The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABEONA THERAPEUTICS INC *W EXP 12/24/201 00289Y115 14,612 1,259,636 SH   SOLE   1,259,636 0 0
ABEONA THERAPEUTICS INC COM 00289Y107 946 59,662 SH   SOLE   59,662 0 0
ABIOMED INC COM 003654100 40,293 215,000 SH   SOLE   215,000 0 0
ABLYNX NV SPONSORED ADR 00372Y105 6,248 250,000 SH   SOLE   250,000 0 0
ACASTI PHARMA INC CL A NEW 00430K402 176 186,559 SH   SOLE   186,559 0 0
ACCELERON PHARMA INC COM 00434H108 68,594 1,616,259 SH   SOLE   1,616,259 0 0
ACER THERAPEUTICS INC COM 00444P108 2,091 150,000 SH   SOLE   150,000 0 0
ACHILLION PHARMACEUTICALS IN COM 00448Q201 2,880 1,000,000 SH   SOLE   1,000,000 0 0
ADMA BIOLOGICS INC COM 000899104 12,266 3,821,102 SH   SOLE   3,821,102 0 0
AFFIMED NV COM N01045108 869 668,214 SH   SOLE   668,214 0 0
AGILE THERAPEUTICS INC COM 00847L100 9,092 3,380,000 SH   SOLE   3,380,000 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 29,553 1,987,400 SH   SOLE   1,987,400 0 0
ALBIREO PHARMA INC COM 01345P106 33,792 1,320,000 SH   SOLE   1,320,000 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 20,981 3,085,458 SH   SOLE   3,085,458 0 0
ALIGN TECHNOLOGY INC COM 016255101 766 3,448 SH   SOLE   3,448 0 0
ALLENA PHARMACEUTICALS INC COM 018119107 2,515 250,000 SH   SOLE   250,000 0 0
ALLIQUA BIOMEDICAL INC COM NEW 019621309 766 423,394 SH   SOLE   423,394 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 169,079 1,330,802 SH   SOLE   1,330,802 0 0
AMGEN INC COM 031162100 8,695 50,000 SH   SOLE   50,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 257,417 17,888,597 SH   SOLE   17,888,597 0 0
ANAPTYSBIO INC COM 032724106 76,183 756,387 SH   SOLE   756,387 0 0
ANI PHARMACEUTICALS INC NOTE 3.000%12/0 00182CAA1 8,642 7,500,000 PRN   SOLE   7,500,000 0 0
ANTARES PHARMA INC COM 036642106 7,454 3,745,662 SH   SOLE   3,745,662 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 747 21,978 SH   SOLE   21,978 0 0
ARGENX SE SPONSORED ADR 04016X101 33,929 537,361 SH   SOLE   537,361 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 24,282 536,626 SH   SOLE   536,626 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 24,416 781,309 SH   SOLE   781,309 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 19,613 2,391,841 SH   SOLE   2,391,841 0 0
AVEO PHARMACEUTICALS INC COM 053588109 8,253 2,958,116 SH   SOLE   2,958,116 0 0
AVEXIS INC COM 05366U100 53,137 480,141 SH   SOLE   480,141 0 0
AZURRX BIOPHARMA INC COM 05502L105 841 227,272 SH   SOLE   227,272 0 0
BEIGENE LTD SPONSORED ADR 07725L102 557 5,700 SH   SOLE   5,700 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 7,045 261,134 SH   SOLE   261,134 0 0
BLUEBIRD BIO INC COM 09609G100 2,565 14,400 SH   SOLE   14,400 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 86,000 1,140,434 SH   SOLE   1,140,434 0 0
BRAINSTORM CELL THERAPEUTICS COM NEW 10501E201 1,568 400,000 SH   SOLE   400,000 0 0
CAPITAL SR LIVING CORP COM 140475104 9,176 680,173 SH   SOLE   680,173 0 0
CAPRICOR THERAPEUTICS INC COM 14070B101 6 4,000 SH   SOLE   4,000 0 0
CAREDX INC COM 14167L103 7,639 1,040,676 SH   SOLE   1,040,676 0 0
CASI PHARMACEUTICALS INC COM 14757U109 272 83,682 SH   SOLE   83,682 0 0
CELLECTIS SA SPONSORED ADS 15117K103 10,203 350,000 SH   SOLE   350,000 0 0
CENTENE CORP DEL COM 15135B101 676 6,699 SH   SOLE   6,699 0 0
CHAMPIONS ONCOLOGY INC COM NEW 15870P307 1,499 386,540 SH   SOLE   386,540 0 0
CLEARSIDE BIOMEDICAL INC COM 185063104 4,341 620,181 SH   SOLE   620,181 0 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 1,420 200,000 SH   SOLE   200,000 0 0
CORIUM INTL INC COM 21887L107 56,191 5,847,133 SH   SOLE   5,847,133 0 0
CURIS INC COM 231269101 666 951,201 SH   SOLE   951,201 0 0
CUTERA INC COM 232109108 543 11,981 SH   SOLE   11,981 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 24,710 2,685,882 SH   SOLE   2,685,882 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 52,571 2,490,381 SH   SOLE   2,490,381 0 0
DBV TECHNOLOGIES SA SPONSORED ADR 23306J101 24,075 978,619 SH   SOLE   978,619 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 2,324 102,500 SH   SOLE   102,500 0 0
DOVA PHARMACEUTICALS INC COM 25985T102 52,099 1,809,015 SH   SOLE   1,809,015 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 2,199 157,679 SH   SOLE   157,679 0 0
ENDOCYTE INC COM 29269A102 6,213 1,451,700 SH   SOLE   1,451,700 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 709 10,769 SH   SOLE   10,769 0 0
EVOLENT HEALTH INC CL A 30050B101 615 50,000 SH   SOLE   50,000 0 0
EXELIXIS SHARES INC COM 30161Q104 1,409 46,361 SH   SOLE   46,361 0 0
FERRARI NV COM N3167Y103 650 6,200 SH   SOLE   6,200 0 0
FIAT CHRYSLER AUTOMOBILES N SHS N31738102 1,106 62,000 SH   SOLE   62,000 0 0
FLEXION THERAPEUTICS INC COM 33938J106 7,712 307,989 SH   SOLE   307,989 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 6,715 1,117,324 SH   SOLE   1,117,324 0 0
GALAPAGOS NV SPON ADR 36315X101 19,343 206,305 SH   SOLE   206,305 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 192,384 4,889,066 SH   SOLE   4,889,066 0 0
GLOBUS MED INC CL A 379577208 4,648 113,100 SH   SOLE   113,100 0 0
HISTOGENICS CORP COM 43358V109 3,644 1,777,777 SH   SOLE   1,777,777 0 0
HUMANA INC COM 444859102 19,225 77,500 SH   SOLE   77,500 0 0
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 394 10,000 SH   SOLE   10,000 0 0
IGNYTA INC COM 451731103 807 30,211 SH   SOLE   30,211 0 0
INVACARE CORP COM 461203101 3,370 200,000 SH   SOLE   200,000 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 25,759 70,585 SH   SOLE   70,585 0 0
INVITAE CORP COM 46185L103 18,200 2,004,500 SH   SOLE   2,004,500 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 38,208 4,776,114 SH   SOLE   4,776,114 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 23,954 427,371 SH   SOLE   427,371 0 0
JUNO THERAPEUTICS INC COM 48205A109 93 300,000 SH Call SOLE   300,000 0 0
KADMON HLDGS INC COM 48283N106 18,772 5,185,847 SH   SOLE   5,185,847 0 0
KERYX BIOPHARMACEUTICALS INC COM 492515101 388 83,386 SH   SOLE   83,386 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 109,046 3,388,611 SH   SOLE   3,388,611 0 0
LANTHEUS HLDGS INC COM 516544103 1,099 53,763 SH   SOLE   53,763 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 17,338 188,893 SH   SOLE   188,893 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 7,407 907,732 SH   SOLE   907,732 0 0
MERIT MED SYS INC COM 589889104 37,757 874,013 SH   SOLE   874,013 0 0
MIRATI THERAPEUTICS INC COM 60468T105 531 29,091 SH   SOLE   29,091 0 0
MOLECULAR TEMPLATES INC COM 608550109 7,255 724,133 SH   SOLE   724,133 0 0
MYOKARDIA INC COM 62857M105 29,922 710,726 SH   SOLE   710,726 0 0
NEOS THERAPEUTICS INC COM 64052L106 3,060 300,000 SH   SOLE   300,000 0 0
NEPTUNE TECHNOLOGIES BIORESO COM 64077P108 19,762 8,374,015 SH   SOLE   8,374,015 0 0
NEUROCRINE BIOSCIENCES COM 64125C109 399,712 5,151,589 SH   SOLE   5,151,589 0 0
NEWLINK GENETICS CORP COM 651511107 3,650 450,000 SH   SOLE   450,000 0 0
ODONATE THERAPEUTICS INC COM 676079106 3,750 150,000 SH   SOLE   150,000 0 0
ONCOMED PHARMACEUTICALS INC COM 68234X102 10,745 2,620,897 SH   SOLE   2,620,897 0 0
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 6,990 500,356 SH   SOLE   500,356 0 0
PERNIX THERAPEUTICS HLDGS IN DBCV 4.250% 4/0 71426VAK4 421 1,000,000 PRN   SOLE   1,000,000 0 0
PFENEX INC COM 717071104 1,383 519,773 SH   SOLE   519,773 0 0
PROGENICS PHARMACEUTICALS IN COM 743187106 368 61,850 SH   SOLE   61,850 0 0
PROTEON THERAPEUTICS INC COM 74371L109 635 334,116 SH   SOLE   334,116 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 55 100,000 SH Call SOLE   100,000 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 69,573 703,820 SH   SOLE   703,820 0 0
QUANTERIX CORP COM 74766Q101 3,637 169,400 SH   SOLE   169,400 0 0
QUOTIENT TECHNOLOGY INC COM G73268107 29,683 6,033,020 SH   SOLE   6,033,020 0 0
REGENERON PHARMACEUTICALS COM 75886F107 7,519 20,000 SH   SOLE   20,000 0 0
REGENXBIO INC COM 75901B107 47,254 1,421,186 SH   SOLE   1,421,186 0 0
RETROPHIN INC COM 761299106 56,310 2,672,525 SH   SOLE   2,672,525 0 0
REVANCE THERAPEUTICS INC COM 761330109 14,300 400,000 SH   SOLE   400,000 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 21,654 745,135 SH   SOLE   745,135 0 0
SELECTA BIOSCIENCES INC COM 816212104 6,206 632,712 SH   SOLE   632,712 0 0
SENSEONICS HLDGS INC COM 81727U105 306 115,000 SH   SOLE   115,000 0 0
SIERRA ONCOLOGY INC COM 82640U107 18,650 5,000,000 SH   SOLE   5,000,000 0 0
SPDR S&P BIOTECH ETF SHS PUT 85 01/05/2018 COM 78464A870 579 600,000 SH Put SOLE   600,000 0 0
SPECTRUM PHARMACEUTICALS INC COM 84763A108 609 32,154 SH   SOLE   32,154 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 1,994 275,000 SH   SOLE   275,000 0 0
SUCAMPO PHARMACEUTICALS INC CL A 864909106 719 40,062 SH   SOLE   40,062 0 0
SYNLOGIC INC COM 87166L100 6,658 686,352 SH   SOLE   686,352 0 0
TELEFLEX INC COM 879369106 31,326 125,900 SH   SOLE   125,900 0 0
TESARO INC COM 881569107 10,721 129,372 SH   SOLE   129,372 0 0
UNIQURE NV SHS N90064101 20,529 1,047,950 SH   SOLE   1,047,950 0 0
UROGEN PHARMA LTD COM M96088105 7,405 199,014 SH   SOLE   199,014 0 0
VALEANT PHARMACEUTICALS INTL COM 91911K102 625 30,092 SH   SOLE   30,092 0 0
VBI VACCINES INC COM NEW 91822J103 41,273 9,665,843 SH   SOLE   9,665,843 0 0
VERONA PHARMA PLC SPONSORED ADR 925050106 2,384 200,000 SH   SOLE   200,000 0 0
VERSARTIS INC COM 92529L102 3,273 1,488,160 SH   SOLE   1,488,160 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 20,774 138,626 SH   SOLE   138,626 0 0
VICAL INC COM NEW 925602203 2,091 1,142,858 SH   SOLE   1,142,858 0 0
VIEWRAY INC COM 92672L107 463 50,000 SH   SOLE   50,000 0 0
VOCERA COMMUNICATIONS INC COM 92857F107 1,063 35,169 SH   SOLE   35,169 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 23,264 662,798 SH   SOLE   662,798 0 0
XENCOR INC COM 98401F105 28,783 1,313,095 SH   SOLE   1,313,095 0 0
ZAI LAB LTD ADR 98887Q104 3,715 175,000 SH   SOLE   175,000 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 24,134 200,000 SH   SOLE   200,000 0 0
ZOGENIX INC COM NEW 98978L204 160,799 3,970,357 SH   SOLE   3,970,357 0 0
ZOSANO PHARMA CORP COM 98979H103 260 500,000 SH   SOLE   500,000 0 0
ZYMEWORKS SHARES COM 98985W102 5,549 777,497 SH   SOLE   777,497 0 0