The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACHAOGEN INC COM 004449104 56,010 5,215,128 SH   DFND   5,215,128 0 0
ADAPTIMMUNE THERAPEUTICS PLC ADR 00653A107 80,334 12,025,999 SH   DFND   12,025,999 0 0
AFFIMED NV COM N01045108 5,056 3,888,888 SH   DFND   3,888,888 0 0
AKARI THERAPEUTICS PLC ADR 00972G108 1,958 452,167 SH   DFND   452,167 0 0
AQUANTIA COM 03842Q108 2,715 239,587 SH   DFND   239,587 0 0
ARCA BIOPHARMA INC COM PAR $.001 00211Y407 1,971 1,460,209 SH   DFND   1,460,209 0 0
ARDELYX INC COM 039697107 92,952 14,083,582 SH   DFND   14,083,582 0 0
ARQULE INC COM 04269E107 4,159 2,520,316 SH   DFND   2,520,316 0 0
ARSANIS INC COM 042873109 25,520 2,000,000 SH   DFND   2,000,000 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 21,782 4,808,483 SH   DFND   4,808,483 0 0
AVEO PHARMACEUTICALS INC COM 053588109 45,652 16,362,694 SH   DFND   16,362,694 0 0
CASCADIAN THERAPEUTICS INC COM NEW 14740B606 33,539 9,064,575 SH   DFND   9,064,575 0 0
CHAMPIONS ONCOLOGY INC COM NEW 15870P307 6,063 1,562,500 SH   DFND   1,562,500 0 0
CLEMENTIA PHARMACEUTICALS IN COM 185575107 40,649 2,141,697 SH   DFND   2,141,697 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 75,623 3,220,728 SH   DFND   3,220,728 0 0
DASAN ZHONE SOLUTIONS INC COM NEW 23305L206 8,855 956,255 SH   DFND   956,255 0 0
DERMIRA INC COM 24983L104 97,520 3,506,649 SH   DFND   3,506,649 0 0
ENDOLOGIX INC COM 29266S106 13,323 2,490,204 SH   DFND   2,490,204 0 0
EPIZYME INC COM 29428V104 81,084 6,460,851 SH   DFND   6,460,851 0 0
ERYTECH PHARMA SA ADR 29604W108 13,763 625,000 SH   DFND   625,000 0 0
GLYCOMIMETICS INC COM 38000Q102 144,128 8,584,128 SH   DFND   8,584,128 0 0
IMMUNOMEDICS INC COM 452907108 44,806 2,772,643 SH   DFND   2,772,643 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 23,537 2,382,286 SH   DFND   2,382,286 0 0
MERSANA THERAPEUTICS INC COM 59045L106 133,810 8,144,267 SH   DFND   8,144,267 0 0
MONGODB INC CL A 60937P106 4,452 150,000 SH   DFND   150,000 0 0
NIGHTSTAR THERAPEUTICS PLC ADR 65413A101 9,371 714,285 SH   DFND   714,285 0 0
OBSEVA SA COM H5861P103 44,765 4,586,563 SH   DFND   4,586,563 0 0
OREXIGEN THERAPEUTICS INC COM NEW 686164302 478 370,900 SH   DFND   370,900 0 0
PROTEOSTASIS THERAPEUTICS INC COM 74373B109 32,396 5,556,778 SH   DFND   5,556,778 0 0
RA PHARMACEUTICALS INC COM 74933V108 29,696 3,493,636 SH   DFND   3,493,636 0 0
REGULUS THERAPEUTICS INC COM 75915K101 11,430 10,989,910 SH   DFND   10,989,910 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 142,752 4,912,306 SH   DFND   4,912,306 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 12,583 3,243,150 SH   DFND   3,243,150 0 0
SENSEONICS HOLDINGS INC COM 81727U105 82,163 30,888,266 SH   DFND   30,888,266 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 30,024 4,141,308 SH   DFND   4,141,308 0 0
SUNESIS PHARMACEUTICALS INC COM PAR 867328700 4,791 1,298,274 SH   DFND   1,298,274 0 0
SYNLOGIC INC COM 87166L100 37,048 3,819,410 SH   DFND   3,819,410 0 0
TESARO INC COM 881569107 851,499 10,275,113 SH   DFND   10,275,113 0 0
TINTRI INC COM 88770Q105 26,792 5,253,358 SH   DFND   5,253,358 0 0
TRACON PHARMACEUTICALS INC COM 89237H100 9,243 2,759,217 SH   DFND   2,759,217 0 0
TREVENA INC COM 89532E109 6,099 3,811,691 SH   DFND   3,811,691 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 9,063 1,250,000 SH   DFND   1,250,000 0 0
VERONA PHARMA PLC ADS 925050106 14,478 1,219,674 SH   DFND   1,219,674 0 0