The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ADVANCE AUTO PARTS INC COM 00751Y106 6,613 42,000 SH   DFND 1 42,000 0 0
ACHILLION PHARMACEUTICALS IN COM 00448Q201 6,837 4,300,000 SH   DFND 1 4,300,000 0 0
ACHIEVE LIFE SCIENCE INC COM NEW 004468203 542 448,000 SH   DFND 1 448,000 0 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 5,619 658,000 SH   DFND 1 658,000 0 0
ALIMERA SCIENCES INC COM 016259103 4,981 6,936,000 SH   DFND 1 6,936,000 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 12,073 124,000 SH   DFND 1 124,000 0 0
AMAG PHARMACEUTICALS INC COM 00163U106 28,527 1,878,000 SH   DFND 1 1,878,000 0 0
APRICUS BIOSCIENCES INC COM NEW 03832V307 883 4,600,000 SH   DFND 1 4,600,000 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 2,262 100,000 SH   DFND 1 100,000 0 0
ASSERTIO THERAPEUTICS INC COM 04545L107 11,834 3,278,000 SH   DFND 1 3,278,000 0 0
ALPHATEC HOLDINGS INC COM NEW 02081G201 7,645 3,338,414 SH   DFND 1 3,338,414 0 0
ANTARES PHARMA INC COM 036642106 28,016 10,300,000 SH   DFND 1 10,300,000 0 0
AYTU BIOSCIENCE INC COM PAR 054754700 79 100,000 SH   DFND 1 100,000 0 0
AUTOZONE INC COM 053332102 13,413 16,000 SH   DFND 1 16,000 0 0
CERECOR INC COM 15671L109 58,556 18,128,799 SH   DFND 1 18,128,799 0 0
CELLECTIS S A SPONSORED ADS 15117K103 9,807 589,000 SH   DFND 1 589,000 0 0
CLOVIS ONCOLOGY INC COM 189464100 90,447 5,036,000 SH   DFND 1 5,036,000 0 0
CATALYST PHARMACEUTICALS INC COM 14888U101 2,650 1,380,000 SH   DFND 1 1,380,000 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 4,914 172,000 SH   DFND 1 172,000 0 0
CITIUS PHARMACEUTICALS INC COM NEW 17322U207 768 738,431 SH   DFND 1 738,431 0 0
NEURALSTEM INC COM NEW 64127R401 185 590,000 SH   DFND 1 590,000 0 0
CVS HEALTH CORP COM 126650100 10,352 158,000 SH   DFND 1 158,000 0 0
CVS HEALTH CORP COM 126650100 13,104 200,000 SH Call DFND 1 200,000 0 0
DEL FRISCOS RESTAURANT GROUP COM 245077102 32,375 4,528,000 SH   DFND 1 4,528,000 0 0
DYNATRONICS CORP COM NEW 268157401 1,532 561,000 SH   DFND 1 561,000 0 0
ENERGIZER HLDGS INC NEW COM 29272W109 48,220 1,068,000 SH   DFND 1 1,068,000 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106 35,415 500,000 SH   DFND 1 500,000 0 0
EDGEWELL PERS CARE CO COM 28035Q102 38,097 1,020,000 SH   DFND 1 1,020,000 0 0
EYEGATE PHARMACEUTICALS INC COM 30233M107 8,029 17,262,853 SH   DFND 1 17,262,853 0 0
FIVE BELOW INC COM 33829M101 6,139 60,000 SH   DFND 1 60,000 0 0
FOOT LOCKER INC COM 344849104 11,278 212,000 SH   DFND 1 212,000 0 0
FLEXION THERAPEUTICS INC COM 33938J106 4,528 400,000 SH   DFND 1 400,000 0 0
FRONTDOOR INC COM 35905A109 15,966 600,000 SH   DFND 1 600,000 0 0
CEDAR FAIR L P DEPOSITRY UNIT 150185106 7,095 150,000 SH   DFND 1 150,000 0 0
INCYTE CORP COM 45337C102 6,359 100,000 SH   DFND 1 100,000 0 0
MALLINCKRODT PUB LTD CO SHS G5785G107 36,340 2,300,000 SH   DFND 1 2,300,000 0 0
MARKER THERAPEUTICS INC COM 57055L107 8,258 1,488,000 SH   DFND 1 1,488,000 0 0
NAKED BRAND GROUP LIMITED ORD SHS Q6519T109 3,256 3,892,000 SH   DFND 1 3,892,000 0 0
OLLIES BARGAIN OUTLT HLDGS I COM 681116109 7,183 108,000 SH   DFND 1 108,000 0 0
ONCONOVA THERAPEUTICS INC COM PAR 68232V405 62 29,216 SH   DFND 1 29,216 0 0
ORAMED PHARM INC COM NEW 68403P203 1,629 542,944 SH   DFND 1 542,944 0 0
OVID THERAPEUTICS INC COM 690469101 3,872 1,600,000 SH   DFND 1 1,600,000 0 0
PROGENICS PHARMACEUTICALS IN COM 743187106 23,940 5,700,000 SH   DFND 1 5,700,000 0 0
PLAYA HOTELS & RESORTS NV SHS N70544106 40,782 5,672,000 SH   DFND 1 5,672,000 0 0
PARATEK PHARMACEUTICALS INC COM 699374302 10,096 1,968,000 SH   DFND 1 1,968,000 0 0
PTC THERAPEUTICS INC COM 69366J200 10,296 300,000 SH   DFND 1 300,000 0 0
PERNIX THERAPEUTICS HLDGS IN DBCV 4.250% 4/0 71426VAK4 5,723 21,760,000 PRN   DFND 1 21,760,000 0 0
PULMATRIX INC COM 74584P103 414 1,723,254 SH   DFND 1 1,723,254 0 0
REGENERON PHARMACEUTICALS COM 75886F107 26,145 70,000 SH   DFND 1 70,000 0 0
CASTLE BRANDS INC COM 148435100 886 1,042,000 SH   DFND 1 1,042,000 0 0
RITTER PHARMACEUTICALS INC COM NEW 767836307 30 50,771 SH   DFND 1 50,771 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 12,893 2,878,000 SH   DFND 1 2,878,000 0 0
SMUCKER J M CO COM NEW 832696405 22,438 240,000 SH   DFND 1 240,000 0 0
SMUCKER J M CO COM NEW 832696405 18,698 200,000 SH Call DFND 1 200,000 0 0
SOLID BIOSCIENCES INC COM 83422E105 8,898 332,000 SH   DFND 1 332,000 0 0
SPECTRUM PHARMACEUTICALS INC COM 84763A108 13,125 1,500,000 SH   DFND 1 1,500,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 374,880 1,500,000 SH Put DFND 1 1,500,000 0 0
STERICYCLE INC COM 858912108 31,480 858,000 SH   DFND 1 858,000 0 0
SIERRA ONCOLOGY INC COM 82640U107 2,112 1,600,000 SH   DFND 1 1,600,000 0 0
SYNTHETIC BIOLOGICS INC COM NEW 87164U201 312 556,904 SH   DFND 1 556,904 0 0
TENAX THERAPEUTICS INC COM NEW 88032L209 102 84,590 SH   DFND 1 84,590 0 0
TARGET CORP COM 87612E106 6,609 100,000 SH   DFND 1 100,000 0 0
TJX COS INC NEW COM 872540109 13,422 300,000 SH   DFND 1 300,000 0 0
TEMPUR SEALY INTL INC COM 88023U101 34,114 824,000 SH   DFND 1 824,000 0 0
UNDER ARMOUR INC CL A 904311107 530 30,000 SH   DFND 1 30,000 0 0
VICAL INC COM NEW 925602203 5,145 4,360,500 SH   DFND 1 4,360,500 0 0
VALERITAS HLDGS INC COM NEW 91914N202 6,461 19,850,000 SH   DFND 1 19,850,000 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 26,658 2,836,000 SH   DFND 1 2,836,000 0 0
WELBILT INC COM 949090104 19,531 1,758,000 SH   DFND 1 1,758,000 0 0
MEDIGUS LTD *W EXP 07/23/202 58471G128 1,749 1,285,715 SH   DFND 1 1,285,715 0 0
ZAFGEN INC COM 98885E103 6,227 1,258,000 SH   DFND 1 1,258,000 0 0