The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC COM 004225108 38,038 1,563,435 SH   DFND   0 1,563,435 0
ACORDA THERAPEUTICS INC COM 00484M106 27,432 723,621 SH   DFND   0 723,621 0
ACTAVIS PLC SHS G0083B108 212,466 1,032,142 SH   DFND   0 1,032,142 0
AGILENT TECHNOLOGIES INC COM 00846U101 112,348 2,009,079 SH   DFND   0 2,009,079 0
ALLERGAN INC COM 018490102 91,882 740,383 SH   DFND   0 740,383 0
AMERICAN EXPRESS CO COM 025816109 52,477 582,882 SH   DFND   0 582,882 0
ANACOR PHARMACEUTICALS INC COM 032420101 20,545 1,026,745 SH   DFND   0 1,026,745 0
ANADARKO PETE CORP COM 032511107 18,040 212,833 SH   DFND   0 212,833 0
BLUEBIRD BIO INC COM 09609G100 6,618 291,031 SH   DFND   0 291,031 0
BRISTOL MYERS SQUIBB CO COM 110122108 401,162 7,722,083 SH   DFND   0 7,722,083 0
BRUKER CORP COM 116794108 16,205 711,052 SH   DFND   0 711,052 0
CASTLIGHT HEALTH INC CL B 14862Q100 2,042 96,223 SH   DFND   0 96,223 0
CBS CORP NEW CL B 124857202 72,223 1,168,656 SH   DFND   0 1,168,656 0
CELLADON CORP COM 15117E107 4,591 385,110 SH   DFND   0 385,110 0
CEMEX SAB DE CV SPON ADR NEW 151290889 5,665 448,556 SH   DFND   0 448,556 0
SCHWAB CHARLES CORP NEW COM 808513105 136,411 4,991,258 SH   DFND   0 4,991,258 0
CIGNA CORPORATION COM 125509109 14,202 169,613 SH   DFND   0 169,613 0
CLOVIS ONCOLOGY INC COM 189464100 74,591 1,076,820 SH   DFND   0 1,076,820 0
CTRIP COM INTL LTD AMERICAN DEP SHS 22943F100 46,498 922,209 SH   DFND   0 922,209 0
DENDREON CORP NOTE 2.875% 1/1 24823QAC1 49,801 67,072,000 PRN   DFND   0 67,072,000 0
ENDO INTL PLC SHS G30401106 154,612 2,252,173 SH   DFND   0 2,252,173 0
EXPEDIA INC DEL COM NEW 30212P303 35,120 484,412 SH   DFND   0 484,412 0
FACEBOOK INC CL A 30303M102 35,973 597,161 SH   DFND   0 597,161 0
FOREST LABS INC COM 345838106 7,661 83,033 SH   DFND   0 83,033 0
GILEAD SCIENCES INC COM 375558103 137,456 1,939,832 SH   DFND   0 1,939,832 0
GOOGLE INC CL A 38259P508 295,293 264,953 SH   DFND   0 264,953 0
HALLIBURTON CO COM 406216101 143,386 2,434,807 SH   DFND   0 2,434,807 0
HCA HOLDINGS INC COM 40412C101 250,101 4,763,828 SH   DFND   0 4,763,828 0
HEALTH NET INC COM 42222G108 74,273 2,183,853 SH   DFND   0 2,183,853 0
HUMANA INC COM 444859102 37,466 332,383 SH   DFND   0 332,383 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 21,954 66,571 SH   DFND   0 66,571 0
ISHARES MSCI EMG MKT ETF 464287234 438,918 10,702,700 SH   DFND   0 10,702,700 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 9,563 309,592 SH   DFND   0 309,592 0
KYTHERA BIOPHARMACEUTICALS I COM 501570105 39,899 1,003,492 SH   DFND   0 1,003,492 0
LIBERTY GLOBAL PLC SHS CL C G5480U120 71,213 1,749,276 SH   DFND   0 1,749,276 0
MACQUARIE INFRASTR CO LLC MEMBERSHIP INT 55608B105 59,144 1,032,730 SH   DFND   0 1,032,730 0
MACROGENICS INC COM 556099109 5,822 209,212 SH   DFND   0 209,212 0
MARTIN MARIETTA MATLS INC COM 573284106 83,846 653,261 SH   DFND   0 653,261 0
MCGRAW HILL FINL INC COM 580645109 91,840 1,203,675 SH   DFND   0 1,203,675 0
MCKESSON CORP COM 58155Q103 85,825 486,067 SH   DFND   0 486,067 0
MEDIVATION INC COM 58501N101 16,421 255,105 SH   DFND   0 255,105 0
MOLINA HEALTHCARE INC COM 60855R100 29,226 778,117 SH   DFND   0 778,117 0
MYRIAD GENETICS INC COM 62855J104 1,384 40,491 SH   DFND   0 40,491 0
OMNICARE INC COM 681904108 15,811 264,968 SH   DFND   0 264,968 0
OREXIGEN THERAPEUTICS INC COM 686164104 33,339 5,129,129 SH   DFND   0 5,129,129 0
PERKINELMER INC COM 714046109 5,248 116,477 SH   DFND   0 116,477 0
PFIZER INC COM 717081103 38,765 1,206,879 SH   DFND   0 1,206,879 0
PRICELINE COM INC COM NEW 741503403 53,185 44,622 SH   DFND   0 44,622 0
PROTHENA CORP PLC SHS G72800108 20,763 541,983 SH   DFND   0 541,983 0
REPROS THERAPEUTICS INC COM NEW 76028H209 19,771 1,114,462 SH   DFND   0 1,114,462 0
REVANCE THERAPEUTICS INC COM 761330109 10,108 320,903 SH   DFND   0 320,903 0
RITE AID CORP COM 767754104 36,209 5,774,926 SH   DFND   0 5,774,926 0
SALESFORCE COM INC COM 79466L302 54,223 949,774 SH   DFND   0 949,774 0
SERVICENOW INC COM 81762P102 67,009 1,118,308 SH   DFND   0 1,118,308 0
SPIRIT AIRLS INC COM 848577102 1,144 19,264 SH   DFND   0 19,264 0
STARWOOD HOTELS&RESORTS WRLD COM 85590A401 216,677 2,722,078 SH   DFND   0 2,722,078 0
TABLEAU SOFTWARE INC CL A 87336U105 27,674 363,753 SH   DFND   0 363,753 0
TENET HEALTHCARE CORP COM NEW 88033G407 49,773 1,162,648 SH   DFND   0 1,162,648 0
TEREX CORP NEW COM 880779103 65,883 1,487,208 SH   DFND   0 1,487,208 0
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 570 404,100 SH Call DFND   0 404,100 0
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 180,679 3,419,353 SH   DFND   0 3,419,353 0
THERAPEUTICSMD INC COM 88338N107 15,243 2,415,733 SH   DFND   0 2,415,733 0
THERMO FISHER SCIENTIFIC INC COM 883556102 76,564 636,756 SH   DFND   0 636,756 0
TIME WARNER CABLE INC COM 88732J207 118,999 867,468 SH   DFND   0 867,468 0
TWENTY FIRST CENTY FOX INC CL A 90130A101 128,605 4,022,685 SH   DFND   0 4,022,685 0
VALEANT PHARMACEUTICALS INTL COM 91911K102 106,748 809,743 SH   DFND   0 809,743 0
VULCAN MATLS CO COM 929160109 111,795 1,682,389 SH   DFND   0 1,682,389 0
WALGREEN CO COM 931422109 187,691 2,842,511 SH   DFND   0 2,842,511 0
WORKDAY INC CL A 98138H101 122,436 1,339,125 SH   DFND   0 1,339,125 0
WYNN RESORTS LTD COM 983134107 104,438 470,123 SH   DFND   0 470,123 0
YAHOO INC COM 984332106 88,917 2,476,788 SH   DFND   0 2,476,788 0
YELP INC CL A 985817105 27,942 363,207 SH   DFND   0 363,207 0