The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101 33,991 206,760 SH   DFND 1 206,760 0 0
ADVANCED ENERGY INDUSTRIES INC COM 007973100 210 3,650 SH   DFND 1 3,650 0 0
AKARI THERAPEUTICS PLC COM 00972G108 2,565 1,500,096 SH   DFND 1 1,500,096 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 422 80,020 SH   DFND 1 80,020 0 0
ALLERGAN PLC SPONSORED ADR G0177J108 32,934 195,700 SH   DFND 1 195,700 0 0
ALLISON TRANSMISSION HOLDINGS,INC COM 01973R101 201 4,270 SH   DFND 1 4,270 0 0
ALPHABET INC CLASS C CL C 38259P706 4,754 3,900 SH   DFND 1 0 0 3,900
ALPINE IMMUNE SCIENCES INC COM 02083G100 735 185,587 SH   DFND 1 185,587 0 0
ALTRIA GROUP INC COM 02209S103 10,466 255,900 SH   DFND 1 255,900 0 0
AMERISOURCEBERGEN CORP COM 03073E105 213 2,590 SH   DFND 1 2,590 0 0
AMGEN INC COM 031162100 6,512 33,650 SH   DFND 1 33,650 0 0
ANAVEX LIFE SCIENCES CORP COM 032797300 1,479 468,110 SH   DFND 1 468,110 0 0
ANHEUSER-BUSCH INBEV NV SPONSORED ADR 03524A108 8,916 93,700 SH   DFND 1 93,700 0 0
APPLIED MATERIALS INC COM 038222105 231 4,630 SH   DFND 1 4,630 0 0
BANK OF NEW YORK MELLON CORP COM 064058100 14,435 319,290 SH   DFND 1 319,290 0 0
BECTON DICKINSON & CO COM 075887109 6,063 23,970 SH   DFND 1 23,970 0 0
BERKSHIRE HATHAWAY INC CLASS A CL A 084670108 233,874 750 SH   DFND 1 750 0 0
BERKSHIRE HATHAWAY INC CLASS B CL B 084670702 562 2,700 SH   DFND 1 2,700 0 0
BHP BILLITON PLC COM 05545E209 9,679 225,930 SH   DFND 1 225,930 0 0
BIOGEN INC COM 09062X103 3,290 14,130 SH   DFND 1 14,130 0 0
BOEING CO COM 097023105 22,029 57,900 SH   DFND 1 57,900 0 0
BRITISH AMERICAN TOBACCO PLC COM 110448107 714 19,350 SH   DFND 1 19,350 0 0
CALITHERA BIOSCIENCES,INC COM 13089P101 155 50,000 SH   DFND 1 50,000 0 0
CELGENE CORP COM 151020104 207 2,080 SH   DFND 1 2,080 0 0
CHINA MOBILE LIMITED SPONSORED ADR 16941M109 2,000 48,300 SH   DFND 1 48,300 0 0
CIGNA CORPORATION COM 125509109 3,995 26,316 SH   DFND 1 26,316 0 0
CISCO SYSTEMS INC COM 17275R102 5,134 103,900 SH   DFND 1 103,900 0 0
COLGATE-PALMOLIVE COMPANY COM 194162103 956 13,000 SH   DFND 1 13,000 0 0
CORCEPT THERAPEUTICS INC COM 218352102 237 16,790 SH   DFND 1 16,790 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 391 130,000 SH   DFND 1 130,000 0 0
DANAHER CORP COM 235851102 31,168 215,800 SH   DFND 1 215,800 0 0
DAVITA HEALTHCARE PARTNERS INC COM 23918K108 2,421 42,420 SH   DFND 1 42,420 0 0
DELUXE CORP COM 248019101 211 4,300 SH   DFND 1 4,300 0 0
DEUTSCHE X-TRACKERS HARVEST CSI 300 CHINA A-SHARES FUND ETF 233051879 7,360 271,680 SH   DFND 1 271,680 0 0
DIAMOND OFFSHORE DRILLING INC COM 25271C102 196 35,200 SH   DFND 1 35,200 0 0
DYNAVAX TECHNOLOGIES CORPORATION COM 268158201 377 105,573 SH   DFND 1 105,573 0 0
COCA COLA CO COM 191216100 2,504 46,000 SH   DFND 1 46,000 0 0
ECOLAB INC COM 278865100 416 2,100 SH   DFND 1 2,100 0 0
EMCOR GROUP INC COM 29084Q100 221 2,570 SH   DFND 1 2,570 0 0
EVOLUS INC COM 30052C107 1,070 68,500 SH   DFND 1 68,500 0 0
EXXON MOBIL CORPORATION COM 30231G102 13,377 189,443 SH   DFND 1 189,443 0 0
FIAT CHRYSLER AUTOMOBILES NV COM N31738102 432 33,350 SH   DFND 1 33,350 0 0
FORTIVE CORP COM 34959J108 9,907 144,500 SH   DFND 1 144,500 0 0
FTS INTERNATIONAL INC COM 30283W104 42 18,640 SH   DFND 1 18,640 0 0
GAMESTOP CORP-CLASS A CL A 36467W109 122 22,120 SH   DFND 1 22,120 0 0
GENERAL ELECTRIC COMPANY COM 369604103 7,015 784,700 SH   DFND 1 784,700 0 0
GENERAL MILLS,INC COM 370334104 364 6,600 SH   DFND 1 6,600 0 0
GILEAD SCIENCES INC COM 375558103 5,338 84,220 SH   DFND 1 84,220 0 0
GRAFTECH INTERNATIONAL LTD COM 384313508 181 14,150 SH   DFND 1 14,150 0 0
INNOVIVA INC COM 45781M101 151 14,340 SH   DFND 1 14,340 0 0
INTERNATIONAL BUSINESS MACHINES CORP COM 459200101 3,084 21,210 SH   DFND 1 21,210 0 0
INTUITIVE SURGICAL INC COM 46120E602 10,070 18,650 SH   DFND 1 18,650 0 0
INTL FLAVORS & FRAGRANCES COM 459506101 665 5,420 SH   DFND 1 5,420 0 0
ISHARES CORE HIGH DIVIDEND ETF ETF 46429B663 3,208 34,070 SH   DFND 1 34,070 0 0
ISHARES MSCI RUSSIA ETF ETF 46434G798 305 7,850 SH   DFND 1 7,850 0 0
ISHARES MSCI SOUTH KOREA ETF ETF 464286772 1,699 30,150 SH   DFND 1 30,150 0 0
ISHARES NASDAQ BIOTECHNOLOGY ETF 464287556 3,235 32,510 SH   DFND 1 32,510 0 0
JACK HENRY & ASSOCIATES INC COM 426281101 2,000 13,700 SH   DFND 1 13,700 0 0
JOHNSON & JOHNSON COM 478160104 40,678 314,410 SH   DFND 1 314,410 0 0
KLA-TENCOR CORP COM 482480100 257 1,610 SH   DFND 1 1,610 0 0
THE KRAFT HEINZ COMPANY COM 500754106 1,320 47,250 SH   DFND 1 47,250 0 0
LAM RESEARCH CORP COM 512807108 236 1,020 SH   DFND 1 1,020 0 0
LINDE PUBLIC LIMITED COMPANY COM G5494J103 29,256 151,020 SH   DFND 1 151,020 0 0
MASTERCARD INC CL A 57636Q104 2,716 10,000 SH   DFND 1 10,000 0 0
MC DERMOTT INTERNATIONAL,INC COM 580037703 153 75,600 SH   DFND 1 75,600 0 0
MEDTRONIC INC COM 585055106 8,331 76,700 SH   DFND 1 76,700 0 0
MERSANA THERAPEUTICS INC COM 59045L106 143 90,246 SH   DFND 1 90,246 0 0
METLIFE INC COM 59156R108 979 20,760 SH   DFND 1 20,760 0 0
THE MICHAELS COS INC COM 59408Q106 151 15,450 SH   DFND 1 15,450 0 0
MOODYS CORPORATION COM 20775CZK3 10,539 51,450 SH   DFND 1 51,450 0 0
NATIONAL OILWELL VARCO INC COM 637071101 931 43,900 SH   DFND 1 43,900 0 0
NDAQ US COM 631103108 1,113 11,200 SH   DFND 1 11,200 0 0
NESTLE SA SPONSORED ADR 641069406 24,621 227,130 SH   DFND 1 227,130 0 0
NIC INC COM 62914B100 240 11,620 SH   DFND 1 11,620 0 0
NOVO NORDISK A/S SPONSORED ADR 670100205 11,001 212,790 SH   DFND 1 212,790 0 0
NOW INC COM 67011P100 639 55,675 SH   DFND 1 55,675 0 0
NUTRIEN LTD COM 67077M108 16,276 326,310 SH   DFND 1 326,310 0 0
OMNICOM GROUP INC COM 681919106 632 8,070 SH   DFND 1 8,070 0 0
PHILLIPS 66 COM 718546104 15,521 151,570 SH   DFND 1 151,570 0 0
THE PROCTER&GAMBLE COMPANY COM 742718109 6,250 50,250 SH   DFND 1 50,250 0 0
PRESTIGE CONSUMER HEALTHCARE COM 74112D101 241 6,960 SH   DFND 1 6,960 0 0
RAYTHEON COMPANY COM 755111507 212 1,080 SH   DFND 1 1,080 0 0
REVANCE THERAPEUTICS INC COM 761330109 1,041 80,100 SH   DFND 1 80,100 0 0
ROCHE HOLDING AG SPONSORED ADR 771195104 8,104 222,320 SH   DFND 1 222,320 0 0
ROPER TECHNOLOGIES INC COM 776696106 25,176 70,600 SH   DFND 1 70,600 0 0
ROYAL DUTCH SHELL PLC CLASS B CL B 780259107 8,938 149,210 SH   DFND 1 149,210 0 0
SEAGATE TECHNOLOGY COM G7945M107 215 4,000 SH   DFND 1 4,000 0 0
SESEN BIO INC COM 817763105 248 211,855 SH   DFND 1 211,855 0 0
SIERRA ONCOLOGY INC COM 82640U107 195 500,138 SH   DFND 1 500,138 0 0
SOPHIRIS BIO INC COM 83578Q209 176 300,900 SH   DFND 1 300,900 0 0
SPDR PORT SHRT TRM TRSRY ETF 78468R101 11,303 376,500 SH   DFND 1 376,500 0 0
SPRING BANK PHARMACEUTICALS COM 849431101 554 160,914 SH   DFND 1 160,914 0 0
STERICYCLE INC COM 858912108 3,025 59,400 SH   DFND 1 59,400 0 0
STORE CAPITAL CORPORATION REIT 862121100 1,373 36,700 SH   DFND 1 36,700 0 0
SYNCHRONY FINANCIAL COM 87165B103 215 6,300 SH   DFND 1 6,300 0 0
TEGNA INC COM 87901J105 189 12,180 SH   DFND 1 12,180 0 0
TG THERAPEUTICS INC COM 88322Q108 281 50,000 SH   DFND 1 50,000 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 291 1,000 SH   DFND 1 1,000 0 0
THE TRAVELERS COMPANIES INC COM 893939AE8 223 1,500 SH   DFND 1 1,500 0 0
UNITED TECHNOLOGIES CORP COM 913017109 2,041 14,950 SH   DFND 1 14,950 0 0
US BANCORP COM 902973304 7,049 127,370 SH   DFND 1 127,370 0 0
VANGUARD CONSUMER STAPLES ETF ETF 92204A207 6,356 40,600 SH   DFND 1 40,600 0 0
VANGUARD FTSE EMERGING MARKETS ETF ETF 922042858 4,747 117,910 SH   DFND 1 117,910 0 0
VANGUARD HEALTH CARE ETF ETF 92204A504 1,122 6,690 SH   DFND 1 6,690 0 0
VANGUARD S&P 500 ETF ETF 922908363 12,976 47,600 SH   DFND 1 47,600 0 0
VANGUARD SMALL- CAP ETF ETF 922908751 2,231 14,500 SH   DFND 1 14,500 0 0
VANGUARD SHORT-TERM BOND ETF ETF 921937827 9,259 114,600 SH   DFND 1 114,600 0 0
VECTOR GROUP LTD COM 92240M108 225 18,890 SH   DFND 1 18,890 0 0
VISA INC CLASS A CL A 92826C839 26,369 153,300 SH   DFND 1 153,300 0 0
WABTEC CORPORATION COM 929740108 9,721 135,270 SH   DFND 1 135,270 0 0
WATERS CORPORATION COM 941848103 11,686 52,350 SH   DFND 1 52,350 0 0
WEIGHT WATCHERS INTL INC COM 948626106 401 10,600 SH   DFND 1 10,600 0 0
WELLS FARGO & CO COM 949746101 82,716 1,639,880 SH   DFND 1 1,639,880 0 0
WESTERN DIGITAL CORP COM 958102105 227 3,810 SH   DFND 1 3,810 0 0
ZAFGEN INC COM 98885E103 148 200,621 SH   DFND 1 200,621 0 0
ZOETIS INC COM 98978V103 1,121 9,000 SH   DFND 1 9,000 0 0