The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABORATORIES SHARES COM 002824100 18 415 SH   SOLE   0 0 0
ABBVIE SHARES COM 00287Y109 25 380 SH   SOLE   0 0 0
ABEONA THERAPEUTICS SHARES CW-19 COM 00289y115 3,690 1,259,636 SH   SOLE   0 0 0
ABEONA THERAPEUTICS SHARES COM 00289Y107 3,114 622,873 SH   SOLE   0 0 0
ABIOMED SHARES COM 003654100 10,642 85,000 SH   SOLE   0 0 0
ACADIA HEALTHCARE COMPANY SHARES COM 00404A109 0 1 SH   SOLE   0 0 0
ACASTI PHARMA SHARES CLASS A COM 00430K402 254 186,559 SH   SOLE   0 0 0
ACCELERON PHARMA SHARES COM 00434H108 17,572 663,857 SH   SOLE   0 0 0
ACELRX PHARMACEUTICALS SHARES COM 00444T100 17,037 5,408,728 SH   SOLE   0 0 0
ACHAOGEN SHARES COM 004449104 593 23,496 SH   SOLE   0 0 0
ACLARIS THERAPEUTICS SHARES COM 00461U105 37,598 1,260,847 SH   SOLE   0 0 0
ADMA BIOLOGICS SHARES COM 000899104 3,519 721,102 SH   SOLE   0 0 0
AEGLEA BIOTHERAPEUTICS SHARES COM 00773J103 43 5,833 SH   SOLE   0 0 0
AERIE PHARMACEUTICALS SHARES COM 00771V108 2,268 50,000 SH   SOLE   0 0 0
AEVI GENOMIC MEDICINE SHARES COM 00835P105 2 940 SH   SOLE   0 0 0
AFFIMED SHARES COM N01045108 1,689 734,301 SH   SOLE   0 0 0
AGENUS SHARES COM 00847G705 14 3,600 SH   SOLE   0 0 0
AGILE THERAPEUTICS SHARES COM 00847L100 0 42 SH   SOLE   0 0 0
AKEBIA THERAPEUTICS SHARES COM 00972D105 457 49,624 SH   SOLE   0 0 0
AKORN SHARES COM 009728106 963 40,000 SH   SOLE   0 0 0
ALCOBRA SHARES COM M2239P109 10 9,109 SH   SOLE   0 0 0
ALDER BIOPHARMACEUTICALS SHARES COM 014339105 7,991 384,169 SH   SOLE   0 0 0
ALDEYRA THERAPEUTICS SHARES COM 01438T106 12,897 2,885,458 SH   SOLE   0 0 0
ALLIQUA BIOMEDICAL SHARES COM 019621200 2,136 4,233,951 SH   SOLE   0 0 0
ALLON THERAPEUTICS SHARES COM 019774108 0 751,124 SH   SOLE   0 0 0
ALLSCRIPTS HEALTHCARE SOLUTIONS SHARES COM 01988P108 545 42,955 SH   SOLE   0 0 0
ALNYLAM PHARMACEUTICALS SHARES COM 02043Q107 56,553 1,103,475 SH   SOLE   0 0 0
AMAG PHARMACEUTICALS SHARES COM 00163U106 12,628 560,000 SH   SOLE   0 0 0
AMGEN SHARES COM 031162100 3,281 20,000 SH   SOLE   0 0 0
AMICUS THERAPEUTICS SHARES COM 03152W109 123,325 17,296,672 SH   SOLE   0 0 0
ANAPTYSBIO SHARES COM 032724106 24,474 881,957 SH   SOLE   0 0 0
ANI PHARMACEUTICALS INC 01DEC19 3.0PCT NOTE 00182CAA1 7,958 7,500,000 PRN   SOLE   0 0 0
ANI PHARMACEUTICALS SHARES COM 00182C103 12,620 254,889 SH   SOLE   0 0 0
ANTARES PHARMA SHARES COM 036642106 8,285 2,917,253 SH   SOLE   0 0 0
ANTHEM SHARES COM 036752103 510 3,081 SH   SOLE   0 0 0
APTEVO THERAPEUTICS SHARES COM 03835L108 1 450 SH   SOLE   0 0 0
ARDELYX SHARES COM 039697107 23,860 1,886,196 SH   SOLE   0 0 0
ARNO THERAPEUTICS SHARES COM 042564203 254 4,177,577 SH   SOLE   0 0 0
ARRAY BIOPHARMA SHARES COM 04269X105 228 25,510 SH   SOLE   0 0 0
ARROWHEAD PHARMACEUTICALS SHARES COM 04280A100 1,567 847,458 SH   SOLE   0 0 0
ASSEMBLY BIOSCIENCES SHARES COM 045396108 16,934 664,354 SH   SOLE   0 0 0
ATRICURE SHARES COM 04963C209 1 55 SH   SOLE   0 0 0
AUDENTES THERAPEUTICS SHARES COM 05070R104 128 7,500 SH   SOLE   0 0 0
AURIS MEDICAL HOLDING SHARES COM H03579101 368 400,000 SH   SOLE   0 0 0
AVADEL PHARMACEUTICALS ADR COM 05337M104 13,632 1,408,240 SH   SOLE   0 0 0
AVEO PHARMACEUTICALS SHARES COM 053588109 3,014 5,108,808 SH   SOLE   0 0 0
AVEXIS SHARES COM 05366U100 34,100 448,501 SH   SOLE   0 0 0
AXOVANT SCIENCES LTD REGISTERED SHARES CALL 25 10/20/2017 COM G0750W104 1,420 200,000 SH Call SOLE   0 0 0
AXOVANT SCIENCES SHARES COM G0750W104 4,631 310,000 SH   SOLE   0 0 0
AZURRX BIOPHARMA SHARES COM 05502L105 877 227,272 SH   SOLE   0 0 0
BELLICUM PHARMACEUTICALS SHARES COM 079481107 1,064 86,200 SH   SOLE   0 0 0
BIO RAD LABORATORIES SHARES CLASS A COM 090572207 9,851 49,416 SH   SOLE   0 0 0
BIOMARIN PHARMACEUTICAL SHARES COM 09061G101 22 250 SH   SOLE   0 0 0
BLUEBIRD BIO SHARES COM 09609G100 422 4,644 SH   SOLE   0 0 0
BLUEPRINT MEDICINES SHARES COM 09627Y109 18,461 461,642 SH   SOLE   0 0 0
BOSTON SCIENTIFIC SHARES COM 101137107 0 3 SH   SOLE   0 0 0
BRAINSTORM CELL THERAPEUTICS INC SHARES (OLD) COM 10501E102 1,700 400,000 SH   SOLE   0 0 0
CAMBREX SHARES COM 132011107 524 9,515 SH   SOLE   0 0 0
CAPITAL SENIOR LIVING SHARES COM 140475104 8,087 575,173 SH   SOLE   0 0 0
CAPRICOR THERAPEUTICS SHARES COM 14070B101 13 4,000 SH   SOLE   0 0 0
CASCADIAN THERAPEUTICS SHARES COM 14740B606 8 1,966 SH   SOLE   0 0 0
CELLDEX THERAPEUTICS SHARES COM 15117B103 25 6,970 SH   SOLE   0 0 0
CENTENE SHARES COM 15135B101 551 7,726 SH   SOLE   0 0 0
CERUS SHARES COM 157085101 3 740 SH   SOLE   0 0 0
CHAMPIONS ONCOLOGY SHARES COM 15870P307 1,163 366,972 SH   SOLE   0 0 0
CHINA BIOLOGIC PRODUCTS SHARES COM 16938C106 24 236 SH   SOLE   0 0 0
CIDARA THERAPEUTICS SHARES COM 171757107 6,445 826,369 SH   SOLE   0 0 0
CLEARSIDE BIOMEDICAL SHARES COM 185063104 5,653 712,062 SH   SOLE   0 0 0
CLOVIS ONCOLOGY SHARES COM 189464100 10,044 157,754 SH   SOLE   0 0 0
CORBUS PHARMACEUTICALS HOLDINGS SHARES COM 21833P103 10,312 1,250,000 SH   SOLE   0 0 0
CORIUM INTERNATIONAL SHARES COM 21887L107 11,096 2,654,485 SH   SOLE   0 0 0
CREDIT SUISSE VELOCITYSHARES DAILY INVERSE VIX SHORT TERM ET COM 22542D795 1 16 SH   SOLE   0 0 0
CRYOLIFE SHARES COM 228903100 2 123 SH   SOLE   0 0 0
CURIS SHARES COM 231269101 1,390 500,000 SH   SOLE   0 0 0
CUTERA SHARES COM 232109108 496 23,981 SH   SOLE   0 0 0
CYTOMX THERAPEUTICS SHARES COM 23284F105 26,434 1,530,659 SH   SOLE   0 0 0
DANAHER SHARES COM 235851102 0 3 SH   SOLE   0 0 0
DBV TECHNOLOGIES ADR REPRESENTING 0.5 SHARES COM 23306J101 20,842 591,765 SH   SOLE   0 0 0
DERMIRA SHARES COM 24983L104 3,943 115,583 SH   SOLE   0 0 0
EIGER BIOPHARMACEUTICALS SHARES COM 28249U105 1,805 157,679 SH   SOLE   0 0 0
EPIZYME SHARES COM 29428V104 20 1,165 SH   SOLE   0 0 0
EVOLENT HEALTH INC SHARES -A- CALL 20 06/16/2017 COM 30050B101 190 50,000 SH Call SOLE   0 0 0
EVOLENT HEALTH SHARES CLASS A COM 30050B101 32,212 1,444,500 SH   SOLE   0 0 0
EXACT SCIENCES SHARES COM 30063P105 9,684 410,000 SH   SOLE   0 0 0
EXELIXIS SHARES COM 30161Q104 1,005 46,361 SH   SOLE   0 0 0
FERRARI SHARES COM N3167Y103 461 6,200 SH   SOLE   0 0 0
FIAT CHRYSLER AUTOMOBILES SHARES COM N31738102 678 62,000 SH   SOLE   0 0 0
FIVE PRIME THERAPEUTICS SHARES COM 33830X104 5 127 SH   SOLE   0 0 0
FOAMIX PHARMACEUTICALS SHARES COM M46135105 6,549 1,322,994 SH   SOLE   0 0 0
FORWARD PHARMA ADR REPRESENTING 1 SHARES COM 34986J105 7,634 354,241 SH   SOLE   0 0 0
GALAPAGOS ADR REPRESENTING SHARES COM 36315X101 23,392 271,405 SH   SOLE   0 0 0
GLOBAL BLOOD THERAPEUTICS SHARES COM 37890U108 142,203 3,858,978 SH   SOLE   0 0 0
HESKA SHARES COM 42805E306 661 6,300 SH   SOLE   0 0 0
HILL ROM HOLDINGS SHARES COM 431475102 560 7,930 SH   SOLE   0 0 0
HISTOGENCIS CORP COM 43358V109 3,075 1,777,777 SH   SOLE   0 0 0
HMS HOLDINGS SHARES COM 40425J101 540 26,553 SH   SOLE   0 0 0
HUMANA SHARES COM 444859102 5,669 27,500 SH   SOLE   0 0 0
IGNYTA SHARES COM 451731103 57 6,584 SH   SOLE   0 0 0
ILLUMINA SHARES COM 452327109 597 3,500 SH   SOLE   0 0 0
IMMUNOMEDICS SHARES COM 452907108 1,941 300,060 SH   SOLE   0 0 0
INCYTE SHARES COM 45337C102 751 5,619 SH   SOLE   0 0 0
INVITAE SHARES COM 46185L103 5,309 480,000 SH   SOLE   0 0 0
IRHYTHM TECHNOLOGIES SHARES COM 450056106 10,192 271,057 SH   SOLE   0 0 0
ISHARES 20 PLUS YEAR TREASURY BOND ETF NOTE 464287432 0 2 PRN   SOLE   0 0 0
ISHARES CORE SandP 500 ETF COM 464287200 0 1 SH   SOLE   0 0 0
ISHARES RUSSELL MID-CAP VALUE ETF COM 464287473 0 2 SH   SOLE   0 0 0
JAZZ PHARMACEUTICALS SHARES COM G50871105 4,354 30,000 SH   SOLE   0 0 0
KADMON SHARES COM 48283N106 18,772 5,185,847 SH   SOLE   0 0 0
LA JOLLA PHARMACEUTICAL SHARES COM 503459604 63,857 2,139,274 SH   SOLE   0 0 0
LANTHEUS HOLDINGS SHARES COM 516544103 672 53,763 SH   SOLE   0 0 0
LHC GROUP SHARES COM 50187A107 256 4,745 SH   SOLE   0 0 0
LION BIOTECHNOLOGIES SHARES COM 53619R102 26,578 3,567,553 SH   SOLE   0 0 0
MASIMO SHARES COM 574795100 554 5,945 SH   SOLE   0 0 0
MCKESSON SHARES COM 58155Q103 534 3,601 SH   SOLE   0 0 0
METASTAT SHARES COM 59140A203 662 500,000 SH   SOLE   0 0 0
MGC DIAGNOSTICS SHARES COM 552768103 2,524 302,327 SH   SOLE   0 0 0
MINERVA NEUROSCIENCES INC COM 603380106 6,565 810,537 SH   SOLE   0 0 0
MYOKARDIA SHARES COM 62857M105 8,214 624,694 SH   SOLE   0 0 0
NEPTUNE TECHNOLOGIES AND BIORESOURCES SHARES COM 64077P108 4,610 6,519,634 SH   SOLE   0 0 0
NEUROCRINE BIOSCIENCES SHARES COM 64125C109 145,771 3,366,530 SH   SOLE   0 0 0
NEVRO SHARES COM 64157F103 20,360 217,292 SH   SOLE   0 0 0
NXSTAGE MEDICAL SHARES COM 67072V103 48,782 1,818,189 SH   SOLE   0 0 0
OBALON THERAPEUTICS SHARES COM 67424L100 0 4 SH   SOLE   0 0 0
OCERA THERAPEUTICS SHARES COM 67552A108 2,817 2,150,000 SH   SOLE   0 0 0
ONCOBIOLOGICS EQUITY WARRANTS SERIES A EXP 18TH FEB 2018 COM 68235M113 370 462,500 SH   SOLE   0 0 0
ONCOBIOLOGICS EQUITY WARRANTS SERIES B EXP 18TH MAY 2018 COM 68235M121 231 462,500 SH   SOLE   0 0 0
ONCOBIOLOGICS SHARES COM 68235M105 3,167 1,181,874 SH   SOLE   0 0 0
OPHTHOTECH SHARES COM 683745103 5 1,600 SH   SOLE   0 0 0
ORASURE TECHNOLOGIES SHARES COM 68554V108 609 47,125 SH   SOLE   0 0 0
PEREGRINE PHARMACEUTICALS INC 10.5 COM 713661403 4,342 200,000 SH   SOLE   0 0 0
PEREGRINE PHARMACEUTICALS SHARES COM 713661304 16 24,332 SH   SOLE   0 0 0
PERNIX THERAPEUTICS HOLD 01APR21 4.25PCT COM 71426VAK4 275 1,000,000 SH   SOLE   0 0 0
PFENEX SHARES COM 717071104 5,187 892,847 SH   SOLE   0 0 0
PHIBRO ANIMAL HEALTH SHARES CLASS A COM 71742Q106 517 18,382 SH   SOLE   0 0 0
PORTOLA PHARMACEUTICALS SHARES COM 737010108 2,268 57,870 SH   SOLE   0 0 0
PRA HEALTH SCIENCES SHARES COM 69354M108 542 8,308 SH   SOLE   0 0 0
PROTEON THERAPEUTICS SHARES COM 74371L109 585 334,116 SH   SOLE   0 0 0
PSIVIDA SHARES COM 74440J101 3,921 2,279,706 SH   SOLE   0 0 0
QUALITY SYSTEMS SHARES COM 747582104 516 33,875 SH   SOLE   0 0 0
QUORUM HEALTH SHARES COM 74909E106 275 50,604 SH   SOLE   0 0 0
QUOTIENT SHARES COM G73268107 20,372 2,917,785 SH   SOLE   0 0 0
R1 RCM SHARES COM 749397105 56 17,976 SH   SOLE   0 0 0
RA PHARMACEUTICALS SHARES COM 74933V108 2,129 100,000 SH   SOLE   0 0 0
RADIUS HEALTH INC REGISTERED SHARES PUT 30 07/21/2017 COM 750469207 570 9,800 SH Put SOLE   0 0 0
RADIUS HEALTH SHARES COM 750469207 35,205 910,872 SH   SOLE   0 0 0
REGENXBIO SHARES COM 75901B107 26,947 1,396,244 SH   SOLE   0 0 0
RETROPHIN SHARES COM 761299106 51,826 2,807,525 SH   SOLE   0 0 0
SAGE THERAPEUTICS INC REGISTERED SHARES CALL 80 05/19/2017 COM 78667J108 1,343 150,000 SH Call SOLE   0 0 0
SAGE THERAPEUTICS INC REGISTERED SHARES CALL 80 06/16/2017 COM 78667J108 623 50,000 SH Call SOLE   0 0 0
SAREPTA THERAPEUTICS SHARES COM 803607100 52,422 1,771,029 SH   SOLE   0 0 0
SELECTA BIOSCIENCES SHARES COM 816212104 2,032 141,875 SH   SOLE   0 0 0
SEVION THERAPEUTICS INC COM 81834Q104 9 59,220 SH   SOLE   0 0 0
SIERRA ONCOLOGY SHARES COM 82640U107 5,667 3,703,704 SH   SOLE   0 0 0
SYNERGY PHARMACEUTICALS SHARES COM 871639308 4,558 978,100 SH   SOLE   0 0 0
TENGION INC COM 88034G208 3 1,826,399 SH   SOLE   0 0 0
TESARO SHARES COM 881569107 37,087 241,028 SH   SOLE   0 0 0
THERAPEUTICSMD SHARES COM 88338N107 8 1,081 SH   SOLE   0 0 0
TRACON PHARMACEUTICALS SHARES COM 89237H100 0 50 SH   SOLE   0 0 0
UNIQURE SHARES COM N90064101 7,317 1,265,963 SH   SOLE   0 0 0
UNITEDHEALTH GROUP SHARES COM 91324P102 2,132 13,000 SH   SOLE   0 0 0
VANDA PHARMACEUTICALS SHARES COM 921659108 507 36,232 SH   SOLE   0 0 0
VBI VACCINES SHARES COM 91822J103 36,046 6,565,843 SH   SOLE   0 0 0
VERSARTIS SHARES COM 92529L102 94,096 4,407,317 SH   SOLE   0 0 0
VERTEX PHARMACEUTICALS SHARES COM 92532F100 32,095 293,509 SH   SOLE   0 0 0
VIVEVE MEDICAL SHARES COM 92852W204 5,942 938,742 SH   SOLE   0 0 0
WAVE LIFE SCIENCES SHARES COM Y95308105 18,293 665,198 SH   SOLE   0 0 0
WELLCARE HEALTHCARE PLANS SHARES COM 94946T106 741 5,283 SH   SOLE   0 0 0
WEST PHARMACEUTICAL SERVICES SHARES COM 955306105 11 138 SH   SOLE   0 0 0
XENCOR SHARES COM 98401F105 38,440 1,607,018 SH   SOLE   0 0 0
XENON PHARMACEUTICALS SHARES COM 98420N105 2,895 723,853 SH   SOLE   0 0 0
ZOGENIX SHARES COM 98978L204 23,906 2,203,302 SH   SOLE   0 0 0
ZOSANO PHARMA SHARES COM 98979H103 950 500,000 SH   SOLE   0 0 0
ZYNERBA PHARMACEUTICALS INC COM 98986X109 5,051 251,328 SH   SOLE   0 0 0