The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC COM 004225108 5,989 140,000 SH Put SOLE   140,000 0 0
ADURO BIOTECH INC COM 00739L101 2,169 1,838,528 SH   SOLE   1,838,528 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 4,503 390,900 SH Call SOLE   390,900 0 0
AETERNA ZENTARIS INC COM 007975402 107 117,443 SH   SOLE   117,443 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 2,388 50,000 SH Call SOLE   50,000 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 1,339 40,000 SH   SOLE   40,000 0 0
ALLAKOS INC COM 01671P100 15,143 158,800 SH Call SOLE   158,800 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 18 4,739 SH   SOLE   4,739 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 4,663 217,500 SH Call SOLE   217,500 0 0
ANAPTYSBIO INC COM 032724106 2,324 143,000 SH   SOLE   143,000 0 0
ANAPTYSBIO INC COM 032724106 3,141 193,300 SH Put SOLE   193,300 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 8,785 286,900 SH Put SOLE   286,900 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 7,358 240,300 SH Call SOLE   240,300 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 2 53 SH   SOLE   53 0 0
APPLIED GENETIC TECHNOL CORP COM 03820J100 908 200,884 SH   SOLE   200,884 0 0
APTOSE BIOSCIENCES INC COM NEW 03835T200 5,725 1,009,735 SH   SOLE   1,009,735 0 0
ARDELYX INC COM 039697107 4,844 645,436 SH   SOLE   645,436 0 0
ARQULE INC COM 04269E107 9,934 497,700 SH Call SOLE   497,700 0 0
ARQULE INC COM 04269E107 2,973 148,930 SH   SOLE   148,930 0 0
ARQULE INC COM 04269E107 6,715 336,400 SH Put SOLE   336,400 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 6,343 100,000 SH Put SOLE   100,000 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 6,343 100,000 SH Call SOLE   100,000 0 0
ARVINAS INC COM 04335A105 127 3,100 SH Call SOLE   3,100 0 0
ARVINAS INC COM 04335A105 127 3,100 SH Put SOLE   3,100 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 9,655 69,400 SH Call SOLE   69,400 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 3,222 157,468 SH   SOLE   157,468 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 3,069 150,000 SH Put SOLE   150,000 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 9,747 481,104 SH   SOLE   481,104 0 0
AXOVANT GENE THERAPIES LTD COM G0750W203 967 188,884 SH   SOLE   188,884 0 0
AXSOME THERAPEUTICS INC COM 05464T104 2,884 27,900 SH Put SOLE   27,900 0 0
BEIGENE LTD SPONSORED ADR 07725L102 12,764 77,000 SH Put SOLE   77,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 625 63,721 SH   SOLE   63,721 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 35 642 SH   SOLE   642 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 10,888 200,000 SH Call SOLE   200,000 0 0
BIOXCEL THERAPEUTICS INC COM 09075P105 2,314 158,373 SH   SOLE   158,373 0 0
CARA THERAPEUTICS INC COM 140755109 285 17,700 SH Call SOLE   17,700 0 0
CARA THERAPEUTICS INC COM 140755109 68 4,200 SH Put SOLE   4,200 0 0
CEL SCI CORP COM PAR NEW 150837607 2,747 300,200 SH Put SOLE   300,200 0 0
CERECOR INC COM 15671L109 2,802 519,800 SH   SOLE   519,800 0 0
CHEMOCENTRYX INC COM 16383L106 1,836 46,423 SH   SOLE   46,423 0 0
CHIASMA INC COM 16706W102 5,472 1,103,297 SH   SOLE   1,103,297 0 0
CHIMERIX INC COM 16934W106 351 172,920 SH   SOLE   172,920 0 0
CLOVIS ONCOLOGY INC COM 189464100 5,355 513,700 SH Call SOLE   513,700 0 0
COHERUS BIOSCIENCES INC COM 19249H103 1,514 84,100 SH Call SOLE   84,100 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 7,534 123,700 SH Put SOLE   123,700 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 798 74,538 SH   SOLE   74,538 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 6,224 100,000 SH Call SOLE   100,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 341 15,500 SH Call SOLE   15,500 0 0
EIDOS THERAPEUTICS INC COM 28249H104 5,739 100,000 SH Call SOLE   100,000 0 0
GILEAD SCIENCES INC COM 375558103 32,490 500,000 SH Call SOLE   500,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 7,949 100,000 SH Call SOLE   100,000 0 0
GOSSAMER BIO INC COM 38341P102 12,052 771,100 SH Put SOLE   771,100 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 10,456 100,000 SH Call SOLE   100,000 0 0
IMMUNOMEDICS INC COM 452907108 9,484 448,200 SH Call SOLE   448,200 0 0
IMMUNOVANT INC COM 45258J102 8,000 504,117 SH   SOLE   504,117 0 0
INCYTE CORP COM 45337C102 6,986 80,000 SH Call SOLE   80,000 0 0
INFLARX NV COM N44821101 1,422 359,128 SH   SOLE   359,128 0 0
INSMED INC COM PAR $.01 457669307 1,461 61,200 SH Call SOLE   61,200 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 8,042 64,900 SH Call SOLE   64,900 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 93,547 754,900 SH Put SOLE   754,900 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 9,164 267,100 SH Call SOLE   267,100 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 31,706 924,100 SH Put SOLE   924,100 0 0
ISHARES TR NASDAQ BIOTECH 464287556 30,128 250,000 SH Put SOLE   250,000 0 0
KALA PHARMACEUTICALS INC COM 483119103 3,776 1,023,431 SH   SOLE   1,023,431 0 0
KALA PHARMACEUTICALS INC COM 483119103 1,459 395,500 SH Call SOLE   395,500 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 3,783 212,420 SH   SOLE   212,420 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 3,836 200,100 SH Put SOLE   200,100 0 0
MACROGENICS INC COM 556099109 109 10,030 SH   SOLE   10,030 0 0
MACROGENICS INC COM 556099109 1,632 150,000 SH Call SOLE   150,000 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 9,111 100,000 SH Put SOLE   100,000 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 4,079 44,770 SH   SOLE   44,770 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 131 8,674 SH   SOLE   8,674 0 0
MALLINCKRODT PUB LTD CO SHS G5785G107 1,787 512,000 SH   SOLE   512,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 530 74,500 SH Call SOLE   74,500 0 0
MINERVA NEUROSCIENCES INC COM 603380106 711 100,000 SH   SOLE   100,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 6,301 48,900 SH Put SOLE   48,900 0 0
MIRATI THERAPEUTICS INC COM 60468T105 12,886 100,000 SH Call SOLE   100,000 0 0
MOLECULAR TEMPLATES INC COM 608550109 572 40,907 SH   SOLE   40,907 0 0
MUSTANG BIO INC COM 62818Q104 1,319 323,235 SH   SOLE   323,235 0 0
MYOKARDIA INC COM 62857M105 4,300 59,000 SH Put SOLE   59,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 774 7,200 SH Call SOLE   7,200 0 0
NOVAVAX INC COM NEW 670002401 100 25,049 SH   SOLE   25,049 0 0
OBSEVA SA COM H5861P103 315 82,573 SH   SOLE   82,573 0 0
OCULAR THERAPEUTIX INC COM 67576A100 593 150,000 SH Call SOLE   150,000 0 0
OCULAR THERAPEUTIX INC COM 67576A100 2,203 557,659 SH   SOLE   557,659 0 0
OTONOMY INC COM 68906L105 4,088 1,067,271 SH   SOLE   1,067,271 0 0
OVID THERAPEUTICS INC COM 690469101 1,453 350,000 SH   SOLE   350,000 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 80 22,000 SH Call SOLE   22,000 0 0
PRECISION BIOSCIENCES INC COM 74019P108 1,111 80,000 SH   SOLE   80,000 0 0
PROGENICS PHARMACEUTICALS IN COM 743187106 666 130,845 SH   SOLE   130,845 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 552 78,326 SH   SOLE   78,326 0 0
PROTEON THERAPEUTICS INC COM 74371L109 138 336,373 SH   SOLE   336,373 0 0
PROTHENA CORP PLC SHS G72800108 472 29,832 SH   SOLE   29,832 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 1,161 132,700 SH Call SOLE   132,700 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 2,723 311,253 SH   SOLE   311,253 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 749 350,000 SH   SOLE   350,000 0 0
SAGE THERAPEUTICS INC COM 78667J108 9,601 133,000 SH   SOLE   133,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 13,240 102,600 SH Call SOLE   102,600 0 0
SIERRA ONCOLOGY INC COM 82640U107 132 386,399 SH   SOLE   386,399 0 0
SOLID BIOSCIENCES INC COM 83422E105 1,360 305,600 SH Call SOLE   305,600 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 33,289 350,000 SH Put SOLE   350,000 0 0
STEALTH BIOTHERAPEUTICS CORP SPONSORED ADS 85789A105 123 37,597 SH   SOLE   37,597 0 0
SUNESIS PHARMACEUTICALS INC COM 867328700 38 111,445 SH   SOLE   111,445 0 0
TG THERAPEUTICS INC COM 88322Q108 3,510 316,200 SH   SOLE   316,200 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 2,136 50,000 SH   SOLE   50,000 0 0
VIKING THERAPEUTICS INC COM 92686J106 1,203 150,000 SH Call SOLE   150,000 0 0
VIKING THERAPEUTICS INC COM 92686J106 1,012 126,159 SH   SOLE   126,159 0 0
VIKING THERAPEUTICS INC COM 92686J106 1,203 150,000 SH Put SOLE   150,000 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 1,077 134,400 SH Call SOLE   134,400 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 2,405 300,000 SH Put SOLE   300,000 0 0
X4 PHARMACEUTICALS INC COM 98420X103 107 10,000 SH   SOLE   10,000 0 0
XENON PHARMACEUTICALS INC COM 98420N105 3,192 243,470 SH   SOLE   243,470 0 0
ZOGENIX INC COM NEW 98978L204 240 4,600 SH Call SOLE   4,600 0 0
ZOGENIX INC COM NEW 98978L204 7,726 148,200 SH Put SOLE   148,200 0 0