The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 11,429 150,000 SH Call SOLE   150,000 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 10,140 240,000 SH Put SOLE   240,000 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 6,338 150,000 SH Call SOLE   150,000 0 0
ACCELERON PHARMA INC COM 00434H108 18,891 210,200 SH Call SOLE   210,200 0 0
ACCELERON PHARMA INC COM 00434H108 28,480 316,900 SH Put SOLE   316,900 0 0
ACCELERON PHARMA INC COM 00434H108 21,501 239,249 SH   SOLE   239,249 0 0
ADMA BIOLOGICS INC COM 000899104 1,814 630,000 SH   SOLE   630,000 0 0
ADURO BIOTECH INC COM 00739L101 9,968 3,638,000 SH   SOLE   3,638,000 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 10,206 224,400 SH Call SOLE   224,400 0 0
AETERNA ZENTARIS INC COM 007975402 60 117,443 SH   SOLE   117,443 0 0
ALBIREO PHARMA INC COM 01345P106 1,645 100,500 SH Call SOLE   100,500 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 17,958 200,000 SH Call SOLE   200,000 0 0
ALLAKOS INC COM 01671P100 1,335 30,000 SH Call SOLE   30,000 0 0
ALLAKOS INC COM 01671P100 1,335 30,000 SH Put SOLE   30,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 13,095 120,300 SH Put SOLE   120,300 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 26,875 246,900 SH Call SOLE   246,900 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 159 39,700 SH Call SOLE   39,700 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 1,396 52,126 SH   SOLE   52,126 0 0
APPLIED GENETIC TECHNOL CORP COM 03820J100 1,790 545,884 SH   SOLE   545,884 0 0
APTINYX INC COM 03836N103 1,277 591,000 SH   SOLE   591,000 0 0
ARDELYX INC COM 039697107 8,313 1,462,234 SH   SOLE   1,462,234 0 0
ARGENX SE SPONSORED ADR 04016X101 8,675 65,856 SH   SOLE   65,856 0 0
ARGENX SE SPONSORED ADR 04016X101 9,880 75,000 SH Call SOLE   75,000 0 0
ARGENX SE SPONSORED ADR 04016X101 16,572 125,800 SH Put SOLE   125,800 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 207 7,200 SH Put SOLE   7,200 0 0
ARTARA THERAPEUTICS INC COM 04300J107 10,368 450,772 SH   SOLE   450,772 0 0
ARVINAS INC COM 04335A105 2,261 56,100 SH Call SOLE   56,100 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 3,761 70,000 SH Put SOLE   70,000 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 2,225 150,000 SH Put SOLE   150,000 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 2,335 157,468 SH   SOLE   157,468 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 1,451 100,000 SH Put SOLE   100,000 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 3,174 218,771 SH   SOLE   218,771 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 5,955 750,000 SH Call SOLE   750,000 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 652 82,143 SH   SOLE   82,143 0 0
AXOVANT GENE THERAPIES LTD COM G0750W203 461 188,884 SH   SOLE   188,884 0 0
AXSOME THERAPEUTICS INC COM 05464T104 22,061 375,000 SH Call SOLE   375,000 0 0
AXSOME THERAPEUTICS INC COM 05464T104 8,825 150,000 SH Put SOLE   150,000 0 0
BAUDAX BIO INC COM 07160F107 434 175,000 SH   SOLE   175,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 891 63,721 SH   SOLE   63,721 0 0
BIOGEN INC COM 09062X103 252 795 SH   SOLE   795 0 0
BIOGEN INC COM 09062X103 45,369 143,400 SH Call SOLE   143,400 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 11,911 350,000 SH Call SOLE   350,000 0 0
BIOXCEL THERAPEUTICS INC COM 09075P105 15,505 693,716 SH   SOLE   693,716 0 0
BIOXCEL THERAPEUTICS INC COM 09075P105 2,309 103,300 SH Call SOLE   103,300 0 0
BLUEBIRD BIO INC COM 09609G100 3,217 70,000 SH Call SOLE   70,000 0 0
BLUEBIRD BIO INC COM 09609G100 299 6,498 SH   SOLE   6,498 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 2,924 50,000 SH Call SOLE   50,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 3,860 66,000 SH Put SOLE   66,000 0 0
BRIDGEBIO PHARMA INC COM 10806X102 2,549 87,900 SH   SOLE   87,900 0 0
BRISTOL-MYERS SQUIBB CO RIGHT 99/99/9999 110122157 3,610 950,000 SH   SOLE   950,000 0 0
CARA THERAPEUTICS INC COM 140755109 259 19,600 SH Call SOLE   19,600 0 0
CARA THERAPEUTICS INC COM 140755109 7,294 552,163 SH   SOLE   552,163 0 0
CASI PHARMACEUTICALS INC COM 14757U109 2,121 1,039,910 SH   SOLE   1,039,910 0 0
CASSAVA SCIENCES INC COM 14817C107 1,233 300,000 SH   SOLE   300,000 0 0
CEL SCI CORP COM PAR NEW 150837607 5,770 500,000 SH Put SOLE   500,000 0 0
CELLECTIS S A SPONSORED ADS 15117K103 285 30,928 SH   SOLE   30,928 0 0
CERECOR INC COM 15671L109 1,399 564,005 SH   SOLE   564,005 0 0
CHEMOCENTRYX INC COM 16383L106 6,027 150,000 SH Call SOLE   150,000 0 0
CHIASMA INC COM 16706W102 7,576 2,075,492 SH   SOLE   2,075,492 0 0
CHIMERIX INC COM 16934W106 300 208,258 SH   SOLE   208,258 0 0
CLOVIS ONCOLOGY INC COM 189464100 4,928 774,900 SH Call SOLE   774,900 0 0
CLOVIS ONCOLOGY INC COM 189464100 2,620 411,918 SH   SOLE   411,918 0 0
COHERUS BIOSCIENCES INC COM 19249H103 1,364 84,100 SH Call SOLE   84,100 0 0
CORTEXYME INC COM 22053A107 1,140 25,000 SH   SOLE   25,000 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 7,596 179,100 SH Put SOLE   179,100 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 3,503 2,366,850 SH   SOLE   2,366,850 0 0
CYTOKINETICS INC COM NEW 23282W605 4,532 384,400 SH Put SOLE   384,400 0 0
CYTOKINETICS INC COM NEW 23282W605 5,895 500,000 SH Call SOLE   500,000 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 207 52,800 SH Put SOLE   52,800 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 894 228,113 SH   SOLE   228,113 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 285 15,500 SH Call SOLE   15,500 0 0
FATE THERAPEUTICS INC COM 31189P102 1,113 50,100 SH Call SOLE   50,100 0 0
FATE THERAPEUTICS INC COM 31189P102 1,113 50,100 SH Put SOLE   50,100 0 0
FIBROGEN INC COM 31572Q808 6,950 200,000 SH Call SOLE   200,000 0 0
FIBROGEN INC COM 31572Q808 2,780 80,000 SH Put SOLE   80,000 0 0
GALAPAGOS NV SPON ADR 36315X101 6,857 35,000 SH Call SOLE   35,000 0 0
GILEAD SCIENCES INC COM 375558103 18,690 250,000 SH Call SOLE   250,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 4,598 90,000 SH Call SOLE   90,000 0 0
ICAD INC COM NEW 44934S206 786 107,103 SH   SOLE   107,103 0 0
IMMUNOMEDICS INC COM 452907108 1,565 116,100 SH Call SOLE   116,100 0 0
IMMUNOVANT INC COM 45258J102 13,113 842,463 SH   SOLE   842,463 0 0
INFLARX NV COM N44821101 1,003 262,600 SH   SOLE   262,600 0 0
INOVIO PHARMACEUTICALS INC COM NEW 45773H201 1,860 250,000 SH Put SOLE   250,000 0 0
INSMED INC COM PAR $.01 457669307 2,772 172,919 SH   SOLE   172,919 0 0
INSMED INC COM PAR $.01 457669307 4,809 300,000 SH Call SOLE   300,000 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 2,262 184,989 SH   SOLE   184,989 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 3,148 50,000 SH Call SOLE   50,000 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 10,835 172,100 SH Put SOLE   172,100 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 3,827 249,002 SH   SOLE   249,002 0 0
INVESCO QQQ TR UNIT SER 1 46090E103 29,552 550,000 SH Put SOLE   550,000 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 1,735 15,154 SH   SOLE   15,154 0 0
ISHARES TR 20 YR TR BD ETF 464287432 65,988 400,000 SH Put SOLE   400,000 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 17,169 150,000 SH Put SOLE   150,000 0 0
KADMON HLDGS INC COM 48283N106 5,518 1,316,846 SH   SOLE   1,316,846 0 0
KALA PHARMACEUTICALS INC COM 483119103 4,342 493,952 SH   SOLE   493,952 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 7,242 946,605 SH   SOLE   946,605 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 10,600 551,800 SH Put SOLE   551,800 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 700 36,422 SH   SOLE   36,422 0 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 5,556 358,924 SH   SOLE   358,924 0 0
KODIAK SCIENCES INC COM 50015M109 563 11,800 SH Put SOLE   11,800 0 0
KURA ONCOLOGY INC COM 50127T109 7,560 759,803 SH   SOLE   759,803 0 0
LIGAND PHARMACEUTICALS INC COM NEW 53220K504 14,544 200,000 SH Call SOLE   200,000 0 0
MACROGENICS INC COM 556099109 2,095 360,030 SH   SOLE   360,030 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 2,693 40,334 SH   SOLE   40,334 0 0
MALLINCKRODT PUB LTD CO SHS G5785G107 385 194,322 SH   SOLE   194,322 0 0
MILLENDO THERAPEUTICS INC COM 60040X103 7,413 1,403,900 SH Put SOLE   1,403,900 0 0
MINERVA NEUROSCIENCES INC COM 603380106 2,056 341,600 SH Call SOLE   341,600 0 0
MINERVA NEUROSCIENCES INC COM 603380106 623 103,504 SH   SOLE   103,504 0 0
MINERVA NEUROSCIENCES INC COM 603380106 1,678 278,700 SH Put SOLE   278,700 0 0
MIRATI THERAPEUTICS INC COM 60468T105 11,446 148,900 SH Put SOLE   148,900 0 0
MUSTANG BIO INC COM 62818Q104 955 356,475 SH   SOLE   356,475 0 0
MYOKARDIA INC COM 62857M105 5,316 113,400 SH Call SOLE   113,400 0 0
MYOKARDIA INC COM 62857M105 19,671 419,600 SH Put SOLE   419,600 0 0
MYOVANT SCIENCES LTD COM G637AM102 3,398 450,000 SH   SOLE   450,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 8,655 100,000 SH Call SOLE   100,000 0 0
NEXTCURE INC COM 65343E108 1,509 40,700 SH Put SOLE   40,700 0 0
OBSEVA SA COM H5861P103 199 82,573 SH   SOLE   82,573 0 0
OCULAR THERAPEUTIX INC COM 67576A100 7,717 1,558,936 SH   SOLE   1,558,936 0 0
OTONOMY INC COM 68906L105 2,694 1,367,271 SH   SOLE   1,367,271 0 0
OTONOMY INC COM 68906L105 591 300,000 SH Call SOLE   300,000 0 0
OVID THERAPEUTICS INC COM 690469101 1,126 377,737 SH   SOLE   377,737 0 0
PFENEX INC COM 717071104 566 64,211 SH   SOLE   64,211 0 0
PROGENICS PHARMACEUTICALS IN COM 743187106 497 130,845 SH   SOLE   130,845 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 1,117 158,222 SH   SOLE   158,222 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 463 54,901 SH   SOLE   54,901 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 18,043 125,000 SH Put SOLE   125,000 0 0
REGENERON PHARMACEUTICALS COM 75886F107 63,478 130,000 SH Put SOLE   130,000 0 0
RELMADA THERAPEUTICS INC COM 75955J402 1,882 55,172 SH   SOLE   55,172 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 2,622 1,680,529 SH   SOLE   1,680,529 0 0
SAGE THERAPEUTICS INC COM 78667J108 5,257 183,051 SH   SOLE   183,051 0 0
SAGE THERAPEUTICS INC COM 78667J108 4,431 154,300 SH Call SOLE   154,300 0 0
SAREPTA THERAPEUTICS INC COM 803607100 10,036 102,600 SH Call SOLE   102,600 0 0
SCPHARMACEUTICALS INC COM 810648105 7,945 1,073,647 SH   SOLE   1,073,647 0 0
SOLID BIOSCIENCES INC COM 83422E105 1,288 539,053 SH   SOLE   539,053 0 0
SOLID BIOSCIENCES INC COM 83422E105 1,075 449,800 SH Call SOLE   449,800 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 244,863 950,000 SH Put SOLE   950,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 64,438 250,000 SH Call SOLE   250,000 0 0
SPDR SER TR S&P BIOTECH 78464A870 19,360 250,000 SH Put SOLE   250,000 0 0
SPDR SER TR S&P BIOTECH 78464A870 19,360 250,000 SH Call SOLE   250,000 0 0
STEALTH BIOTHERAPEUTICS CORP SPONSORED ADS 85789A105 47 37,597 SH   SOLE   37,597 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 6,412 3,392,787 SH   SOLE   3,392,787 0 0
SUNESIS PHARMACEUTICALS INC COM 867328700 46 111,445 SH   SOLE   111,445 0 0
TRICIDA INC COM 89610F101 3,956 179,800 SH   SOLE   179,800 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 4,443 100,000 SH Call SOLE   100,000 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 633 14,252 SH   SOLE   14,252 0 0
VERASTEM INC COM 92337C104 13,866 5,252,427 SH   SOLE   5,252,427 0 0
VIKING THERAPEUTICS INC COM 92686J106 590 126,159 SH   SOLE   126,159 0 0
XENON PHARMACEUTICALS INC COM 98420N105 5,030 443,582 SH   SOLE   443,582 0 0
ZOGENIX INC COM NEW 98978L204 13,588 549,459 SH   SOLE   549,459 0 0
ZOGENIX INC COM NEW 98978L204 18,533 749,400 SH Put SOLE   749,400 0 0
ZOGENIX INC COM NEW 98978L204 5,265 212,900 SH Call SOLE   212,900 0 0