The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ABBVIE INC | CALL | 00287Y909 | 53,156 | 930,600 | SH | Call | DFND | 0 | 930,600 | 0 | |
| ABBVIE INC | COM | 00287Y109 | 136,878 | 2,396,328 | SH | DFND | 0 | 2,396,328 | 0 | ||
| ACADIA HEALTHCARE COMPANY IN | COM | 00404A109 | 7,209 | 130,817 | SH | DFND | 0 | 130,817 | 0 | ||
| ACCURAY INC | COM | 004397105 | 34,011 | 5,884,218 | SH | DFND | 0 | 5,884,218 | 0 | ||
| ACORDA THERAPEUTICS INC | NOTE 1.750% 6/1 | 00484MAA4 | 32,115 | 36,008,000 | PRN | DFND | 0 | 36,008,000 | 0 | ||
| ACORDA THERAPEUTICS INC | COM | 00484M106 | 12,650 | 478,268 | SH | DFND | 0 | 478,268 | 0 | ||
| AERIE PHARMACEUTICALS INC | COM | 00771V108 | 28,955 | 2,381,135 | SH | DFND | 0 | 2,381,135 | 0 | ||
| AETNA INC NEW | COM | 00817Y108 | 12,834 | 114,231 | SH | DFND | 0 | 114,231 | 0 | ||
| ALDER BIOPHARMACEUTICALS INC | COM | 014339105 | 86,759 | 3,542,647 | SH | DFND | 0 | 3,542,647 | 0 | ||
| ALIBABA GROUP HLDG LTD | SPONSORED ADS | 01609W102 | 12,652 | 160,096 | SH | DFND | 0 | 160,096 | 0 | ||
| ALLERGAN PLC | SHS | G0177J108 | 84,190 | 314,106 | SH | DFND | 0 | 314,106 | 0 | ||
| ALPHABET INC | CAP STK CL A | 02079K305 | 77,904 | 102,115 | SH | DFND | 0 | 102,115 | 0 | ||
| AMAZON COM INC | COM | 023135106 | 75,786 | 127,664 | SH | DFND | 0 | 127,664 | 0 | ||
| AMERICAN TOWER CORP NEW | COM | 03027X100 | 12,635 | 123,422 | SH | DFND | 0 | 123,422 | 0 | ||
| AMSURG CORP | COM | 03232P405 | 11,371 | 152,424 | SH | DFND | 0 | 152,424 | 0 | ||
| ANTHEM INC | COM | 036752103 | 72,123 | 518,909 | SH | DFND | 0 | 518,909 | 0 | ||
| APPLE INC | COM | 037833100 | 118,227 | 1,084,753 | SH | DFND | 0 | 1,084,753 | 0 | ||
| APPLIED MATLS INC | COM | 038222105 | 33,345 | 1,574,379 | SH | DFND | 0 | 1,574,379 | 0 | ||
| BECTON DICKINSON & CO | COM | 075887109 | 22,195 | 146,190 | SH | DFND | 0 | 146,190 | 0 | ||
| BLACKROCK INC | COM | 09247X101 | 64,422 | 189,158 | SH | DFND | 0 | 189,158 | 0 | ||
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 25,640 | 1,420,511 | SH | DFND | 0 | 1,420,511 | 0 | ||
| BRISTOL MYERS SQUIBB CO | CALL | 110122908 | 57,166 | 894,900 | SH | Call | DFND | 0 | 894,900 | 0 | |
| BRISTOL MYERS SQUIBB CO | CALL | 110122908 | 59,606 | 933,100 | SH | Call | DFND | 0 | 933,100 | 0 | |
| BRISTOL MYERS SQUIBB CO | COM | 110122108 | 118,202 | 1,850,371 | SH | DFND | 0 | 1,850,371 | 0 | ||
| BROOKDALE SR LIVING INC | COM | 112463104 | 31,966 | 2,012,993 | SH | DFND | 0 | 2,012,993 | 0 | ||
| CBRE GROUP INC | CL A | 12504L109 | 12,732 | 441,779 | SH | DFND | 0 | 441,779 | 0 | ||
| CHARTER COMMUNICATIONS INC D | CL A NEW | 16117M305 | 28,947 | 142,999 | SH | DFND | 0 | 142,999 | 0 | ||
| CIRRUS LOGIC INC | COM | 172755100 | 9,735 | 267,373 | SH | DFND | 0 | 267,373 | 0 | ||
| CLOVIS ONCOLOGY INC | NOTE 2.500% 9/1 | 189464AB6 | 3,243 | 4,747,000 | PRN | DFND | 0 | 4,747,000 | 0 | ||
| CLOVIS ONCOLOGY INC | CALL | 189464900 | 15,439 | 804,100 | SH | Call | DFND | 0 | 804,100 | 0 | |
| CLOVIS ONCOLOGY INC | COM | 189464100 | 35,988 | 1,874,384 | SH | DFND | 0 | 1,874,384 | 0 | ||
| CTRIP COM INTL LTD | AMERICAN DEP SHS | 22943F100 | 21,570 | 487,352 | SH | DFND | 0 | 487,352 | 0 | ||
| DAVITA HEALTHCARE PARTNERS I | COM | 23918K108 | 12,738 | 173,585 | SH | DFND | 0 | 173,585 | 0 | ||
| DEXCOM INC | COM | 252131107 | 11,581 | 170,535 | SH | DFND | 0 | 170,535 | 0 | ||
| DIMENSION THERAPEUTICS INC | COM | 25433V105 | 5,523 | 725,169 | SH | DFND | 0 | 725,169 | 0 | ||
| EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 85,476 | 969,007 | SH | DFND | 0 | 969,007 | 0 | ||
| FACEBOOK INC | CL A | 30303M102 | 38,778 | 339,858 | SH | DFND | 0 | 339,858 | 0 | ||
| GILEAD SCIENCES INC | COM | 375558103 | 76,706 | 835,032 | SH | DFND | 0 | 835,032 | 0 | ||
| GLOBAL BLOOD THERAPEUTICS IN | COM | 37890U108 | 11,784 | 742,986 | SH | DFND | 0 | 742,986 | 0 | ||
| HCA HOLDINGS INC | COM | 40412C101 | 159,081 | 2,038,188 | SH | DFND | 0 | 2,038,188 | 0 | ||
| HERBALIFE LTD | NOTE 2.000% 8/1 | 42703MAB9 | 26,764 | 27,735,000 | PRN | DFND | 0 | 27,735,000 | 0 | ||
| HERBALIFE LTD | COM USD SHS | G4412G101 | 30,063 | 488,347 | SH | DFND | 0 | 488,347 | 0 | ||
| HERON THERAPEUTICS INC | COM | 427746102 | 58,365 | 3,073,470 | SH | DFND | 0 | 3,073,470 | 0 | ||
| HOLOGIC INC | COM | 436440101 | 15,680 | 454,488 | SH | DFND | 0 | 454,488 | 0 | ||
| HORTONWORKS INC | COM | 440894103 | 15,322 | 1,355,970 | SH | DFND | 0 | 1,355,970 | 0 | ||
| INNOVIVA INC | COM | 45781M101 | 18,711 | 1,486,214 | SH | DFND | 0 | 1,486,214 | 0 | ||
| INTERSECT ENT INC | COM | 46071F103 | 1,085 | 57,089 | SH | DFND | 0 | 57,089 | 0 | ||
| ISHARES TR | IBOXX HI YD ETF | 464288513 | 23,470 | 287,300 | SH | Call | DFND | 0 | 287,300 | 0 | |
| ISHARES TR | MSCI EMG MKT ETF | 464287234 | 19,868 | 580,100 | SH | Call | DFND | 0 | 580,100 | 0 | |
| ISHARES TR | NASDQ BIOTEC ETF | 464287956 | 110,766 | 424,700 | SH | Call | DFND | 0 | 424,700 | 0 | |
| ISHARES TR | NASDQ BIOTEC ETF | 464287556 | 20,999 | 80,513 | SH | DFND | 0 | 80,513 | 0 | ||
| JAZZ PHARMACEUTICALS PLC | CALL | G50871905 | 27,677 | 212,000 | SH | Call | DFND | 0 | 212,000 | 0 | |
| JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 99,790 | 764,384 | SH | DFND | 0 | 764,384 | 0 | ||
| JD COM INC | SPON ADR CL A | 47215P106 | 6,106 | 230,412 | SH | DFND | 0 | 230,412 | 0 | ||
| KITE PHARMA INC | COM | 49803L109 | 14,405 | 313,765 | SH | DFND | 0 | 313,765 | 0 | ||
| KURA ONCOLOGY INC | COM | 50127T109 | 6,245 | 1,541,952 | SH | DFND | 0 | 1,541,952 | 0 | ||
| LAM RESEARCH CORP | COM | 512807108 | 90,748 | 1,098,646 | SH | DFND | 0 | 1,098,646 | 0 | ||
| LENDINGCLUB CORP | COM | 52603A109 | 40,816 | 4,917,584 | SH | DFND | 0 | 4,917,584 | 0 | ||
| MARKETAXESS HLDGS INC | COM | 57060D108 | 13,127 | 105,161 | SH | DFND | 0 | 105,161 | 0 | ||
| MEDICINES CO | NOTE 2.500% 1/1 | 584688AE5 | 14,167 | 12,482,000 | PRN | DFND | 0 | 12,482,000 | 0 | ||
| MEDICINES CO | COM | 584688105 | 70,727 | 2,226,207 | SH | DFND | 0 | 2,226,207 | 0 | ||
| MICROSOFT CORP | COM | 594918104 | 75,505 | 1,367,103 | SH | DFND | 0 | 1,367,103 | 0 | ||
| MYOKARDIA INC | COM | 62857M105 | 8,189 | 764,632 | SH | DFND | 0 | 764,632 | 0 | ||
| NETFLIX INC | COM | 64110L106 | 37,812 | 369,873 | SH | DFND | 0 | 369,873 | 0 | ||
| OREXIGEN THERAPEUTICS INC | NOTE 2.750%12/0 | 686164AB0 | 6,629 | 16,072,000 | PRN | DFND | 0 | 16,072,000 | 0 | ||
| PALO ALTO NETWORKS INC | COM | 697435105 | 81,123 | 497,262 | SH | DFND | 0 | 497,262 | 0 | ||
| PAYPAL HLDGS INC | COM | 70450Y103 | 57,408 | 1,487,245 | SH | DFND | 0 | 1,487,245 | 0 | ||
| PENUMBRA INC | COM | 70975L107 | 2,900 | 63,045 | SH | DFND | 0 | 63,045 | 0 | ||
| PIONEER NAT RES CO | COM | 723787107 | 12,524 | 88,985 | SH | DFND | 0 | 88,985 | 0 | ||
| RITE AID CORP | COM | 767754104 | 15,389 | 1,888,169 | SH | DFND | 0 | 1,888,169 | 0 | ||
| SAGE THERAPEUTICS INC | COM | 78667J108 | 6,350 | 198,058 | SH | DFND | 0 | 198,058 | 0 | ||
| SALESFORCE COM INC | COM | 79466L302 | 25,951 | 351,492 | SH | DFND | 0 | 351,492 | 0 | ||
| SPDR SERIES TRUST | S&P BIOTECH | 78464A870 | 28,103 | 544,000 | SH | Call | DFND | 0 | 544,000 | 0 | |
| SPECTRANETICS CORP | MTNF 2.625% 6/0 | 84760CAA5 | 9,408 | 11,825,000 | PRN | DFND | 0 | 11,825,000 | 0 | ||
| SPECTRANETICS CORP | COM | 84760C107 | 4,263 | 293,580 | SH | DFND | 0 | 293,580 | 0 | ||
| SYNCHRONY FINL | COM | 87165B103 | 50,614 | 1,766,019 | SH | DFND | 0 | 1,766,019 | 0 | ||
| TWENTY FIRST CENTY FOX INC | CL A | 90130A101 | 31,587 | 1,132,946 | SH | DFND | 0 | 1,132,946 | 0 | ||
| UNIVERSAL HLTH SVCS INC | CL B | 913903100 | 67,530 | 541,456 | SH | DFND | 0 | 541,456 | 0 | ||
| VOYAGER THERAPEUTICS INC | COM | 92915B106 | 7,345 | 893,541 | SH | DFND | 0 | 893,541 | 0 | ||
| VULCAN MATLS CO | COM | 929160109 | 52,054 | 493,071 | SH | DFND | 0 | 493,071 | 0 | ||
| WALGREENS BOOTS ALLIANCE INC | COM | 931427108 | 101,031 | 1,199,318 | SH | DFND | 0 | 1,199,318 | 0 | ||
| ZELTIQ AESTHETICS INC | COM | 98933Q108 | 24,393 | 898,129 | SH | DFND | 0 | 898,129 | 0 | ||