESALE CORP COMMON STOCK 22160K105 51,412 180,309 SH   DFND 1,2 180,309 0 0
CROWN CASTLE INTL CORP (REIT) COMMON STOCK 22822V101 43,779 303,176 SH   DFND 1,2 303,176 0 0
CROWN CASTLE INTL CORP CV PFD SER A 6.875 PERCENT 08-01-20 (REIT) CONV PREFRD STCK 22822V309 800 640 SH   DFND 1,2 640 0 0
CSX CORP COMMON STOCK 126408103 57,420 1,002,094 SH   DFND 1,2 1,002,094 0 0
DANAHER CORP COMMON STOCK 235851102 71,370 515,645 SH   DFND 1,2 515,645 0 0
DEERE AND CO COMMON STOCK 244199105 30,833 223,168 SH   DFND 1,2 223,168 0 0
DELL TECHNOLOGIES INC CL C COMMON STOCK 24703L202 1,302 32,920 SH   DFND 1,2 32,920 0 0
DESPEGAR.COM CORP COMMON STOCK G27358103 4,213 743,000 SH   DFND 1,2 743,000 0 0
DIAGEO PLC ADR COMMON STOCK 25243Q205 306 2,410 SH   DFND 1,2 2,410 0 0
DIGITAL REALTY TRUST INC (REIT) COMMON STOCK 253868103 2,516 18,111 SH   DFND 1,2 18,111 0 0
DOMINO'S PIZZA INC COMMON STOCK 25754A201 1,248 3,851 SH   DFND 1,2 3,851 0 0
DOW INC COMMON STOCK 260557103 1,963 67,125 SH   DFND 1,2 67,125 0 0
DUPONT DE NEMOURS INC COMMON STOCK 26614N102 1,370 40,169 SH   DFND 1,2 40,169 0 0
EAST WEST BANCORP INC COMMON STOCK 27579R104 381 14,795 SH   DFND 1,2 14,795 0 0
EDISON INTERNATIONAL COMMON STOCK 281020107 21,312 388,968 SH   DFND 1,2 388,968 0 0
EDWARDS LIFESCIENCES CORP COMMON STOCK 28176E108 44,920 238,153 SH   DFND 1,2 238,153 0 0
ELASTIC NV (BEARER) COMMON STOCK N14506104 1,614 28,918 SH   DFND 1,2 28,918 0 0
ELECTRONIC ARTS COMMON STOCK 285512109 104 1,042 SH   DFND 1,2 1,042 0 0
ELI LILLY AND CO COMMON STOCK 532457108 50,845 366,528 SH   DFND 1,2 366,528 0 0
ENBRIDGE INC COMMON STOCK 29250N105 79,970 2,747,805 SH   DFND 1,2 2,747,805 0 0
ENEL AMERICAS SA ADR COMMON STOCK 29274F104 3,788 625,118 SH   DFND 1,2 625,118 0 0
EOG RESOURCES INC COMMON STOCK 26875P101 34,881 971,066 SH   DFND 1,2 971,066 0 0
EQUIFAX INC COMMON STOCK 294429105 45,779 383,252 SH   DFND 1,2 383,252 0 0
EQUINIX INC (REIT) COMMON STOCK 29444U700 80,131 128,298 SH   DFND 1,2 128,298 0 0
EQUITRANS MIDSTREAM CORP COMMON STOCK 294600101 9,097 1,808,496 SH   DFND 1,2 1,808,496 0 0
ESTEE LAUDER COMPANIES INC (THE) CL A COMMON STOCK 518439104 29,619 185,885 SH   DFND 1,2 185,885 0 0
EVEREST RE GROUP LTD COMMON STOCK G3223R108 4,574 23,770 SH   DFND 1,2 23,770 0 0
EXELON CORP COMMON STOCK 30161N101 486 13,209 SH   DFND 1,2 13,209 0 0
FACEBOOK INC CL A COMMON STOCK 30303M102 140,104 839,951 SH   DFND 1,2 839,951 0 0
FISERV INC COMMON STOCK 337738108 61,885 651,491 SH   DFND 1,2 651,491 0 0
FLIR SYSTEMS INC COMMON STOCK 302445101 1,269 39,789 SH   DFND 1,2 39,789 0 0
GENERAL ELECTRIC CO COMMON STOCK 369604103 569 71,692 SH   DFND 1,2 71,692 0 0
GENERAL MILLS INC COMMON STOCK 370334104 281 5,323 SH   DFND 1,2 5,323 0 0
GENPACT LTD COMMON STOCK G3922B107 1,419 48,607 SH   DFND 1,2 48,607 0 0
GERDAU SA PN ADR COMMON STOCK 373737105 7,548 3,951,774 SH   DFND 1,2 3,951,774 0 0
GILEAD SCIENCES INC COMMON STOCK 375558103 9,697 129,708 SH   DFND 1,2 129,708 0 0
GLAXOSMITHKLINE PLC ADR COMMON STOCK 37733W105 139 3,670 SH   DFND 1,2 3,670 0 0
GLOBAL PAYMENTS INC COMMON STOCK 37940X102 70,961 492,000 SH   DFND 1,2 492,000 0 0
GLOBANT SA COMMON STOCK L44385109 309 3,512 SH   DFND 1,2 3,512 0 0
GODADDY INC CL A COMMON STOCK 380237107 44,853 785,381 SH   DFND 1,2 785,381 0 0
GOL LINHAS AEREAS INTELIGENTES SA PN ADR COMMON STOCK 38045R206 5,133 1,202,100 SH   DFND 1,2 1,202,100 0 0
GOLDMAN SACHS GROUP INC COMMON STOCK 38141G104 911 5,893 SH   DFND 1,2 5,893 0 0
HALLIBURTON CO COMMON STOCK 406216101 228 33,245 SH   DFND 1,2 33,245 0 0
HDFC BANK LTD ADR COMMON STOCK 40415F101 32,463 844,078 SH   DFND 1,2 844,078 0 0
HEICO CORP COMMON STOCK 422806109 10,403 139,431 SH   DFND 1,2 139,431 0 0
HEICO CORP CL A COMMON STOCK 422806208 11,232 175,776 SH   DFND 1,2 175,776 0 0
HELMERICH AND PAYNE COMMON STOCK 423452101 2 150 SH   DFND 1,2 150 0 0
HEXCEL CORPORATION COMMON STOCK 428291108 67 1,801 SH   DFND 1,2 1,801 0 0
HILTON GRAND VACATIONS INC COMMON STOCK 43283X105 20,833 1,321,045 SH   DFND 1,2 1,321,045 0 0
HILTON WORLDWIDE HOLDINGS INC COMMON STOCK 43300A203 9,221 135,133 SH   DFND 1,2 135,133 0 0
HOME DEPOT INC COMMON STOCK 437076102 3,487 18,676 SH   DFND 1,2 18,676 0 0
HONEYWELL INTERNATIONAL INC COMMON STOCK 438516106 10,044 75,073 SH   DFND 1,2 75,073 0 0
HORMEL FOODS CORP COMMON STOCK 440452100 167 3,588 SH   DFND 1,2 3,588 0 0
HP INC COMMON STOCK 40434L105 163 9,365 SH   DFND 1,2 9,365 0 0
HUAZHU GROUP LTD ADR COMMON STOCK 44332N106 50,295 1,750,603 SH   DFND 1,2 1,750,603 0 0
HUMANA INC COMMON STOCK 444859102 320 1,020 SH   DFND 1,2 1,020 0 0
HUNTINGTON BANCSHARES INC COMMON STOCK 446150104 118 14,354 SH   DFND 1,2 14,354 0 0
HUTCHISON CHINA MEDITECH LTD ADR COMMON STOCK 44842L103 86,671 4,855,544 SH   DFND 1,2 4,855,544 0 0
HUYA INC ADR COMMON STOCK 44852D108 34,524 2,036,834 SH   DFND 1,2 2,036,834 0 0
ICICI BANK LTD ADR COMMON STOCK 45104G104 43,030 5,062,336 SH   DFND 1,2 5,062,336 0 0
IDEX CORP COMMON STOCK 45167R104 3,328 24,099 SH   DFND 1,2 24,099 0 0
IDEXX LABORATORIES INC COMMON STOCK 45168D104 4,161 17,178 SH   DFND 1,2 17,178 0 0
INCYTE CORP COMMON STOCK 45337C102 26,145 357,024 SH   DFND 1,2 357,024 0 0
INFOSYS LTD ADR COMMON STOCK 456788108 787 95,869 SH   DFND 1,2 95,869 0 0
INSULET CORP COMMON STOCK 45784P101 4,884 29,476 SH   DFND 1,2 29,476 0 0
INTEL CORP COMMON STOCK 458140100 48,649 898,909 SH   DFND 1,2 898,909 0 0
INTERCONTINENTAL EXCHANGE INC COMMON STOCK 45866F104 70,446 872,402 SH   DFND 1,2 872,402 0 0
INTUITIVE SURGICAL INC COMMON STOCK 46120E602 17,810 35,965 SH   DFND 1,2 35,965 0 0
IRIDIUM COMMUNICATIONS INC COMMON STOCK 46269C102 2,231 99,908 SH   DFND 1,2 99,908 0 0
JACK HENRY AND ASSOCIATES INC COMMON STOCK 426281101 38,962 250,978 SH   DFND 1,2 250,978 0 0
JOHNSON AND JOHNSON COMMON STOCK 478160104 9 70 SH   DFND 1,2 70 0 0
JOHNSON CONTROLS INTERNATIONAL PLC COMMON STOCK G51502105 298 11,063 SH   DFND 1,2 11,063 0 0
JPMORGAN CHASE AND CO COMMON STOCK 46625H100 69,844 775,783 SH   DFND 1,2 775,783 0 0
KARUNA THERAPEUTICS INC COMMON STOCK 48576A100 16,368 227,338 SH   DFND 1,2 227,338 0 0
KLA CORP COMMON STOCK 482480100 380 2,642 SH   DFND 1,2 2,642 0 0
KONINKLIJKE PHILIPS NV (USD) COMMON STOCK 500472303 98 2,450 SH   DFND 1,2 2,450 0 0
LAS VEGAS SANDS CORP COMMON STOCK 517834107 3,601 84,785 SH   DFND 1,2 84,785 0 0
LENNOX INTERNATIONAL INC COMMON STOCK 526107107 2,565 14,112 SH   DFND 1,2 14,112 0 0
LINDE PLC COMMON STOCK G5494J103 6,060 35,029 SH   DFND 1,2 35,029 0 0
LIVERAMP HOLDINGS INC COMMON STOCK 53815P108 18,298 555,836 SH   DFND 1,2 555,836 0 0
LOGITECH INTERNATIONAL SA COMMON STOCK H50430232 20,114 462,712 SH   DFND 1,2 462,712 0 0
LOMA NEGRA CIA ADR COMMON STOCK 54150E104 11,129 3,135,056 SH   DFND 1,2 3,135,056 0 0
LYONDELLBASELL INDUSTRIES NV COMMON STOCK N53745100 2,222 44,765 SH   DFND 1,2 44,765 0 0
MARRIOTT INTERNATIONAL INC CL A COMMON STOCK 571903202 1,872 25,028 SH   DFND 1,2 25,028 0 0
MARSH AND MCLENNAN COMPANIES INC COMMON STOCK 571748102 47,360 547,772 SH   DFND 1,2 547,772 0 0
MASTERCARD INC CL A COMMON STOCK 57636Q104 23,225 96,145 SH   DFND 1,2 96,145 0 0
MELCO RESORTS AND ENTERTAINMENT LTD ADR COMMON STOCK 585464100 1,818 146,635 SH   DFND 1,2 146,635 0 0
MERCADOLIBRE INC COMMON STOCK 58733R102 28,316 57,956 SH   DFND 1,2 57,956 0 0
MERCK AND CO INC COMMON STOCK 58933Y105 4,322 56,172 SH   DFND 1,2 56,172 0 0
METLIFE INC COMMON STOCK 59156R108 256 8,358 SH   DFND 1,2 8,358 0 0
MGM RESORTS INTERNATIONAL COMMON STOCK 552953101 927 78,569 SH   DFND 1,2 78,569 0 0
MICRO FOCUS INTERNATIONAL PLC ADR COMMON STOCK 594837403 537 105,951 SH   DFND 1,2 105,951 0 0
MICRON TECHNOLOGY INC COMMON STOCK 595112103 57,542 1,368,088 SH   DFND 1,2 1,368,088 0 0
MICROSOFT CORP COMMON STOCK 594918104 175,477 1,112,654 SH   DFND 1,2 1,112,654 0 0
MONDELEZ INTERNATIONAL INC COMMON STOCK 609207105 47,552 949,526 SH   DFND 1,2 949,526 0 0
MOODYS CORP COMMON STOCK 615369105 59,940 283,406 SH   DFND 1,2 283,406 0 0
MORGAN STANLEY COMMON STOCK 617446448 917 26,973 SH   DFND 1,2 26,973 0 0
MOTOROLA SOLUTIONS INC COMMON STOCK 620076307 1,014 7,632 SH   DFND 1,2 7,632 0 0
MSCI INC COMMON STOCK 55354G100 37,699 130,466 SH   DFND 1,2 130,466 0 0
NASDAQ INC COMMON STOCK 631103108 28,768 302,985 SH   DFND 1,2 302,985 0 0
NETAPP INC COMMON STOCK 64110D104 6,647 159,445 SH   DFND 1,2 159,445 0 0
NETEASE INC ADR COMMON STOCK 64110W102 18,208 56,730 SH   DFND 1,2 56,730 0 0
NETFLIX INC COMMON STOCK 64110L106 95,317 253,841 SH   DFND 1,2 253,841 0 0
NEUROCRINE BIOSCIENCES INC COMMON STOCK 64125C109 41,751 482,396 SH   DFND 1,2 482,396 0 0
NEWMONT CORP COMMON STOCK 651639106 5,139 113,500 SH   DFND 1,2 113,500 0 0
NEXA RESOURCES SA COMMON STOCK L67359106 4,241 1,218,800 SH   DFND 1,2 1,218,800 0 0
NEXTERA ENERGY INC COMMON STOCK 65339F101 126 523 SH   DFND 1,2 523 0 0
NIKE INC CL B COMMON STOCK 654106103 52,996 640,517 SH   DFND 1,2 640,517 0 0
NORFOLK SOUTHERN CORP COMMON STOCK 655844108 970 6,646 SH   DFND 1,2 6,646 0 0
NORTHROP GRUMMAN CORP COMMON STOCK 666807102 50,858 168,098 SH   DFND 1,2 168,098 0 0
NORWEGIAN CRUISE LINE HOLDINGS LTD COMMON STOCK G66721104 1,662 151,650 SH   DFND 1,2 151,650 0 0
NOVO NORDISK A/S CL B ADR COMMON STOCK 670100205 222 3,695 SH   DFND 1,2 3,695 0 0
NOVOCURE LTD COMMON STOCK G6674U108 3,629 53,885 SH   DFND 1,2 53,885 0 0
NUTRIEN LTD (USD) COMMON STOCK 67077M108 3,649 106,928 SH   DFND 1,2 106,928 0 0
ON SEMICONDUCTOR CORP COMMON STOCK 682189105 5,750 462,249 SH   DFND 1,2 462,249 0 0
ONECONNECT FINANCIAL TECHNOLOGY CO LTD ADR COMMON STOCK 68248T105 27,600 2,719,200 SH   DFND 1,2 2,719,200 0 0
PAYPAL HOLDINGS INC COMMON STOCK 70450Y103 11,691 122,115 SH   DFND 1,2 122,115 0 0
PEPSICO INC COMMON STOCK 713448108 444 3,700 SH   DFND 1,2 3,700 0 0
PETROLEO BRASILEIRO ON ADR (PETROBRAS) COMMON STOCK 71654V408 62,066 11,284,783 SH   DFND 1,2 11,284,783 0 0
PETROLEO BRASILEIRO PN ADR (PETROBRAS) COMMON STOCK 71654V101 2,346 435,320 SH   DFND 1,2 435,320 0 0
PFIZER INC COMMON STOCK 717081103 5,966 182,781 SH   DFND 1,2 182,781 0 0
PHILIP MORRIS INTERNATIONAL COMMON STOCK 718172109 58,935 807,778 SH   DFND 1,2 807,778 0 0
PINTEREST INC CL A COMMON STOCK 72352L106 1,952 126,412 SH   DFND 1,2 126,412 0 0
PNC FINANCIAL SERVICES GROUP INC COMMON STOCK 693475105 381 3,976 SH   DFND 1,2 3,976 0 0
PROCTER AND GAMBLE CO COMMON STOCK 742718109 640 5,820 SH   DFND 1,2 5,820 0 0
QUALCOMM INC COMMON STOCK 747525103 1,067 15,778 SH   DFND 1,2 15,778 0 0
RAYTHEON TECHNOLOGIES CORP COMMON STOCK 75513E101 26,719 283,246 SH   DFND 1,2 283,246 0 0
REGENERON PHARMACEUTICALS COMMON STOCK 75886F107 10,862 22,244 SH   DFND 1,2 22,244 0 0
RENAISSANCERE HOLDINGS LTD COMMON STOCK G7496G103 32,719 219,120 SH   DFND 1,2 219,120 0 0
RESTAURANT BRANDS INTERNATIONAL INC (USD) COMMON STOCK 76131D103 2,267 56,622 SH   DFND 1,2 56,622 0 0
ROYAL CARIBBEAN CRUISES LTD COMMON STOCK V7780T103 10,535 327,480 SH   DFND 1,2 327,480 0 0
ROYAL DUTCH SHELL PLC B ADR COMMON STOCK 780259107 460 14,080 SH   DFND 1,2 14,080 0 0
RYANAIR HOLDINGS PLC ADR COMMON STOCK 783513203 3,399 64,014 SH   DFND 1,2 64,014 0 0
SAGE THERAPEUTICS INC COMMON STOCK 78667J108 8,150 283,786 SH   DFND 1,2 283,786 0 0
SANDP GLOBAL INC COMMON STOCK 78409V104 996 4,065 SH   DFND 1,2 4,065 0 0
SAREPTA THERAPEUTICS INC COMMON STOCK 803607100 29 300 SH   DFND 1,2 300 0 0
SCHLUMBERGER LTD COMMON STOCK 806857108 4,085 302,843 SH   DFND 1,2 302,843 0 0
SEA LTD CL A ADR COMMON STOCK 81141R100 781 17,627 SH   DFND 1,2 17,627 0 0
SEATTLE GENETICS INC COMMON STOCK 812578102 138,186 1,197,659 SH   DFND 1,2 1,197,659 0 0
SEMPRA ENERGY COMMON STOCK 816851109 13,011 115,150 SH   DFND 1,2 115,150 0 0
SEMPRA ENERGY CV PFD SER A 6.0 PERCENT 01-15-21 CONV PREFRD STCK 816851406 498 5,383 SH   DFND 1,2 5,383 0 0
SERVICENOW INC COMMON STOCK 81762P102 51,071 178,208 SH   DFND 1,2 178,208 0 0
SHERWIN-WILLIAMS CO COMMON STOCK 824348106 7,473 16,263 SH   DFND 1,2 16,263 0 0
SHOPIFY INC CL A S/V (USD) COMMON STOCK 82509L107 6,392 15,332 SH   DFND 1,2 15,332 0 0
SMARTSHEET INC CL A COMMON STOCK 83200N103 3,181 76,643 SH   DFND 1,2 76,643 0 0
SPOTIFY TECHNOLOGY SA COMMON STOCK L8681T102 4,224 34,786 SH   DFND 1,2 34,786 0 0
STARS GROUP INC (THE) (USD) COMMON STOCK 85570W100 642 31,454 SH   DFND 1,2 31,454 0 0
STATE STREET CORP COMMON STOCK 857477103 104 1,961 SH   DFND 1,2 1,961 0 0
SVB FINANCIAL GROUP COMMON STOCK 78486Q101 28,832 190,837 SH   DFND 1,2 190,837 0 0
SVMK INC COMMON STOCK 78489X103 32,493 2,405,094 SH   DFND 1,2 2,405,094 0 0
TAIWAN SEMICONDUCTOR MFG CO ADR COMMON STOCK 874039100 87,914 1,839,590 SH   DFND 1,2 1,839,590 0 0
TC ENERGY CORP COMMON STOCK 87807B107 533 12,000 SH   DFND 1,2 12,000 0 0
TE CONNECTIVITY LTD COMMON STOCK H84989104 3,746 59,476 SH   DFND 1,2 59,476 0 0
TESLA INC COMMON STOCK 88160R101 28,392 54,183 SH   DFND 1,2 54,183 0 0
TEVA PHARMACEUTICAL INDUSTRIES LTD ADR COMMON STOCK 881624209 1,648 183,563 SH   DFND 1,2 183,563 0 0
TEXAS INSTRUMENTS INC COMMON STOCK 882508104 4,927 49,300 SH   DFND 1,2 49,300 0 0
THERMO FISHER SCIENTIFIC INC COMMON STOCK 883556102 11,646 41,065 SH   DFND 1,2 41,065 0 0
TORONTO DOMINION BANK (THE) (USD) COMMON STOCK 891160509 9 205 SH   DFND 1,2 205 0 0
TRANSDIGM GROUP INC COMMON STOCK 893641100 46,484 145,175 SH   DFND 1,2 145,175 0 0
TRIMBLE INC COMMON STOCK 896239100 39,436 1,238,959 SH   DFND 1,2 1,238,959 0 0
TRINITY INDUSTRIES INC COMMON STOCK 896522109 1,793 111,548 SH   DFND 1,2 111,548 0 0
TRIP.COM GROUP LTD ADR COMMON STOCK 89677Q107 52,827 2,252,731 SH   DFND 1,2 2,252,731 0 0
TRUIST FINANCIAL CORP COMMON STOCK 89832Q109 1,092 35,409 SH   DFND 1,2 35,409 0 0
TWILIO INC CL A COMMON STOCK 90138F102 170 1,898 SH   DFND 1,2 1,898 0 0
UBER TECHNOLOGIES INC COMMON STOCK 90353T100 820 29,360 SH   DFND 1,2 29,360 0 0
ULTRAGENYX PHARMACEUTICAL INC COMMON STOCK 90400D108 20,015 450,495 SH   DFND 1,2 450,495 0 0
UNION PACIFIC CORP COMMON STOCK 907818108 527 3,735 SH   DFND 1,2 3,735 0 0
UNITEDHEALTH GROUP INC COMMON STOCK 91324P102 55,497 222,538 SH   DFND 1,2 222,538 0 0
VALE SA ON ADR COMMON STOCK 91912E105 73,702 8,890,485 SH   DFND 1,2 8,890,485 0 0
VERISIGN INC COMMON STOCK 92343E102 1,388 7,708 SH   DFND 1,2 7,708 0 0
VERIZON COMMUNICATIONS INC COMMON STOCK 92343V104 3,507 65,269 SH   DFND 1,2 65,269 0 0
VERTEX PHARMACEUTICALS INC COMMON STOCK 92532F100 38,456 161,614 SH   DFND 1,2 161,614 0 0
VIOMI TECHNOLOGY CO LTD ADR COMMON STOCK 92762J103 136 31,311 SH   DFND 1,2 31,311 0 0
VISA INC CL A COMMON STOCK 92826C839 110,718 687,176 SH   DFND 1,2 687,176 0 0
WALGREENS BOOTS ALLIANCE INC COMMON STOCK 931427108 2,103 45,968 SH   DFND 1,2 45,968 0 0
WASTE CONNECTIONS INC (USD) COMMON STOCK 94106B101 45,813 591,141 SH   DFND 1,2 591,141 0 0
WASTE MANAGEMENT INC COMMON STOCK 94106L109 210 2,269 SH   DFND 1,2 2,269 0 0
WELBILT INC COMMON STOCK 949090104 922 179,730 SH   DFND 1,2 179,730 0 0
WELLS FARGO AND CO COMMON STOCK 949746101 90 3,131 SH   DFND 1,2 3,131 0 0
WESTINGHOUSE AIR BRAKE TECHNOLOGIES CORP (DBA WABTEC CORP) COMMON STOCK 929740108 25,527 530,372 SH   DFND 1,2 530,372 0 0
WHEATON PRECIOUS METALS CORP COMMON STOCK 962879102 1,080 39,315 SH   DFND 1,2 39,315 0 0
WILLIAMS COMPANIES INC (THE) COMMON STOCK 969457100 1,056 74,634 SH   DFND 1,2 74,634 0 0
WORKDAY INC CL A COMMON STOCK 98138H101 784 6,017 SH   DFND 1,2 6,017 0 0
WYNN RESORTS LTD COMMON STOCK 983134107 19,317 320,942 SH   DFND 1,2 320,942 0 0
YANDEX NV A COMMON STOCK N97284108 104,960 3,082,516 SH   DFND 1,2 3,082,516 0 0
YUM! BRANDS INC COMMON STOCK 988498101 32,402 472,822 SH   DFND 1,2 472,822 0 0
ZENDESK INC COMMON STOCK 98936J101 1,955 30,539 SH   DFND 1,2 30,539 0 0
ZOETIS INC CL A COMMON STOCK 98978V103 8,772 74,531 SH   DFND 1,2 74,531 0 0