The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101 27,976 142,210 SH   DFND 1 142,210 0 0
58.COM, INC SPONSORED ADR 31680Q104 225 3,240 SH   DFND 1 3,240 0 0
ABEONA THERAPEUTICS INC COM 00289Y107 530 33,101 SH   DFND 1 33,101 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 916 60,000 SH   DFND 1 60,000 0 0
ACHAOGEN INC COM 004449104 520 60,000 SH   DFND 1 60,000 0 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 775 30,000 SH   DFND 1 30,000 0 0
ADVANCED ENERGY INDUSTRIES, INC COM 007973100 222 3,830 SH   DFND 1 3,830 0 0
AKARI THERAPEUTICS PLC COM 00972G108 1,646 843,849 SH   DFND 1 843,849 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 857 107,858 SH   DFND 1 107,858 0 0
ALLERGAN PLC SPONSORED ADR G0177J108 19,461 116,730 SH   DFND 1 116,730 0 0
ALLIANCE DATA SYSTEMS CORPORATION COM 018581108 285 1,220 SH   DFND 1 1,220 0 0
ALLISON TRANSMISSION HOLDINGS,INC COM 01973R101 252 6,220 SH   DFND 1 6,220 0 0
ALPHABET INC CLASS C CL C 38259P706 4,351 3,900 SH   DFND 1 0 0 3,900
ALTRIA GROUP INC COM 02209S103 1,846 32,500 SH   DFND 1 32,500 0 0
AMC NETWORKS INC COM 00164V103 316 5,080 SH   DFND 1 5,080 0 0
AMERICAN EXPRESS CO COM 025816109 1,725 17,600 SH   DFND 1 17,600 0 0
AMGEN INC COM 031162100 8,884 48,130 SH   DFND 1 48,130 0 0
ANHEUSER-BUSCH INBEV NV SPONSORED ADR 03524A108 6,952 69,000 SH   DFND 1 69,000 0 0
ANTHEM INC COM 036752103 271 1,140 SH   DFND 1 1,140 0 0
AUTOHOME INC SPONSORED ADR 05278C107 270 2,670 SH   DFND 1 2,670 0 0
BAIDU INC COM 056752108 277 1,140 SH   DFND 1 1,140 0 0
BECTON DICKINSON & CO COM 075887109 5,462 22,800 SH   DFND 1 22,800 0 0
BERKSHIRE HATHAWAY INC CLASS A CL A 084670108 201,377 714 SH   DFND 1 714 0 0
BHP BILLITON PLC COM 05545E209 9,463 210,530 SH   DFND 1 210,530 0 0
BIODELIVERY SCIENCES INTERNATIONAL INC COM 09060J106 713 241,567 SH   DFND 1 241,567 0 0
BIOGEN INC COM 09062X103 5,787 19,940 SH   DFND 1 19,940 0 0
BOEING CO COM 097023105 21,573 64,300 SH   DFND 1 64,300 0 0
BRIGHT SCHOLAR EDUCATION HOLDINGS LTD SPONSORED ADR 109199109 268 16,140 SH   DFND 1 16,140 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 3,436 62,080 SH   DFND 1 62,080 0 0
BRITISH AMERICAN TOBACCO PLC COM 110448107 976 19,350 SH   DFND 1 19,350 0 0
THE BUCKLE, INC COM 118440106 307 11,400 SH   DFND 1 11,400 0 0
CA INC COM 12673P105 267 7,490 SH   DFND 1 7,490 0 0
CALITHERA BIOSCIENCES,INC COM 13089P101 500 100,000 SH   DFND 1 100,000 0 0
CANNAE HOLDINGS INC COM 13765N107 249 13,400 SH   DFND 1 13,400 0 0
CELGENE CORP COM 151020104 5,112 64,370 SH   DFND 1 64,370 0 0
CHECK POINT SOFTWARE TECHNOLOGIES LTD COM M22465104 245 2,510 SH   DFND 1 2,510 0 0
CHINA MOBILE LIMITED SPONSORED ADR 16941M109 1,323 29,800 SH   DFND 1 29,800 0 0
CIGNA CORPORATION COM 125509109 255 1,500 SH   DFND 1 1,500 0 0
CIRRUS LOGIC, INC COM 172755100 250 6,530 SH   DFND 1 6,530 0 0
CISCO SYSTEMS INC COM 17275R102 6,799 158,000 SH   DFND 1 158,000 0 0
COCA COLA CO COM 191216100 2,018 46,000 SH   DFND 1 46,000 0 0
COLGATE-PALMOLIVE COMPANY COM 194162103 7,499 115,700 SH   DFND 1 115,700 0 0
CORCEPT THERAPEUTICS INC COM 218352102 472 30,000 SH   DFND 1 30,000 0 0
CTRIP.COM INTERNATIONAL, LTD SPONSORED ADR 22943F100 288 6,050 SH   DFND 1 6,050 0 0
DANAHER CORP COM 235851102 21,295 215,800 SH   DFND 1 215,800 0 0
DAVITA HEALTHCARE PARTNERS INC COM 23918K108 18,745 269,940 SH   DFND 1 269,940 0 0
DELUXE CORP COM 248019101 228 3,440 SH   DFND 1 3,440 0 0
DEUTSCHE X-TRACKERS HARVEST CSI 300 CHINA A-SHARES FUND ETF 233051879 1,610 60,700 SH   DFND 1 60,700 0 0
DIAMOND OFFSHORE DRILLING INC COM 25271C102 734 35,200 SH   DFND 1 35,200 0 0
DYNAVAX TECHNOLOGIES CORPORATION COM 268158201 1,994 130,755 SH   DFND 1 130,755 0 0
ECOLAB INC COM 278865100 295 2,100 SH   DFND 1 2,100 0 0
EXPRESS SCRIPTS HOLDING INC COM 30219G108 8,627 111,740 SH   DFND 1 111,740 0 0
EXXON MOBIL CORPORATION COM 30231G102 10,787 130,393 SH   DFND 1 130,393 0 0
F5 NETWORKS, INC COM 315616102 286 1,660 SH   DFND 1 1,660 0 0
FORTIVE CORP COM 34959J108 10,926 141,700 SH   DFND 1 141,700 0 0
GENERAL ELECTRIC COMPANY COM 369604103 6,891 506,300 SH   DFND 1 506,300 0 0
GENERAL MILLS,INC COM 370334104 7,568 171,000 SH   DFND 1 171,000 0 0
GILEAD SCIENCES INC COM 375558103 8,462 119,450 SH   DFND 1 119,450 0 0
GRAY TELEVISION, INC COM 389375106 346 21,890 SH   DFND 1 21,890 0 0
H&R BLOCK, INC COM 093671105 222 9,760 SH   DFND 1 9,760 0 0
HOLOGIC, INC COM 436440101 272 6,850 SH   DFND 1 6,850 0 0
HOSTESS BRANDS,INC COM 44109J106 242 17,810 SH   DFND 1 17,810 0 0
HOULIHAN LOKEY, INC COM 441593100 294 5,740 SH   DFND 1 5,740 0 0
ISHARES CORE HIGH DIVIDEND ETF COM 46429B663 450 5,300 SH   DFND 1 5,300 0 0
INTERDIGITAL INC COM 45867G101 265 3,270 SH   DFND 1 3,270 0 0
INTERNATIONAL BUSINESS MACHINES CORP COM 459200101 31,655 226,590 SH   DFND 1 226,590 0 0
INTUITIVE SURGICAL INC COM 46120E602 8,924 18,650 SH   DFND 1 18,650 0 0
ISHARES NASDAQ BIOTECHNOLOGY ETF 464287556 2,844 25,900 SH   DFND 1 25,900 0 0
JACK HENRY & ASSOCIATES INC COM 426281101 1,786 13,700 SH   DFND 1 13,700 0 0
JOHNSON & JOHNSON COM 478160104 29,961 246,920 SH   DFND 1 246,920 0 0
KBR, INC COM 48242W106 270 15,040 SH   DFND 1 15,040 0 0
KLA-TENCOR CORPORATION COM 482480100 243 2,370 SH   DFND 1 2,370 0 0
THE KRAFT HEINZ COMPANY COM 500754106 12,769 203,260 SH   DFND 1 203,260 0 0
LINN ENERGY INC COM 53601P304 260 6,720 SH   DFND 1 6,720 0 0
LOEWS CORPORATION COM 540424108 468 9,700 SH   DFND 1 9,700 0 0
MASTERCARD INC CL A 57636Q104 1,965 10,000 SH   DFND 1 10,000 0 0
MC DERMOTT INTERNATIONAL,INC COM 580037703 1,506 76,638 SH   DFND 1 76,638 0 0
MCDONADLD'S CORP COM 580135101 1,576 10,060 SH   DFND 1 10,060 0 0
MCKESSON CORPORATION COM 58155Q103 232 1,740 SH   DFND 1 1,740 0 0
MEDTRONIC INC COM 585055106 4,340 50,700 SH   DFND 1 50,700 0 0
THE MICHAELS COS INC COM 59408Q106 271 14,120 SH   DFND 1 14,120 0 0
MSG NETWORKS INC COM 553573106 276 11,540 SH   DFND 1 11,540 0 0
NATIONAL OILWELL VARCO INC COM 637071101 9,769 225,100 SH   DFND 1 225,100 0 0
NESTLE SA SPONSORED ADR 641069406 14,798 191,110 SH   DFND 1 191,110 0 0
NOVO NORDISK A/S SPONSORED ADR 670100205 15,637 339,040 SH   DFND 1 339,040 0 0
NOW INC COM 67011P100 742 55,675 SH   DFND 1 55,675 0 0
NUTRIEN LTD COM 67077M108 20,466 376,360 SH   DFND 1 376,360 0 0
OCULAR THERAPEUTIX INC COM 67576A100 540 80,011 SH   DFND 1 80,011 0 0
OMNICOM GROUP INC COM 681919106 419 5,500 SH   DFND 1 5,500 0 0
ONESMART INTERNATIONAL EDUCATION GROUP LIMITED SPONSORED ADR 68276W103 266 23,940 SH   DFND 1 23,940 0 0
ORACLE CORPORATION COM 68389X105 247 5,600 SH   DFND 1 5,600 0 0
PACCAR INC COM 693718108 230 3,710 SH   DFND 1 3,710 0 0
PHILLIPS 66 COM 718546104 27,569 245,470 SH   DFND 1 245,470 0 0
PRAXAIR INC COM 74005P104 23,884 151,020 SH   DFND 1 151,020 0 0
PREMIER, INC COM 74051N102 298 8,200 SH   DFND 1 8,200 0 0
THE PROCTER&GAMBLE COMPANY COM 742718109 13,598 174,200 SH   DFND 1 174,200 0 0
PROGENICS PHARMACEUTICALS INC COM 743187106 1,608 200,000 SH   DFND 1 200,000 0 0
RE/MAX HOLDINGS, INC COM 75524W108 234 4,470 SH   DFND 1 4,470 0 0
RMR GROUP INC COM 74967R106 260 3,310 SH   DFND 1 3,310 0 0
ROCHE HOLDING AG SPONSORED ADR 771195104 4,606 166,700 SH   DFND 1 166,700 0 0
ROPER TECHNOLOGIES INC COM 776696106 19,595 71,020 SH   DFND 1 71,020 0 0
ROYAL DUTCH SHELL PLC CLASS B CL B 780259107 4,868 67,000 SH   DFND 1 67,000 0 0
SANOFI-AVENTIS SA SPONSORED ADR 80105N105 5,483 137,040 SH   DFND 1 137,040 0 0
SAREPTA THERAPEUTICS INC COM 803607100 1,322 10,000 SH   DFND 1 10,000 0 0
SENSATA TECHNOLOGIES HOLDING COM G8060N102 856 18,000 SH   DFND 1 18,000 0 0
SINCLAIR BROADCAST GROUP, INC COM 829226109 279 8,670 SH   DFND 1 8,670 0 0
STERICYCLE INC COM 858912108 3,108 47,600 SH   DFND 1 47,600 0 0
STORE CAPITAL CORPORATION REIT 862121100 1,006 36,700 SH   DFND 1 36,700 0 0
SYNCHRONY FINANCIAL COM 87165B103 210 6,300 SH   DFND 1 6,300 0 0
SYNERGY PHARMACEUTICALS INC COM 871639308 4,002 2,300,000 SH   DFND 1 2,300,000 0 0
SYNTEL INC COM 87162H103 1,003 31,270 SH   DFND 1 31,270 0 0
TARO PHARMACEUTICAL INDUSTRIES LTD COM M8737E108 296 2,560 SH   DFND 1 2,560 0 0
TEGNA INC COM 87901J105 258 23,790 SH   DFND 1 23,790 0 0
TG THERAPEUTICS INC COM 88322Q108 2,104 160,000 SH   DFND 1 160,000 0 0
UNITED TECHNOLOGIES CORP COM 913017109 20,711 165,650 SH   DFND 1 165,650 0 0
UNITED THERAPEUTICS CORPORATION COM 91307C102 260 2,300 SH   DFND 1 2,300 0 0
US BANCORP COM 902973304 5,647 112,900 SH   DFND 1 112,900 0 0
VANGUARD CONSUMER STAPLES ETF ETF 92204A207 3,547 26,420 SH   DFND 1 26,420 0 0
VANGUARD FTSE EMERGING MARKETS ETF COM 922042858 717 17,000 SH   DFND 1 17,000 0 0
VANGUARD S&P 500 ETF COM 922908363 6,410 25,690 SH   DFND 1 25,690 0 0
VISA INC CLASS A CL A 92826C839 22,768 171,900 SH   DFND 1 171,900 0 0
WABTEC CORPORATION COM 929740108 19,003 192,770 SH   DFND 1 192,770 0 0
WALKER & DUNLOP INC COM 93148P102 244 4,390 SH   DFND 1 4,390 0 0
WARRIOR MET COAL INC COM 93627C101 317 11,500 SH   DFND 1 11,500 0 0
WATERS CORPORATION COM 941848103 10,028 51,800 SH   DFND 1 51,800 0 0
WELLS FARGO & CO COM 949746101 85,623 1,544,420 SH   DFND 1 1,544,420 0 0
YUM!BRANDS, INC COM 988498101 234 2,990 SH   DFND 1 2,990 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADR 98980A105 327 16,330 SH   DFND 1 16,330 0 0