The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2U INC Common Stock 90214J101 38,590 459,243 SH   OTR   360,578 9,760 88,905
3D SYSTEMS CORP Common Stock 88554D205 3,226 278,302 SH   SOLE   278,302 0 0
ADOBE SYSTEMS INC Common Stock 00724F101 7,725 35,752 SH   SOLE   35,752 0 0
AERONAUTICS LTD Common Stock M0R84M115 358 136,746 SH   SOLE   136,746 0 0
AEROVIRONMENT INC Common Stock 008073108 7,920 174,036 SH   OTR   66,173 0 107,863
ALBEMARLE CORP Common Stock 012653101 1,650 17,794 SH   SOLE   17,794 0 0
ALIBABA GROUP HOLDING-SP ADR ADR 01609W102 26,868 146,385 SH   OTR   107,424 5,211 33,750
ALIGN TECHNOLOGY INC Common Stock 016255101 4,541 18,084 SH   SOLE   18,084 0 0
ALLEGHENY TECHNOLOGIES INC Common Stock 01741R102 74 3,145 SH   SOLE   3,145 0 0
ALNYLAM PHARMACEUTICALS INC Common Stock 02043Q107 1,323 11,112 SH   SOLE   11,112 0 0
ALPHABET INC-CL C Common Stock 02079K107 14,455 14,010 SH   OTR   9,758 0 4,252
AMAZON.COM INC Common Stock 023135106 78,897 54,512 SH   OTR   41,617 1,528 11,367
AMETEK INC Common Stock 031100100 659 8,677 SH   SOLE   8,677 0 0
ANSYS INC Common Stock 03662Q105 3,574 22,812 SH   SOLE   22,812 0 0
APPLE INC Common Stock 037833100 41,823 249,275 SH   OTR   184,385 7,671 57,219
APTIV PLC Common Stock G6095L109 27,811 327,299 SH   OTR   215,789 14,280 97,230
AQUABOUNTY TECHNOLOGIES Common Stock 03842K200 278 94,239 SH   SOLE   94,239 0 0
ARCONIC INC Common Stock 03965L100 481 20,871 SH   SOLE   20,871 0 0
ARCTURUS THERAPEUTICS LTD Common Stock M1492T105 1,821 331,165 SH   SOLE   331,165 0 0
ARKEMA SA Common Stock F0392W125 78 602 SH   SOLE   602 0 0
ARRK CORP Common Stock J0198N101 616 524,418 SH   SOLE   524,418 0 0
ASX Ltd Common Stock Q0604U105 173 4,017 SH   SOLE   4,017 0 0
ATHENAHEALTH INC Common Stock 04685W103 70,142 490,404 SH   OTR   357,269 16,882 116,253
AUDIOCODES LTD Common Stock M15342104 550 76,885 SH   SOLE   76,885 0 0
AUTODESK INC Common Stock 052769106 21,037 167,521 SH   OTR   115,966 7,105 44,450
BAIDU INC - SPON ADR ADR 056752108 71,792 321,664 SH   OTR   219,767 10,515 91,382
BAYER AG REG Common Stock D0712D163 44 390 SH   OTR   0 390 0
BERTRANDT AG Common Stock D1014N107 532 4,671 SH   SOLE   4,671 0 0
BEZEQ THE ISRAELI TELECOMMUNICATION CORP LTD Common Stock M2012Q100 448 350,866 SH   SOLE   350,866 0 0
BIOGEN INC Common Stock 09062X103 3,855 14,080 SH   SOLE   14,080 0 0
BITCOIN INVESTMENT TRUST Open-End Fund 09173T108 17,916 1,707,939 SH   OTR   761,193 386,454 560,292
BLACKBERRY LTD Common Stock 09228F103 1 64 SH   SOLE   64 0 0
BLUEBIRD BIO INC Common Stock 09609G100 33,706 197,399 SH   OTR   121,719 8,194 67,486
BOX INC - CLASS A Common Stock 10316T104 4,958 241,263 SH   SOLE   241,263 0 0
CAMTEK LTD Common Stock M20791105 574 85,069 SH   SOLE   85,069 0 0
CARPENTER TECHNOLOGY Common Stock 144285103 77 1,750 SH   SOLE   1,750 0 0
Cboe Global Markets Inc Common Stock 12503M108 101 884 SH   SOLE   884 0 0
CELGENE CORP Common Stock 151020104 4,195 47,022 SH   SOLE   47,022 0 0
CELLCOM ISRAEL LTD Common Stock M2196U109 416 58,983 SH   SOLE   58,983 0 0
CELLECTIS - ADR ADR 15117K103 2,760 87,597 SH   SOLE   87,597 0 0
CERAGON NETWORKS LTD Common Stock M22013102 704 261,557 SH   SOLE   261,557 0 0
CERUS CORP Common Stock 157085101 28,781 5,251,984 SH   OTR   3,540,471 62,418 1,649,095
Charles Schwab Corp/The Common Stock 808513105 164 3,131 SH   SOLE   3,131 0 0
CHECK POINT SOFTWARE TECH Common Stock M22465104 547 5,505 SH   SOLE   5,505 0 0
COGNEX CORP Common Stock 192422103 1,718 33,040 SH   SOLE   33,040 0 0
COMPUGEN LTD Common Stock M25722105 17,772 3,993,751 SH   OTR   3,806,963 43,659 143,129
CONFORMIS INC Common Stock 20717E101 1,020 703,161 SH   SOLE   703,161 0 0
CORNERSTONE ONDEMAND INC Common Stock 21925Y103 1,592 40,712 SH   SOLE   40,712 0 0
CRISPR THERAPEUTICS AG Common Stock H17182108 3,316 72,534 SH   SOLE   72,534 0 0
CTRIP.COM INTERNATIONAL-ADR ADR 22943F100 90 1,926 SH   SOLE   1,926 0 0
CYBERARK SOFTWARE LTD/ISRAEL Common Stock M2682V108 696 13,638 SH   SOLE   13,638 0 0
DAIMLER AG-UNSPONSORED ADR ADR 233825207 1,503 70,810 SH   SOLE   70,810 0 0
DANEL (ADIR YEOSHUA) LTD Common Stock M27013107 482 9,629 SH   SOLE   9,629 0 0
DASSAULT SYSTEMES SE Common Stock F2457H472 2,238 16,491 SH   SOLE   16,491 0 0
DEERE & CO Common Stock 244199105 2,051 13,203 SH   SOLE   13,203 0 0
Domino's Pizza Inc Common Stock 25754A201 76 326 SH   SOLE   326 0 0
DOWDUPONT INC Common Stock 26078J100 67 1,055 SH   SOLE   1,055 0 0
EASTMAN CHEMICAL CO Common Stock 277432100 86 816 SH   SOLE   816 0 0
EASTMAN KODAK CO Common Stock 277461406 44 8,137 SH   SOLE   8,137 0 0
EDITAS MEDICINE INC Common Stock 28106W103 53,710 1,620,208 SH   OTR   1,006,490 63,774 549,944
ELBIT SYSTEMS LTD Common Stock M3760D101 1,695 13,941 SH   SOLE   13,941 0 0
ELBIT SYSTEMS LTD Common Stock M3760D101 493 4,113 SH   SOLE   4,113 0 0
EVOGENE LTD Common Stock M4119S104 197 62,159 SH   SOLE   62,159 0 0
EXONE CO/THE Common Stock 302104104 12,183 1,673,432 SH   OTR   1,282,990 9,623 380,819
FACEBOOK INC-A Common Stock 30303M102 24,726 154,739 SH   OTR   105,051 5,252 44,436
FANUC CORP Common Stock J13440102 55 220 SH   OTR   0 220 0
FANUC CORP-UNSP ADR ADR 307305102 3,384 133,062 SH   SOLE   133,062 0 0
FARO TECHNOLOGIES INC Common Stock 311642102 720 12,327 SH   SOLE   12,327 0 0
FENNER PLC Common Stock G33656102 101 11,870 SH   SOLE   11,870 0 0
FirstRand Ltd Common Stock S5202Z131 197 34,982 SH   SOLE   34,982 0 0
Fiserv Inc Common Stock 337738108 242 3,394 SH   SOLE   3,394 0 0
FIVE PRIME THERAPEUTICS INC Common Stock 33830X104 1,183 68,854 SH   SOLE   68,854 0 0
FMS ENTERPRISES MIGUN LTD Common Stock M42619102 476 14,629 SH   SOLE   14,629 0 0
FOAMIX PHARMACEUTICALS LTD Common Stock M46135105 463 90,263 SH   SOLE   90,263 0 0
FOUNDATION MEDICINE INC Common Stock 350465100 6,885 87,434 SH   OTR   28,648 2,679 56,107
GENERAL ELECTRIC CO Common Stock 369604103 486 36,073 SH   SOLE   36,073 0 0
GENERAL MOTORS CO Common Stock 37045V100 3,394 93,407 SH   SOLE   93,407 0 0
GILAT SATELLITE NETWORKS LTD Common Stock M51474118 602 70,404 SH   SOLE   70,404 0 0
GILEAD SCIENCES INC Common Stock 375558103 2,750 36,475 SH   SOLE   36,475 0 0
Guidewire Software Inc Common Stock 40171V100 280 3,459 SH   SOLE   3,459 0 0
HDFC Bank Ltd ADR 40415F101 121 1,230 SH   SOLE   1,230 0 0
HEXAGON AB Common Stock W40063104 677 11,414 SH   SOLE   11,414 0 0
HEXCEL CORP Common Stock 428291108 81 1,256 SH   SOLE   1,256 0 0
HILAN LTD Common Stock M5299H123 552 24,892 SH   SOLE   24,892 0 0
HORTONWORKS INC Common Stock 440894103 27,736 1,361,628 SH   OTR   969,050 9,149 383,429
HP INC Common Stock 40434L105 2,722 124,195 SH   SOLE   124,195 0 0
HUBSPOT INC Common Stock 443573100 11,112 102,602 SH   SOLE   102,602 0 0
ILLUMINA INC Common Stock 452327109 59,483 251,600 SH   OTR   160,266 14,558 76,776
INCYTE CORP Common Stock 45337C102 2,525 30,303 SH   SOLE   30,303 0 0
INFINEON TECHNOLOGIES-ADR ADR 45662N103 1,947 72,135 SH   SOLE   72,135 0 0
INOVIO PHARMACEUTICALS INC Common Stock 45773H201 3,129 664,410 SH   SOLE   664,410 0 0
INTELLIA THERAPEUTICS INC Common Stock 45826J105 75,987 3,602,976 SH   OTR   2,652,509 166,726 783,741
Interactive Brokers Group Inc Common Stock 45841N107 313 4,652 SH   SOLE   4,652 0 0
Intercontinental Exchange Inc Common Stock 45866F104 125 1,719 SH   SOLE   1,719 0 0
Intuit Inc Common Stock 461202103 302 1,740 SH   SOLE   1,740 0 0
INVITAE CORP Common Stock 46185L103 32,489 6,927,275 SH   OTR   5,083,774 86,604 1,756,897
IONIS PHARMACEUTICALS INC Common Stock 462222100 15,512 351,905 SH   OTR   221,583 0 130,322
IOVANCE BIOTHERAPEUTICS INC Common Stock 462260100 1,100 65,096 SH   SOLE   65,096 0 0
ITURAN LOCATION AND CONTROL Common Stock M6158M104 529 17,019 SH   SOLE   17,019 0 0
JD.COM INC-ADR ADR 47215P106 47,100 1,163,258 SH   OTR   878,826 34,492 249,940
JOUNCE THERAPEUTICS INC Common Stock 481116101 2,082 93,143 SH   SOLE   93,143 0 0
K2M GROUP HOLDINGS INC Common Stock 48273J107 954 50,347 SH   SOLE   50,347 0 0
KAMADA LTD Common Stock M6240T109 477 104,097 SH   SOLE   104,097 0 0
KONINKLIJKE DSM NV Common Stock N5017D122 91 921 SH   SOLE   921 0 0
LENDINGCLUB CORP Common Stock 52603A109 41,757 11,930,701 SH   OTR   8,854,577 396,335 2,679,789
LENDINGTREE INC Common Stock 52603B107 9,546 29,089 SH   OTR   16,171 0 12,918
MAGICJACK VOCALTEC LTD Common Stock M6787E101 575 68,498 SH   SOLE   68,498 0 0
MATERIALISE NV-ADR ADR 57667T100 14,489 1,239,461 SH   OTR   1,217,710 9,134 12,617
MATRIX IT LTD Common Stock M6859E153 530 47,016 SH   SOLE   47,016 0 0
MAZOR ROBOTICS LTD-SPON ADR ADR 57886P103 4,230 68,940 SH   SOLE   68,940 0 0
MEDIDATA SOLUTIONS INC Common Stock 58471A105 44,719 711,972 SH   OTR   514,356 29,941 167,675
MELLANOX TECHNOLOGIES LTD Common Stock M51363113 717 9,838 SH   SOLE   9,838 0 0
MENSCH UND MASCHINE SOFTWARE Common Stock D5345W108 1,831 67,714 SH   SOLE   67,714 0 0
MERCADOLIBRE INC Common Stock 58733R102 16,897 47,411 SH   OTR   34,639 0 12,772
MGI DIGITAL GRAPHIC TECHNOLO Common Stock F4090S113 2,441 33,662 SH   SOLE   33,662 0 0
MGT CAPITAL INVESTMENTS INC Common Stock 55302P202 3,086 2,401,343 SH   OTR   2,368,406 32,937 0
MICROSOFT CORP Common Stock 594918104 6,471 70,898 SH   SOLE   70,898 0 0
MOOG INC Common Stock 615394202 571 6,934 SH   SOLE   6,934 0 0
MSCI Inc Common Stock 55354G100 134 898 SH   SOLE   898 0 0
NANO DIMENSION LTD - ADR ADR 63008G104 667 358,402 SH   SOLE   358,402 0 0
NANOSTRING TECHNOLOGIES INC Common Stock 63009R109 16,780 2,234,402 SH   OTR   2,197,287 37,115 0
Nasdaq Inc Common Stock 631103108 223 2,588 SH   SOLE   2,588 0 0
NETFLIX INC Common Stock 64110L106 54,551 184,699 SH   OTR   139,421 8,491 36,787
NICE LTD ADR 653656108 574 6,108 SH   SOLE   6,108 0 0
NINTENDO CO LTD Common Stock J51699106 75 171 SH   OTR   0 171 0
NINTENDO CO LTD-UNSPONS ADR ADR 654445303 18,372 330,964 SH   OTR   232,500 0 98,464
NOVA MEASURING INSTRUMENTS Common Stock M7516K103 562 20,721 SH   SOLE   20,721 0 0
NVIDIA CORP Common Stock 67066G104 70,283 303,480 SH   OTR   227,224 8,951 67,305
ORBOTECH LTD Common Stock M75253100 660 10,613 SH   SOLE   10,613 0 0
ORGANOVO HOLDINGS INC Common Stock 68620A104 11,583 11,245,582 SH   OTR   11,129,543 116,039 0
PACIFIC BIOSCIENCES OF CALIF Common Stock 69404D108 8,784 4,284,697 SH   OTR   4,229,961 54,736 0
PARTNER COMMUNICATIONS CO Common Stock M78465107 451 100,281 SH   SOLE   100,281 0 0
PAYPAL HOLDINGS INC Common Stock 70450Y103 21,465 282,918 SH   OTR   215,656 2,466 64,796
PLURISTEM THERAPEUTICS INC Common Stock 72940R102 1,051 767,424 SH   SOLE   767,424 0 0
POINTER TELOCATION LTD Common Stock M7946T104 457 31,437 SH   SOLE   31,437 0 0
POLYONE CORPORATION Common Stock 73179P106 76 1,798 SH   SOLE   1,798 0 0
PRAXAIR INC Common Stock 74005P104 75 517 SH   SOLE   517 0 0
PRODWAYS GROUP SA Common Stock F7329W102 2,403 456,241 SH   SOLE   456,241 0 0
PROTO LABS INC Common Stock 743713109 19,064 162,181 SH   OTR   114,784 1,848 45,549
PTC INC Common Stock 69370C100 1,920 24,616 SH   SOLE   24,616 0 0
RADA ELECTRONIC INDS LTD Common Stock M81863124 485 205,596 SH   SOLE   205,596 0 0
RADCOM LTD Common Stock M81865111 564 30,744 SH   SOLE   30,744 0 0
RADWARE LTD Common Stock M81873107 614 28,764 SH   SOLE   28,764 0 0
Rakuten Inc Common Stock J64264104 164 20,000 SH   SOLE   20,000 0 0
RAKUTEN INC-ADR ADR 75102W108 1,560 189,992 SH   SOLE   189,992 0 0
RED HAT INC Common Stock 756577102 31,579 211,214 SH   OTR   149,188 8,196 53,830
REDFIN CORP Common Stock 75737F108 33,782 1,479,735 SH   OTR   1,121,057 48,882 309,796
REDHILL BIOPHARMA LTD-SP ADR ADR 757468103 534 103,754 SH   SOLE   103,754 0 0
REGENERON PHARMACEUTICALS Common Stock 75886F107 1,145 3,325 SH   SOLE   3,325 0 0
RENISHAW PLC Common Stock G75006117 2,407 38,111 SH   SOLE   38,111 0 0
ROCKWELL AUTOMATION INC Common Stock 773903109 1,459 8,378 SH   SOLE   8,378 0 0
SALESFORCE.COM INC Common Stock 79466L302 36,008 309,610 SH   OTR   217,223 7,986 84,401
SANDVIK AB Common Stock W74857165 78 4,274 SH   SOLE   4,274 0 0
SAPIENS INTERNATIONAL CORP Common Stock N7716A151 410 48,068 SH   SOLE   48,068 0 0
SBI Holdings Inc/Japan Common Stock J6991H100 369 16,100 SH   SOLE   16,100 0 0
SERES THERAPEUTICS INC Common Stock 81750R102 17,665 2,406,723 SH   OTR   1,686,673 109,202 610,848
SERVICENOW INC Common Stock 81762P102 7,035 42,518 SH   SOLE   42,518 0 0
SHOPIFY INC - CLASS A Common Stock 82509L107 9,463 75,955 SH   SOLE   75,955 0 0
SIEMENS AG Common Stock D69671218 528 4,149 SH   SOLE   4,149 0 0
SIGMA LABS INC Common Stock 826598302 31 21,438 SH   SOLE   21,438 0 0
SILICOM LTD Common Stock M84116108 268 7,798 SH   SOLE   7,798 0 0
SLM SOLUTIONS GROUP AG Common Stock D6T690109 2,095 53,012 SH   SOLE   53,012 0 0
SOFTBANK GROUP CORP Common Stock J75963108 41 555 SH   OTR   0 555 0
SOFTBANK GROUP CORP-UNSP ADR ADR 83404D109 17,333 463,500 SH   OTR   321,351 2,758 139,391
SOLAREDGE TECHNOLOGIES INC Common Stock 83417M104 843 16,022 SH   SOLE   16,022 0 0
SPLUNK INC Common Stock 848637104 32,116 326,416 SH   OTR   235,391 12,558 78,467
SQUARE INC - A Common Stock 852234103 53,654 1,090,524 SH   OTR   775,322 45,154 270,048
Starbucks Corp Common Stock 855244109 204 3,517 SH   SOLE   3,517 0 0
STRATASYS LTD Common Stock M85548101 97,642 4,838,530 SH   OTR   3,259,490 195,730 1,383,310
STRYKER CORP Common Stock 863667101 624 3,879 SH   SOLE   3,879 0 0
SUNY CELLULAR COMMUNICATION Common Stock M8708U107 553 862,942 SH   SOLE   862,942 0 0
SYROS PHARMACEUTICALS INC Common Stock 87184Q107 19,533 1,504,890 SH   OTR   1,226,683 17,159 261,048
TAIWAN SEMICONDUCTOR-SP ADR ADR 874039100 9,505 217,209 SH   SOLE   217,209 0 0
TARO PHARMACEUTICAL INDUS Common Stock M8737E108 536 5,431 SH   SOLE   5,431 0 0
TELADOC INC Common Stock 87918A105 3,666 90,972 SH   SOLE   90,972 0 0
TENCENT HOLDINGS LTD-UNS ADR ADR 88032Q109 37,200 698,076 SH   OTR   521,276 20,390 156,410
TERADYNE INC Common Stock 880770102 24,242 530,343 SH   OTR   351,640 27,513 151,190
TESLA INC Common Stock 88160R101 83,931 315,377 SH   OTR   300,691 14,686 0
TEVA PHARMACEUTICAL-SP ADR ADR 881624209 477 27,926 SH   SOLE   27,926 0 0
TORAY INDUSTRIES INC Common Stock J89494116 73 7,792 SH   SOLE   7,792 0 0
TOWER SEMICONDUCTOR LTD Common Stock M87915274 458 17,029 SH   SOLE   17,029 0 0
TOYOTA MOTOR CORP -SPON ADR ADR 892331307 1,823 13,984 SH   SOLE   13,984 0 0
Trade Me Group Ltd Common Stock Q9162N106 34 10,506 SH   SOLE   10,506 0 0
TransUnion Common Stock 89400J107 193 3,401 SH   SOLE   3,401 0 0
TRIMBLE INC Common Stock 896239100 4,091 114,020 SH   SOLE   114,020 0 0
TWILIO INC - A Common Stock 90138F102 2,050 53,688 SH   SOLE   53,688 0 0
TWITTER INC Common Stock 90184L102 78,240 2,696,996 SH   OTR   1,897,519 97,419 702,058
ULTRA CLEAN HOLDINGS INC Common Stock 90385V107 480 24,935 SH   SOLE   24,935 0 0
UNITED PARCEL SERVICE-CL B Common Stock 911312106 495 4,730 SH   SOLE   4,730 0 0
UROGEN PHARMA LTD Common Stock M96088105 671 13,502 SH   SOLE   13,502 0 0
VASCULAR BIOGENICS LTD Common Stock M96883109 173 75,354 SH   SOLE   75,354 0 0
VERACYTE INC Common Stock 92337F107 15,631 2,811,294 SH   OTR   2,783,656 27,638 0
Verisk Analytics Inc Common Stock 92345Y106 67 648 SH   SOLE   648 0 0
Visa Inc Common Stock 92826C839 136 1,136 SH   SOLE   1,136 0 0
VOLKSWAGEN AG-SPONS ADR ADR 928662303 9 229 SH   SOLE   229 0 0
Wirecard AG ADR 97654L108 67 1,122 SH   SOLE   1,122 0 0
WIX.COM LTD Common Stock M98068105 783 9,838 SH   SOLE   9,838 0 0
Workday Inc Common Stock 98138H101 161 1,265 SH   SOLE   1,265 0 0
Xero Ltd Common Stock Q98665104 141 5,491 SH   SOLE   5,491 0 0
XILINX INC Common Stock 983919101 39,248 543,297 SH   OTR   394,501 16,199 132,597