The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCURAY INC COM 004397105 1,868 674,300 SH   SOLE 674,300 0 0
ACHILLION PHARMACEUTICALS COM 00448Q201 1,580 438,884 SH   SOLE 438,884 0 0
ADVAXIS INC COM NEW 007624307 93 350,000 SH   SOLE 350,000 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 5,531 287,748 SH   SOLE 287,748 0 0
AILERON THERAPEUTICS INC COM 00887A105 67 99,502 SH   SOLE 99,502 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 3,246 828,038 SH   SOLE 828,038 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 11,995 636,013 SH   SOLE 636,013 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 264 50,000 SH   SOLE 50,000 0 0
ALECTOR INC COM 014442107 2,091 145,000 SH   SOLE 145,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 4,090 169,800 SH   SOLE 169,800 0 0
APPLIED GENETIC TECHNOL CORP COM 03820J100 1,494 359,190 SH   SOLE 359,190 0 0
ARCTURUS THERAPEUTICS HLDG I COM 03969T109 1,786 173,914 SH   SOLE 173,914 0 0
ARDELYX INC COM 039697107 2,728 580,524 SH   SOLE 580,524 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 4,300 93,942 SH   SOLE 93,942 0 0
ARGENX SE SPONSORED ADR 04016X101 2,504 21,969 SH   SOLE 21,969 0 0
ARQULE INC COM 04269E107 3,802 530,262 SH   SOLE 530,262 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 5,825 60,480 SH   SOLE 60,480 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 497 50,573 SH   SOLE 50,573 0 0
ATRICURE INC COM 04963C209 7,949 318,729 SH   SOLE 318,729 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 1,242 100,000 SH   SOLE 100,000 0 0
BELLICUM PHARMACEUTICALS INC COM 079481107 210 200,000 SH   SOLE 200,000 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 1,385 483,388 SH   SOLE 483,388 0 0
BIOHAVEN PHARMACEUTICALS HOLD COM G11196105 3,963 95,000 SH   SOLE 95,000 0 0
BIOTELEMETRY INC COM 090672106 1,845 45,300 SH   SOLE 45,300 0 0
BIOXCEL THERAPEUTICS INC COM 09075P105 898 127,500 SH   SOLE 127,500 0 0
BLUEBIRD BIO INC COM 09609G100 2,341 25,500 SH   SOLE 25,500 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 9,053 123,218 SH   SOLE 123,218 0 0
CARA THERAPEUTICS INC COM 140755109 6,927 378,924 SH   SOLE 378,924 0 0
CARDIOVASCULAR SYSTEMS INC COM 141619106 2,195 46,200 SH   SOLE 46,200 0 0
CIDARA THERAPEUTICS INC COM 171757107 199 99,993 SH   SOLE 99,993 0 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 1,448 297,300 SH   SOLE 297,300 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 1,792 349,996 SH   SOLE 349,996 0 0
CYTOKINETICS INC COM NEW 23282W605 4,765 418,727 SH   SOLE 418,727 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 738 100,000 SH   SOLE 100,000 0 0
DERMIRA INC COM 24983L104 665 104,000 SH   SOLE 104,000 0 0
DEXCOM INC COM 252131107 5,423 36,338 SH   SOLE 36,338 0 0
DEXCOM INC NOTE 0.750% 5/1 252131AF4 397 250,000 PRN   SOLE 250,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 1,699 118,314 SH   SOLE 118,314 0 0
ELOXX PHARMACEUTICALS INC COM 29014R103 1,695 375,000 SH   SOLE 375,000 0 0
EPIZYME INC COM 29428V104 1,258 121,986 SH   SOLE 121,986 0 0
EVELO BIOSCIENCES INC COM 299734103 122 20,000 SH   SOLE 20,000 0 0
FATE THERAPEUTICS INC COM 31189P102 7,299 470,000 SH   SOLE 470,000 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 929 305,500 SH   SOLE 305,500 0 0
GALAPAGOS NV SPON ADR 36315X101 8,016 52,509 SH   SOLE 52,509 0 0
GAMIDA CELL LTD SHS M47364100 1,182 272,909 SH   SOLE 272,909 0 0
GENOCEA BIOSCIENCES INC COM NEW 372427401 1,573 542,564 SH   SOLE 542,564 0 0
GRITSTONE ONCOLOGY INC COM 39868T105 432 50,000 SH   SOLE 50,000 0 0
INOGEN INC COM 45780L104 1,102 23,000 SH   SOLE 23,000 0 0
INSMED INC COM PAR $.01 457669307 529 30,000 SH   SOLE 30,000 0 0
ISHARES TR NASDAQ BIOTECH ETF 464287556 6,458 64,900 SH   SOLE 64,900 0 0
JOHNSON AND JOHNSON COM 478160104 1,216 9,400 SH   SOLE 9,400 0 0
KADMON HOLDINGS INC COM 48283N106 2,233 886,177 SH   SOLE 886,177 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 287 24,725 SH   SOLE 24,725 0 0
KARUNA THERAPEUTICS INC COM 48576A100 183 11,192 SH   SOLE 11,192 0 0
KURA ONCOLOGY INC COM 50127T109 1,572 103,658 SH   SOLE 103,658 0 0
LINEAGE CELL THERAPEUTICS IN COM 53566P109 93 95,000 SH   SOLE 95,000 0 0
LUMINEX CORP COM 55027E102 4,214 204,091 SH   SOLE 204,091 0 0
MACROGENICS INC COM 556099109 2,552 200,000 SH   SOLE 200,000 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 569 6,600 SH   SOLE 6,600 0 0
MASIMO CORPORATION COM 574795100 446 3,000 SH   SOLE 3,000 0 0
MENLO THERAPEUTICS INC COM 586858102 3,839 856,936 SH   SOLE 856,936 0 0
MERSANA THERAPEUTICS INC COM 59045L106 793 501,736 SH   SOLE 501,736 0 0
NATUS MEDICAL INC COM 639050103 1,366 42,900 SH   SOLE 42,900 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 5,813 64,508 SH   SOLE 64,508 0 0
NEURONETICS INC COM 64131A105 883 106,247 SH   SOLE 106,247 0 0
NEVRO CORP COM 64157F103 1,823 21,210 SH   SOLE 21,210 0 0
OBSEVA SA COM H5861P103 535 64,231 SH   SOLE 64,231 0 0
ORAMED PHARMACEUTICALS INC COM NEW 68403P203 51 16,000 SH   SOLE 16,000 0 0
PHASEBIO PHARMACEUTICALS INC COM 717224109 1,503 360,542 SH   SOLE 360,542 0 0
PREVAIL THERAPEUTICS INC COM 74140Y101 921 75,000 SH   SOLE 75,000 0 0
PROQR THERAPEUTICS N V SHS EURO N71542109 1,506 261,521 SH   SOLE 261,521 0 0
RADIUS HEALTH INC COM NEW 750469207 567 22,000 SH   SOLE 22,000 0 0
RADIUS HEALTH INC NOTE 3.000% 9/0 750469AA6 3,665 4,000,000 PRN   SOLE 4,000,000 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 295 157,700 SH   SOLE 157,700 0 0
SAGE THERAPEUTICS INC COM 78667J108 17,509 124,806 SH   SOLE 124,806 0 0
SCYNEXIS INC COM 811292101 1,356 1,272,927 SH   SOLE 1,272,927 0 0
SPERO THERAPEUTICS INC COM 84833T103 418 39,395 SH   SOLE 39,395 0 0
STEREOTAXIS INC COM NEW 85916J409 48,019 13,680,554 SH   SOLE 13,680,554 0 0
SUNESIS PHARMACEUTICALS INC COM 867328700 663 920,995 SH   SOLE 920,995 0 0
SUTRO BIOPHARMA INC COM 869367102 364 40,000 SH   SOLE 40,000 0 0
SYNLOGIC INC COM 87166L100 991 432,830 SH   SOLE 432,830 0 0
TRANSLATE BIO INC COM 89374L104 3,610 364,229 SH   SOLE 364,229 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 1,779 47,308 SH   SOLE 47,308 0 0
UROGEN PHARMA LTD COM M96088105 357 15,000 SH   SOLE 15,000 0 0
VIKING THERAPEUTICS INC COM 92686J106 1,439 209,200 SH   SOLE 209,200 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 4,056 197,554 SH   SOLE 197,554 0 0
XENON PHARMACEUTICALS INC COM 98420N105 2,979 330,667 SH   SOLE 330,667 0 0
ZAFGEN INC COM 98885E103 226 305,500 SH   SOLE 305,500 0 0
ZOGENIX INC COM NEW 98978L204 5,716 142,764 SH   SOLE 142,764 0 0