The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2U INC Common Stock 90214J101 19,848 237,528 SH   OTR   181,389 0 56,139
3D SYSTEMS CORP Common Stock 88554D205 3,298 238,797 SH   SOLE   238,797 0 0
3M CO Common Stock 88579Y101 58 294 SH   SOLE   294 0 0
ADOBE SYSTEMS INC Common Stock 00724F101 10,579 43,392 SH   SOLE   43,392 0 0
AERONAUTICS LTD Common Stock M0R84M115 378 186,501 SH   SOLE   186,501 0 0
AEROVIRONMENT INC Common Stock 008073108 10,972 153,610 SH   OTR   56,258 0 97,352
ALIBABA GROUP HOLDING-SP ADR ADR 01609W102 32,444 174,874 SH   OTR   134,647 6,477 33,750
ALIGN TECHNOLOGY INC Common Stock 016255101 4,866 14,221 SH   SOLE   14,221 0 0
ALLEGHENY TECHNOLOGIES INC Common Stock 01741R102 61 2,440 SH   SOLE   2,440 0 0
ALNYLAM PHARMACEUTICALS INC Common Stock 02043Q107 1,907 19,362 SH   SOLE   19,362 0 0
ALPHABET INC-CL C Common Stock 02079K107 16,302 14,612 SH   OTR   10,360 0 4,252
AMAZON.COM INC Common Stock 023135106 87,349 51,388 SH   OTR   41,701 1,540 8,147
AMETEK INC Common Stock 031100100 482 6,682 SH   SOLE   6,682 0 0
ANSYS INC Common Stock 03662Q105 3,625 20,814 SH   SOLE   20,814 0 0
APPLE INC Common Stock 037833100 78,270 422,828 SH   OTR   324,964 13,503 84,361
APTIV PLC Common Stock G6095L109 39,740 433,705 SH   OTR   310,016 19,216 104,473
AQUABOUNTY TECHNOLOGIES Common Stock 03842K200 568 170,697 SH   SOLE   170,697 0 0
ARCONIC INC Common Stock 03965L100 431 25,358 SH   SOLE   25,358 0 0
ARCTURUS THERAPEUTICS LTD Common Stock M1492T105 4,526 533,773 SH   SOLE   533,773 0 0
ARKEMA SA Common Stock F0392W125 56 473 SH   SOLE   473 0 0
ARRK CORP Common Stock J0198N101 584 539,201 SH   SOLE   539,201 0 0
ASX Ltd Common Stock Q0604U105 191 4,017 SH   SOLE   4,017 0 0
ATHENAHEALTH INC Common Stock 04685W103 87,373 549,035 SH   OTR   411,329 13,925 123,781
AUDIOCODES LTD Common Stock M15342104 599 77,046 SH   SOLE   77,046 0 0
AUTODESK INC Common Stock 052769106 4,450 33,947 SH   SOLE   33,947 0 0
BAIDU INC - SPON ADR ADR 056752108 100,940 415,392 SH   OTR   298,636 14,244 102,512
BAYER AG REG Common Stock D0712D163 43 390 SH   OTR   0 390 0
BELLICUM PHARMACEUTICALS INC Common Stock 079481107 2,094 283,772 SH   SOLE   283,772 0 0
BERTRANDT AG Common Stock D1014N107 500 5,265 SH   SOLE   5,265 0 0
BEZEQ THE ISRAELI TELECOMMUNICATION CORP LTD Common Stock M2012Q100 496 440,715 SH   SOLE   440,715 0 0
BIOGEN INC Common Stock 09062X103 4,078 14,050 SH   SOLE   14,050 0 0
BITCOIN INVESTMENT TRUST Open-End Fund 09173T108 14,898 1,746,550 SH   OTR   735,078 451,180 560,292
BLUEBIRD BIO INC Common Stock 09609G100 41,328 263,321 SH   OTR   179,659 11,118 72,544
BRISTOL-MYERS SQUIBB CO Common Stock 110122108 2,111 38,147 SH   SOLE   38,147 0 0
CAMTEK LTD Common Stock M20791105 555 75,444 SH   SOLE   75,444 0 0
CARPENTER TECHNOLOGY Common Stock 144285103 66 1,246 SH   SOLE   1,246 0 0
Cboe Global Markets Inc Common Stock 12503M108 97 932 SH   SOLE   932 0 0
CELGENE CORP Common Stock 151020104 7,280 91,659 SH   SOLE   91,659 0 0
CELLCOM ISRAEL LTD Common Stock M2196U109 405 71,377 SH   SOLE   71,377 0 0
CELLECTIS - ADR ADR 15117K103 6,910 244,263 SH   SOLE   244,263 0 0
CERAGON NETWORKS LTD Common Stock M22013102 732 205,069 SH   SOLE   205,069 0 0
CERUS CORP Common Stock 157085101 37,988 5,695,371 SH   OTR   3,990,842 63,256 1,641,273
Charles Schwab Corp/The Common Stock 808513105 169 3,302 SH   SOLE   3,302 0 0
CHECK POINT SOFTWARE TECH Common Stock M22465104 515 5,268 SH   SOLE   5,268 0 0
COGNEX CORP Common Stock 192422103 1,926 43,170 SH   SOLE   43,170 0 0
COMPUGEN LTD Common Stock M25722105 17,730 5,372,874 SH   OTR   5,180,161 49,584 143,129
CONFORMIS INC Common Stock 20717E101 1,448 1,158,321 SH   SOLE   1,158,321 0 0
CORNERSTONE ONDEMAND INC Common Stock 21925Y103 1,408 29,696 SH   SOLE   29,696 0 0
CRISPR THERAPEUTICS AG Common Stock H17182108 27,449 467,140 SH   OTR   355,062 17,789 94,289
CYBERARK SOFTWARE LTD/ISRAEL Common Stock M2682V108 651 10,342 SH   SOLE   10,342 0 0
DAIMLER AG-UNSPONSORED ADR ADR 233825207 1,357 84,552 SH   SOLE   84,552 0 0
DANEL (ADIR YEOSHUA) LTD Common Stock M27013107 491 11,099 SH   SOLE   11,099 0 0
DASSAULT SYSTEMES SE Common Stock F2457H472 1,987 14,179 SH   SOLE   14,179 0 0
DEERE & CO Common Stock 244199105 1,987 14,216 SH   SOLE   14,216 0 0
Domino's Pizza Inc Common Stock 25754A201 97 343 SH   SOLE   343 0 0
DOWDUPONT INC Common Stock 26078J100 63 962 SH   SOLE   962 0 0
EASTMAN CHEMICAL CO Common Stock 277432100 60 598 SH   SOLE   598 0 0
EASTMAN KODAK CO Common Stock 277461406 50 13,077 SH   SOLE   13,077 0 0
EDITAS MEDICINE INC Common Stock 28106W103 78,166 2,181,572 SH   OTR   1,484,794 86,902 609,876
ELBIT SYSTEMS LTD Common Stock M3760D101 1,546 13,023 SH   SOLE   13,023 0 0
ELBIT SYSTEMS LTD Common Stock M3760D101 509 4,332 SH   SOLE   4,332 0 0
EVELO BIOSCIENCES INC Common Stock 299734103 1,497 126,831 SH   SOLE   126,831 0 0
EVOGENE LTD Common Stock M4119S104 479 167,347 SH   SOLE   167,347 0 0
EVONIK INDUSTRIES AG Common Stock 299766204 58 1,731 SH   SOLE   1,731 0 0
EXONE CO/THE Common Stock 302104104 12,420 1,754,274 SH   OTR   1,373,455 0 380,819
FACEBOOK INC-A Common Stock 30303M102 12,755 65,637 SH   OTR   64,956 681 0
FANUC CORP Common Stock J13440102 44 220 SH   OTR   0 220 0
FANUC CORP-UNSP ADR ADR 307305102 734 37,019 SH   SOLE   37,019 0 0
FARO TECHNOLOGIES INC Common Stock 311642102 439 8,083 SH   SOLE   8,083 0 0
FirstRand Ltd Common Stock S5202Z131 162 34,982 SH   SOLE   34,982 0 0
Fiserv Inc Common Stock 337738108 265 3,578 SH   SOLE   3,578 0 0
FIVE PRIME THERAPEUTICS INC Common Stock 33830X104 2,895 183,094 SH   SOLE   183,094 0 0
FMS ENTERPRISES MIGUN LTD Common Stock M42619102 464 17,178 SH   SOLE   17,178 0 0
FOAMIX PHARMACEUTICALS LTD Common Stock M46135105 532 106,243 SH   SOLE   106,243 0 0
FOUNDATION MEDICINE INC Common Stock 350465100 2,698 19,733 SH   OTR   0 0 19,733
GENERAL ELECTRIC CO Common Stock 369604103 585 43,008 SH   SOLE   43,008 0 0
GENERAL MOTORS CO Common Stock 37045V100 3,417 86,731 SH   SOLE   86,731 0 0
GILAT SATELLITE NETWORKS LTD Common Stock M51474118 599 64,780 SH   SOLE   64,780 0 0
GILEAD SCIENCES INC Common Stock 375558103 2,051 28,946 SH   SOLE   28,946 0 0
Guidewire Software Inc Common Stock 40171V100 324 3,649 SH   SOLE   3,649 0 0
HDFC Bank Ltd ADR 40415F101 136 1,297 SH   SOLE   1,297 0 0
HENKEL AG & CO KGAA Common Stock 42550U109 55 495 SH   SOLE   495 0 0
HEXAGON AB Common Stock W40063104 467 8,363 SH   SOLE   8,363 0 0
HEXCEL CORP Common Stock 428291108 65 975 SH   SOLE   975 0 0
HILAN LTD Common Stock M5299H123 528 24,022 SH   SOLE   24,022 0 0
HORTONWORKS INC Common Stock 440894103 18,196 998,662 SH   OTR   724,231 0 274,431
HP INC Common Stock 40434L105 2,969 130,842 SH   SOLE   130,842 0 0
HUBSPOT INC Common Stock 443573100 11,950 95,299 SH   SOLE   95,299 0 0
ILLUMINA INC Common Stock 452327109 92,966 332,865 SH   OTR   234,423 16,117 82,325
INCYTE CORP Common Stock 45337C102 2,943 43,924 SH   SOLE   43,924 0 0
INFINEON TECHNOLOGIES-ADR ADR 45662N103 1,361 53,209 SH   SOLE   53,209 0 0
INOVIO PHARMACEUTICALS INC Common Stock 45773H201 4,683 1,194,657 SH   OTR   1,172,261 22,396 0
INTELLIA THERAPEUTICS INC Common Stock 45826J105 123,492 4,513,584 SH   OTR   3,479,906 208,363 825,315
Interactive Brokers Group Inc Common Stock 45841N107 316 4,906 SH   SOLE   4,906 0 0
Intercontinental Exchange Inc Common Stock 45866F104 133 1,812 SH   SOLE   1,812 0 0
Intuit Inc Common Stock 461202103 267 1,307 SH   SOLE   1,307 0 0
INTUITIVE SURGICAL INC Common Stock 46120E602 1,545 3,230 SH   SOLE   3,230 0 0
INVITAE CORP Common Stock 46185L103 64,785 8,814,227 SH   OTR   6,958,975 98,355 1,756,897
IONIS PHARMACEUTICALS INC Common Stock 462222100 8,881 213,127 SH   OTR   102,356 0 110,771
IOVANCE BIOTHERAPEUTICS INC Common Stock 462260100 1,570 122,623 SH   SOLE   122,623 0 0
ITURAN LOCATION AND CONTROL Common Stock M6158M104 506 16,681 SH   SOLE   16,681 0 0
JD.COM INC-ADR ADR 47215P106 68,823 1,766,968 SH   OTR   1,373,293 54,138 339,537
K2M GROUP HOLDINGS INC Common Stock 48273J107 699 31,082 SH   SOLE   31,082 0 0
KAMADA LTD Common Stock M6240T109 616 119,537 SH   SOLE   119,537 0 0
KONINKLIJKE DSM NV Common Stock N5017D122 60 599 SH   SOLE   599 0 0
LENDINGCLUB CORP Common Stock 52603A109 58,667 15,479,488 SH   OTR   12,002,131 508,463 2,968,894
LENDINGTREE INC Common Stock 52603B107 9,377 43,860 SH   SOLE   43,860 0 0
MAGICJACK VOCALTEC LTD Common Stock M6787E101 555 65,344 SH   SOLE   65,344 0 0
MATERIALISE NV-ADR ADR 57667T100 19,394 1,494,142 SH   OTR   1,470,809 10,716 12,617
MATRIX IT LTD Common Stock M6859E153 504 47,361 SH   SOLE   47,361 0 0
MAZOR ROBOTICS LTD-SPON ADR ADR 57886P103 3,569 64,296 SH   SOLE   64,296 0 0
MEDIDATA SOLUTIONS INC Common Stock 58471A105 50,571 627,743 SH   OTR   480,229 20,575 126,939
MELLANOX TECHNOLOGIES LTD Common Stock M51363113 591 7,013 SH   SOLE   7,013 0 0
MERCADOLIBRE INC Common Stock 58733R102 34,140 114,208 SH   OTR   87,009 2,612 24,587
MGI DIGITAL GRAPHIC TECHNOLO Common Stock F4090S113 2,596 37,496 SH   SOLE   37,496 0 0
MGT CAPITAL INVESTMENTS INC Common Stock 55302P202 2,317 3,091,503 SH   OTR   3,052,859 38,644 0
MICHELIN (CGDE) Common Stock 591680103 1 11 SH   SOLE   11 0 0
MICROSOFT CORP Common Stock 594918104 30,718 311,510 SH   OTR   256,402 8,052 47,056
MOOG INC Common Stock 615394202 540 6,928 SH   SOLE   6,928 0 0
MSCI Inc Common Stock 55354G100 130 783 SH   SOLE   783 0 0
NANO DIMENSION LTD - ADR ADR 63008G104 703 334,774 SH   SOLE   334,774 0 0
NANOSTRING TECHNOLOGIES INC Common Stock 63009R109 35,916 2,625,472 SH   OTR   2,583,321 42,151 0
Nasdaq Inc Common Stock 631103108 204 2,232 SH   SOLE   2,232 0 0
NETFLIX INC Common Stock 64110L106 69,758 178,212 SH   OTR   136,309 7,503 34,400
NICE LTD ADR 653656108 586 5,646 SH   SOLE   5,646 0 0
NINTENDO CO LTD Common Stock J51699106 56 171 SH   OTR   0 171 0
NOVA MEASURING INSTRUMENTS Common Stock M7516K103 526 19,291 SH   SOLE   19,291 0 0
NVIDIA CORP Common Stock 67066G104 73,802 311,533 SH   OTR   247,023 8,064 56,446
ORBOTECH LTD Common Stock M75253100 563 9,105 SH   SOLE   9,105 0 0
ORGANOVO HOLDINGS INC Common Stock 68620A104 20,805 14,860,438 SH   OTR   14,728,652 131,786 0
PACIFIC BIOSCIENCES OF CALIF Common Stock 69404D108 22,441 6,321,293 SH   OTR   6,243,166 78,127 0
PARTNER COMMUNICATIONS CO Common Stock M78465107 430 114,641 SH   SOLE   114,641 0 0
PAYPAL HOLDINGS INC Common Stock 70450Y103 11,733 140,907 SH   SOLE   140,907 0 0
PERCEPTRON INC Common Stock 71361F100 587 55,612 SH   SOLE   55,612 0 0
PLURISTEM THERAPEUTICS INC Common Stock 72940R102 1,753 1,436,501 SH   SOLE   1,436,501 0 0
POINTER TELOCATION LTD Common Stock M7946T104 430 35,794 SH   SOLE   35,794 0 0
POLYONE CORPORATION Common Stock 73179P106 62 1,435 SH   SOLE   1,435 0 0
PRAXAIR INC Common Stock 74005P104 67 424 SH   SOLE   424 0 0
PRODWAYS GROUP SA Common Stock F7329W102 2,673 536,161 SH   SOLE   536,161 0 0
PROTO LABS INC Common Stock 743713109 9,334 78,469 SH   OTR   37,620 0 40,849
PTC INC Common Stock 69370C100 2,114 22,530 SH   SOLE   22,530 0 0
RADCOM LTD Common Stock M81865111 580 29,363 SH   SOLE   29,363 0 0
RADWARE LTD Common Stock M81873107 620 24,521 SH   SOLE   24,521 0 0
Rakuten Inc Common Stock J64264104 166 24,600 SH   SOLE   24,600 0 0
RAKUTEN INC-ADR ADR 75102W108 1,501 222,428 SH   SOLE   222,428 0 0
RED HAT INC Common Stock 756577102 45,964 342,069 SH   OTR   264,498 10,973 66,598
REDFIN CORP Common Stock 75737F108 30,031 1,300,606 SH   OTR   957,255 47,781 295,570
REDHILL BIOPHARMA LTD-SP ADR ADR 757468103 961 112,648 SH   SOLE   112,648 0 0
REGENERON PHARMACEUTICALS Common Stock 75886F107 6,411 18,582 SH   SOLE   18,582 0 0
RENISHAW PLC Common Stock G75006117 2,813 40,232 SH   SOLE   40,232 0 0
ROCKWELL AUTOMATION INC Common Stock 773903109 1,301 7,826 SH   SOLE   7,826 0 0
SALESFORCE.COM INC Common Stock 79466L302 50,179 367,884 SH   OTR   274,818 10,417 82,649
SANDVIK AB Common Stock W74857165 59 3,342 SH   SOLE   3,342 0 0
SAPIENS INTERNATIONAL CORP Common Stock N7716A151 604 61,856 SH   SOLE   61,856 0 0
SBI Holdings Inc/Japan Common Stock J6991H100 415 16,100 SH   SOLE   16,100 0 0
SERES THERAPEUTICS INC Common Stock 81750R102 28,091 3,266,428 SH   OTR   2,518,228 137,352 610,848
SERVICENOW INC Common Stock 81762P102 6,288 36,461 SH   SOLE   36,461 0 0
SHOPIFY INC - CLASS A Common Stock 82509L107 12,411 85,073 SH   SOLE   85,073 0 0
SIEMENS AG Common Stock D69671218 597 4,512 SH   SOLE   4,512 0 0
SILICOM LTD Common Stock M84116108 574 14,929 SH   SOLE   14,929 0 0
SLM SOLUTIONS GROUP AG Common Stock D6T690109 2,541 66,547 SH   SOLE   66,547 0 0
SNAP INC - A Common Stock 83304A106 3,331 254,507 SH   SOLE   254,507 0 0
SOFTBANK GROUP CORP Common Stock J75963108 40 555 SH   OTR   0 555 0
SOFTBANK GROUP CORP-UNSP ADR ADR 83404D109 10,646 298,614 SH   SOLE   298,614 0 0
SOLAREDGE TECHNOLOGIES INC Common Stock 83417M104 467 9,754 SH   SOLE   9,754 0 0
SPLUNK INC Common Stock 848637104 37,111 374,446 SH   OTR   286,108 14,400 73,938
SPOTIFY TECHNOLOGY SA Common Stock L8681T102 34,036 202,304 SH   OTR   157,152 6,849 38,303
SQUARE INC - A Common Stock 852234103 84,210 1,366,161 SH   OTR   1,021,315 50,160 294,686
Starbucks Corp Common Stock 855244109 182 3,727 SH   SOLE   3,727 0 0
STRATASYS LTD Common Stock M85548101 130,319 6,808,746 SH   OTR   4,904,098 280,173 1,624,475
STRYKER CORP Common Stock 863667101 619 3,663 SH   SOLE   3,663 0 0
SUNY CELLULAR COMMUNICATION Common Stock M8708U107 499 913,944 SH   SOLE   913,944 0 0
SYROS PHARMACEUTICALS INC Common Stock 87184Q107 18,373 1,799,553 SH   OTR   1,520,862 17,643 261,048
TAIWAN SEMICONDUCTOR-SP ADR ADR 874039100 33,316 911,273 SH   OTR   777,422 19,694 114,157
TARO PHARMACEUTICAL INDUS Common Stock M8737E108 623 5,385 SH   SOLE   5,385 0 0
TELADOC INC Common Stock 87918A105 7,517 129,484 SH   SOLE   129,484 0 0
TENCENT HOLDINGS LTD-UNS ADR ADR 88032Q109 56,289 1,120,180 SH   OTR   880,710 31,864 207,606
TERADYNE INC Common Stock 880770102 55,771 1,464,955 SH   OTR   1,016,908 65,357 382,690
TESLA INC Common Stock 88160R101 152,227 443,874 SH   OTR   424,147 19,727 0
TEVA PHARMACEUTICAL-SP ADR ADR 881624209 741 30,487 SH   SOLE   30,487 0 0
TORAY INDUSTRIES INC Common Stock J89494116 53 6,736 SH   SOLE   6,736 0 0
TOWER SEMICONDUCTOR LTD Common Stock M87915274 407 18,492 SH   SOLE   18,492 0 0
TOYOTA MOTOR CORP -SPON ADR ADR 892331307 1,683 13,066 SH   SOLE   13,066 0 0
Trade Me Group Ltd Common Stock Q9162N106 33 10,506 SH   SOLE   10,506 0 0
TransUnion Common Stock 89400J107 246 3,437 SH   SOLE   3,437 0 0
TRIMBLE INC Common Stock 896239100 5,233 159,356 SH   SOLE   159,356 0 0
TWITTER INC Common Stock 90184L102 120,435 2,757,845 SH   OTR   2,085,106 101,838 570,901
ULTRA CLEAN HOLDINGS INC Common Stock 90385V107 596 35,874 SH   SOLE   35,874 0 0
UNITED PARCEL SERVICE-CL B Common Stock 911312106 577 5,435 SH   SOLE   5,435 0 0
UROGEN PHARMA LTD Common Stock M96088105 470 9,438 SH   SOLE   9,438 0 0
VERACYTE INC Common Stock 92337F107 35,125 3,760,659 SH   OTR   3,729,271 31,388 0
Verisk Analytics Inc Common Stock 92345Y106 76 702 SH   SOLE   702 0 0
Visa Inc Common Stock 92826C839 159 1,198 SH   SOLE   1,198 0 0
VOLKSWAGEN AG-SPONS ADR ADR 928662303 7 215 SH   SOLE   215 0 0
Wirecard AG ADR 97654L108 96 1,183 SH   SOLE   1,183 0 0
WIX.COM LTD Common Stock M98068105 609 6,073 SH   SOLE   6,073 0 0
Workday Inc Common Stock 98138H101 162 1,334 SH   SOLE   1,334 0 0
Xero Ltd Common Stock Q98665104 115 3,465 SH   SOLE   3,465 0 0
XILINX INC Common Stock 983919101 46,770 716,666 SH   OTR   531,112 22,225 163,329
ZILLOW GROUP INC - C Common Stock 98954M200 7,941 134,461 SH   SOLE   134,461 0 0
ZUORA INC - CLASS A Common Stock 98983V106 4,059 149,221 SH   SOLE   149,221 0 0