The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2U Inc COM 90214J101 100,307 4,181,193 SH   SOLE   4,181,193 0 0
Aerojet Rocketdyne Holdings In COM 007800105 289 6,340 SH   SOLE   0 0 6,340
AeroVironment Inc COM 008073108 52,715 853,824 SH   SOLE   419,494 0 434,330
Agnico Eagle Mines Ltd COM 008474108 7,050 114,424 SH   SOLE   114,424 0 0
Alamos Gold Inc COM 011532108 4,385 728,447 SH   SOLE   728,447 0 0
Albemarle Corp COM 012653101 3,628 49,673 SH   SOLE   49,673 0 0
Alcoa Corp COM 013872106 1,143 53,144 SH   SOLE   53,144 0 0
Alibaba Group Holding Ltd COM 01609W102 137,353 647,584 SH   SOLE   0 0 647,584
Alphabet Inc COM 02079K107 13,122 9,814 SH   SOLE   0 0 9,814
Amazon.com Inc COM 023135106 114,723 62,085 SH   SOLE   0 0 62,085
AngloGold Ashanti Ltd COM 035128206 5,418 242,521 SH   SOLE   242,521 0 0
ANSYS Inc COM 03662Q105 7,319 28,435 SH   SOLE   0 0 28,435
Apple Inc COM 037833100 218,674 744,674 SH   SOLE   0 0 744,674
Aptiv PLC COM G6095L109 35,092 369,506 SH   SOLE   85,132 0 284,374
AquaBounty Technologies Inc COM 03842K200 817 376,324 SH   SOLE   0 0 376,324
Archer-Daniels-Midland Co COM 039483102 5,131 110,703 SH   SOLE   110,703 0 0
Arcturus Therapeutics Holdings COM 03969T109 3,050 280,548 SH   SOLE   0 0 280,548
Autodesk Inc COM 052769106 36,497 198,935 SH   SOLE   162,132 0 36,803
B2Gold Corp COM 11777Q209 7,032 1,753,730 SH   SOLE   1,753,730 0 0
Baidu Inc COM 056752108 52,277 413,582 SH   SOLE   0 0 413,582
Baker Hughes Co COM 05722G100 7,264 283,425 SH   SOLE   281,109 0 2,316
Banco Bradesco SA COM 059460303 730 81,547 SH   SOLE   0 0 81,547
Barrick Gold Corp COM 067901108 7,090 381,372 SH   SOLE   381,372 0 0
Bellicum Pharmaceuticals Inc COM 079481107 2,968 2,300,682 SH   SOLE   0 0 2,300,682
BHP Group PLC COM 05545E209 20,929 445,198 SH   SOLE   445,198 0 0
Bluebird Bio Inc COM 09609G100 21,825 248,719 SH   SOLE   0 0 248,719
Boeing Co/The COM 097023105 338 1,037 SH   SOLE   0 0 1,037
BP PLC COM 055622104 8,871 235,044 SH   SOLE   235,044 0 0
Bristol-Myers Squibb Co COM 110122108 36,422 567,404 SH   SOLE   0 0 567,404
Bunge Ltd COM G16962105 2,320 40,307 SH   SOLE   40,307 0 0
Cabot Oil & Gas Corp COM 127097103 4,081 234,410 SH   SOLE   230,107 0 4,303
Cactus Inc COM 127203107 1,723 50,214 SH   SOLE   50,214 0 0
Callon Petroleum Co COM 13123X102 3,339 691,265 SH   SOLE   691,265 0 0
Calyxt Inc COM 13173L107 3,940 562,030 SH   SOLE   0 0 562,030
Canadian Natural Resources Ltd COM 136385101 4,217 130,349 SH   SOLE   130,349 0 0
CareDx Inc COM 14167L103 13,136 609,009 SH   SOLE   0 0 609,009
Caterpillar Inc COM 149123101 6,230 42,185 SH   SOLE   0 0 42,185
Cellectis SA COM 15117K103 21,899 1,279,147 SH   SOLE   0 0 1,279,147
Cellular Biomedicine Group Inc COM 15117P102 8,653 532,825 SH   SOLE   0 0 532,825
Cerus Corp COM 157085101 41,209 9,765,054 SH   SOLE   7,280,617 0 2,484,437
CF Industries Holdings Inc COM 125269100 3,865 80,951 SH   SOLE   80,951 0 0
Charles Schwab Corp/The COM 808513105 30,307 637,235 SH   SOLE   0 0 637,235
Chevron Corp COM 166764100 11,222 93,122 SH   SOLE   91,978 0 1,144
China Biologic Products Holdin COM G21515104 14,743 126,678 SH   SOLE   0 0 126,678
China Petroleum & Chemical Cor COM 16941R108 1,544 25,677 SH   SOLE   25,677 0 0
Codexis Inc COM 192005106 21,955 1,373,076 SH   SOLE   0 0 1,373,076
Compugen Ltd COM M25722105 48,574 8,149,982 SH   SOLE   6,168,753 0 1,981,229
Concho Resources Inc COM 20605P101 6,862 78,358 SH   SOLE   77,210 0 1,148
ConocoPhillips COM 20825C104 4,194 64,498 SH   SOLE   64,498 0 0
Corteva Inc COM 22052L104 20,178 682,625 SH   SOLE   168,591 0 514,034
CRISPR Therapeutics AG COM H17182108 185,733 3,049,553 SH   SOLE   2,079,677 0 969,876
Deere & Co COM 244199105 14,817 85,518 SH   SOLE   0 0 85,518
Diamondback Energy Inc COM 25278X109 6,929 74,622 SH   SOLE   73,675 0 947
DocuSign Inc COM 256163106 27,316 368,588 SH   SOLE   0 0 368,588
Domino's Pizza Inc COM 25754A201 6,854 23,330 SH   SOLE   0 0 23,330
Dril-Quip Inc COM 262037104 1,242 26,482 SH   SOLE   26,482 0 0
DuPont de Nemours Inc COM 26614N102 2,719 42,355 SH   SOLE   42,355 0 0
Editas Medicine Inc COM 28106W103 146,517 4,948,227 SH   SOLE   3,322,869 0 1,625,358
Elbit Systems Ltd COM M3760D101 2,660 17,156 SH   SOLE   0 0 17,156
EOG Resources Inc COM 26875P101 5,159 61,597 SH   SOLE   60,569 0 1,028
Eventbrite Inc COM 29975E109 78,025 3,868,354 SH   SOLE   1,271,803 0 2,596,551
ExOne Co/The COM 302104104 12,023 1,611,681 SH   SOLE   1,611,681 0 0
Exxon Mobil Corp COM 30231G102 13,188 188,995 SH   SOLE   187,313 0 1,682
Facebook Inc COM 30303M102 28,929 140,946 SH   SOLE   0 0 140,946
Fate Therapeutics Inc COM 31189P102 16,044 819,810 SH   SOLE   0 0 819,810
FLIR Systems Inc COM 302445101 7,879 151,307 SH   SOLE   0 0 151,307
Freeport-McMoRan Inc COM 35671D857 7,600 579,268 SH   SOLE   579,268 0 0
Garmin Ltd COM H2906T109 4,970 50,946 SH   SOLE   0 0 50,946
General Motors Co COM 37045V100 6,006 164,086 SH   SOLE   0 0 164,086
Guardant Health Inc COM 40131M109 29,405 376,307 SH   SOLE   0 0 376,307
Guidewire Software Inc COM 40171V100 38,866 354,067 SH   SOLE   0 0 354,067
Halliburton Co COM 406216101 10,082 412,023 SH   SOLE   409,369 0 2,654
HDFC Bank Ltd COM 40415F101 56,468 891,089 SH   SOLE   0 0 891,089
HEICO Corp COM 422806109 448 3,925 SH   SOLE   0 0 3,925
Hess Corp COM 42809H107 2,264 33,890 SH   SOLE   33,890 0 0
Honeywell International Inc COM 438516106 64 359 SH   SOLE   0 0 359
Illumina Inc COM 452327109 276,428 833,268 SH   SOLE   537,973 0 295,295
Incyte Corp COM 45337C102 15,853 181,550 SH   SOLE   0 0 181,550
Inovio Pharmaceuticals Inc COM 45773H201 16,657 5,047,608 SH   SOLE   0 0 5,047,608
Intellia Therapeutics Inc COM 45826J105 105,309 7,178,520 SH   SOLE   4,881,242 0 2,297,278
Interactive Brokers Group Inc COM 45841N107 24,565 526,930 SH   SOLE   0 0 526,930
Intercontinental Exchange Inc COM 45866F104 69,514 751,092 SH   SOLE   0 0 751,092
International Paper Co COM 460146103 8,476 184,052 SH   SOLE   184,052 0 0
Intrexon Corp COM 46122T102 17,108 3,121,849 SH   SOLE   0 0 3,121,849
Intuit Inc COM 461202103 48,534 185,293 SH   SOLE   0 0 185,293
Invitae Corp COM 46185L103 162,220 10,057,040 SH   SOLE   7,677,137 0 2,379,903
Ionis Pharmaceuticals Inc COM 462222100 25,655 424,683 SH   SOLE   0 0 424,683
Iovance Biotherapeutics Inc COM 462260100 36,718 1,326,509 SH   SOLE   0 0 1,326,509
Iridium Communications Inc COM 46269C102 809 32,839 SH   SOLE   0 0 32,839
JD.com Inc COM 47215P106 14,246 404,382 SH   SOLE   0 0 404,382
Kratos Defense & Security Solu COM 50077B207 7,689 426,926 SH   SOLE   0 0 426,926
L3Harris Technologies Inc COM 502431109 441 2,227 SH   SOLE   0 0 2,227
LendingClub Corp COM 52603A208 73,858 5,852,428 SH   SOLE   3,285,039 0 2,567,389
LendingTree Inc COM 52603B107 154,423 508,907 SH   SOLE   219,389 0 289,518
Liberty Oilfield Services Inc COM 53115L104 3,564 320,479 SH   SOLE   317,880 0 2,599
Linde PLC COM G5494J103 2,754 12,937 SH   SOLE   12,937 0 0
Lockheed Martin Corp COM 539830109 503 1,291 SH   SOLE   0 0 1,291
Marathon Petroleum Corp COM 56585A102 4,055 67,299 SH   SOLE   66,553 0 746
Materialise NV COM 57667T100 48,834 2,667,051 SH   SOLE   2,654,048 0 13,003
MercadoLibre Inc COM 58733R102 148,807 260,179 SH   SOLE   81,847 0 178,332
Mosaic Co/The COM 61945C103 2,158 99,744 SH   SOLE   99,744 0 0
NanoString Technologies Inc COM 63009R109 106,567 3,830,602 SH   SOLE   3,023,350 0 807,252
Nasdaq Inc COM 631103108 32,266 301,270 SH   SOLE   0 0 301,270
Netflix Inc COM 64110L106 46,213 142,822 SH   SOLE   120,064 0 22,758
Newmont Goldcorp Corp COM 651639106 3,119 71,795 SH   SOLE   71,795 0 0
Nucor Corp COM 670346105 5,997 106,561 SH   SOLE   106,561 0 0
Nutrien Ltd COM 67077M108 14,836 309,668 SH   SOLE   309,668 0 0
NVIDIA Corp COM 67066G104 136,324 579,364 SH   SOLE   114,486 0 464,878
NXP Semiconductors NV COM N6596X109 14,186 111,475 SH   SOLE   0 0 111,475
Occidental Petroleum Corp COM 674599105 5,609 136,118 SH   SOLE   134,416 0 1,702
Oceaneering International Inc COM 675232102 2,027 135,964 SH   SOLE   135,964 0 0
Oil States International Inc COM 678026105 4,061 248,977 SH   SOLE   246,545 0 2,432
ONEOK Inc COM 682680103 1,905 25,175 SH   SOLE   23,725 0 1,450
Organovo Holdings Inc COM 68620A104 4,556 12,807,832 SH   SOLE   8,339,088 0 4,468,744
Packaging Corp of America COM 695156109 3,510 31,342 SH   SOLE   31,342 0 0
Patterson-UTI Energy Inc COM 703481101 2,602 247,763 SH   SOLE   244,924 0 2,839
PayPal Holdings Inc COM 70450Y103 77,284 714,466 SH   SOLE   0 0 714,466
PerkinElmer Inc COM 714046109 11,490 118,329 SH   SOLE   0 0 118,329
Personalis Inc COM 71535D106 10,473 960,830 SH   SOLE   0 0 960,830
Petroleo Brasileiro SA COM 71654V408 1,509 94,648 SH   SOLE   94,648 0 0
Phillips 66 COM 718546104 2,824 25,352 SH   SOLE   25,352 0 0
Pinduoduo Inc COM 722304102 65,408 1,729,447 SH   SOLE   0 0 1,729,447
Pinterest Inc COM 72352L106 53,913 2,892,341 SH   SOLE   1,106,523 0 1,785,818
Pioneer Natural Resources Co COM 723787107 4,072 26,898 SH   SOLE   26,374 0 524
Pluristem Therapeutics Inc COM 72940R300 853 216,415 SH   SOLE   0 0 216,415
Proto Labs Inc COM 743713109 65,635 646,335 SH   SOLE   641,092 0 5,243
Regeneron Pharmaceuticals Inc COM 75886F107 54,528 145,223 SH   SOLE   0 0 145,223
Rio Tinto PLC COM 767204100 18,264 307,674 SH   SOLE   307,674 0 0
Roku Inc COM 77543R102 75,264 562,092 SH   SOLE   562,092 0 0
Royal Dutch Shell PLC COM 780259206 12,292 208,403 SH   SOLE   208,403 0 0
Rubius Therapeutics Inc COM 78116T103 13,642 1,436,013 SH   SOLE   0 0 1,436,013
salesforce.com Inc COM 79466L302 123,609 760,015 SH   SOLE   319,143 0 440,872
Sarepta Therapeutics Inc COM 803607100 15,724 121,855 SH   SOLE   0 0 121,855
Schlumberger Ltd COM 806857108 14,754 367,018 SH   SOLE   364,569 0 2,449
Seres Therapeutics Inc COM 81750R102 28,543 8,273,223 SH   SOLE   5,434,478 0 2,838,745
Shopify Inc COM 82509L107 77,779 195,631 SH   SOLE   0 0 195,631
Snap Inc COM 83304A106 32,089 1,965,050 SH   SOLE   0 0 1,965,050
Southern Copper Corp COM 84265V105 2,996 70,526 SH   SOLE   70,526 0 0
Spirit AeroSystems Holdings In COM 848574109 288 3,949 SH   SOLE   0 0 3,949
Splunk Inc COM 848637104 157,794 1,053,578 SH   SOLE   395,538 0 658,040
Spotify Technology SA COM L8681T102 18,574 124,202 SH   SOLE   76,602 0 47,600
Square Inc COM 852234103 405,735 6,485,530 SH   SOLE   2,636,856 0 3,848,674
Steel Dynamics Inc COM 858119100 4,898 143,880 SH   SOLE   143,880 0 0
Stratasys Ltd COM M85548101 110,390 5,458,115 SH   SOLE   5,428,013 0 30,102
Suncor Energy Inc COM 867224107 7,082 215,926 SH   SOLE   213,085 0 2,841
Synopsys Inc COM 871607107 5,162 37,085 SH   SOLE   0 0 37,085
Syros Pharmaceuticals Inc COM 87184Q107 34,375 4,974,662 SH   SOLE   3,133,118 0 1,841,544
Taiwan Semiconductor Manufactu COM 874039100 62,467 1,075,161 SH   SOLE   0 0 1,075,161
TechnipFMC PLC COM G87110105 6,120 285,445 SH   SOLE   282,587 0 2,858
Teck Resources Ltd COM 878742204 4,493 258,660 SH   SOLE   258,660 0 0
Teladoc Health Inc COM 87918A105 76,885 918,355 SH   SOLE   329,364 0 588,991
Teledyne Technologies Inc COM 879360105 261 754 SH   SOLE   0 0 754
Teradyne Inc COM 880770102 47,018 689,516 SH   SOLE   495,861 0 193,655
Tesla Inc COM 88160R101 294,478 703,937 SH   SOLE   591,759 0 112,178
Thermo Fisher Scientific Inc COM 883556102 23,821 73,324 SH   SOLE   0 0 73,324
TOTAL SA COM 89151E109 12,285 222,159 SH   SOLE   222,159 0 0
Trade Desk Inc/The COM 88339J105 53,438 205,705 SH   SOLE   205,705 0 0
TransUnion COM 89400J107 33,775 394,524 SH   SOLE   0 0 394,524
Trimble Inc COM 896239100 17,749 425,735 SH   SOLE   0 0 425,735
Twilio Inc COM 90138F102 51,202 520,976 SH   SOLE   0 0 520,976
Twitter Inc COM 90184L102 66,208 2,065,786 SH   SOLE   1,909,703 0 156,083
United Parcel Service Inc COM 911312106 4,754 40,611 SH   SOLE   0 0 40,611
Univar Solutions Inc COM 91336L107 2,148 88,614 SH   SOLE   88,614 0 0
Valero Energy Corp COM 91913Y100 2,194 23,425 SH   SOLE   23,425 0 0
Veracyte Inc COM 92337F107 85,247 3,053,251 SH   SOLE   2,095,684 0 957,567
Verisk Analytics Inc COM 92345Y106 31,595 211,561 SH   SOLE   0 0 211,561
Vertex Pharmaceuticals Inc COM 92532F100 26,907 122,890 SH   SOLE   0 0 122,890
Virgin Galactic Holdings Inc COM 92766K106 220 19,073 SH   SOLE   0 0 19,073
Weyerhaeuser Co COM 962166104 6,507 215,449 SH   SOLE   215,449 0 0
Williams Cos Inc/The COM 969457100 2,226 93,826 SH   SOLE   93,826 0 0
Workday Inc COM 98138H101 53,447 325,007 SH   SOLE   151,708 0 173,299
Xilinx Inc COM 983919101 97,043 992,561 SH   SOLE   751,267 0 241,294
Zillow Group Inc COM 98954M200 216,857 4,720,432 SH   SOLE   1,675,934 0 3,044,498
Zscaler Inc COM 98980G102 11,642 250,376 SH   SOLE   250,376 0 0