The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACHAOGEN INC COM 004449104 83,181 5,215,128 SH   DFND   5,215,128 0 0
ADAPTIMMUNE THERAPEUTICS PLC ADR 00653A107 98,493 12,025,999 SH   DFND   12,025,999 0 0
AFFIMED NV COM N01045108 8,750 3,888,888 SH   DFND   3,888,888 0 0
AKARI THERAPEUTICS PLC ADR 00972G108 2,776 452,167 SH   DFND   452,167 0 0
ARCA BIOPHARMA INC COM PAR $.001 00211Y407 1,679 1,460,209 SH   DFND   1,460,209 0 0
ARDELYX INC COM 039697107 78,868 14,083,582 SH   DFND   14,083,582 0 0
ARQULE INC COM 04269E107 2,798 2,520,316 SH   DFND   2,520,316 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 30,149 4,808,483 SH   DFND   4,808,483 0 0
AVEO PHARMACEUTICALS INC COM 053588109 59,724 16,362,694 SH   DFND   16,362,694 0 0
CARE COM INC COM 141633107 51,817 3,260,989 SH   DFND   3,260,989 0 0
CASCADIAN THERAPEUTICS INC COM NEW 14740B606 37,074 9,064,575 SH   DFND   9,064,575 0 0
CATALYST BIOSCIENCES INC COM NEW 14888D208 220 43,492 SH   DFND   43,492 0 0
CERECOR INC COM 15671L109 506 595,435 SH   DFND   595,435 0 0
CHAMPIONS ONCOLOGY INC COM NEW 15870P307 5,734 1,562,500 SH   DFND   1,562,500 0 0
CLEMENTIA PHARMACEUTICALS IN COM 185575107 36,173 2,141,697 SH   DFND   2,141,697 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 57,554 3,220,728 SH   DFND   3,220,728 0 0
DASAN ZHONE SOLUTIONS INC COM NEW 23305L206 6,531 956,255 SH   DFND   956,255 0 0
DERMIRA INC COM 24983L104 94,680 3,506,649 SH   DFND   3,506,649 0 0
ENDOLOGIX INC COM 29266S106 11,106 2,490,204 SH   DFND   2,490,204 0 0
EPIZYME INC COM 29428V104 123,079 6,460,851 SH   DFND   6,460,851 0 0
GLYCOMIMETICS INC COM 38000Q102 120,092 8,584,128 SH   DFND   8,584,128 0 0
IMMUNOMEDICS INC COM 452907108 38,762 2,772,643 SH   DFND   2,772,643 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 29,278 2,382,286 SH   DFND   2,382,286 0 0
MERSANA THERAPEUTICS INC COM 59045L106 140,814 8,144,267 SH   DFND   8,144,267 0 0
NIGHTSTAR THERAPEUTICS PLC ADR 65413A101 13,714 714,285 SH   DFND   714,285 0 0
OBSEVA SA COM H5861P103 27,160 3,336,563 SH   DFND   3,336,563 0 0
OREXIGEN THERAPEUTICS INC COM NEW 686164302 786 370,900 SH   DFND   370,900 0 0
PIXELWORKS INC COM NEW 72581M305 1,694 359,555 SH   DFND   359,555 0 0
PROTEOSTASIS THERAPEUTICS INC COM 74373B109 7,469 3,556,778 SH   DFND   3,556,778 0 0
RA PHARMACEUTICALS INC COM 74933V108 51,007 3,493,636 SH   DFND   3,493,636 0 0
REGULUS THERAPEUTICS INC COM 75915K101 13,737 10,989,910 SH   DFND   10,989,910 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 8,238 3,243,150 SH   DFND   3,243,150 0 0
ROKA BIOSCIENCE INC COM NEW 775431208 652 893,471 SH   DFND   893,471 0 0
SENSEONICS HOLDINGS INC COM 81727U105 106,627 33,425,275 SH   DFND   33,425,275 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 28,575 4,141,308 SH   DFND   4,141,308 0 0
SUCAMPO PHARMACEUTICALS INC CL A 864909106 14,850 1,258,507 SH   DFND   1,258,507 0 0
SUNESIS PHARMACEUTICALS INC COM PAR 867328700 2,519 1,298,274 SH   DFND   1,298,274 0 0
SYNLOGIC INC COM 87166L100 72,626 3,819,410 SH   DFND   3,819,410 0 0
TESARO INC COM 881569107 1,326,517 10,275,113 SH   DFND   10,275,113 0 0
TINTRI INC COM 88770Q105 16,496 5,253,358 SH   DFND   5,253,358 0 0
TRACON PHARMACEUTICALS INC COM 89237H100 8,692 2,759,217 SH   DFND   2,759,217 0 0
TREVENA INC COM 89532E109 9,720 3,811,691 SH   DFND   3,811,691 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 5,408 1,050,000 SH   DFND   1,050,000 0 0
VERONA PHARMA PLC ADS 925050106 18,722 1,219,674 SH   DFND   1,219,674 0 0