The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACORDA THERAPEUTICS INC NOTE 1.750% 6/1 00484MAA4 14,723 17,207,017 PRN   DFND   0 17,207,017 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 96,820 571,376 SH   DFND   0 571,376 0
ALIGN TECHNOLOGY INC COM 016255101 42,549 155,459 SH   DFND   0 155,459 0
ALLENA PHARMACEUTICALS INC COM 018119107 3,211 788,958 SH   DFND   0 788,958 0
ALLERGAN PLC SHS G0177J108 298,963 1,785,597 SH   DFND   0 1,785,597 0
AMGEN INC CALL 031162900 32,544 176,600 SH Call DFND   0 176,600 0
AMGEN INC PUT 031162950 153,303 831,900 SH Put DFND   0 831,900 0
ANTHEM INC COM 036752103 53,399 189,219 SH   DFND   0 189,219 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 107,198 1,828,378 SH   DFND   0 1,828,378 0
AUDENTES THERAPEUTICS INC COM 05070R104 122,238 3,228,679 SH   DFND   0 3,228,679 0
AVANTOR INC COM 05352A100 19,088 999,873 SH   DFND   0 999,873 0
AVROBIO INC COM 05455M100 4,056 249,431 SH   DFND   0 249,431 0
AXONICS MODULATION TECH INC COM 05465P101 4,356 106,328 SH   DFND   0 106,328 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 178,100 2,079,388 SH   DFND   0 2,079,388 0
CARDIOVASCULAR SYS INC DEL COM 141619106 18,259 425,315 SH   DFND   0 425,315 0
CATALENT INC COM 148806102 33,449 617,019 SH   DFND   0 617,019 0
COHERUS BIOSCIENCES INC COM 19249H103 32,221 1,457,985 SH   DFND   0 1,457,985 0
COUPA SOFTWARE INC COM 22266L106 23,668 186,935 SH   DFND   0 186,935 0
CROWDSTRIKE HLDGS INC CL A 22788C105 3,987 58,384 SH   DFND   0 58,384 0
CTRIP COM INTL LTD SPONSORED ADS 22943F100 34,221 927,160 SH   DFND   0 927,160 0
DERMIRA INC COM 24983L104 38,666 4,044,542 SH   DFND   0 4,044,542 0
DERMIRA INC NOTE 3.000% 5/1 24983LAB0 26,441 30,558,000 PRN   DFND   0 30,558,000 0
DEXCOM INC COM 252131107 61,689 411,696 SH   DFND   0 411,696 0
DISNEY WALT CO COM DISNEY 254687106 55,675 398,702 SH   DFND   0 398,702 0
DROPBOX INC CL A 26210C104 15,233 608,087 SH   DFND   0 608,087 0
EDWARDS LIFESCIENCES CORP COM 28176E108 84,308 456,359 SH   DFND   0 456,359 0
EQUILLIUM INC COM 29446K106 7,985 1,410,832 SH   DFND   0 1,410,832 0
ESPERION THERAPEUTICS INC NE COM 29664W105 72,344 1,555,112 SH   DFND   0 1,555,112 0
EXACT SCIENCES CORP COM 30063P105 49,380 418,329 SH   DFND   0 418,329 0
FAIR ISAAC CORP COM 303250104 17,653 56,215 SH   DFND   0 56,215 0
FATE THERAPEUTICS INC COM 31189P102 31,419 1,547,730 SH   DFND   0 1,547,730 0
FLUIDIGM CORP DEL COM 34385P108 16,955 1,376,257 SH   DFND   0 1,376,257 0
GILEAD SCIENCES INC COM 375558103 92,171 1,364,288 SH   DFND   0 1,364,288 0
GODADDY INC CL A 380237107 54,888 782,442 SH   DFND   0 782,442 0
HCA HEALTHCARE INC COM 40412C101 85,126 629,767 SH   DFND   0 629,767 0
HUMANA INC COM 444859102 149,146 562,177 SH   DFND   0 562,177 0
ICON PLC SHS G4705A100 20,074 130,375 SH   DFND   0 130,375 0
ICU MED INC COM 44930G107 97,386 386,592 SH   DFND   0 386,592 0
INOGEN INC COM 45780L104 9,418 141,077 SH   DFND   0 141,077 0
INSPIRE MED SYS INC COM 457730109 2,484 40,963 SH   DFND   0 40,963 0
INTUIT COM 461202103 56,904 217,747 SH   DFND   0 217,747 0
INVESCO QQQ TR PUT 46090E953 707,296 3,787,600 SH Put DFND   0 3,787,600 0
IQVIA HLDGS INC COM 46266C105 102,707 638,326 SH   DFND   0 638,326 0
IRHYTHM TECHNOLOGIES INC COM 450056106 54,009 682,963 SH   DFND   0 682,963 0
ISHARES TR PUT 464287954 47,866 1,115,500 SH Put DFND   0 1,115,500 0
KARUNA THERAPEUTICS INC COM 48576A100 14,213 773,031 SH   DFND   0 773,031 0
MADISON SQUARE GARDEN CO NEW CL A 55825T103 28,657 102,368 SH   DFND   0 102,368 0
MERIT MED SYS INC COM 589889104 26,456 444,187 SH   DFND   0 444,187 0
MICROCHIP TECHNOLOGY INC COM 595017104 65,331 753,529 SH   DFND   0 753,529 0
MICROSOFT CORP COM 594918104 53,929 402,579 SH   DFND   0 402,579 0
MOLINA HEALTHCARE INC COM 60855R100 77,424 540,898 SH   DFND   0 540,898 0
MYOKARDIA INC COM 62857M105 89,119 1,777,409 SH   DFND   0 1,777,409 0
NEON THERAPEUTICS INC COM 64050Y100 578 121,848 SH   DFND   0 121,848 0
NETFLIX INC COM 64110L106 38,803 105,639 SH   DFND   0 105,639 0
NEVRO CORP COM 64157F103 53,863 830,834 SH   DFND   0 830,834 0
NEW YORK TIMES CO CL A 650111107 42,454 1,301,486 SH   DFND   0 1,301,486 0
PACIRA BIOSCIENCES COM 695127100 31,937 734,346 SH   DFND   0 734,346 0
PAYPAL HLDGS INC COM 70450Y103 59,799 522,446 SH   DFND   0 522,446 0
PENUMBRA INC COM 70975L107 123,488 771,799 SH   DFND   0 771,799 0
PERKINELMER INC COM 714046109 20,556 213,370 SH   DFND   0 213,370 0
PFIZER INC CALL 717081903 57,295 1,322,600 SH Call DFND   0 1,322,600 0
PFIZER INC COM 717081103 70,728 1,632,685 SH   DFND   0 1,632,685 0
PRINCIPIA BIOPHARMA INC COM 74257L108 19,732 594,516 SH   DFND   0 594,516 0
PROGRESSIVE CORP OHIO COM 743315103 52,233 653,485 SH   DFND   0 653,485 0
PUMA BIOTECHNOLOGY INC COM 74587V107 36,076 2,838,376 SH   DFND   0 2,838,376 0
QUALCOMM INC CALL 747525903 117,064 1,538,900 SH Call DFND   0 1,538,900 0
SALESFORCE COM INC COM 79466L302 90,850 598,759 SH   DFND   0 598,759 0
SAREPTA THERAPEUTICS INC COM 803607100 83,084 546,786 SH   DFND   0 546,786 0
SEA LTD SPONSORED ADS 81141R100 38,373 1,155,123 SH   DFND   0 1,155,123 0
SIENNA BIOPHARMACEUTICALS IN COM 82622H108 2,248 2,583,712 SH   DFND   0 2,583,712 0
SPARK THERAPEUTICS INC COM 84652J103 15,828 154,599 SH   DFND   0 154,599 0
SPDR SERIES TRUST CALL 78464A900 33,154 378,000 SH Call DFND   0 378,000 0
SQUARE INC CL A 852234103 35,347 487,346 SH   DFND   0 487,346 0
STRYKER CORP COM 863667101 88,163 428,849 SH   DFND   0 428,849 0
TENET HEALTHCARE CORP COM NEW 88033G407 30,674 1,484,683 SH   DFND   0 1,484,683 0
THERMO FISHER SCIENTIFIC INC COM 883556102 47,184 160,666 SH   DFND   0 160,666 0
TRADEWEB MKTS INC CL A 892672106 2,942 67,157 SH   DFND   0 67,157 0
TWILIO INC CL A 90138F102 43,106 316,142 SH   DFND   0 316,142 0
TWITTER INC COM 90184L102 44,952 1,288,027 SH   DFND   0 1,288,027 0
UNIQURE NV SHS N90064101 13,657 174,754 SH   DFND   0 174,754 0
UNITEDHEALTH GROUP INC COM 91324P102 14,963 61,321 SH   DFND   0 61,321 0
VOYAGER THERAPEUTICS INC COM 92915B106 57,635 2,117,388 SH   DFND   0 2,117,388 0
WELLCARE HEALTH PLANS INC COM 94946T106 136,903 480,244 SH   DFND   0 480,244 0
WRIGHT MED GROUP N V ORD SHS N96617118 35,286 1,183,313 SH   DFND   0 1,183,313 0
ZIMMER BIOMET HLDGS INC COM 98956P102 137,225 1,165,494 SH   DFND   0 1,165,494 0