The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Adobe Inc Common Stock 00724F101 7,548 23,718 SH   SOLE   23,718 0 0
Aerojet Rocketdyne Holdings In Common Stock 007800105 238 5,693 SH   SOLE   5,693 0 0
AeroVironment Inc Common Stock 008073108 22,605 370,821 SH   SOLE   300,283 44,930 25,608
Alibaba Group Holding Ltd ADR 01609W102 20,415 104,970 SH   SOLE   72,578 10,183 22,209
Align Technology Inc Common Stock 016255101 258 1,484 SH   SOLE   1,484 0 0
Allegheny Technologies Inc Common Stock 01741R102 18 2,130 SH   SOLE   2,130 0 0
Alphabet Inc Common Stock 02079K305 1,571 1,352 SH   SOLE   1,352 0 0
Altair Engineering Inc Common Stock 021369103 965 36,416 SH   SOLE   36,416 0 0
Amazon.com Inc Common Stock 023135106 27,846 14,282 SH   SOLE   12,944 0 1,338
AMETEK Inc Common Stock 031100100 294 4,084 SH   SOLE   4,084 0 0
ANSYS Inc Common Stock 03662Q105 2,962 12,741 SH   SOLE   12,741 0 0
Apple Inc Common Stock 037833100 22,200 87,302 SH   SOLE   70,959 0 16,343
AquaBounty Technologies Inc Common Stock 03842K200 747 458,408 SH   SOLE   458,408 0 0
Howmet Aerospace Inc Common Stock 443201108 127 9,850 SH   SOLE   9,850 0 0
Arcturus Therapeutics Holdings Common Stock 03969T109 21,261 1,564,457 SH   SOLE   1,564,457 0 0
Autodesk Inc Common Stock 052769106 68,359 437,918 SH   SOLE   334,505 44,033 59,380
Baidu Inc ADR 056752108 1,582 15,694 SH   SOLE   15,694 0 0
Renishaw PLC Common Stock G75006117 1,358 34,609 SH   SOLE   34,609 0 0
CareDx Inc Common Stock 14167L103 17,205 788,144 SH   SOLE   788,144 0 0
Carpenter Technology Corp Common Stock 144285103 16 844 SH   SOLE   844 0 0
Castle Biosciences Inc Common Stock 14843C105 6,572 220,452 SH   SOLE   220,452 0 0
Cellectis SA ADR 15117K103 14,242 1,548,046 SH   SOLE   1,363,749 174,111 10,186
Cellular Biomedicine Group Inc Common Stock 15117P102 6,322 399,632 SH   SOLE   399,632 0 0
Cerus Corp Common Stock 157085101 65,124 14,005,056 SH   SOLE   11,619,631 311,251 2,074,174
Codexis Inc Common Stock 192005106 11,040 989,249 SH   SOLE   989,249 0 0
Deere & Co Common Stock 244199105 2,410 17,447 SH   SOLE   17,447 0 0
DuPont de Nemours Inc Common Stock 26614N102 22 648 SH   SOLE   648 0 0
Eastman Chemical Co Common Stock 277432100 24 512 SH   SOLE   512 0 0
Eastman Kodak Co Common Stock 277461406 20 11,467 SH   SOLE   11,467 0 0
Editas Medicine Inc Common Stock 28106W103 105,812 5,335,941 SH   SOLE   4,128,742 445,150 762,049
Eventbrite Inc Common Stock 29975E109 464 63,530 SH   SOLE   3,314 9,767 50,449
ExOne Co/The Common Stock 302104104 16,650 2,605,683 SH   SOLE   2,224,864 0 380,819
FLIR Systems Inc Common Stock 302445101 3,826 119,984 SH   SOLE   119,984 0 0
Facebook Inc Common Stock 30303M102 1,012 6,066 SH   SOLE   6,066 0 0
FARO Technologies Inc Common Stock 311642102 332 7,462 SH   SOLE   7,462 0 0
Fate Therapeutics Inc Common Stock 31189P102 12,328 555,082 SH   SOLE   555,082 0 0
General Electric Co Common Stock 369604103 208 26,189 SH   SOLE   26,189 0 0
Grayscale Bitcoin Trust BTC Open-End Fund 389637109 20,226 2,840,675 SH   SOLE   1,561,407 511,706 767,562
Guardant Health Inc Common Stock 40131M109 17,237 247,651 SH   SOLE   247,651 0 0
Guidewire Software Inc Common Stock 40171V100 975 12,292 SH   SOLE   12,292 0 0
HDFC Bank Ltd ADR 40415F101 2,031 52,809 SH   SOLE   52,809 0 0
HP Inc Common Stock 40434L105 1,329 76,567 SH   SOLE   76,567 0 0
Hexcel Corp Common Stock 428291108 19 512 SH   SOLE   512 0 0
HubSpot Inc Common Stock 443573100 6,791 50,989 SH   SOLE   50,989 0 0
Illumina Inc Common Stock 452327109 274,220 1,004,026 SH   SOLE   786,687 85,525 131,814
Incyte Corp Common Stock 45337C102 14,960 204,284 SH   SOLE   204,284 0 0
Inovio Pharmaceuticals Inc Common Stock 45773H201 12,186 1,637,926 SH   SOLE   1,637,926 0 0
Intellia Therapeutics Inc Common Stock 45826J105 125,226 10,239,286 SH   SOLE   8,559,768 740,852 938,666
Interactive Brokers Group Inc Common Stock 45841N107 1,309 30,321 SH   SOLE   30,321 0 0
Intercontinental Exchange Inc Common Stock 45866F104 3,168 39,232 SH   SOLE   39,232 0 0
Intuit Inc Common Stock 461202103 1,961 8,526 SH   SOLE   8,526 0 0
Intuitive Surgical Inc Common Stock 46120E602 2,796 5,647 SH   SOLE   5,647 0 0
OC Oerlikon Corp AG Common Stock H59187106 215 26,791 SH   SOLE   26,791 0 0
Invitae Corp Common Stock 46185L103 220,015 16,094,750 SH   SOLE   12,826,319 1,049,935 2,218,496
Ionis Pharmaceuticals Inc Common Stock 462222100 5,659 119,681 SH   SOLE   119,681 0 0
Iovance Biotherapeutics Inc Common Stock 462260100 26,558 887,179 SH   SOLE   887,179 0 0
Iridium Communications Inc Common Stock 46269C102 36,575 1,637,951 SH   SOLE   1,268,741 157,278 211,932
JD.com Inc ADR 47215P106 3,117 76,962 SH   SOLE   76,962 0 0
SGL Carbon SE Common Stock D6949M108 21 7,817 SH   SOLE   7,817 0 0
Kaiser Aluminum Corp Common Stock 483007704 200 2,887 SH   SOLE   2,887 0 0
Komatsu Ltd ADR 500458401 3,356 204,514 SH   SOLE   204,514 0 0
Kratos Defense & Security Solu Common Stock 50077B207 3,832 276,862 SH   SOLE   276,862 0 0
Henkel AG & Co KGaA Preference D3207M110 31 386 SH   SOLE   386 0 0
Bertrandt AG Common Stock D1014N107 175 5,157 SH   SOLE   5,157 0 0
LendingClub Corp Common Stock 52603A208 43,180 5,500,633 SH   SOLE   4,644,507 127,913 728,213
LendingTree Inc Common Stock 52603B107 87,236 475,685 SH   SOLE   360,881 38,659 76,145
Dassault Systemes SE Common Stock F2457H472 1,220 8,237 SH   SOLE   8,237 0 0
Lincoln Electric Holdings Inc Common Stock 533900106 217 3,141 SH   SOLE   3,141 0 0
Siemens AG Common Stock D69671218 200 2,399 SH   SOLE   2,399 0 0
Materialise NV ADR 57667T100 62,751 3,379,164 SH   SOLE   3,072,602 73,645 232,917
MercadoLibre Inc Common Stock 58733R102 23,366 47,825 SH   SOLE   31,403 7,808 8,614
Microsoft Corp Common Stock 594918104 1,345 8,527 SH   SOLE   8,527 0 0
Bezeq The Israeli Telecommunic Common Stock M2012Q100 560 774,147 SH   SOLE   774,147 0 0
Bet Shemesh Engines Holdings 1 Common Stock M20119109 352 14,025 SH   SOLE   14,025 0 0
Moog Inc Common Stock 615394202 163 3,224 SH   SOLE   3,224 0 0
Rakuten Inc Common Stock J64264104 1,158 152,213 SH   SOLE   152,213 0 0
Danel Adir Yeoshua Ltd Common Stock M27013107 438 6,275 SH   SOLE   6,275 0 0
Hilan Ltd Common Stock M5299H123 418 13,286 SH   SOLE   13,286 0 0
Nano Dimension Ltd ADR 63008G203 71 75,731 SH   SOLE   75,731 0 0
NanoString Technologies Inc Common Stock 63009R109 73,392 3,051,660 SH   SOLE   2,787,727 255,664 8,269
Elbit Systems Ltd Common Stock M3760D101 2,369 18,551 SH   SOLE   18,551 0 0
SBI Holdings Inc/Japan Common Stock J6991H100 1,893 129,300 SH   SOLE   129,300 0 0
Partner Communications Co Ltd Common Stock M78465107 508 136,332 SH   SOLE   136,332 0 0
Netflix Inc Common Stock 64110L106 13,697 36,477 SH   SOLE   27,492 1,894 7,091
Nice Ltd ADR 653656108 473 3,295 SH   SOLE   3,295 0 0
FirstRand Ltd Common Stock S5202Z131 58 13,580 SH   SOLE   13,580 0 0
NVIDIA Corp Common Stock 67066G104 41,757 158,409 SH   SOLE   121,655 17,034 19,720
NuVasive Inc Common Stock 670704105 198 3,907 SH   SOLE   3,907 0 0
Matrix IT Ltd Common Stock M6859E153 433 26,419 SH   SOLE   26,419 0 0
Organovo Holdings Inc Common Stock 68620A104 9,394 22,912,766 SH   SOLE   22,842,197 70,569 0
Toray Industries Inc Common Stock J89494116 25 5,808 SH   SOLE   5,808 0 0
PTC Inc Common Stock 69370C100 1,089 17,786 SH   SOLE   17,786 0 0
Pacific Biosciences of Califor Common Stock 69404D108 12,831 4,193,059 SH   SOLE   4,193,059 0 0
One Software Technologies Ltd Common Stock M9866H102 486 7,376 SH   SOLE   7,376 0 0
PayPal Holdings Inc Common Stock 70450Y103 10,424 108,882 SH   SOLE   104,332 4,550 0
Personalis Inc Common Stock 71535D106 8,910 1,104,065 SH   SOLE   1,104,065 0 0
Straumann Holding AG Common Stock H8300N119 1,199 1,606 SH   SOLE   1,606 0 0
Pinduoduo Inc ADR 722304102 7,678 213,112 SH   SOLE   213,112 0 0
Pinterest Inc Common Stock 72352L106 86,602 5,608,922 SH   SOLE   4,561,180 419,526 628,216
Pluristem Therapeutics Inc Common Stock 72940R300 2,423 660,150 SH   SOLE   660,150 0 0
PolyOne Corp Common Stock 73179P106 22 1,171 SH   SOLE   1,171 0 0
Proto Labs Inc Common Stock 743713109 122,012 1,602,676 SH   SOLE   1,229,553 150,407 222,716
Wirecard AG Common Stock D22359133 1,302 11,536 SH   SOLE   11,536 0 0
Rakuten Inc ADR 75102W108 102 13,623 SH   SOLE   13,623 0 0
Redhill Biopharma Ltd ADR 757468103 436 96,151 SH   SOLE   96,151 0 0
Regeneron Pharmaceuticals Inc Common Stock 75886F107 43 89 SH   SOLE   89 0 0
Roku Inc Common Stock 77543R102 147,566 1,686,850 SH   SOLE   1,326,491 147,920 212,439
Rubius Therapeutics Inc Common Stock 78116T103 1,416 318,121 SH   SOLE   28,130 270,697 19,294
salesforce.com Inc Common Stock 79466L302 19,896 138,189 SH   SOLE   50,749 39,789 47,651
Charles Schwab Corp/The Common Stock 808513105 1,204 35,805 SH   SOLE   35,805 0 0
Seres Therapeutics Inc Common Stock 81750R102 30,871 8,647,311 SH   SOLE   7,152,461 649,867 844,983
Shopify Inc Common Stock 82509L107 168 402 SH   SOLE   402 0 0
Snap Inc Common Stock 83304A106 12,667 1,065,328 SH   SOLE   1,065,328 0 0
SolarEdge Technologies Inc Common Stock 83417M104 465 5,683 SH   SOLE   5,683 0 0
Splunk Inc Common Stock 848637104 95,287 754,867 SH   SOLE   588,884 67,951 98,032
Square Inc Common Stock 852234103 250,317 4,778,869 SH   SOLE   3,703,086 405,410 670,373
Stryker Corp Common Stock 863667101 236 1,415 SH   SOLE   1,415 0 0
Syros Pharmaceuticals Inc Common Stock 87184Q107 34,983 5,899,398 SH   SOLE   5,143,384 92,721 663,293
Taiwan Semiconductor Manufactu ADR 874039100 3,404 71,236 SH   SOLE   71,236 0 0
Teladoc Health Inc Common Stock 87918A105 19,701 127,094 SH   SOLE   73,708 26,795 26,591
Tencent Holdings Ltd ADR 88032Q109 22,811 464,671 SH   SOLE   423,600 38,335 2,736
Teradyne Inc Common Stock 880770102 39,112 722,022 SH   SOLE   571,292 78,618 72,112
Tesla Inc Common Stock 88160R101 312,644 596,649 SH   SOLE   535,039 58,845 2,765
Teva Pharmaceutical Industries ADR 881624209 504 56,123 SH   SOLE   56,123 0 0
Trade Desk Inc/The Common Stock 88339J105 5,778 29,939 SH   SOLE   29,939 0 0
3D Systems Corp Common Stock 88554D205 1,123 145,604 SH   SOLE   145,604 0 0
3M Co Common Stock 88579Y101 32 232 SH   SOLE   232 0 0
TransUnion Common Stock 89400J107 1,067 16,123 SH   SOLE   16,123 0 0
Trimble Inc Common Stock 896239100 5,916 185,873 SH   SOLE   185,873 0 0
Twilio Inc Common Stock 90138F102 13,632 152,325 SH   SOLE   152,325 0 0
Twist Bioscience Corp Common Stock 90184D100 19,696 644,093 SH   SOLE   644,093 0 0
Twitter Inc Common Stock 90184L102 34,284 1,395,937 SH   SOLE   820,007 216,879 359,051
2U Inc Common Stock 90214J101 143,422 6,758,820 SH   SOLE   5,325,329 531,142 902,349
Ultra Clean Holdings Inc Common Stock 90385V107 170 12,354 SH   SOLE   12,354 0 0
United Parcel Service Inc Common Stock 911312106 242 2,586 SH   SOLE   2,586 0 0
Veracyte Inc Common Stock 92337F107 79,393 3,265,859 SH   SOLE   3,190,818 75,041 0
Verisk Analytics Inc Common Stock 92345Y106 1,176 8,436 SH   SOLE   8,436 0 0
Workday Inc Common Stock 98138H101 7,729 59,357 SH   SOLE   59,357 0 0
Xilinx Inc Common Stock 983919101 120,968 1,552,066 SH   SOLE   1,234,268 124,117 193,681
Xerox Holdings Corp Common Stock 98421M106 22 1,162 SH   SOLE   1,162 0 0
Zillow Group Inc Common Stock 98954M101 113,760 3,348,848 SH   SOLE   2,493,679 325,643 529,526
Koninklijke DSM NV Common Stock N5017D122 37 329 SH   SOLE   329 0 0
Arkema SA Common Stock F0392W125 28 408 SH   SOLE   408 0 0
MGI Digital Graphic Technology Common Stock F4090S113 1,089 29,116 SH   SOLE   29,116 0 0
Sandvik AB Common Stock W74857165 31 2,212 SH   SOLE   2,212 0 0
Hexagon AB Common Stock W40063104 312 7,347 SH   SOLE   7,347 0 0
Cellcom Israel Ltd Common Stock M2196U109 535 182,654 SH   SOLE   182,654 0 0
Evonik Industries AG Common Stock D2R90Y117 30 1,430 SH   SOLE   1,430 0 0
Fattal Holdings 1998 Ltd Common Stock M4148G105 126 3,668 SH   SOLE   3,668 0 0
Meituan Dianping Common Stock G59669104 2,945 243,727 SH   SOLE   243,727 0 0
SLM Solutions Group AG Common Stock D6T690109 837 108,313 SH   SOLE   108,313 0 0
ZhongAn Online P&C Insurance C Common Stock Y989DF109 2,101 636,100 SH   SOLE   636,100 0 0
Adyen NV Common Stock N3501V104 2,432 2,877 SH   SOLE   2,877 0 0
Atlassian Corp PLC Common Stock G06242104 6,028 43,915 SH   SOLE   43,915 0 0
Medtronic PLC Common Stock G5960L103 229 2,544 SH   SOLE   2,544 0 0
Aptiv PLC Common Stock G6095L109 2,715 55,136 SH   SOLE   53,235 1,901 0
Sapiens International Corp NV Common Stock G7T16G103 431 22,637 SH   SOLE   22,637 0 0
CRISPR Therapeutics AG Common Stock H17182108 181,754 4,285,632 SH   SOLE   3,342,383 337,686 605,563
Spotify Technology SA Common Stock L8681T102 6,764 55,695 SH   SOLE   37,241 17,130 1,324
Allot Ltd Common Stock M0854Q105 572 60,495 SH   SOLE   60,495 0 0
AudioCodes Ltd Common Stock M15342104 494 20,677 SH   SOLE   20,677 0 0
Camtek Ltd/Israel Common Stock M20791105 387 46,013 SH   SOLE   46,013 0 0
Ceragon Networks Ltd Common Stock M22013102 327 259,697 SH   SOLE   259,697 0 0
Check Point Software Technolog Common Stock M22465104 507 5,044 SH   SOLE   5,044 0 0
Compugen Ltd Common Stock M25722105 74,969 10,326,360 SH   SOLE   9,953,375 212,075 160,910
CyberArk Software Ltd Common Stock M2682V108 354 4,133 SH   SOLE   4,133 0 0
Evogene Ltd Common Stock M4119S104 302 256,129 SH   SOLE   256,129 0 0
Galmed Pharmaceuticals Ltd Common Stock M47238106 305 88,243 SH   SOLE   88,243 0 0
Fiverr International Ltd Common Stock M4R82T106 552 21,942 SH   SOLE   21,942 0 0
Mellanox Technologies Ltd Common Stock M51363113 585 4,826 SH   SOLE   4,826 0 0
Ituran Location and Control Lt Common Stock M6158M104 320 22,516 SH   SOLE   22,516 0 0
Nova Measuring Instruments Ltd Common Stock M7516K103 475 14,555 SH   SOLE   14,555 0 0
Radware Ltd Common Stock M81873107 473 22,426 SH   SOLE   22,426 0 0
Stratasys Ltd Common Stock M85548101 156,232 9,795,137 SH   SOLE   7,517,884 733,741 1,543,512
Taro Pharmaceutical Industries Common Stock M8737E108 415 6,779 SH   SOLE   6,779 0 0
Tower Semiconductor Ltd Common Stock M87915274 362 22,757 SH   SOLE   22,757 0 0
UroGen Pharma Ltd Common Stock M96088105 300 16,821 SH   SOLE   16,821 0 0
Wix.com Ltd Common Stock M98068105 408 4,047 SH   SOLE   4,047 0 0
NXP Semiconductors NV Common Stock N6596X109 3,281 39,559 SH   SOLE   39,559 0 0
Bayer AG Common Stock D0712D163 22 390 SH   SOLE   0 390 0
FANUC Corp Common Stock J13440102 30 220 SH   SOLE   0 220 0
Nintendo Co Ltd Common Stock J51699106 66 171 SH   SOLE   0 171 0
SoftBank Group Corp Common Stock J75963108 39 1,110 SH   SOLE   0 1,110 0
DocuSign Inc Common Stock 256163106 1,246 13,489 SH   SOLE   13,489 0 0
Zscaler Inc Common Stock 98980G102 6,639 109,084 SH   SOLE   109,084 0 0
Wirecard AG ADR 97654L108 202 3,594 SH   SOLE   3,594 0 0
GMO internet Inc Common Stock J1822R104 45 2,700 SH   SOLE   2,700 0 0
Discovery Ltd Common Stock S2192Y109 841 191,917 SH   SOLE   191,917 0 0
Inmode Ltd Common Stock M5425M103 280 13,013 SH   SOLE   13,013 0 0
Perion Network Ltd Common Stock M78673114 323 66,012 SH   SOLE   66,012 0 0
Silvergate Capital Corp Common Stock 82837P408 470 49,251 SH   SOLE   49,251 0 0
Alteryx Inc Common Stock 02156B103 5,866 61,638 SH   SOLE   61,638 0 0
Meituan Dianping ADR 58533E103 401 16,871 SH   SOLE   16,871 0 0
Z Holdings Corp Common Stock J9894K105 2,868 888,120 SH   SOLE   888,120 0 0
Sea Ltd ADR 81141R100 9,895 223,322 SH   SOLE   223,322 0 0
Z Holdings Corp ADR 98877X101 419 66,488 SH   SOLE   66,488 0 0
Pure Storage Inc Common Stock 74624M102 53,112 4,318,047 SH   SOLE   3,615,952 344,340 357,755
Synopsys Inc Common Stock 871607107 7,445 57,808 SH   SOLE   57,808 0 0
HUYA Inc ADR 44852D108 9,384 553,613 SH   SOLE   553,613 0 0
RADA Electronic Industries Ltd Common Stock M81863124 306 87,438 SH   SOLE   87,438 0 0
Sol-Gel Technologies Ltd Common Stock M8694L103 290 41,098 SH   SOLE   41,098 0 0
PagerDuty Inc Common Stock 69553P100 45,058 2,607,525 SH   SOLE   2,203,031 89,553 314,941
Bellicum Pharmaceuticals Inc Common Stock 079481404 0 49 SH   SOLE   49 0 0
Precigen Inc Common Stock 74017N105 1 281 SH   SOLE   281 0 0
Caterpillar Inc Common Stock 149123101 3,084 26,577 SH   SOLE   26,577 0 0
Rockwell Automation Inc Common Stock 773903109 1,471 9,747 SH   SOLE   9,747 0 0
Menlo Therapeutics Inc Common Stock 586858102 197 73,329 SH   SOLE   73,329 0 0