The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2U Inc COM 90214J101 106,223 5,005,788 SH   SOLE   5,005,788 0 0
Aerojet Rocketdyne Holdings In COM 007800105 269 6,430 SH   SOLE   0 0 6,430
AeroVironment Inc COM 008073108 31,859 522,625 SH   SOLE   227,142 0 295,483
Agnico Eagle Mines Ltd COM 008474108 3,483 87,543 SH   SOLE   87,543 0 0
Alamos Gold Inc COM 011532108 2,786 557,245 SH   SOLE   557,245 0 0
Albemarle Corp COM 012653101 836 14,833 SH   SOLE   14,833 0 0
Alibaba Group Holding Ltd COM 01609W102 105,302 541,456 SH   SOLE   0 0 541,456
Alphabet Inc COM 02079K107 6,707 5,768 SH   SOLE   0 0 5,768
Alteryx Inc COM 02156B103 27,357 287,450 SH   SOLE   0 0 287,450
Amazon.com Inc COM 023135106 117,301 60,163 SH   SOLE   0 0 60,163
AngloGold Ashanti Ltd COM 035128206 3,086 185,557 SH   SOLE   185,557 0 0
ANSYS Inc COM 03662Q105 4,231 18,199 SH   SOLE   0 0 18,199
Apple Inc COM 037833100 145,116 570,673 SH   SOLE   0 0 570,673
Aptiv PLC COM G6095L109 6,825 138,614 SH   SOLE   0 0 138,614
AquaBounty Technologies Inc COM 03842K200 578 354,384 SH   SOLE   0 0 354,384
Archer-Daniels-Midland Co COM 039483102 2,978 84,653 SH   SOLE   84,653 0 0
Arcturus Therapeutics Holdings COM 03969T109 3,466 255,066 SH   SOLE   0 0 255,066
Autodesk Inc COM 052769106 64,471 413,011 SH   SOLE   359,085 0 53,926
B2Gold Corp COM 11777Q209 4,117 1,345,300 SH   SOLE   1,345,300 0 0
Baidu Inc COM 056752108 7,283 72,263 SH   SOLE   0 0 72,263
Baker Hughes Co COM 05722G100 2,525 240,497 SH   SOLE   236,484 0 4,013
Banco Bradesco SA COM 059460303 416 102,377 SH   SOLE   0 0 102,377
Barrick Gold Corp COM 067901108 5,344 291,730 SH   SOLE   291,730 0 0
Bellicum Pharmaceuticals Inc COM 079481404 1,025 217,696 SH   SOLE   0 0 217,696
BHP Group PLC COM 05545E209 10,699 352,631 SH   SOLE   352,631 0 0
Bluebird Bio Inc COM 09609G100 4,879 106,151 SH   SOLE   0 0 106,151
Boeing Co/The COM 097023105 92 618 SH   SOLE   0 0 618
BP PLC COM 055622104 4,385 179,775 SH   SOLE   179,775 0 0
Bristol-Myers Squibb Co COM 110122108 23,023 413,034 SH   SOLE   0 0 413,034
Bunge Ltd COM G16962105 1,257 30,624 SH   SOLE   30,624 0 0
Cabot Oil & Gas Corp COM 127097103 1,406 81,816 SH   SOLE   77,082 0 4,734
Cactus Inc COM 127203107 606 52,210 SH   SOLE   52,210 0 0
Calyxt Inc COM 13173L107 1,662 499,087 SH   SOLE   0 0 499,087
Canadian Natural Resources Ltd COM 136385101 1,700 125,481 SH   SOLE   125,481 0 0
CareDx Inc COM 14167L103 21,719 994,935 SH   SOLE   0 0 994,935
Caterpillar Inc COM 149123101 8,314 71,650 SH   SOLE   0 0 71,650
Cellectis SA COM 15117K103 11,878 1,291,073 SH   SOLE   0 0 1,291,073
Cellular Biomedicine Group Inc COM 15117P102 7,541 476,673 SH   SOLE   0 0 476,673
Cerus Corp COM 157085101 49,799 10,709,561 SH   SOLE   7,980,002 0 2,729,559
CF Industries Holdings Inc COM 125269100 1,686 61,985 SH   SOLE   61,985 0 0
Charles Schwab Corp/The COM 808513105 26,986 802,672 SH   SOLE   0 0 802,672
Chevron Corp COM 166764100 7,296 100,689 SH   SOLE   98,819 0 1,870
China Biologic Products Holdin COM G21515104 12,329 114,227 SH   SOLE   0 0 114,227
China Petroleum & Chemical Cor COM 16941R108 956 19,624 SH   SOLE   19,624 0 0
Codexis Inc COM 192005106 15,614 1,399,119 SH   SOLE   0 0 1,399,119
Compugen Ltd COM M25722105 60,699 8,360,770 SH   SOLE   6,263,428 0 2,097,342
Concho Resources Inc COM 20605P101 2,604 60,774 SH   SOLE   59,091 0 1,683
ConocoPhillips COM 20825C104 1,499 48,685 SH   SOLE   48,685 0 0
Corteva Inc COM 22052L104 14,255 606,596 SH   SOLE   145,770 0 460,826
CRISPR Therapeutics AG COM H17182108 159,739 3,766,541 SH   SOLE   2,802,711 0 963,830
Deere & Co COM 244199105 9,928 71,858 SH   SOLE   0 0 71,858
Diamondback Energy Inc COM 25278X109 1,928 73,583 SH   SOLE   71,349 0 2,234
DocuSign Inc COM 256163106 26,468 286,445 SH   SOLE   0 0 286,445
Domino's Pizza Inc COM 25754A201 4,521 13,951 SH   SOLE   0 0 13,951
Dril-Quip Inc COM 262037104 638 20,919 SH   SOLE   20,919 0 0
Editas Medicine Inc COM 28106W103 101,285 5,107,677 SH   SOLE   3,637,375 0 1,470,302
Elbit Systems Ltd COM M3760D101 1,659 12,994 SH   SOLE   0 0 12,994
EOG Resources Inc COM 26875P101 1,909 53,152 SH   SOLE   51,646 0 1,506
ExOne Co/The COM 302104104 10,450 1,635,394 SH   SOLE   1,635,394 0 0
Exxon Mobil Corp COM 30231G102 5,951 156,719 SH   SOLE   153,952 0 2,767
Facebook Inc COM 30303M102 21,853 131,015 SH   SOLE   0 0 131,015
Fate Therapeutics Inc COM 31189P102 20,567 926,009 SH   SOLE   0 0 926,009
FLIR Systems Inc COM 302445101 8,828 276,811 SH   SOLE   0 0 276,811
Freeport-McMoRan Inc COM 35671D857 2,989 442,870 SH   SOLE   442,870 0 0
Garmin Ltd COM H2906T109 3,679 49,078 SH   SOLE   0 0 49,078
Guardant Health Inc COM 40131M109 26,887 386,312 SH   SOLE   0 0 386,312
Guidewire Software Inc COM 40171V100 20,044 252,728 SH   SOLE   0 0 252,728
Halliburton Co COM 406216101 2,255 329,218 SH   SOLE   325,506 0 3,712
HDFC Bank Ltd COM 40415F101 43,217 1,123,681 SH   SOLE   0 0 1,123,681
HEICO Corp COM 422806109 266 3,561 SH   SOLE   0 0 3,561
Hess Corp COM 42809H107 976 29,303 SH   SOLE   29,303 0 0
Honeywell International Inc COM 438516106 210 1,571 SH   SOLE   0 0 1,571
Illumina Inc COM 452327109 281,567 1,030,928 SH   SOLE   707,293 0 323,635
Incyte Corp COM 45337C102 20,868 284,964 SH   SOLE   0 0 284,964
Inovio Pharmaceuticals Inc COM 45773H201 20,192 2,713,984 SH   SOLE   0 0 2,713,984
Intellia Therapeutics Inc COM 45826J105 86,726 7,091,263 SH   SOLE   5,033,463 0 2,057,800
Interactive Brokers Group Inc COM 45841N107 30,810 713,694 SH   SOLE   0 0 713,694
Intercontinental Exchange Inc COM 45866F104 61,661 763,607 SH   SOLE   0 0 763,607
International Paper Co COM 460146103 4,377 140,603 SH   SOLE   140,603 0 0
Intuit Inc COM 461202103 39,271 170,742 SH   SOLE   0 0 170,742
Invitae Corp COM 46185L103 178,969 13,092,125 SH   SOLE   9,844,029 0 3,248,096
Ionis Pharmaceuticals Inc COM 462222100 18,019 381,112 SH   SOLE   0 0 381,112
Iovance Biotherapeutics Inc COM 462260100 33,543 1,120,522 SH   SOLE   0 0 1,120,522
Iridium Communications Inc COM 46269C102 29,135 1,304,756 SH   SOLE   1,267,330 0 37,426
JD.com Inc COM 47215P106 10,302 254,365 SH   SOLE   0 0 254,365
Kratos Defense & Security Solu COM 50077B207 6,050 437,140 SH   SOLE   0 0 437,140
L3Harris Technologies Inc COM 502431109 362 2,011 SH   SOLE   0 0 2,011
LendingClub Corp COM 52603A208 50,374 6,417,106 SH   SOLE   4,034,666 0 2,382,440
LendingTree Inc COM 52603B107 144,501 787,943 SH   SOLE   353,270 0 434,673
Liberty Oilfield Services Inc COM 53115L104 868 322,807 SH   SOLE   318,169 0 4,638
Linde PLC COM G5494J103 3,880 22,427 SH   SOLE   22,427 0 0
Lockheed Martin Corp COM 539830109 449 1,326 SH   SOLE   0 0 1,326
Marathon Petroleum Corp COM 56585A102 1,279 54,154 SH   SOLE   52,439 0 1,715
Materialise NV COM 57667T100 52,719 2,838,938 SH   SOLE   2,824,091 0 14,847
MercadoLibre Inc COM 58733R102 120,011 245,633 SH   SOLE   35,998 0 209,635
Mosaic Co/The COM 61945C103 845 78,098 SH   SOLE   78,098 0 0
NanoString Technologies Inc COM 63009R109 86,550 3,598,769 SH   SOLE   2,869,994 0 728,775
Netflix Inc COM 64110L106 17,700 47,138 SH   SOLE   34,875 0 12,263
Newmont Corp COM 651639106 3,625 80,051 SH   SOLE   80,051 0 0
Nucor Corp COM 670346105 2,936 81,504 SH   SOLE   81,504 0 0
Nutrien Ltd COM 67077M108 8,036 236,775 SH   SOLE   236,775 0 0
NVIDIA Corp COM 67066G104 117,010 443,893 SH   SOLE   139,781 0 304,112
NXP Semiconductors NV COM N6596X109 8,325 100,390 SH   SOLE   0 0 100,390
Occidental Petroleum Corp COM 674599105 1,217 105,087 SH   SOLE   102,366 0 2,721
Oceaneering International Inc COM 675232102 313 106,556 SH   SOLE   106,556 0 0
Oil States International Inc COM 678026105 399 196,749 SH   SOLE   193,732 0 3,017
ONEOK Inc COM 682680103 454 20,814 SH   SOLE   18,696 0 2,118
Organovo Holdings Inc COM 68620A104 5,251 12,807,832 SH   SOLE   8,339,088 0 4,468,744
Packaging Corp of America COM 695156109 2,075 23,899 SH   SOLE   23,899 0 0
PagerDuty Inc COM 69553P100 30,130 1,743,608 SH   SOLE   1,743,608 0 0
Patterson-UTI Energy Inc COM 703481101 459 195,308 SH   SOLE   191,562 0 3,746
PayPal Holdings Inc COM 70450Y103 85,607 894,163 SH   SOLE   0 0 894,163
Personalis Inc COM 71535D106 9,803 1,214,710 SH   SOLE   0 0 1,214,710
Petroleo Brasileiro SA COM 71654V408 410 74,635 SH   SOLE   74,635 0 0
Phillips 66 COM 718546104 1,273 23,726 SH   SOLE   23,726 0 0
Pinduoduo Inc COM 722304102 60,726 1,685,442 SH   SOLE   0 0 1,685,442
Pinterest Inc COM 72352L106 135,577 8,780,905 SH   SOLE   4,052,043 0 4,728,862
Pioneer Natural Resources Co COM 723787107 1,707 24,333 SH   SOLE   23,623 0 710
Pluristem Therapeutics Inc COM 72940R300 750 204,362 SH   SOLE   0 0 204,362
Precigen Inc COM 74017N105 9,361 2,753,134 SH   SOLE   0 0 2,753,134
Proto Labs Inc COM 743713109 93,746 1,231,388 SH   SOLE   1,181,487 0 49,901
Pure Storage Inc COM 74624M102 47,950 3,898,413 SH   SOLE   2,954,586 0 943,827
Regeneron Pharmaceuticals Inc COM 75886F107 30,101 61,646 SH   SOLE   0 0 61,646
Rio Tinto PLC COM 767204100 10,710 235,078 SH   SOLE   235,078 0 0
Rockwell Automation Inc COM 773903109 3,247 21,513 SH   SOLE   0 0 21,513
Roku Inc COM 77543R102 117,304 1,340,922 SH   SOLE   1,340,922 0 0
Royal Dutch Shell PLC COM 780259206 5,563 159,455 SH   SOLE   159,455 0 0
salesforce.com Inc COM 79466L302 51,609 358,443 SH   SOLE   65,365 0 293,078
Sarepta Therapeutics Inc COM 803607100 10,695 109,335 SH   SOLE   0 0 109,335
Schlumberger Ltd COM 806857108 4,622 342,624 SH   SOLE   338,466 0 4,158
Sea Ltd COM 81141R100 36,709 828,454 SH   SOLE   80,529 0 747,925
Seres Therapeutics Inc COM 81750R102 30,053 8,418,320 SH   SOLE   5,781,472 0 2,636,848
Snap Inc COM 83304A106 35,478 2,983,891 SH   SOLE   552,485 0 2,431,406
Southern Copper Corp COM 84265V105 1,519 53,959 SH   SOLE   53,959 0 0
Spirit AeroSystems Holdings In COM 848574109 119 4,966 SH   SOLE   0 0 4,966
Splunk Inc COM 848637104 131,493 1,041,691 SH   SOLE   459,888 0 581,803
Spotify Technology SA COM L8681T102 3,850 31,701 SH   SOLE   0 0 31,701
Square Inc COM 852234103 376,832 7,194,197 SH   SOLE   3,355,928 0 3,838,269
Steel Dynamics Inc COM 858119100 2,482 110,130 SH   SOLE   110,130 0 0
Stratasys Ltd COM M85548101 87,176 5,465,567 SH   SOLE   5,434,920 0 30,647
Suncor Energy Inc COM 867224107 2,700 170,855 SH   SOLE   166,549 0 4,306
Synopsys Inc COM 871607107 3,500 27,174 SH   SOLE   0 0 27,174
Syros Pharmaceuticals Inc COM 87184Q107 29,206 4,925,206 SH   SOLE   3,331,769 0 1,593,437
Taiwan Semiconductor Manufactu COM 874039100 48,173 1,008,023 SH   SOLE   0 0 1,008,023
TechnipFMC PLC COM G87110105 1,690 250,807 SH   SOLE   246,307 0 4,500
Teck Resources Ltd COM 878742204 1,497 197,988 SH   SOLE   197,988 0 0
Teladoc Health Inc COM 87918A105 32,104 207,109 SH   SOLE   26,375 0 180,734
Teledyne Technologies Inc COM 879360105 170 572 SH   SOLE   0 0 572
Teradyne Inc COM 880770102 49,775 918,860 SH   SOLE   736,319 0 182,541
Tesla Inc COM 88160R101 258,641 493,589 SH   SOLE   433,510 0 60,079
Thermo Fisher Scientific Inc COM 883556102 26,294 92,714 SH   SOLE   0 0 92,714
TOTAL SA COM 89151E109 6,327 169,904 SH   SOLE   169,904 0 0
TransUnion COM 89400J107 24,269 366,718 SH   SOLE   0 0 366,718
Trimble Inc COM 896239100 16,300 512,081 SH   SOLE   0 0 512,081
Twilio Inc COM 90138F102 47,865 534,869 SH   SOLE   0 0 534,869
Twist Bioscience Corp COM 90184D100 24,638 805,706 SH   SOLE   0 0 805,706
Twitter Inc COM 90184L102 22,644 922,006 SH   SOLE   791,767 0 130,239
United Parcel Service Inc COM 911312106 5,420 58,021 SH   SOLE   0 0 58,021
Univar Solutions Inc COM 91336L107 870 81,156 SH   SOLE   81,156 0 0
Valero Energy Corp COM 91913Y100 1,413 31,146 SH   SOLE   31,146 0 0
Veracyte Inc COM 92337F107 79,918 3,287,467 SH   SOLE   2,303,412 0 984,055
Verisk Analytics Inc COM 92345Y106 26,619 190,980 SH   SOLE   0 0 190,980
Vertex Pharmaceuticals Inc COM 92532F100 26,275 110,423 SH   SOLE   0 0 110,423
Virgin Galactic Holdings Inc COM 92766K106 227 15,347 SH   SOLE   0 0 15,347
Weyerhaeuser Co COM 962166104 2,793 164,768 SH   SOLE   164,768 0 0
Williams Cos Inc/The COM 969457100 1,040 73,469 SH   SOLE   73,469 0 0
Workday Inc COM 98138H101 60,927 467,880 SH   SOLE   273,902 0 193,978
Xilinx Inc COM 983919101 94,944 1,218,167 SH   SOLE   989,772 0 228,395
Zillow Group Inc COM 98954M200 181,375 5,035,394 SH   SOLE   2,394,246 0 2,641,148
Zscaler Inc COM 98980G102 16,072 264,075 SH   SOLE   264,075 0 0