The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101 33,559 193,600 SH   DFND 1 193,600 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 495 18,535 SH   DFND 1 18,535 0 0
ADVANCED ENERGY INDUSTRIES INC COM 007973100 205 3,650 SH   DFND 1 3,650 0 0
AKARI THERAPEUTICS PLC COM 00972G108 2,828 1,400,096 SH   DFND 1 1,400,096 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 267 44,520 SH   DFND 1 44,520 0 0
ALLERGAN PLC SPONSORED ADR G0177J108 32,766 195,700 SH   DFND 1 195,700 0 0
ALPHABET INC CLASS C CL C 38259P706 4,216 3,900 SH   DFND 1 0 0 3,900
ALPINE IMMUNE SCIENCES INC COM 02083G100 511 121,363 SH   DFND 1 121,363 0 0
ALTRIA GROUP INC COM 02209S103 11,637 245,770 SH   DFND 1 245,770 0 0
AMERISOURCEBERGEN CORP COM 03073E105 221 2,590 SH   DFND 1 2,590 0 0
AMGEN INC COM 031162100 6,201 33,650 SH   DFND 1 33,650 0 0
ANAVEX LIFE SCIENCES CORP COM 032797300 587 174,080 SH   DFND 1 174,080 0 0
ANHEUSER-BUSCH INBEV NV SPONSORED ADR 03524A108 10,958 123,800 SH   DFND 1 123,800 0 0
APPLIED MATERIALS INC COM 038222105 208 4,630 SH   DFND 1 4,630 0 0
BANK OF NEW YORK MELLON CORP COM 064058100 13,995 316,990 SH   DFND 1 316,990 0 0
BECTON DICKINSON & CO COM 075887109 6,041 23,970 SH   DFND 1 23,970 0 0
BERKSHIRE HATHAWAY INC CLASS A CL A 084670108 237,171 745 SH   DFND 1 745 0 0
BERKSHIRE HATHAWAY INC CLASS B CL B 084670702 576 2,700 SH   DFND 1 2,700 0 0
BHP BILLITON PLC COM 05545E209 11,547 225,930 SH   DFND 1 225,930 0 0
BIOGEN INC COM 09062X103 3,305 14,130 SH   DFND 1 14,130 0 0
BOEING CO COM 097023105 21,076 57,900 SH   DFND 1 57,900 0 0
BRITISH AMERICAN TOBACCO PLC COM 110448107 675 19,350 SH   DFND 1 19,350 0 0
CALITHERA BIOSCIENCES,INC COM 13089P101 195 50,000 SH   DFND 1 50,000 0 0
CELGENE CORP COM 151020104 3,289 35,580 SH   DFND 1 35,580 0 0
CHINA MOBILE LIMITED SPONSORED ADR 16941M109 2,188 48,300 SH   DFND 1 48,300 0 0
CIGNA CORPORATION COM 125509109 4,146 26,316 SH   DFND 1 26,316 0 0
CISCO SYSTEMS INC COM 17275R102 5,686 103,900 SH   DFND 1 103,900 0 0
COCA COLA CO COM 191216100 2,342 46,000 SH   DFND 1 46,000 0 0
COLGATE-PALMOLIVE COMPANY COM 194162103 10,184 142,090 SH   DFND 1 142,090 0 0
CORCEPT THERAPEUTICS INC COM 218352102 187 16,790 SH   DFND 1 16,790 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 486 130,000 SH   DFND 1 130,000 0 0
DANAHER CORP COM 235851102 30,842 215,800 SH   DFND 1 215,800 0 0
DAVITA HEALTHCARE PARTNERS INC COM 23918K108 2,387 42,420 SH   DFND 1 42,420 0 0
DEUTSCHE X-TRACKERS HARVEST CSI 300 CHINA A-SHARES FUND ETF 233051879 7,407 263,040 SH   DFND 1 263,040 0 0
DIAMOND OFFSHORE DRILLING INC COM 25271C102 312 35,200 SH   DFND 1 35,200 0 0
DYNAVAX TECHNOLOGIES CORPORATION COM 268158201 421 105,573 SH   DFND 1 105,573 0 0
ECOLAB INC COM 278865100 415 2,100 SH   DFND 1 2,100 0 0
EMCOR GROUP INC COM 29084Q100 226 2,570 SH   DFND 1 2,570 0 0
EQUIFAX INC COM 294429AN5 377 2,790 SH   DFND 1 2,790 0 0
EVOLUS INC COM 30052C107 1,001 68,500 SH   DFND 1 68,500 0 0
EXXON MOBIL CORPORATION COM 30231G102 10,598 138,303 SH   DFND 1 138,303 0 0
FORTIVE CORP COM 34959J108 11,551 141,700 SH   DFND 1 141,700 0 0
FTS INTERNATIONAL INC COM 30283W104 104 18,640 SH   DFND 1 18,640 0 0
GAMESTOP CORP-CLASS A CL A 36467W109 121 22,120 SH   DFND 1 22,120 0 0
GENERAL ELECTRIC COMPANY COM 369604103 11,595 1,104,300 SH   DFND 1 1,104,300 0 0
GENERAL MILLS,INC COM 370334104 3,792 72,200 SH   DFND 1 72,200 0 0
GILEAD SCIENCES INC COM 375558103 5,690 84,220 SH   DFND 1 84,220 0 0
GRAFTECH INTERNATIONAL LTD COM 384313508 163 14,150 SH   DFND 1 14,150 0 0
HP INC COM 40434L105 204 9,790 SH   DFND 1 9,790 0 0
H&R BLOCK INC COM 093671105 222 7,590 SH   DFND 1 7,590 0 0
INNOVIVA INC COM 45781M101 209 14,340 SH   DFND 1 14,340 0 0
INTERNATIONAL BUSINESS MACHINES CORP COM 459200101 3,132 22,710 SH   DFND 1 22,710 0 0
INTUITIVE SURGICAL INC COM 46120E602 9,783 18,650 SH   DFND 1 18,650 0 0
INTL FLAVORS & FRAGRANCES COM 459506101 474 3,270 SH   DFND 1 3,270 0 0
ISHARES CORE HIGH DIVIDEND ETF ETF 46429B663 2,758 29,190 SH   DFND 1 29,190 0 0
ISHARES MSCI RUSSIA ETF ETF 46434G798 309 7,850 SH   DFND 1 7,850 0 0
ISHARES MSCI SOUTH KOREA ETF ETF 464286772 422 7,050 SH   DFND 1 7,050 0 0
ISHARES NASDAQ BIOTECHNOLOGY ETF 464287556 3,547 32,510 SH   DFND 1 32,510 0 0
JACK HENRY & ASSOCIATES INC COM 426281101 1,835 13,700 SH   DFND 1 13,700 0 0
JOHNSON & JOHNSON COM 478160104 43,680 313,610 SH   DFND 1 313,610 0 0
THE KRAFT HEINZ COMPANY COM 500754106 1,287 41,450 SH   DFND 1 41,450 0 0
LINDE PUBLIC LIMITED COMPANY COM G5494J103 30,325 151,020 SH   DFND 1 151,020 0 0
MANPOWERGROUP INC COM 56418H100 222 2,300 SH   DFND 1 2,300 0 0
MASTERCARD INC CL A 57636Q104 2,645 10,000 SH   DFND 1 10,000 0 0
MC DERMOTT INTERNATIONAL,INC COM 580037703 730 75,600 SH   DFND 1 75,600 0 0
MEDTRONIC INC COM 585055106 7,470 76,700 SH   DFND 1 76,700 0 0
MERITOR INC COM 59001K100 205 8,470 SH   DFND 1 8,470 0 0
MERSANA THERAPEUTICS INC COM 59045L106 365 90,246 SH   DFND 1 90,246 0 0
THE MICHAELS COS INC COM 59408Q106 134 15,450 SH   DFND 1 15,450 0 0
MOODYS CORPORATION COM 20775CZK3 10,049 51,450 SH   DFND 1 51,450 0 0
NATIONAL OILWELL VARCO INC COM 637071101 976 43,900 SH   DFND 1 43,900 0 0
NDAQ US COM 631103108 1,077 11,200 SH   DFND 1 11,200 0 0
NEKTAR THERAPEUTICS COM 640268108 210 5,900 SH   DFND 1 5,900 0 0
NESTLE SA SPONSORED ADR 641069406 23,485 227,130 SH   DFND 1 227,130 0 0
NIC INC COM 62914B100 186 11,620 SH   DFND 1 11,620 0 0
NOVO NORDISK A/S SPONSORED ADR 670100205 10,861 212,790 SH   DFND 1 212,790 0 0
NOW INC COM 67011P100 822 55,675 SH   DFND 1 55,675 0 0
NUTRIEN LTD COM 67077M108 17,445 326,310 SH   DFND 1 326,310 0 0
OMNICOM GROUP INC COM 681919106 661 8,070 SH   DFND 1 8,070 0 0
PHILLIPS 66 COM 718546104 14,178 151,570 SH   DFND 1 151,570 0 0
PRESTIGE CONSUMER HEALTHCARE COM 74112D101 220 6,960 SH   DFND 1 6,960 0 0
THE PROCTER&GAMBLE COMPANY COM 742718109 10,126 92,350 SH   DFND 1 92,350 0 0
PROTEOSTASIS THERAPEUTICS IN COM 74373B109 23 23,367 SH   DFND 1 23,367 0 0
REVANCE THERAPEUTICS INC COM 761330109 1,039 80,100 SH   DFND 1 80,100 0 0
ROCHE HOLDING AG SPONSORED ADR 771195104 5,851 166,700 SH   DFND 1 166,700 0 0
ROPER TECHNOLOGIES INC COM 776696106 25,858 70,600 SH   DFND 1 70,600 0 0
ROYAL DUTCH SHELL PLC CLASS B CL B 780259107 7,511 114,250 SH   DFND 1 114,250 0 0
SESEN BIO INC COM 817763105 318 211,855 SH   DFND 1 211,855 0 0
SIERRA ONCOLOGY INC COM 82640U107 141 252,100 SH   DFND 1 252,100 0 0
SOPHIRIS BIO INC COM 83578Q209 254 300,900 SH   DFND 1 300,900 0 0
SPRING BANK PHARMACEUTICALS COM 849431101 226 61,336 SH   DFND 1 61,336 0 0
STERICYCLE INC COM 858912108 2,836 59,400 SH   DFND 1 59,400 0 0
STORE CAPITAL CORPORATION REIT 862121100 1,218 36,700 SH   DFND 1 36,700 0 0
SYNCHRONY FINANCIAL COM 87165B103 218 6,300 SH   DFND 1 6,300 0 0
TEGNA INC COM 87901J105 185 12,180 SH   DFND 1 12,180 0 0
TG THERAPEUTICS INC COM 88322Q108 433 50,000 SH   DFND 1 50,000 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 294 1,000 SH   DFND 1 1,000 0 0
THE TRAVELERS COMPANIES INC COM 893939AE8 224 1,500 SH   DFND 1 1,500 0 0
UNITED TECHNOLOGIES CORP COM 913017109 1,946 14,950 SH   DFND 1 14,950 0 0
US BANCORP COM 902973304 6,580 125,570 SH   DFND 1 125,570 0 0
VANGUARD CONSUMER STAPLES ETF ETF 92204A207 6,040 40,600 SH   DFND 1 40,600 0 0
VANGUARD FTSE EMERGING MARKETS ETF ETF 922042858 4,279 100,610 SH   DFND 1 100,610 0 0
VANGUARD HEALTH CARE ETF ETF 92204A504 1,164 6,690 SH   DFND 1 6,690 0 0
VANGUARD S&P 500 ETF ETF 922908363 11,880 44,140 SH   DFND 1 44,140 0 0
VANGUARD SMALL- CAP ETF ETF 922908751 1,811 11,560 SH   DFND 1 11,560 0 0
VANGUARD SHORT-TERM BOND ETF ETF 921937827 9,229 114,600 SH   DFND 1 114,600 0 0
VECTOR GROUP LTD COM 92240M108 184 18,890 SH   DFND 1 18,890 0 0
VIKING THERAPEUTICS IN COM 92686J106 415 50,000 SH   DFND 1 50,000 0 0
VISA INC CLASS A CL A 92826C839 26,605 153,300 SH   DFND 1 153,300 0 0
WABTEC CORPORATION COM 929740108 15,443 215,200 SH   DFND 1 215,200 0 0
WATERS CORPORATION COM 941848103 11,268 52,350 SH   DFND 1 52,350 0 0
WEIGHT WATCHERS INTL INC COM 948626106 202 10,600 SH   DFND 1 10,600 0 0
WELLS FARGO & CO COM 949746101 68,417 1,445,840 SH   DFND 1 1,445,840 0 0
ZAFGEN INC COM 98885E103 179 150,521 SH   DFND 1 150,521 0 0
ZOETIS INC COM 98978V103 1,021 9,000 SH   DFND 1 9,000 0 0