SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL OMB Number: 3235-0104 Estimated average burden hours per response: 0.5

1. Name and Address of Reporting Person* Keefer Jason (Last) (First) (Middle) 7015 ALBERT EINSTEIN DRIVE (Street) COLUMBIA MD 21046 (City) (State) (Zip)	2. Date of Event Requiring Statement (Month/Day/Year) 06/21/2017	3. Issuer Name and Ticker or Trading Symbol OSIRIS THERAPEUTICS, INC. [ OSIR ]
		4. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director 10% Owner X Officer (give title below) Other (specify below) Interim President & CEO	5. If Amendment, Date of Original Filed (Month/Day/Year)
			6. Individual or Joint/Group Filing (Check Applicable Line) X Form filed by One Reporting Person Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Incentive Stock Option (right to buy)	02/17/2015(1)	02/17/2025	Common Stock	15,000	$16.24	D
Incentive Stock Option (right to buy)	09/21/2016(2)	09/21/2026	Common Stock	1,000	$19.2	D

Explanation of Responses:

1. 3,750 shares underlying this option shall vest on each of February 17, 2015, February 17, 2016, February 17, 2017 and February 17, 2018, subject to Reporting Person's continued service through the applicable vesting date.

2. 250 shares underlying this option shall vest on each of September 21, 2016, September 21, 2017, September 21, 2018 and September 21, 2019, subject to Reporting Person's continued service through the applicable vesting date.

Remarks:

	/s/ Jason Keefer	09/21/2017
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.