The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
22ND CENTY GROUP INC COM 90137F103 1,178 1,080,750 SH   DFND 1 1,080,750 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 418 103,282 SH   DFND 1 103,282 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 373 128,539 SH   DFND 1 128,539 0 0
AETERNA ZENTARIS INC COM NO PAR 007975402 275 56,800 SH   DFND 1 56,800 0 0
AFFIMED N V COM N01045108 654 363,161 SH   DFND 1 363,161 0 0
ALCOBRA LTD SHS M2239P109 300 142,973 SH   DFND 1 142,973 0 0
ALON USA PARTNERS LP UT LTDPART INT 02052T109 960 100,000 SH   DFND 1 100,000 0 0
AMAZON COM INC COM 023135106 44,992 60,000 SH Put DFND 1 60,000 0 0
ANCHOR BANCORP WA COM 032838104 2,029 74,603 SH   DFND 1 74,603 0 0
APPLIED DNA SCIENCES INC COM NEW 03815U201 266 143,838 SH   DFND 1 143,838 0 0
APRICUS BIOSCIENCES INC COM NEW 03832V307 263 202,475 SH   DFND 1 202,475 0 0
ARBUTUS BIOPHARMA CORP COM 03879J100 257 105,085 SH   DFND 1 105,085 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 548 353,428 SH   DFND 1 353,428 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 815 388,008 SH   DFND 1 388,008 0 0
BANK AMER CORP COM 060505104 26,927 1,218,425 SH   DFND 1 1,218,425 0 0
BELLATRIX EXPLORATION LTD COM 078314101 23,040 18,000,000 SH   DFND 1 18,000,000 0 0
BIOBLAST PHARMA LTD SHS M20156101 282 270,793 SH   DFND 1 270,793 0 0
BROADCOM LTD PUT Y09827959 27,399 155,000 SH Put DFND 1 155,000 0 0
CAPNIA INC COM 14066L105 288 355,497 SH   DFND 1 355,497 0 0
CASCADIAN THERAPEUTICS INC COM NEW 14740B606 988 229,286 SH   DFND 1 229,286 0 0
CATERPILLAR INC DEL COM 149123101 4,637 50,000 SH   DFND 1 50,000 0 0
CELLECT BIOTECHNOLOGY LTD *W EXP 07/28/202 15116C110 350 113,347 SH   DFND 1 113,347 0 0
CELSION CORPORATION COM PAR 15117N404 200 657,890 SH   DFND 1 657,890 0 0
CENTRAL FD CDA LTD CL A 153501101 1,355 120,000 SH   DFND 1 120,000 0 0
CHARLES & COLVARD LTD COM 159765106 203 184,742 SH   DFND 1 184,742 0 0
CHIASMA INC COM 16706W102 400 205,380 SH   DFND 1 205,380 0 0
CHIPOTLE MEXICAN GRILL INC COM 169656105 868 2,300 SH   DFND 1 2,300 0 0
CIRRUS LOGIC INC PUT 172755950 10,262 181,500 SH Put DFND 1 181,500 0 0
COMBIMATRIX CORPORATION *W EXP 03/18/202 20009T147 327 123,238 SH   DFND 1 123,238 0 0
CPS TECHNOLOGIES CORP COM 12619F104 36 19,506 SH   DFND 1 19,506 0 0
CVR REFNG LP COMUNIT REP LT 12663P107 520 50,000 SH   DFND 1 50,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 287 99,658 SH   DFND 1 99,658 0 0
DU PONT E I DE NEMOURS & CO COM 263534109 3,670 50,000 SH   DFND 1 50,000 0 0
ELLIS PERRY INTL INC COM 288853104 9,660 387,790 SH   DFND 1 387,790 0 0
ENDOCYTE INC COM 29269A102 276 108,426 SH   DFND 1 108,426 0 0
ENTERTAINMENT GAMING ASIA IN COM PAR 29383V305 72 51,831 SH   DFND 1 51,831 0 0
ENTRAVISION COMMUNICATIONS C CL A 29382R107 8,645 1,235,000 SH   DFND 1 1,235,000 0 0
ETFS PLATINUM TR SH BEN INT 26922V101 259 3,000 SH   DFND 1 3,000 0 0
FUEL TECH INC COM 359523107 165 143,845 SH   DFND 1 143,845 0 0
HEMISPHERX BIOPHARMA INC COM NEW 42366C301 739 1,071,627 SH   DFND 1 1,071,627 0 0
HIGHWAY HLDGS LTD ORD G4481U106 1,273 618,702 SH   DFND 1 618,702 0 0
IMMUNOCELLULAR THERAPEUTICS *W EXP 08/12/202 452536121 240 117,188 SH   DFND 1 117,188 0 0
INTEL CORP PUT 458140950 3,627 100,000 SH Put DFND 1 100,000 0 0
INTERNATIONAL BUSINESS MACHS COM 459200101 13,279 80,000 SH Put DFND 1 80,000 0 0
INVENTERGY GLOBAL INC COM NEW 46123X409 154 205,149 SH   DFND 1 205,149 0 0
ISORAY INC COM 46489V104 235 404,895 SH   DFND 1 404,895 0 0
IZEA INC COM 46603N301 301 66,734 SH   DFND 1 66,734 0 0
JAGUAR ANIMAL HEALTH INC COM 47008L106 135 188,200 SH   DFND 1 188,200 0 0
JPMORGAN CHASE & CO COM 46625H100 2,589 30,000 SH   DFND 1 30,000 0 0
MEI PHARMA INC COM NEW 55279B202 1,968 1,366,859 SH   DFND 1 1,366,859 0 0
MICROSOFT CORP COM 594918104 19,872 319,787 SH   DFND 1 319,787 0 0
MOBILE TELESYSTEMS PJSC SPONSORED ADR 607409109 2,062 226,292 SH   DFND 1 226,292 0 0
MOTOROLA SOLUTIONS INC COM NEW 620076307 8,007 96,600 SH Put DFND 1 96,600 0 0
MOUNTAIN PROV DIAMONDS INC COM NEW 62426E402 213 31,700 SH   DFND 1 31,700 0 0
NABRIVA THERAPEUTICS AG SPONSORED ADR 62957M104 155 26,029 SH   DFND 1 26,029 0 0
NIVALIS THERAPEUTICS INC COM 65481J109 422 188,287 SH   DFND 1 188,287 0 0
NOVAN INC COM 66988N106 1,107 40,986 SH   DFND 1 40,986 0 0
NUVECTRA CORP COM 67075N108 283 56,253 SH   DFND 1 56,253 0 0
NXT ID INC *W EXP 02/09/201 67091J123 742 269,900 SH   DFND 1 269,900 0 0
ONCONOVA THERAPEUTICS INC *W EXP 07/07/202 68232V116 213 93,750 SH   DFND 1 93,750 0 0
ONCOSEC MED INC COM NEW 68234L207 280 227,293 SH   DFND 1 227,293 0 0
OVASCIENCE INC COM 69014Q101 637 416,297 SH   DFND 1 416,297 0 0
PAIN THERAPEUTICS INC COM 69562K100 262 459,667 SH   DFND 1 459,667 0 0
POTASH CORP SASK INC COM 73755L107 1,176 65,000 SH   DFND 1 65,000 0 0
PSIVIDA CORP COM 74440J101 225 131,463 SH   DFND 1 131,463 0 0
QORVO INC COM 74736K101 1,055 20,000 SH Put DFND 1 20,000 0 0
RANDGOLD RES LTD ADR 752344309 5,230 68,504 SH   DFND 1 68,504 0 0
RESEARCH FRONTIERS INC COM 760911107 289 158,937 SH   DFND 1 158,937 0 0
REXAHN PHARMACEUTICALS INC COM 761640101 768 5,409,500 SH   DFND 1 5,409,500 0 0
RF INDS LTD COM PAR $0.01 749552105 191 109,234 SH   DFND 1 109,234 0 0
ROYAL BK CDA MONTREAL QUE CALL 780087902 7,448 110,000 SH Put DFND 1 110,000 0 0
SANGAMO BIOSCIENCES INC COM 800677106 306 100,209 SH   DFND 1 100,209 0 0
SECOND SIGHT MED PRODS INC COM 81362J100 61 31,097 SH   DFND 1 31,097 0 0
SERVICEMASTER GLOBAL HLDGS I COM 81761R109 1,884 50,000 SH   DFND 1 50,000 0 0
SKYWORKS SOLUTIONS INC PUT 83088M952 7,466 100,000 SH Put DFND 1 100,000 0 0
SONOMA PHARMACEUTICALS INC *W EXP 01/21/202 83558L113 1,018 202,014 SH   DFND 1 202,014 0 0
SPARK NETWORKS INC COM 84651P100 251 299,107 SH   DFND 1 299,107 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 28,819 128,925 SH   DFND 1 128,925 0 0
STANLEY FURNITURE CO INC COM NEW 854305208 212 235,047 SH   DFND 1 235,047 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 221 92,219 SH   DFND 1 92,219 0 0
TEEKAY CORPORATION COM Y8564W103 6,132 763,597 SH   DFND 1 763,597 0 0
THE ONE GROUP HOSPITALITY IN COM 88338K103 3,838 1,728,915 SH   DFND 1 1,728,915 0 0
TUESDAY MORNING CORP COM NEW 899035505 295 54,611 SH   DFND 1 54,611 0 0
UQM TECHNOLOGIES INC COM 903213106 243 565,204 SH   DFND 1 565,204 0 0
VERASTEM INC COM 92337C104 386 344,443 SH   DFND 1 344,443 0 0
VITAL THERAPIES INC COM 92847R104 270 62,137 SH   DFND 1 62,137 0 0
VULCAN MATLS CO COM 929160109 10,488 83,800 SH   DFND 1 83,800 0 0
WISDOMTREE TR JAPN HEDGE EQT 97717W851 8,174 165,000 SH   DFND 1 165,000 0 0