The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
21VIANET GROUP INC SPONSORED ADR 90138A103 61,327 10,778,004 SH   DFND 5,18 10,778,004 0 0
AC IMMUNE SA SHS H00263105 14,940 1,337,500 SH   DFND 8,17,20 1,337,500 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 211,182 1,505,325 SH   DFND 1,2,8,11,14,16 1,505,325 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 6,130,391 35,495,289 SH   DFND 1,4,14,15,16 35,495,289 0 0
AMAZON COM INC COM 023135106 126,643 131,735 SH   DFND 1,14,16 131,735 0 0
AMGEN INC COM 031162100 35,151 188,527 SH   DFND 1,14,16 188,527 0 0
AMYRIS INC COM NEW 03236M200 10,568 3,302,585 SH   DFND 2,8,11 3,302,585 0 0
AMYRIS INC NOTE 6.500% 5/1 03236MAC5 5,440 10,000,000 PRN   DFND 2,8,11 10,000,000 0 0
ANTERO RES CORP COM 03674X106 194,137 9,755,618 SH   DFND 6,16 9,755,618 0 0
ATHENE HLDG LTD CL A G0684D107 46,421 862,204 SH   DFND 4,12,14,16 862,204 0 0
BANK AMER CORP COM 060505104 20,224 798,123 SH   DFND 1,14,16 798,123 0 0
BEIGENE LTD SPONSORED ADR 07725L102 39,315 380,000 SH   DFND 8,17,20 380,000 0 0
BIOGEN INC COM 09062X103 37,150 118,644 SH   DFND 1,14,16 118,644 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 323,205 3,472,712 SH   DFND 2,8,11,17,20 3,472,712 0 0
BROADCOM LTD SHS Y09827109 91,207 376,050 SH   DFND 1,14,16 376,050 0 0
CELGENE CORP COM 151020104 37,243 255,406 SH   DFND 1,14,16 255,406 0 0
CHINA BIOLOGIC PRODS HLDGS I COM G21515104 3,414 36,995 SH   DFND 8,17,20 36,995 0 0
COGNEX CORP COM 192422103 1,727 15,660 SH   DFND 1,14,16 15,660 0 0
COHERUS BIOSCIENCES INC COM 19249H103 87,524 6,556,116 SH   DFND 8,17,20 6,556,116 0 0
CTRIP COM INTL LTD AMERICAN DEP SHS 22943F100 382,730 7,256,928 SH   DFND 1,4,6,14,16 7,256,928 0 0
DIAMONDBACK ENERGY INC COM 25278X109 1,701 17,360 SH   DFND 7 17,360 0 0
EMERSON ELEC CO COM 291011104 1,760 28,000 SH   DFND 1,14,16 28,000 0 0
EROS INTL PLC SHS NEW G3788M114 39,401 2,755,310 SH   DFND 4,13,14,16 2,755,310 0 0
GILEAD SCIENCES INC COM 375558103 901,414 11,125,816 SH   DFND 1,8,14,16,17,20 11,125,816 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 4,824 20,337 SH   DFND 1,14,16 20,337 0 0
GRACE W R & CO DEL NEW COM 38388F108 157,828 2,187,501 SH   DFND 6,16 2,187,501 0 0
ICICI BK LTD ADR 45104G104 24,045 2,808,987 SH   DFND 2,8 2,808,987 0 0
IHS MARKIT LTD SHS G47567105 764,197 17,336,588 SH   DFND 5,18 17,336,588 0 0
ILLUMINA INC COM 452327109 55,230 277,261 SH   DFND 1,14,16 277,261 0 0
INCYTE CORP COM 45337C102 29,437 252,160 SH   DFND 1,14,16 252,160 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 19,645 790,527 SH   DFND 6,8,16,17 790,527 0 0
JD COM INC SPON ADR CL A 47215P106 279,111 7,306,572 SH   DFND 6,16 7,306,572 0 0
JPMORGAN CHASE & CO COM 46625H100 25,247 264,337 SH   DFND 1,14,16 264,337 0 0
JUNO THERAPEUTICS INC COM 48205A109 41,081 915,750 SH   DFND 8,17,20 915,750 0 0
KKR REAL ESTATE FIN TR INC COM 48251K100 51,317 2,439,024 SH   DFND 1,14,16 2,439,024 0 0
LEVEL 3 COMMUNICATIONS INC COM NEW 52729N308 3,465,538 65,031,667 SH   DFND   65,031,667 0 0
MARIN SOFTWARE INC COM 56804T106 4,424 2,528,205 SH   DFND 4,14,15,16 2,528,205 0 0
MASTERCARD INCORPORATED CL A 57636Q104 130,337 923,068 SH   DFND 1,14,16 923,068 0 0
MONSANTO CO NEW COM 61166W101 51,425 429,184 SH   DFND 1,14,16 429,184 0 0
MORGAN STANLEY COM NEW 617446448 5,215 108,260 SH   DFND 1,14,16 108,260 0 0
NETSHOES CAYMAN LTD COM G6455X107 27,235 2,071,127 SH   DFND 7 2,071,127 0 0
NEWFIELD EXPL CO COM 651290108 187,694 6,326,046 SH   DFND 1,14,16 6,326,046 0 0
PAYPAL HLDGS INC COM 70450Y103 344,991 5,387,963 SH   DFND 4,8,10,14,16 5,387,963 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 263,859 4,883,568 SH   DFND 2,8,11,17,20 4,883,568 0 0
PPG INDS INC COM 693506107 187,726 1,727,645 SH   DFND 1,14,16 1,727,645 0 0
RADIUS HEALTH INC COM NEW 750469207 746 19,344 SH   DFND 7 19,344 0 0
REGENERON PHARMACEUTICALS COM 75886F107 85,230 190,621 SH   DFND 1,8,14,16,17,20 190,621 0 0
ROCKWELL AUTOMATION INC COM 773903109 1,783 10,005 SH   DFND 1,14,16 10,005 0 0
ROYAL DUTCH SHELL PLC SPON ADR B 780259107 179,419 2,868,867 SH   DFND 6,16 2,868,867 0 0
SENSEONICS HLDGS INC COM 81727U105 901 282,582 SH   DFND 7 282,582 0 0
SPDR SERIES TRUST S&P REGL BKG 78464A698 29,271 515,700 SH   DFND 1,14,16 515,700 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 284,384 1,503,087 SH   DFND 2,8,11 1,503,087 0 0
TUNIU CORP SPONSORED ADS CL 89977P106 64,081 8,194,444 SH   DFND 5,18 8,194,444 0 0
TURQUOISE HILL RES LTD COM 900435108 226,963 73,213,884 SH   DFND 3,18,19 73,213,884 0 0
UNIVAR INC COM 91336L107 409,984 14,171,599 SH   DFND 3,18,19 14,171,599 0 0
VANTIV INC CL A 92210H105 69,206 982,057 SH   DFND 1,14,16 982,057 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 37,186 244,582 SH   DFND 1,14,16 244,582 0 0
VIRTU FINL INC CL A 928254101 329,354 20,330,503 SH   DFND 1,7,9,14,16 20,330,503 0 0
VISA INC COM CL A 92826C839 346,532 3,292,775 SH   DFND 1,14,16 3,292,775 0 0
WELLS FARGO CO NEW COM 949746101 14,359 260,364 SH   DFND 1,14,16 260,364 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADR 98980A105 170,962 12,176,750 SH   DFND 1,14,16 12,176,750 0 0