The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2U Inc Common Stock 90214J101 36,668 517,544 SH   SOLE   436,394 6,697 74,453
3D Systems Corp Common Stock 88554D205 1,919 178,320 SH   SOLE   178,320 0 0
Adobe Inc Common Stock 00724F101 8,311 31,188 SH   SOLE   31,188 0 0
Aerovironment Inc Common Stock 008073108 8,305 121,405 SH   SOLE   62,466 0 58,939
Alibaba Group Holding Ltd ADR 01609W102 23,862 130,787 SH   SOLE   93,229 7,719 29,839
Align Technology Inc Common Stock 016255101 5,804 20,414 SH   SOLE   20,414 0 0
Allegheny Technologies Inc Common Stock 01741R102 49 1,898 SH   SOLE   1,898 0 0
Alphabet Inc Common Stock 02079K107 3,304 2,816 SH   SOLE   2,816 0 0
Amazon.com Inc Common Stock 023135106 26,781 15,039 SH   SOLE   11,361 0 3,678
AMETEK Inc Common Stock 031100100 526 6,335 SH   SOLE   6,335 0 0
ANSYS Inc Common Stock 03662Q105 3,510 19,209 SH   SOLE   19,209 0 0
Apple Inc Common Stock 037833100 42,195 222,136 SH   SOLE   182,879 13,454 25,803
Aptiv PLC Common Stock G6095L109 6,903 86,835 SH   SOLE   84,092 2,743 0
Arconic Inc Common Stock 03965L100 398 20,807 SH   SOLE   20,807 0 0
Arcturus Therapeutics Ltd Common Stock M1492T105 6,332 927,144 SH   SOLE   927,144 0 0
Arkema SA Common Stock F0392W125 48 500 SH   SOLE   500 0 0
Arrk Corp Common Stock J0198N101 557 581,601 SH   SOLE   581,601 0 0
AudioCodes Ltd Common Stock M15342104 492 35,553 SH   SOLE   35,553 0 0
Autodesk Inc Common Stock 052769106 5,175 33,212 SH   SOLE   33,212 0 0
Baidu Inc ADR 056752108 159,226 965,887 SH   SOLE   739,640 52,282 173,965
Bertrandt AG Common Stock D1014N107 361 5,092 SH   SOLE   5,092 0 0
Bezeq The Israeli Telecommunic Common Stock M2012Q100 352 503,335 SH   SOLE   503,335 0 0
Grayscale Bitcoin Trust BTC Open-End Fund 389637109 18,687 3,909,488 SH   SOLE   1,473,293 657,244 1,778,951
Bluebird Bio Inc Common Stock 09609G100 24,466 155,508 SH   SOLE   101,212 11,984 42,312
Camtek Ltd/Israel Common Stock M20791105 587 65,847 SH   SOLE   65,847 0 0
Carpenter Technology Corp Common Stock 144285103 51 1,108 SH   SOLE   1,108 0 0
Celgene Corp Common Stock 151020104 3 28 SH   SOLE   28 0 0
Cellcom Israel Ltd Common Stock M2196U109 308 84,977 SH   SOLE   84,977 0 0
Cellectis SA ADR 15117K103 17,131 934,076 SH   SOLE   829,755 92,479 11,842
Ceragon Networks Ltd Common Stock M22013102 420 116,973 SH   SOLE   116,973 0 0
Cerus Corp Common Stock 157085101 47,594 7,639,433 SH   SOLE   5,913,558 84,602 1,641,273
Check Point Software Technolog Common Stock M22465104 553 4,370 SH   SOLE   4,370 0 0
Cognex Corp Common Stock 192422103 3,507 68,945 SH   SOLE   68,945 0 0
Compugen Ltd Common Stock M25722105 34,070 8,229,555 SH   SOLE   8,016,066 70,360 143,129
CRISPR Therapeutics AG Common Stock H17182108 72,262 2,023,017 SH   SOLE   1,531,124 107,757 384,136
CyberArk Software Ltd Common Stock M2682V108 701 5,891 SH   SOLE   5,891 0 0
Danel Adir Yeoshua Ltd Common Stock M27013107 501 9,441 SH   SOLE   9,441 0 0
Dassault Systemes SE Common Stock F2457H472 1,624 10,901 SH   SOLE   10,901 0 0
Deere & Co Common Stock 244199105 1,702 10,647 SH   SOLE   10,647 0 0
DowDuPont Inc Common Stock 26078J100 29 820 SH   SOLE   820 0 0
Eastman Chemical Co Common Stock 277432100 45 590 SH   SOLE   590 0 0
Eastman Kodak Co Common Stock 277461406 45 15,069 SH   SOLE   15,069 0 0
Editas Medicine Inc Common Stock 28106W103 111,478 4,559,434 SH   SOLE   3,442,581 258,471 858,382
Elbit Systems Ltd Common Stock M3760D101 2,510 19,460 SH   SOLE   19,460 0 0
Evogene Ltd Common Stock M4119S104 525 286,748 SH   SOLE   286,748 0 0
ExOne Co/The Common Stock 302104104 18,433 2,171,191 SH   SOLE   1,790,372 0 380,819
FARO Technologies Inc Common Stock 311642102 454 10,334 SH   SOLE   10,334 0 0
Foamix Pharmaceuticals Ltd Common Stock M46135105 440 117,367 SH   SOLE   117,367 0 0
General Electric Co Common Stock 369604103 460 46,058 SH   SOLE   46,058 0 0
General Motors Co Common Stock 37045V100 1,703 45,894 SH   SOLE   45,894 0 0
Gilat Satellite Networks Ltd Common Stock M51474118 414 50,705 SH   SOLE   50,705 0 0
Hexagon AB Common Stock W40063104 491 9,408 SH   SOLE   9,408 0 0
Hexcel Corp Common Stock 428291108 53 762 SH   SOLE   762 0 0
Hilan Ltd Common Stock M5299H123 527 19,032 SH   SOLE   19,032 0 0
HP Inc Common Stock 40434L105 1,825 93,921 SH   SOLE   93,921 0 0
HubSpot Inc Common Stock 443573100 8,636 51,959 SH   SOLE   51,959 0 0
Illumina Inc Common Stock 452327109 145,078 466,953 SH   SOLE   361,521 24,211 81,221
Incyte Corp Common Stock 45337C102 5,789 67,305 SH   SOLE   67,305 0 0
Inovio Pharmaceuticals Inc Common Stock 45773H201 10,927 2,929,597 SH   SOLE   2,929,597 0 0
Intellia Therapeutics Inc Common Stock 45826J105 136,319 7,981,198 SH   SOLE   6,544,686 467,224 969,288
Invitae Corp Common Stock 46185L103 204,445 8,729,523 SH   SOLE   6,946,501 197,702 1,585,320
Ionis Pharmaceuticals Inc Common Stock 462222100 13,391 164,978 SH   SOLE   164,978 0 0
Ituran Location and Control Lt Common Stock M6158M104 488 14,300 SH   SOLE   14,300 0 0
JD.com Inc ADR 47215P106 2,177 72,203 SH   SOLE   72,203 0 0
Kamada Ltd Common Stock M6240T109 484 86,028 SH   SOLE   86,028 0 0
Koninklijke DSM NV Common Stock N5017D122 57 521 SH   SOLE   521 0 0
LendingClub Corp Common Stock 52603A109 66,290 21,453,157 SH   SOLE   17,868,069 271,344 3,313,744
LendingTree Inc Common Stock 52603B107 76,046 216,309 SH   SOLE   168,095 10,843 37,371
Materialise NV ADR 57667T100 43,272 2,749,159 SH   SOLE   2,466,270 40,865 242,024
Matrix IT Ltd Common Stock M6859E153 494 39,064 SH   SOLE   39,064 0 0
Medidata Solutions Inc Common Stock 58471A105 81,871 1,117,845 SH   SOLE   882,301 57,455 178,089
Mellanox Technologies Ltd Common Stock M51363113 651 5,498 SH   SOLE   5,498 0 0
MercadoLibre Inc Common Stock 58733R102 10,842 21,354 SH   SOLE   18,099 2,981 274
Microsoft Corp Common Stock 594918104 1,500 12,721 SH   SOLE   12,721 0 0
Nano Dimension Ltd ADR 63008G104 571 804,275 SH   SOLE   804,275 0 0
NanoString Technologies Inc Common Stock 63009R109 83,193 3,476,526 SH   SOLE   3,339,995 129,176 7,355
Netflix Inc Common Stock 64110L106 68,237 191,375 SH   SOLE   146,789 12,050 32,536
Nice Ltd ADR 653656108 538 4,394 SH   SOLE   4,394 0 0
Nova Measuring Instruments Ltd Common Stock M7516K103 496 19,690 SH   SOLE   19,690 0 0
NVIDIA Corp Common Stock 67066G104 231,466 1,289,075 SH   SOLE   1,033,677 56,409 198,989
Organovo Holdings Inc Common Stock 68620A104 19,839 19,998,670 SH   SOLE   19,848,076 150,594 0
Partner Communications Co Ltd Common Stock M78465107 380 99,311 SH   SOLE   99,311 0 0
PayPal Holdings Inc Common Stock 70450Y103 17,327 166,862 SH   SOLE   166,862 0 0
Pluristem Therapeutics Inc Common Stock 72940R102 3,679 3,793,249 SH   SOLE   3,793,249 0 0
PolyOne Corp Common Stock 73179P106 44 1,508 SH   SOLE   1,508 0 0
Prodways Group SA Common Stock F7329W102 2,070 602,907 SH   SOLE   602,907 0 0
Proto Labs Inc Common Stock 743713109 30,619 291,222 SH   SOLE   220,270 15,465 55,487
PTC Inc Common Stock 69370C100 1,411 15,308 SH   SOLE   15,308 0 0
RADCOM Ltd Common Stock M81865111 427 57,532 SH   SOLE   57,532 0 0
Radware Ltd Common Stock M81873107 524 20,037 SH   SOLE   20,037 0 0
Redhill Biopharma Ltd ADR 757468103 548 65,918 SH   SOLE   65,918 0 0
Regeneron Pharmaceuticals Inc Common Stock 75886F107 5,435 13,237 SH   SOLE   13,237 0 0
Renishaw PLC Common Stock G75006117 1,794 37,257 SH   SOLE   37,257 0 0
salesforce.com Inc Common Stock 79466L302 55,095 347,885 SH   SOLE   242,666 21,659 83,560
Sandvik AB Common Stock W74857165 52 3,205 SH   SOLE   3,205 0 0
Sapiens International Corp NV Common Stock G7T16G103 591 38,699 SH   SOLE   38,699 0 0
Seres Therapeutics Inc Common Stock 81750R102 36,327 5,287,713 SH   SOLE   4,352,669 298,574 636,470
Shopify Inc Common Stock 82509L107 8,947 43,303 SH   SOLE   43,303 0 0
Siemens AG Common Stock D69671218 408 3,793 SH   SOLE   3,793 0 0
Silicom Ltd Common Stock M84116108 519 13,572 SH   SOLE   13,572 0 0
SLM Solutions Group AG Common Stock D6T690109 1,926 176,946 SH   SOLE   176,946 0 0
SoftBank Group Corp - ADR ADR 83404D109 270 5,554 SH   SOLE   5,554 0 0
SolarEdge Technologies Inc Common Stock 83417M104 459 12,175 SH   SOLE   12,175 0 0
Splunk Inc Common Stock 848637104 52,504 421,383 SH   SOLE   293,393 25,887 102,103
Square Inc Common Stock 852234103 159,795 2,132,878 SH   SOLE   1,571,999 112,647 448,232
Stratasys Ltd Common Stock M85548101 172,931 7,259,928 SH   SOLE   5,363,708 369,007 1,527,213
Syros Pharmaceuticals Inc Common Stock 87184Q107 27,353 2,992,700 SH   SOLE   2,670,985 31,634 290,081
Taro Pharmaceutical Industries Common Stock M8737E108 539 4,986 SH   SOLE   4,986 0 0
Teladoc Health Inc Common Stock 87918A105 40,959 736,673 SH   SOLE   613,583 34,205 88,885
Tencent Holdings Ltd ADR 88032Q109 103,311 2,246,874 SH   SOLE   1,772,018 116,673 358,183
Teradyne Inc Common Stock 880770102 75,655 1,898,968 SH   SOLE   1,339,132 126,686 433,150
Tesla Inc Common Stock 88160R101 210,972 753,850 SH   SOLE   708,329 42,380 3,141
Teva Pharmaceutical Industries ADR 881624209 384 24,462 SH   SOLE   24,462 0 0
Toray Industries Inc Common Stock J89494116 41 6,399 SH   SOLE   6,399 0 0
Tower Semiconductor Ltd Common Stock M87915274 524 31,661 SH   SOLE   31,661 0 0
Trimble Inc Common Stock 896239100 6,791 168,084 SH   SOLE   168,084 0 0
Twitter Inc Common Stock 90184L102 153,259 4,661,175 SH   SOLE   3,586,104 260,385 814,686
Ultra Clean Holdings Inc Common Stock 90385V107 467 45,165 SH   SOLE   45,165 0 0
United Parcel Service Inc Common Stock 911312106 472 4,222 SH   SOLE   4,222 0 0
UroGen Pharma Ltd Common Stock M96088105 333 9,007 SH   SOLE   9,007 0 0
Veracyte Inc Common Stock 92337F107 86,546 3,459,073 SH   SOLE   3,427,163 31,910 0
Wix.com Ltd Common Stock M98068105 547 4,523 SH   SOLE   4,523 0 0
Xilinx Inc Common Stock 983919101 12,930 101,977 SH   SOLE   101,977 0 0
Nintendo Co Ltd Common Stock J51699106 49 171 SH   SOLE   0 171 0
FANUC Corp Common Stock J13440102 37 220 SH   SOLE   0 220 0
Bayer AG Common Stock D0712D163 25 390 SH   SOLE   0 390 0
SoftBank Group Corp Common Stock J75963108 54 555 SH   SOLE   0 555 0
Fiserv Inc Common Stock 337738108 165 1,873 SH   SOLE   1,873 0 0
Guidewire Software Inc Common Stock 40171V100 1,705 17,546 SH   SOLE   17,546 0 0
HDFC Bank Ltd ADR 40415F101 771 6,650 SH   SOLE   6,650 0 0
Interactive Brokers Group Inc Common Stock 45841N107 1,017 19,604 SH   SOLE   19,604 0 0
Intuit Inc Common Stock 461202103 1,606 6,143 SH   SOLE   6,143 0 0
MSCI Inc Common Stock 55354G100 156 783 SH   SOLE   783 0 0
Nasdaq Inc Common Stock 631103108 724 8,274 SH   SOLE   8,274 0 0
Charles Schwab Corp/The Common Stock 808513105 736 17,212 SH   SOLE   17,212 0 0
TransUnion Common Stock 89400J107 843 12,617 SH   SOLE   12,617 0 0
Verisk Analytics Inc Common Stock 92345Y106 1,354 10,180 SH   SOLE   10,180 0 0
Visa Inc Common Stock 92826C839 35 223 SH   SOLE   223 0 0
Wirecard AG - ADR ADR 97654L108 203 3,242 SH   SOLE   3,242 0 0
Workday Inc Common Stock 98138H101 38 198 SH   SOLE   198 0 0
Moog Inc Common Stock 615394202 455 5,234 SH   SOLE   5,234 0 0
Stryker Corp Common Stock 863667101 509 2,578 SH   SOLE   2,578 0 0
MGI Digital Graphic Technology Common Stock F4090S113 2,096 40,525 SH   SOLE   40,525 0 0
AquaBounty Technologies Inc Common Stock 03842K200 735 335,420 SH   SOLE   335,420 0 0
Iovance Biotherapeutics Inc Common Stock 462260100 6,576 691,494 SH   SOLE   691,494 0 0
Infineon Technologies AG ADR 45662N103 15 738 SH   SOLE   738 0 0
Rakuten Inc - ADR ADR 75102W108 2,155 226,891 SH   SOLE   226,891 0 0
Taiwan Semiconductor Manufactu ADR 874039100 2,942 71,835 SH   SOLE   71,835 0 0
Intercontinental Exchange Inc Common Stock 45866F104 993 13,041 SH   SOLE   13,041 0 0
Zillow Group Inc Common Stock 98954M200 69,053 1,987,696 SH   SOLE   1,538,133 113,393 336,170
Zuora Inc Common Stock 98983V106 7,578 378,316 SH   SOLE   378,316 0 0
Spotify Technology SA Common Stock L8681T102 63,290 455,979 SH   SOLE   344,812 24,169 86,998
Intuitive Surgical Inc Common Stock 46120E602 2,811 4,926 SH   SOLE   4,926 0 0
Bellicum Pharmaceuticals Inc Common Stock 079481107 4,649 1,379,629 SH   SOLE   1,379,629 0 0
Henkel AG & Co KGaA Common Stock D3207M102 41 426 SH   SOLE   426 0 0
3M Co Common Stock 88579Y101 51 245 SH   SOLE   245 0 0
Evonik Industries AG Common Stock D2R90Y117 38 1,399 SH   SOLE   1,399 0 0
Advanced Micro Devices Inc Common Stock 007903107 13,635 534,292 SH   SOLE   534,292 0 0
GrubHub Inc Common Stock 400110102 11,651 167,706 SH   SOLE   167,706 0 0
Kratos Defense & Security Solu Common Stock 50077B207 1,875 119,952 SH   SOLE   119,952 0 0
NXP Semiconductors NV Common Stock N6596X109 1,877 21,233 SH   SOLE   21,233 0 0
Rubius Therapeutics Inc Common Stock 78116T103 9,586 529,615 SH   SOLE   426,360 93,635 9,620
Opera Ltd ADR 68373M107 69 10,492 SH   SOLE   10,492 0 0
Medtronic PLC Common Stock G5960L103 436 4,784 SH   SOLE   4,784 0 0
Attunity Ltd Common Stock M15332121 438 18,666 SH   SOLE   18,666 0 0
Galmed Pharmaceuticals Ltd Common Stock M47238106 439 53,749 SH   SOLE   53,749 0 0
Intec Pharma Ltd Common Stock M53644106 409 55,838 SH   SOLE   55,838 0 0
ASX Ltd Common Stock Q0604U105 77 1,579 SH   SOLE   1,579 0 0
FirstRand Ltd - F Share Common Stock S5202Z131 170 34,982 SH   SOLE   34,982 0 0
GMO internet Inc Common Stock J1822R104 44 2,700 SH   SOLE   2,700 0 0
Rakuten Inc Common Stock J64264104 237 24,600 SH   SOLE   24,600 0 0
SBI Holdings Inc/Japan Common Stock J6991H100 361 16,100 SH   SOLE   16,100 0 0
Trade Me Group Ltd Common Stock Q9162N106 35 10,506 SH   SOLE   10,506 0 0
Eventbrite Inc Common Stock 29975E109 14,032 731,953 SH   SOLE   579,084 51,328 101,541
Pinduoduo Inc ADR 722304102 10,162 409,739 SH   SOLE   409,739 0 0
Twilio Inc Common Stock 90138F102 6,092 47,157 SH   SOLE   47,157 0 0
Atlassian Corp PLC Common Stock G06242104 5,409 48,130 SH   SOLE   48,130 0 0
Codexis Inc Common Stock 192005106 6,392 311,368 SH   SOLE   303,858 7,510 0
NuVasive Inc Common Stock 670704105 510 8,984 SH   SOLE   8,984 0 0
Xerox Corp Common Stock 984121608 65 2,021 SH   SOLE   2,021 0 0
LINE Corp - ADR ADR 53567X101 252 7,166 SH   SOLE   7,166 0 0
Wabtec Corp Common Stock 929740108 18 246 SH   SOLE   246 0 0
LINE Corp Common Stock J38932109 1,364 38,687 SH   SOLE   38,687 0 0
Adyen NV Common Stock N3501V104 1,079 1,378 SH   SOLE   1,378 0 0
ZhongAn Online P&C Insurance C Common Stock Y989DF109 1,390 386,900 SH   SOLE   386,900 0 0
Meituan Dianping Common Stock G59669104 1,143 169,600 SH   SOLE   169,600 0 0
Wirecard AG Common Stock D22359133 880 7,019 SH   SOLE   7,019 0 0
FirstRand Ltd Common Stock S5202Z131 552 126,433 SH   SOLE   126,433 0 0
Rakuten Inc Common Stock J64264104 1,404 148,400 SH   SOLE   148,400 0 0
SBI Holdings Inc/Japan Common Stock J6991H100 1,298 58,300 SH   SOLE   58,300 0 0
Cellular Biomedicine Group Inc Common Stock 15117P102 4,944 285,762 SH   SOLE   285,762 0 0
Bristol-Myers Squibb Co Common Stock 110122108 9,271 194,317 SH   SOLE   167,435 24,513 2,369
Cloudera Inc Common Stock 18914U100 16,550 1,512,759 SH   SOLE   979,473 0 533,286
Nutanix Inc Common Stock 67059N108 7,096 188,019 SH   SOLE   188,019 0 0
KLA-Tencor Corp Common Stock 482480100 256 2,144 SH   SOLE   2,144 0 0
FMS Enterprises Migun Ltd Common Stock M42619102 483 17,503 SH   SOLE   17,503 0 0
Brainsway Ltd Common Stock M2043H103 485 78,847 SH   SOLE   78,847 0 0
Intercure Ltd Common Stock M549GJ103 1,052 323,056 SH   SOLE   323,056 0 0
Xero Ltd Common Stock Q98665104 121 3,465 SH   SOLE   3,465 0 0