The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
21VIANET GROUP INC SPONSORED ADR 90138A103 54,106 10,778,004 SH   DFND 5,18 10,778,004 0 0
AC IMMUNE SA SHS H00263105 11,770 1,337,500 SH   DFND 8,17,20 1,337,500 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 176,777 1,452,922 SH   DFND 1,2,8,11,14,16 1,452,922 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 5,001,286 35,495,289 SH   DFND 1,4,14,15,16 35,495,289 0 0
AMAZON COM INC COM 023135106 127,519 131,735 SH   DFND 1,14,16 131,735 0 0
AMGEN INC COM 031162100 26,060 151,310 SH   DFND 1,14,16 151,310 0 0
AMYRIS INC COM NEW 03236M200 10,502 3,302,585 SH   DFND 2,8,11 3,302,585 0 0
AMYRIS INC NOTE 6.500% 5/1 03236MAC5 5,592 10,000,000 PRN   DFND 2,8,11 10,000,000 0 0
ANTERO RES CORP COM 03674X106 210,819 9,755,618 SH   DFND 6,16 9,755,618 0 0
ATHENE HLDG LTD CL A G0684D107 42,774 862,204 SH   DFND 4,12,14,16 862,204 0 0
BANK AMER CORP COM 060505104 19,362 798,123 SH   DFND 1,14,16 798,123 0 0
BEIGENE LTD SPONSORED ADR 07725L102 17,100 380,000 SH   DFND 8,17,20 380,000 0 0
BIOGEN INC COM 09062X103 25,841 95,226 SH   DFND 1,14,16 95,226 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 315,392 3,472,712 SH   DFND 2,8,11,17,20 3,472,712 0 0
BROADCOM LTD SHS Y09827109 87,638 376,050 SH   DFND 1,14,16 376,050 0 0
CELGENE CORP COM 151020104 26,778 206,187 SH   DFND 1,14,16 206,187 0 0
COGNEX CORP COM 192422103 285 3,360 SH   DFND 1,14,16 3,360 0 0
COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102 724 10,900 SH   DFND 1,14,16 10,900 0 0
CTRIP COM INTL LTD AMERICAN DEP SHS 22943F100 285,307 5,297,205 SH   DFND 4,6,14,16 5,297,205 0 0
EMERSON ELEC CO COM 291011104 307 5,146 SH   DFND 1,14,16 5,146 0 0
EROS INTL PLC SHS NEW G3788M114 31,548 2,755,310 SH   DFND 4,13,14,16 2,755,310 0 0
GILEAD SCIENCES INC COM 375558103 787,485 11,125,816 SH   DFND 1,8,14,16,17,20 11,125,816 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 4,513 20,337 SH   DFND 1,14,16 20,337 0 0
GRACE W R & CO DEL NEW COM 38388F108 157,522 2,187,501 SH   DFND 6,16 2,187,501 0 0
ICICI BK LTD ADR 45104G104 25,197 2,808,987 SH   DFND 2,8 2,808,987 0 0
IHS MARKIT LTD SHS G47567105 932,473 21,173,310 SH   DFND 5,18 21,173,310 0 0
ILLUMINA INC COM 452327109 48,110 277,261 SH   DFND 1,14,16 277,261 0 0
INCYTE CORP COM 45337C102 25,346 201,304 SH   DFND 1,14,16 201,304 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 12,648 790,527 SH   DFND 6,8,16,17 790,527 0 0
JD COM INC SPON ADR CL A 47215P106 286,564 7,306,572 SH   DFND 6,16 7,306,572 0 0
JPMORGAN CHASE & CO COM 46625H100 24,160 264,337 SH   DFND 1,14,16 264,337 0 0
JUNO THERAPEUTICS INC COM 48205A109 27,372 915,750 SH   DFND 8,17,20 915,750 0 0
KKR REAL ESTATE FIN TR INC COM 48251K100 52,439 2,439,024 SH   DFND 1,14,16 2,439,024 0 0
LEVEL 3 COMMUNICATIONS INC COM NEW 52729N308 3,856,378 65,031,667 SH   DFND   65,031,667 0 0
MARIN SOFTWARE INC COM 56804T106 3,287 2,528,205 SH   DFND 4,14,15,16 2,528,205 0 0
MASTERCARD INCORPORATED CL A 57636Q104 32,428 267,006 SH   DFND 1,14,16 267,006 0 0
MONSANTO CO NEW COM 61166W101 25,511 215,534 SH   DFND 1,14,16 215,534 0 0
MORGAN STANLEY COM NEW 617446448 4,824 108,260 SH   DFND 1,14,16 108,260 0 0
NETSHOES CAYMAN LTD COM G6455X107 39,414 2,071,127 SH   DFND 7 2,071,127 0 0
NEWFIELD EXPL CO COM 651290108 180,039 6,326,046 SH   DFND 1,14,16 6,326,046 0 0
NQ MOBILE INC ADR REPSTG CL A 64118U108 828 243,458 SH   DFND 4,14,16 243,458 0 0
PAYPAL HLDGS INC COM 70450Y103 289,172 5,387,963 SH   DFND 4,8,10,14,16 5,387,963 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 274,310 4,883,568 SH   DFND 2,8,11,17,20 4,883,568 0 0
PPG INDS INC COM 693506107 189,972 1,727,645 SH   DFND 1,14,16 1,727,645 0 0
RADIUS HEALTH INC COM NEW 750469207 875 19,344 SH   DFND 7 19,344 0 0
REGENERON PHARMACEUTICALS COM 75886F107 87,203 177,553 SH   DFND 1,8,14,16,17,20 177,553 0 0
ROCKWELL AUTOMATION INC COM 773903109 309 1,910 SH   DFND 1,14,16 1,910 0 0
ROYAL DUTCH SHELL PLC SPON ADR B 780259107 133,351 2,449,948 SH   DFND 6,16 2,449,948 0 0
SENSEONICS HLDGS INC COM 81727U105 509 282,582 SH   DFND 7 282,582 0 0
SPDR SERIES TRUST S&P REGL BKG 78464A698 28,338 515,700 SH   DFND 1,14,16 515,700 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 262,244 1,503,087 SH   DFND 2,8,11 1,503,087 0 0
TUNIU CORP SPONSORED ADS CL 89977P106 65,801 8,194,444 SH   DFND 5,18 8,194,444 0 0
TURQUOISE HILL RES LTD COM 900435108 194,017 73,213,884 SH   DFND 3,18,19 73,213,884 0 0
UNIVAR INC COM 91336L107 413,811 14,171,599 SH   DFND 3,18,19 14,171,599 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 25,026 194,199 SH   DFND 1,14,16 194,199 0 0
VIRTU FINL INC CL A 928254101 217,407 12,317,682 SH   DFND 7,9 12,317,682 0 0
VISA INC COM CL A 92826C839 142,760 1,522,287 SH   DFND 1,14,16 1,522,287 0 0
WELLS FARGO CO NEW COM 949746101 14,427 260,364 SH   DFND 1,14,16 260,364 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADR 98980A105 169,987 12,176,750 SH   DFND 1,14,16 12,176,750 0 0