The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101 25,998 118,430 SH   DFND 1 118,430 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 899 40,000 SH   DFND 1 40,000 0 0
ACHAOGEN INC COM 004449104 777 60,000 SH   DFND 1 60,000 0 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 717 30,000 SH   DFND 1 30,000 0 0
AKARI THERAPEUTICS PLC COM 00972G108 1,158 636,343 SH   DFND 1 636,343 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 809 107,858 SH   DFND 1 107,858 0 0
ALLERGAN PLC SPONSORED ADR G0177J108 16,689 99,170 SH   DFND 1 99,170 0 0
ALPHABET INC - CL C CL C 38259P706 4,024 3,900 SH   DFND 1 0 0 3,900
ALTRIA GROUP INC COM 02209S103 1,321 21,200 SH   DFND 1 21,200 0 0
AMAG PHARMACEUTICALS INC COM 00163U106 880 43,691 SH   DFND 1 43,691 0 0
AMERICAN EXPRESS CO COM 025816109 1,642 17,600 SH   DFND 1 17,600 0 0
AMGEN INC COM 031162100 10,138 59,470 SH   DFND 1 59,470 0 0
ANHEUSER-BUSCH INBEV NV SPONSORED ADR 03524A108 1,110 10,100 SH   DFND 1 10,100 0 0
APPLE INC COM 037833100 227 1,350 SH   DFND 1 1,350 0 0
BAIDU INC COM 056752108 250 1,120 SH   DFND 1 1,120 0 0
BECTON DICKINSON & CO COM 075887109 4,941 22,800 SH   DFND 1 22,800 0 0
BERKSHIRE HATHAWAY INC CL A 084670108 213,258 713 SH   DFND 1 713 0 0
BEST BUY CO INC COM 086516101 284 4,060 SH   DFND 1 4,060 0 0
BHP BILLITON PLC SPONSORED ADR 05545E209 7,829 197,050 SH   DFND 1 197,050 0 0
BIODELIVERY SCIENCES INTERNATIONAL INC COM 09060J106 1,125 500,000 SH   DFND 1 500,000 0 0
BIOGEN INC COM 09062X103 6,221 22,720 SH   DFND 1 22,720 0 0
BOEING CO COM 097023105 21,083 64,300 SH   DFND 1 64,300 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 4,908 77,600 SH   DFND 1 77,600 0 0
CA INC COM 12673P105 208 6,130 SH   DFND 1 6,130 0 0
CELGENE CORP COM 151020104 7,096 79,540 SH   DFND 1 79,540 0 0
CHANGYOUCOM LTD COM 15911M107 205 7,340 SH   DFND 1 7,340 0 0
CHICAGO BRIDGE & IRON COMPANY N Y REGISTRY SH 167250109 1,339 93,000 SH   DFND 1 93,000 0 0
CHINA MOBILE LIMITED SPONSORED ADR 16941M109 1,363 29,800 SH   DFND 1 29,800 0 0
CIGNA CORPORATION COM 125509109 216 1,290 SH   DFND 1 1,290 0 0
CISCO SYSTEMS INC COM 17275R102 7,029 163,890 SH   DFND 1 163,890 0 0
COCA COLA CO COM 191216100 1,998 46,000 SH   DFND 1 46,000 0 0
CSG SYSTEMS INTERNATIONAL INC COM 126349109 242 5,350 SH   DFND 1 5,350 0 0
DANAHER CORP COM 235851102 21,129 215,800 SH   DFND 1 215,800 0 0
DAVITA HEALTHCARE PARTNERS INC COM 23918K108 22,019 333,920 SH   DFND 1 333,920 0 0
DEUTSCHE X-TRACKERS HARVEST CSI 300 CHINA A-SHARES FUND ETF 233051879 1,623 51,900 SH   DFND 1 51,900 0 0
DIAMOND OFFSHORE DRILLING INC COM 25271C102 2,740 186,900 SH   DFND 1 186,900 0 0
DYNAVAX TECHNOLOGIES CORPORATION COM 268158201 2,159 108,755 SH   DFND 1 108,755 0 0
ECOLAB INC COM 278865100 288 2,100 SH   DFND 1 2,100 0 0
EXPRESS SCRIPTS HOLDING INC COM 30219G108 9,298 134,600 SH   DFND 1 134,600 0 0
EXXON MOBIL CORPORATION COM 30231G102 7,162 95,993 SH   DFND 1 95,993 0 0
FORTIVE CORP COM 34959J108 10,985 141,700 SH   DFND 1 141,700 0 0
GENERAL ELECTRIC COMPANY COM 369604103 4,202 311,700 SH   DFND 1 311,700 0 0
GENTEX CORPORATION COM 371901109 223 9,680 SH   DFND 1 9,680 0 0
GILEAD SCIENCES INC COM 375558103 11,152 147,930 SH   DFND 1 147,930 0 0
INTERNATIONAL BUSINESS MACHINES CORP COM 459200101 46,819 305,150 SH   DFND 1 305,150 0 0
INTUITIVE SURGICAL INC COM 46120E602 9,623 23,310 SH   DFND 1 23,310 0 0
ISHARES NASDAQ BIOTECHNOLOGY ETF 464287556 2,274 21,300 SH   DFND 1 21,300 0 0
JACK HENRY & ASSOCIATES INC COM 426281101 1,657 13,700 SH   DFND 1 13,700 0 0
JOHNSON & JOHNSON COM 478160104 25,116 195,990 SH   DFND 1 195,990 0 0
THE KRAFT HEINZ COMPANY COM 500754106 2,994 48,070 SH   DFND 1 48,070 0 0
LOEWS CORPORATION COM 540424108 482 9,700 SH   DFND 1 9,700 0 0
MASTERCARD INC CL A 57636Q104 1,752 10,000 SH   DFND 1 10,000 0 0
MCDONADLD'S CORP COM 580135101 1,573 10,060 SH   DFND 1 10,060 0 0
MEDTRONIC INC COM 585055106 4,067 50,700 SH   DFND 1 50,700 0 0
MICHAEL KORS HOLDINGS LTD COM G60754101 327 5,260 SH   DFND 1 5,260 0 0
MONSANTO COMPANY COM 61166W101 450 3,860 SH   DFND 1 3,860 0 0
NATIONAL OILWELL VARCO INC COM 637071101 12,287 333,800 SH   DFND 1 333,800 0 0
NESTLE SA SPONSORED ADR 641069406 4,983 63,030 SH   DFND 1 63,030 0 0
NOVO NORDISK A/S SPONSORED ADR 670100205 20,872 423,800 SH   DFND 1 423,800 0 0
NOW INC COM 67011P100 569 55,675 SH   DFND 1 55,675 0 0
NUTRIEN LTD COM 67077M108 17,787 376,360 SH   DFND 1 376,360 0 0
NVR INC COM 62944T105 252 90 SH   DFND 1 90 0 0
OCULAR THERAPEUTIX INC COM 67576A100 521 80,011 SH   DFND 1 80,011 0 0
OMNICOM GROUP INC COM 681919106 400 5,500 SH   DFND 1 5,500 0 0
PHILLIPS 66 COM 718546104 23,545 245,470 SH   DFND 1 245,470 0 0
PRAXAIR INC COM 74005P104 21,896 151,740 SH   DFND 1 151,740 0 0
PROGENICS PHARMACEUTICALS INC COM 743187106 1,492 200,000 SH   DFND 1 200,000 0 0
RAYTHEON COMPANY COM 755111507 278 1,290 SH   DFND 1 1,290 0 0
ROBERT HALF INTERNATIONAL INC COM 770323103 247 4,260 SH   DFND 1 4,260 0 0
ROCHE HOLDING AG SPONSORED ADR 771195104 4,772 166,700 SH   DFND 1 166,700 0 0
ROPER TECHNOLOGIES INC COM 776696106 19,935 71,020 SH   DFND 1 71,020 0 0
SANOFI-AVENTIS SA SPONSORED ADR 80105N105 6,866 171,300 SH   DFND 1 171,300 0 0
SAREPTATHERAPEUTICS INC COM 803607100 1,852 25,000 SH   DFND 1 25,000 0 0
SENSATA TECHNOLOGIES HOLDING COM G8060N102 933 18,000 SH   DFND 1 18,000 0 0
SILICON MOTION TECHNOLOGY CORPORATION COM 82706C108 204 4,230 SH   DFND 1 4,230 0 0
STERICYCLE INC COM 858912108 2,786 47,600 SH   DFND 1 47,600 0 0
STEVEN MADDEN LTD COM 556269108 232 5,290 SH   DFND 1 5,290 0 0
STORE CAPITAL CORPORATION REIT 862121100 911 36,700 SH   DFND 1 36,700 0 0
SYNCHRONY FINANCIAL COM 87165B103 211 6,300 SH   DFND 1 6,300 0 0
SYNERGY PHARMACEUTICALS INC COM 871639308 3,660 2,000,000 SH   DFND 1 2,000,000 0 0
SYNTEL INC COM 87162H103 798 31,270 SH   DFND 1 31,270 0 0
TG THERAPEUTICS INC COM 88322Q108 2,272 160,000 SH   DFND 1 160,000 0 0
TUNIU CORPORATION COM 89977P106 142 23,520 SH   DFND 1 23,520 0 0
UBIQUITI NETWORKS INC COM 90347A100 272 3,950 SH   DFND 1 3,950 0 0
UNITED RENTALS INC COM 911363109 271 1,570 SH   DFND 1 1,570 0 0
UNITED TECHNOLOGIES CORP COM 913017109 20,842 165,650 SH   DFND 1 165,650 0 0
UNITED THERAPEUTICS CORPORATION COM 91307C102 1,291 11,490 SH   DFND 1 11,490 0 0
USANA HEALTH SCIENCES INC COM 90328M107 295 3,440 SH   DFND 1 3,440 0 0
US BANCORP COM 902973304 5,701 112,900 SH   DFND 1 112,900 0 0
VANGUARD FTSE EMERGING MARKETS ETF ETF 922042858 517 11,000 SH   DFND 1 11,000 0 0
VANGUARD S&P 500 ETF ETF 922908363 5,665 23,400 SH   DFND 1 23,400 0 0
VERISIGN INC COM 92343E102 264 2,230 SH   DFND 1 2,230 0 0
VIPSHOP HOLDINGS LTD COM 92763W103 240 14,450 SH   DFND 1 14,450 0 0
VISA INC CL A 92826C839 20,563 171,900 SH   DFND 1 171,900 0 0
WABTEC CORPORATION COM 929740108 15,691 192,770 SH   DFND 1 192,770 0 0
WATERS CORPORATION COM 941848103 10,290 51,800 SH   DFND 1 51,800 0 0
WELLS FARGO & CO COM 949746101 80,943 1,544,420 SH   DFND 1 1,544,420 0 0