The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABORATORIES COM 002824100 1,921 50,000 SH   SOLE   0 0 0
ABEONA THERAPEUTICS COM 00289Y107 4,085 842,173 SH   SOLE   0 0 0
ABEONA THERAPEUTICS CW-19 WARRANTS 00289y115 3,778 1,259,636 SH   SOLE   0 0 0
ABIOMED COM 003654100 12 109 SH   SOLE   0 0 0
ACORDA THERAPEUTICS COM 00484M106 13,536 720,000 SH   SOLE   0 0 0
ACADIA PHARMACEUTICALS INC CALL 40 01/20/2017 COM 004225108 0 5,200 SH Call SOLE   0 0 0
ACADIA PHARMACEUTICALS INC CALL 40 01/20/2017 COM 004225108 7 94,800 SH Call SOLE   0 0 0
ACASTI PHARMA CLASS A COM 00430K402 233 186,559 SH   SOLE   0 0 0
ACCELERON PHARMA COM 00434H108 15,822 619,987 SH   SOLE   0 0 0
ACCRETIVE HEALTH COM 00438V103 709 315,000 SH   SOLE   0 0 0
ACELRX PHARMACEUTICALS COM 00444T100 14,063 5,408,728 SH   SOLE   0 0 0
ACLARIS THERAPEUTICS COM 00461U105 34,219 1,260,847 SH   SOLE   0 0 0
ADMA BIOLOGICS COM 000899104 3,692 721,102 SH   SOLE   0 0 0
AEGLEA BIOTHERAPEUTICS COM 00773J103 451 103,585 SH   SOLE   0 0 0
AERIE PHARMACEUTICALS COM 00771V108 1,893 50,000 SH   SOLE   0 0 0
AEVI GENOMIC MEDICINE WARRANT WARRANTS 58436Q120 106 150,000 SH   SOLE   0 0 0
AEVI GENOMIC MEDICINE COM 00835P105 1,520 293,460 SH   SOLE   0 0 0
AFFIMED COM N01045108 1,322 734,301 SH   SOLE   0 0 0
AGENUS COM 00847G705 297 72,187 SH   SOLE   0 0 0
AGILE THERAPEUTICS COM 00847L100 3,770 661,446 SH   SOLE   0 0 0
AKEBIA THERAPEUTICS COM 00972D105 5,593 537,256 SH   SOLE   0 0 0
ALDER BIOPHARMACEUTICALS COM 014339105 7,991 384,169 SH   SOLE   0 0 0
ALDEYRA THERAPEUTICS COM 01438T106 10,381 1,940,458 SH   SOLE   0 0 0
ALLIQUA BIOMEDICAL COM 019621200 1,133 1,921,951 SH   SOLE   0 0 0
ALLON THERAPEUTICS COM 019774108 0 751,124 SH   SOLE   0 0 0
ALNYLAM PHARMACEUTICALS COM 02043Q107 4,436 118,475 SH   SOLE   0 0 0
AMAG PHARMACEUTICALS COM 00163U106 679 19,524 SH   SOLE   0 0 0
AMICUS THERAPEUTICS COM 03152W109 85,964 17,296,672 SH   SOLE   0 0 0
AMN HEALTHCARE COM 001744101 484 12,585 SH   SOLE   0 0 0
ANI PHARMACEUTICALS COM 00182C103 16,192 267,100 SH   SOLE   0 0 0
ANI PHARMACEUTICALS INC 01DEC19 3.0PCT NOTE 00182CAA1 8,700 7,500,000 PRN   SOLE   0 0 0
ANTARES PHARMA COM 036642106 6,797 2,917,253 SH   SOLE   0 0 0
APPLIED GENETIC TECHNOLOGIES COM 03820J100 470 50,251 SH   SOLE   0 0 0
APTEVO THERAPEUTICS COM 03835L108 2,411 988,133 SH   SOLE   0 0 0
ARDELYX COM 039697107 26,073 1,836,196 SH   SOLE   0 0 0
ARIAD PHARMACEUTICALS COM 04033A100 19 1,551 SH   SOLE   0 0 0
ARNO THERAPEUTICS INC COM 042564203 781 4,177,577 SH   SOLE   0 0 0
ARROWHEAD Pharmaceuticals com 04280a100 1,313 847,458 SH   SOLE   0 0 0
ASSEMBLY BIOSCIENCES COM 045396108 8,679 714,354 SH   SOLE   0 0 0
ATRICURE COM 04963C209 1,847 94,400 SH   SOLE   0 0 0
AUDENTES THERAPEUTICS COM 05070R104 137 7,500 SH   SOLE   0 0 0
AVADEL PHARMACEUTICALS COM 05337M104 14,424 1,388,240 SH   SOLE   0 0 0
AVEO PHARMACEUTICALS COM 053588109 1,678 3,108,808 SH   SOLE   0 0 0
AVEXIS COM 05366U100 22,602 473,531 SH   SOLE   0 0 0
AVINGER COM 053734109 4 1,062 SH   SOLE   0 0 0
AZURRX BIOPHARMA COM 05502L105 1,077 227,272 SH   SOLE   0 0 0
BARCLAYS BANK IPATH SandP 500 VIX SHORT TERM FUTURES ETN EXP COM 06740Q252 1,046 41,000 SH   SOLE   0 0 0
BIO RAD LABORATORIES CLASS A COM 090572207 4,451 24,416 SH   SOLE   0 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 8,420 1,330,240 SH   SOLE   0 0 0
BIOGEN INC COM 09062X103 545 1,922 SH   SOLE   0 0 0
BIOMARIN PHARMACEUTICAL COM 09061G101 21 250 SH   SOLE   0 0 0
BLUEPRINT MEDICINES COM 09627Y109 7,680 273,820 SH   SOLE   0 0 0
BOSTON SCIENTIFIC COM 101137107 0 3 SH   SOLE   0 0 0
BRAINSTORM CELL THERAPEUTICS COM 10501E201 1,016 400,000 SH   SOLE   0 0 0
BRUKER COM 116794108 0 3 SH   SOLE   0 0 0
CAPITAL SENIOR LIVING COM 140475104 5,222 320,173 SH   SOLE   0 0 0
CAPRICOR THERAPEUTICS COM 14070B101 11 4,000 SH   SOLE   0 0 0
CASCADIAN THERAPEUTICS COM 14740B606 2,355 546,498 SH   SOLE   0 0 0
CATALENT COM 148806102 0 3 SH   SOLE   0 0 0
CELGENE COM 151020104 3,010 26,000 SH   SOLE   0 0 0
CEMPRA COM 15130J109 62 22,321 SH   SOLE   0 0 0
CHAMPIONS ONCOLOGY COM 15870P307 942 372,597 SH   SOLE   0 0 0
CHINA BIOLOGIC PRODUCTS COM 16938C106 25 236 SH   SOLE   0 0 0
CIDARA THERAPEUTICS COM 171757107 8,043 773,369 SH   SOLE   0 0 0
CLEARSIDE BIOMEDICAL COM 185063104 6,365 712,062 SH   SOLE   0 0 0
CLOVIS ONCOLOGY COM 189464100 7,452 167,754 SH   SOLE   0 0 0
COLLEGIUM PHARMACEUTICAL COM 19459J104 3,063 196,728 SH   SOLE   0 0 0
COLUCID PHARMACEUTICALS COM 19716T101 23,346 641,364 SH   SOLE   0 0 0
CORBUS PHARMACEUTICALS HOLDINGS INC CALL 15 01/20/2017 COM 21833P103 0 1,600 SH Call SOLE   0 0 0
CORBUS PHARMACEUTICALS HOLDINGS INC COM 21833P103 10,562 1,250,000 SH   SOLE   0 0 0
CROSS COUNTRY HEALTHCARE COM 227483104 544 34,819 SH   SOLE   0 0 0
CRYOLIFE COM 228903100 2 123 SH   SOLE   0 0 0
CYNOSURE CLASS A COM 232577205 82 1,800 SH   SOLE   0 0 0
CYTOMX THERAPEUTICS COM 23284F105 10,152 923,763 SH   SOLE   0 0 0
DANAHER COM 235851102 0 3 SH   SOLE   0 0 0
DAVITA COM 23918K108 0 3 SH   SOLE   0 0 0
DBV TECHNOLOGIES ADR REPRESENTING 0.5 COM 23306J101 21,452 610,643 SH   SOLE   0 0 0
DERMIRA COM 24983L104 9,875 325,583 SH   SOLE   0 0 0
DYNAVAX TECHNOLOGIES CALL 4 01/2017 COM 268158201 5 15,600 SH Call SOLE   0 0 0
EAGLE PHARMACEUTICALS COM 269796108 39,527 498,198 SH   SOLE   0 0 0
EIGER BIOPHARMACEUTICALS COM 28249U105 1,836 157,679 SH   SOLE   0 0 0
ELI LILLY & CO CALL 90 01/20/2017 COM 532457108 3 100,000 SH Call SOLE   0 0 0
ENDO INTERNATIONAL COM G30401106 213 12,920 SH   SOLE   0 0 0
ENZO BIOCHEM COM 294100102 582 83,893 SH   SOLE   0 0 0
EVOLENT HEALTH CLASS A COM 30050B101 4,555 307,800 SH   SOLE   0 0 0
EXACT SCIENCES CORP PUT 17 01/20/2017 COM 30063P105 670 200,000 SH Put SOLE   0 0 0
EXELIXIS COM 30161Q104 691 46,361 SH   SOLE   0 0 0
EXPRESS SCRIPTS HOLDING COM 30219G108 457 6,639 SH   SOLE   0 0 0
FERRARI COM N3167Y103 360 6,200 SH   SOLE   0 0 0
FIAT CHRYSLER AUTOMOBILES COM N31738102 565 62,000 SH   SOLE   0 0 0
FIVE PRIME THERAPEUTICS COM 33830X104 8,181 163,255 SH   SOLE   0 0 0
FIVE STAR QUALITY CARE COM 33832D106 183 67,797 SH   SOLE   0 0 0
FLEX PHARMA COM 33938A105 1 237 SH   SOLE   0 0 0
FOAMIX PHARMACEUTICALS COM M46135105 14,685 1,322,994 SH   SOLE   0 0 0
FORWARD PHARMA ADR REPRESENTING 1 COM 34986J105 5,918 394,241 SH   SOLE   0 0 0
GALAPAGOS ADR REPRESENTING COM 36315X101 20,631 304,531 SH   SOLE   0 0 0
GENVEC COM 37246C406 180 56,131 SH   SOLE   0 0 0
GLAUKOS COM 377322102 10 300 SH   SOLE   0 0 0
GLOBAL BLOOD THERAPEUTICS COM 37890U108 45,213 3,128,978 SH   SOLE   0 0 0
HILL ROM HOLDINGS COM 431475102 445 7,930 SH   SOLE   0 0 0
HISTOGENCIS CORP COM 43358V109 2,968 1,777,777 SH   SOLE   0 0 0
HUMANA COM 444859102 454 2,227 SH   SOLE   0 0 0
HUMANA INC CALL 210 04/21/2017 COM 444859102 528 40,000 SH Call SOLE   0 0 0
ICON COM G4705A100 517 6,873 SH   SOLE   0 0 0
IGNYTA COM 451731103 35 6,584 SH   SOLE   0 0 0
IMMUNE DESIGN COM 45252L103 428 77,725 SH   SOLE   0 0 0
IMPAX LABORATORIES COM 45256B101 0 1 SH   SOLE   0 0 0
INC RESEARCH HOLDINGS CLASS A COM 45329R109 665 12,636 SH   SOLE   0 0 0
INCYTE COM 45337C102 563 5,619 SH   SOLE   0 0 0
INNOCOLL COM G4783X105 7 9,433 SH   SOLE   0 0 0
INOGEN COM 45780L104 8 125 SH   SOLE   0 0 0
INTELLIA THERAPEUTICS COM 45826J105 192 14,673 SH   SOLE   0 0 0
INVITAE COM 46185L103 3,970 500,000 SH   SOLE   0 0 0
IRHYTHM TECHNOLOGIES COM 450056106 10,567 352,241 SH   SOLE   0 0 0
IRIDEX COM 462684101 308 21,885 SH   SOLE   0 0 0
ISHARES 20 PLUS YEAR TREASURY BOND ETF NOTE 464287432 0 2 PRN   SOLE   0 0 0
ISHARES CORE SandP 500 ETF COM 464287200 0 1 SH   SOLE   0 0 0
ISHARES RUSSELL MID-CAP VALUE ETF COM 464287473 0 2 SH   SOLE   0 0 0
JAZZ PHARMACEUTICALS COM G50871105 5,670 52,000 SH   SOLE   0 0 0
JOHNSON and JOHNSON COM 478160104 0 2 SH   SOLE   0 0 0
KADMON COM 48283N106 11,821 2,209,657 SH   SOLE   0 0 0
LA JOLLA PHARMACEUTICAL COM 503459604 23,127 1,319,274 SH   SOLE   0 0 0
LANTHEUS HOLDINGS COM 516544103 462 53,763 SH   SOLE   0 0 0
LION BIOTECHNOLOGIES INC COM 53619R102 24,794 3,567,553 SH   SOLE   0 0 0
LHC GROUP COM 50187A107 217 4,745 SH   SOLE   0 0 0
MAGELLAN HEALTH COM 559079207 565 7,508 SH   SOLE   0 0 0
MCKESSON COM 58155Q103 432 3,078 SH   SOLE   0 0 0
MEDICINES CO PUT 32 04/21/2017 COM 584688105 1,070 200,000 SH Put SOLE   0 0 0
MERRIMACK PHARMACEUTICALS COM 590328100 200 48,910 SH   SOLE   0 0 0
METASTAT INC COM 59140A203 618 500,000 SH   SOLE   0 0 0
MGC DIAGNOSTICS COM 552768103 2,602 329,733 SH   SOLE   0 0 0
MINERVA NEUROSCIENCES INC COM 603380106 9,523 810,537 SH   SOLE   0 0 0
MIRATI THERAPEUTICS COM 60468T105 2 521 SH   SOLE   0 0 0
MOLINA HEALTHCARE COM 60855R100 379 6,981 SH   SOLE   0 0 0
MYOKARDIA COM 62857M105 8,089 624,694 SH   SOLE   0 0 0
MYOVANT SCIENCES COM G637AM102 2,815 226,322 SH   SOLE   0 0 0
NEOS THERAPEUTICS COM 64052L106 6 1,056 SH   SOLE   0 0 0
NEPTUNE TECHNOLOGIES AND BIORESOURCES COM 64077P108 6,004 6,519,634 SH   SOLE   0 0 0
NEUROCRINE BIOSCIENCES COM 64125C109 128,349 3,316,523 SH   SOLE   0 0 0
NEURODERM COM M74231107 1,284 57,825 SH   SOLE   0 0 0
NIVALIS THERAPEUTICS COM 65481J109 274 122,275 SH   SOLE   0 0 0
NOVAVAX COM 670002104 423 335,413 SH   SOLE   0 0 0
NXSTAGE MEDICAL COM 67072V103 50,533 1,927,989 SH   SOLE   0 0 0
ONCOBIOLOGICS COM 68235M105 3,759 1,248,990 SH   SOLE   0 0 0
ONCOBIOLOGICS INC WTS W EXP 2/18/2017 68235M121 518 656,382 SH   SOLE   0 0 0
ONCOBIOLOGICS INC WTS W EXP 2/18/2017 68235M113 124 656,382 SH   SOLE   0 0 0
OPHTHOTECH CORP CALL 55 01/20/2017 COM 683745103 0 20,000 SH Call SOLE   0 0 0
OPHTHOTECH CORP CALL 70 01/20/2017 COM 683745103 0 400 SH Call SOLE   0 0 0
OPHTHOTECH CORP CALL 75 01/20/2017 COM 683745103 5 200,000 SH Call SOLE   0 0 0
OPHTHOTECH CORP PUT 20 01/20/2017 COM 683745103 24 1,600 SH Put SOLE   0 0 0
PEREGRINE PHARMACEUTICALS COM 713661304 8 24,332 SH   SOLE   0 0 0
PEREGRINE PHARMACEUTICALS INC 10.5 COM 713661403 3,982 200,000 SH   SOLE   0 0 0
PERNIX THERAPEUTICS HOLD 01APR21 4.25PCT Note 71426VAK4 246 1,000,000 PRN   SOLE   0 0 0
PFENEX COM 717071104 8,293 914,376 SH   SOLE   0 0 0
PFIZER COM 717081103 1,786 55,000 SH   SOLE   0 0 0
PHASERX COM 71723F103 310 200,000 SH   SOLE   0 0 0
PROTEON THERAPEUTICS COM 74371L109 635 334,116 SH   SOLE   0 0 0
PSIVIDA COM 74440J101 3,898 2,279,706 SH   SOLE   0 0 0
PSYCHEMEDICS COM 744375205 164 6,626 SH   SOLE   0 0 0
PUMA BIOTECHNOLOGY COM 74587V107 225 7,344 SH   SOLE   0 0 0
QUORUM HEALTH COM 74909e106 731 100,604 SH   SOLE   0 0 0
QUOTIENT COM G73268107 13,815 2,854,486 SH   SOLE   0 0 0
RA PHARMACEUTICALS COM 74933V108 2,506 165,000 SH   SOLE   0 0 0
RADIUS HEALTH COM 750469207 10,035 263,872 SH   SOLE   0 0 0
REGENXBIO COM 75901B107 23,786 1,282,286 SH   SOLE   0 0 0
RETROPHIN COM 761299106 50,872 2,687,412 SH   SOLE   0 0 0
SANGAMO BIOSCIENCES COM 800677106 1 272 SH   SOLE   0 0 0
SAREPTA THERAPEUTICS COM 803607100 75,976 2,769,829 SH   SOLE   0 0 0
SAREPTA THERAPEUTICS INC PUT 50 01/20/2017 COM 803607100 249 10,900 SH Put SOLE   0 0 0
SCYNEXIS COM 811292101 546 171,185 SH   SOLE   0 0 0
SELECTA BIOSCIENCES COM 816212104 2,433 141,875 SH   SOLE   0 0 0
SEVION THERAPEUTICS INC COM 81834Q104 8 59,220 SH   SOLE   0 0 0
SPDR DOW JONES INDUSTRIAL AVERAGE ETF COM 78467X109 1 3 SH   SOLE   0 0 0
SPDR GOLD SHARES ETF COM 78463V107 0 1 SH   SOLE   0 0 0
SPDR SandP BIOTECH ETF COM 78464A870 3 50 SH   SOLE   0 0 0
STEMLINE THERAPEUTICS COM 85858C107 115 10,702 SH   SOLE   0 0 0
SUCAMPO PHARMACEUTICALS CLASS A COM 864909106 416 30,694 SH   SOLE   0 0 0
SUPERNUS PHARMACEUTICALS COM 868459108 11 421 SH   SOLE   0 0 0
SYNERGY PHARMACEUTICALS COM 871639308 2,986 490,300 SH   SOLE   0 0 0
TENGION INC COM 88034G208 1 1,826,399 SH   SOLE   0 0 0
TESARO COM 881569107 92,521 687,993 SH   SOLE   0 0 0
THERAPEUTICSMD COM 88338N107 1,731 300,000 SH   SOLE   0 0 0
THERMO FISHER SCIENTIFIC COM 883556102 0 2 SH   SOLE   0 0 0
TRACON PHARMACEUTICALS COM 89237H100 490 100,000 SH   SOLE   0 0 0
UNIQURE COM N90064101 7,089 1,265,963 SH   SOLE   0 0 0
UNITED THERAPEUTICS COM 91307C102 682 4,753 SH   SOLE   0 0 0
UNITEDHEALTH GROUP COM 91324P102 516 3,223 SH   SOLE   0 0 0
VBI VACCINES COM 91822J103 20,354 6,565,843 SH   SOLE   0 0 0
VERICEL COM 92346J108 28 9,385 SH   SOLE   0 0 0
VERSARTIS COM 92529L102 61,889 4,153,685 SH   SOLE   0 0 0
VERTEX PHARMACEUTICALS COM 92532F100 6,299 85,509 SH   SOLE   0 0 0
WAVE LIFE SCIENCES COM Y95308105 18,088 665,198 SH   SOLE   0 0 0
WELLCARE HEALTHCARE PLANS COM 94946T106 693 5,056 SH   SOLE   0 0 0
WEST PHARMACEUTICAL SERVICES COM 955306105 12 138 SH   SOLE   0 0 0
XENCOR COM 98401F105 46,982 1,785,018 SH   SOLE   0 0 0
XENON PHARMACEUTICALS COM 98420N105 5,700 740,272 SH   SOLE   0 0 0
ZOETIS CLASS A COM 98978V103 0 3 SH   SOLE   0 0 0
ZOGENIX COM 98978L204 9,149 752,999 SH   SOLE   0 0 0
ZYNERBA PHARMACEUTICALS COM 98986X109 13,128 842,128 SH   SOLE   0 0 0