The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 5,555 115,000 SH   DFND 1,2,3,4 115,000 0 0
AIT THERAPEUTICS INC COM 001448109 2,225 400,859 SH   DFND 1,2,3,4 400,859 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 25,418 150,000 SH   DFND 1,2,3,4 150,000 0 0
ALLERGAN PLC SHS G0177J108 8,372 50,000 SH   DFND 1,2,3,4 50,000 0 0
ALPHABET INC CAP STK CL A 02079K305 23,066 21,302 SH   DFND 1,2,3,4 21,302 0 0
AMAZON COM INC COM 023135106 25,833 13,642 SH   DFND 1,2,3,4 13,642 0 0
AMERICAN AIRLS GROUP INC COM 02376R102 7,775 238,428 SH   DFND 1,2,3,4 238,428 0 0
ARAMARK COM 03852U106 23,493 651,500 SH   DFND 1,2,3,4 651,500 0 0
ARGENX SE SPONSORED ADR 04016X101 29,784 210,372 SH   DFND 1,2,3,4 210,372 0 0
ARQULE INC COM 04269E107 10,855 985,917 SH   DFND 1,2,3,4 985,917 0 0
ARRAY BIOPHARMA INC COM 04269X105 4,465 96,380 SH   DFND 1,2,3,4 96,380 0 0
ATHENEX INC COM 04685N103 11,245 567,935 SH   DFND 1,2,3,4 567,935 0 0
AUTOHOME INC SP ADR RP CL A 05278C107 6,370 74,400 SH Put DFND 1,2,3,4 74,400 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 43,852 1,001,410 SH   DFND 1,2,3,4 1,001,410 0 0
BOEING CO COM 097023105 18,524 50,890 SH   DFND 1,2,3,4 50,890 0 0
BOSTON SCIENTIFIC CORP COM 101137107 22,857 531,813 SH   DFND 1,2,3,4 531,813 0 0
CANADIAN PAC RY LTD COM 13645T100 19,189 81,574 SH   DFND 1,2,3,4 81,574 0 0
CARA THERAPEUTICS INC COM 140755109 4,311 200,500 SH   DFND 1,2,3,4 200,500 0 0
CENTENE CORP DEL COM 15135B101 9,784 186,583 SH   DFND 1,2,3,4 186,583 0 0
CONSTELLIUM NV CL A N22035104 20,775 2,069,219 SH   DFND 1,2,3,4 2,069,219 0 0
COTY INC COM CL A 222070203 22,151 1,653,061 SH   DFND 1,2,3,4 1,653,061 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 2,255 100,000 SH Put DFND 1,2,3,4 100,000 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 6,683 296,346 SH   DFND 1,2,3,4 296,346 0 0
DELL TECHNOLOGIES INC CL C 24703L202 378 7,446 SH   DFND 1,2,3,4 7,446 0 0
DESTINATION MATERNITY CORP COM 25065D100 231 174,816 SH   DFND 1,2,3,4 174,816 0 0
DISNEY WALT CO COM DISNEY 254687106 8,378 60,000 SH Call DFND 1,2,3,4 60,000 0 0
DISNEY WALT CO COM DISNEY 254687106 13,381 95,823 SH   DFND 1,2,3,4 95,823 0 0
ELDORADO RESORTS INC COM 28470R102 33,650 730,401 SH   DFND 1,2,3,4 730,401 0 0
FLEXION THERAPEUTICS INC COM 33938J106 11,426 928,924 SH   DFND 1,2,3,4 928,924 0 0
FREEPORT-MCMORAN INC CL B 35671D857 36,466 3,140,882 SH   DFND 1,2,3,4 3,140,882 0 0
GENOCEA BIOSCIENCES INC COM NEW 372427401 2,612 666,222 SH   DFND 1,2,3,4 666,222 0 0
GREAT ELM CAP GROUP INC COM NEW 39036P209 5,448 1,267,030 SH   DFND 1,2,3,4 1,267,030 0 0
GTY TECHNOLOGY HOLDINGS INC COM 362409104 8,220 1,200,000 SH   DFND 1,2,3,4 1,200,000 0 0
HERON THERAPEUTICS INC COM 427746102 15,445 830,821 SH   DFND 1,2,3,4 830,821 0 0
HUYA INC ADS REP SHS A 44852D108 16,192 655,282 SH   DFND 1,2,3,4 655,282 0 0
INVESCO QQQ TR UNIT SER 1 46090E103 48,552 260,000 SH Put DFND 1,2,3,4 260,000 0 0
IQVIA HLDGS INC COM 46266C105 4,525 28,121 SH   DFND 1,2,3,4 28,121 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 134,508 865,000 SH Put DFND 1,2,3,4 865,000 0 0
KEMPHARM INC NOTE 5.500% 2/0 488445AB3 1,395 3,000,000 PRN   DFND 1,2,3,4 3,000,000 0 0
LATTICE SEMICONDUCTOR CORP COM 518415104 9,753 668,468 SH   DFND 1,2,3,4 668,468 0 0
LIONS GATE ENTMNT CORP CL A VTG 535919401 6,760 551,836 SH   DFND 1,2,3,4 551,836 0 0
MARVELL TECHNOLOGY GROUP LTD ORD G5876H105 7,357 308,200 SH   DFND 1,2,3,4 308,200 0 0
MICROSOFT CORP COM 594918104 38,656 288,567 SH   DFND 1,2,3,4 288,567 0 0
MIDDLEBY CORP COM 596278101 20,662 152,259 SH   DFND 1,2,3,4 152,259 0 0
MODERNA INC COM 60770K107 157 10,700 SH Put DFND 1,2,3,4 10,700 0 0
MOLECULAR TEMPLATES INC COM 608550109 4,307 515,792 SH   DFND 1,2,3,4 515,792 0 0
NEW ORIENTAL ED & TECH GRP I SPON ADR 647581107 9,842 101,903 SH   DFND 1,2,3,4 101,903 0 0
NOMAD FOODS LTD USD ORD SHS G6564A105 12,713 595,199 SH   DFND 1,2,3,4 595,199 0 0
NORFOLK SOUTHERN CORP COM 655844108 19,840 99,531 SH   DFND 1,2,3,4 99,531 0 0
ONESPAWORLD HOLDINGS LIMITED COM P73684113 6,212 400,750 SH   DFND 1,2,3,4 400,750 0 0
PFIZER INC COM 717081103 13,663 315,400 SH Put DFND 1,2,3,4 315,400 0 0
PTC THERAPEUTICS INC COM 69366J200 6,175 137,219 SH   DFND 1,2,3,4 137,219 0 0
RAMACO RES INC COM 75134P303 1,470 276,246 SH   DFND 1,2,3,4 276,246 0 0
RAPID7 INC COM 753422104 8,724 150,825 SH   DFND 1,2,3,4 150,825 0 0
REGENERON PHARMACEUTICALS COM 75886F107 12,793 40,871 SH   DFND 1,2,3,4 40,871 0 0
ROYAL CARIBBEAN CRUISES LTD COM V7780T103 9,801 80,861 SH   DFND 1,2,3,4 80,861 0 0
SALESFORCE COM INC COM 79466L302 7,229 47,646 SH   DFND 1,2,3,4 47,646 0 0
SANDERSON FARMS INC COM 800013104 10,548 77,238 SH   DFND 1,2,3,4 77,238 0 0
SELECT SECTOR SPDR TR SBI CONS STPLS 81369Y308 569 9,800 SH   DFND 1,2,3,4 9,800 0 0
SESEN BIO INC COM 817763105 9,249 6,166,175 SH   DFND 1,2,3,4 6,166,175 0 0
SOL GEL TECHNOLOGIES SHS M8694L103 2,828 310,594 SH   DFND 1,2,3,4 310,594 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 35,084 400,000 SH Put DFND 1,2,3,4 400,000 0 0
STEALTH BIOTHERAPEUTICS CORP SPONSORED ADS 85789A105 2,231 178,453 SH   DFND 1,2,3,4 178,453 0 0
TRILOGY METALS INC NEW COM 89621C105 2,962 1,004,135 SH   DFND 1,2,3,4 1,004,135 0 0
UNITEDHEALTH GROUP INC COM 91324P102 13,497 55,312 SH   DFND 1,2,3,4 55,312 0 0
WILLSCOT CORP COM 971375126 12,129 806,476 SH   DFND 1,2,3,4 806,476 0 0
ZEBRA TECHNOLOGIES CORP CL A 989207105 25,358 121,047 SH   DFND 1,2,3,4 121,047 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 11,036 93,731 SH   DFND 1,2,3,4 93,731 0 0