The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AAC HLDGS INC COM 000307108 35,631 1,601,376 SH   DFND 1 1,601,376 0 0
ACCURAY INC NOTE 3.750% 8/0 004397AB1 30,841 30,511,000 PRN   DFND 1 30,511,000 0 0
ACHILLION PHARMACEUTICALS IN COM 00448Q201 11,519 1,667,000 SH   DFND 1 1,667,000 0 0
ACURA PHARMACEUTICALS INC COM PAR $0.01 00509L802 2,410 1,025,641 SH   DFND 1 1,025,641 0 0
ADEPTUS HEALTH INC CL A 006855100 44,041 545,328 SH   DFND 1 545,328 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 14,332 807,875 SH   DFND 1 807,875 0 0
AETNA INC NEW COM 00817Y108 69,589 636,039 SH   DFND 1 636,039 0 0
AKARI THERAPEUTICS PLC SPONSORED ADR 00972G108 27,611 1,150,700 SH   DFND 1 1,150,700 0 0
AKORN INC COM 009728106 4,580 160,667 SH   DFND 1 160,667 0 0
ALCOBRA LTD SHS M2239P109 6,024 997,349 SH   DFND 1 997,349 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 4,026 690,538 SH   DFND 1 690,538 0 0
ALIMERA SCIENCES INC COM 016259103 9,769 4,420,580 SH   DFND 1 4,420,580 0 0
ALLIQUA BIOMEDICAL INC COM NEW 019621200 5,318 1,677,546 SH   DFND 1 1,677,546 0 0
ALLSCRIPTS HEALTHCARE SOLUTN NOTE 1.250% 7/0 01988PAD0 99,819 100,750,000 PRN   DFND 1 100,750,000 0 0
ALPHATEC HOLDINGS INC COM 02081G102 1,644 4,982,738 SH   DFND 1 4,982,738 0 0
ANTARES PHARMA INC COM 036642106 26,267 15,451,124 SH   DFND 1 15,451,124 0 0
ANTHEM INC COM 036752103 19,713 140,806 SH   DFND 1 140,806 0 0
ARENA PHARMACEUTICALS INC COM 040047102 8,864 4,640,877 SH   DFND 1 4,640,877 0 0
ARRAY BIOPHARMA INC COM 04269X105 44,366 9,729,361 SH   DFND 1 9,729,361 0 0
ARRAY BIOPHARMA INC NOTE 3.000% 6/0 04269XAA3 43,864 45,000,000 PRN   DFND 1 45,000,000 0 0
ATYR PHARMA INC COM 002120103 4,735 461,530 SH   DFND 1 461,530 0 0
AXOGEN INC COM 05463X106 13,932 3,381,439 SH   DFND 1 3,381,439 0 0
AXOVANT SCIENCES LTD COM G0750W104 6,262 484,664 SH   DFND 1 484,664 0 0
BIODELIVERY SCIENCES INTL IN COM 09060J106 3,892 700,000 SH   DFND 1 700,000 0 0
BIOGEN INC COM 09062X103 1,605 5,500 SH   DFND 1 5,500 0 0
BIOTELEMETRY INC COM 090672106 2,720 222,215 SH   DFND 1 222,215 0 0
BIOTIE THERAPIES OYJ SPONSORED ADR 09074D103 2,874 219,558 SH   DFND 1 219,558 0 0
BLUEBIRD BIO INC COM 09609G100 41,321 483,000 SH   DFND 1 483,000 0 0
BOVIE MEDICAL CORP COM 10211F100 1,342 688,229 SH   DFND 1 688,229 0 0
BROOKDALE SR LIVING INC COM 112463104 12,789 557,000 SH   DFND 1 557,000 0 0
CARDINAL HEALTH INC COM 14149Y108 615 8,000 SH   DFND 1 8,000 0 0
CAREDX INC COM 14167L103 955 229,000 SH   DFND 1 229,000 0 0
CAS MED SYS INC COM PAR $0.004 124769209 4,000 3,200,000 SH   DFND 1 3,200,000 0 0
CATABASIS PHARMACEUTICALS IN COM 14875P107 5,084 628,482 SH   DFND 1 628,482 0 0
CHARLES RIV LABS INTL INC COM 159864107 36,917 581,188 SH   DFND 1 581,188 0 0
CIDARA THERAPEUTICS INC COM 171757107 3,022 237,583 SH   DFND 1 237,583 0 0
CORSICANTO LTD NOTE 3.500% 1/1 220480AB3 917 1,000,000 PRN   DFND 1 1,000,000 0 0
DAVITA HEALTHCARE PARTNERS I COM 23918K108 51,788 716,000 SH   DFND 1 716,000 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 16,438 461,869 SH   DFND 1 461,869 0 0
DERMA SCIENCES INC COM PAR $.01 249827502 4,720 1,002,201 SH   DFND 1 1,002,201 0 0
DISCOVERY LABORATORIES INC N COM NEW 254668403 2,561 8,537,995 SH   DFND 1 8,537,995 0 0
DYAX CORP COM 26746E103 54,555 2,857,773 SH   DFND 1 2,857,773 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 13,807 97,119 SH   DFND 1 97,119 0 0
EGALET CORP COM 28226B104 6,288 477,123 SH   DFND 1 477,123 0 0
EHEALTH INC COM 28238P109 41,819 3,264,588 SH   DFND 1 3,264,588 0 0
ENDOCHOICE HLDGS INC COM 29272U103 20,422 1,797,709 SH   DFND 1 1,797,709 0 0
ENDOLOGIX INC COM 29266S106 28,776 2,347,113 SH   DFND 1 2,347,113 0 0
ENDOLOGIX INC NOTE 2.250%12/1 29266SAA4 36,877 40,941,000 PRN   DFND 1 40,941,000 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 778 32,970 SH   DFND 1 32,970 0 0
ESSA PHARMA INC COM 29668H104 11,580 1,859,282 SH   DFND 1 1,859,282 0 0
FLAMEL TECHNOLOGIES SA SPONSORED ADR 338488109 66,428 4,072,809 SH   DFND 1 4,072,809 0 0
FLUIDIGM CORP DEL NOTE 2.750% 2/0 34385PAA6 25,235 35,000,000 PRN   DFND 1 35,000,000 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 6,956 948,934 SH   DFND 1 948,934 0 0
GALAPAGOS NV SPON ADR 36315X101 17,957 441,085 SH   DFND 1 441,085 0 0
GENESIS HEALTHCARE INC CL A COM 37185X106 9,429 1,538,232 SH   DFND 1 1,538,232 0 0
GENOCEA BIOSCIENCES INC COM 372427104 3,434 501,257 SH   DFND 1 501,257 0 0
GENOMIC HEALTH INC COM 37244C101 23,139 1,093,516 SH   DFND 1 1,093,516 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 87,771 2,282,722 SH   DFND 1 2,282,722 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 37,549 890,620 SH   DFND 1 890,620 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 35,737 391,122 SH   DFND 1 391,122 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 676 50,349 SH   DFND 1 50,349 0 0
HEALTHWAYS INC COM 422245100 27,411 2,465,042 SH   DFND 1 2,465,042 0 0
HEALTHWAYS INC NOTE 1.500% 7/0 422245AB6 47,869 51,925,000 PRN   DFND 1 51,925,000 0 0
HEARTWARE INTL INC COM 422368100 7,020 134,200 SH   DFND 1 134,200 0 0
HEARTWARE INTL INC NOTE 3.500%12/1 422368AA8 37,712 39,226,000 PRN   DFND 1 39,226,000 0 0
HORIZON PHARMA PLC SHS G4617B105 160,173 8,081,407 SH   DFND 1 8,081,407 0 0
ILLUMINA INC COM 452327109 1,934 11,000 SH   DFND 1 11,000 0 0
IMPRIVATA INC COM 45323J103 20,456 1,151,140 SH   DFND 1 1,151,140 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 33,046 3,910,721 SH   DFND 1 3,910,721 0 0
INVUITY INC COM NEW 46187J205 2,819 201,068 SH   DFND 1 201,068 0 0
INVITAE CORP COM 46185L103 1,203 166,666 SH   DFND 1 166,666 0 0
JAZZ INVESTMENTS I LTD NOTE 1.875% 8/1 472145AB7 5,098 5,000,000 PRN   DFND 1 5,000,000 0 0
KEMPHARM INC COM 488445107 27,529 1,420,497 SH   DFND 1 1,420,497 0 0
KINDRED BIOSCIENCES INC COM 494577109 1,452 279,204 SH   DFND 1 279,204 0 0
KINDRED HEALTHCARE INC COM 494580103 1,136 72,100 SH   DFND 1 72,100 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 1,806 65,000 SH   DFND 1 65,000 0 0
LOXO ONCOLOGY INC COM 548862101 19,022 1,088,225 SH   DFND 1 1,088,225 0 0
MACROGENICS INC COM 556099109 11,931 557,000 SH   DFND 1 557,000 0 0
MALLINCKRODT PUB LTD CO SHS G5785G107 20,329 317,931 SH   DFND 1 317,931 0 0
MAZOR ROBOTICS LTD SPONSORED ADS 57886P103 2,525 228,909 SH   DFND 1 228,909 0 0
MCKESSON CORP COM 58155Q103 34,350 185,646 SH   DFND 1 185,646 0 0
MIRATI THERAPEUTICS INC COM 60468T105 3,788 110,049 SH   DFND 1 110,049 0 0
MYLAN N V SHS EURO N59465109 51,332 1,275,000 SH   DFND 1 1,275,000 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 14,090 880,622 SH   DFND 1 880,622 0 0
NEOS THERAPEUTICS INC COM 64052L106 9,630 458,332 SH   DFND 1 458,332 0 0
NIVALIS THERAPEUTICS INC COM 65481J109 48,409 3,732,412 SH   DFND 1 3,732,412 0 0
NOVAVAX INC COM 670002104 7,353 1,040,000 SH   DFND 1 1,040,000 0 0
NUVASIVE INC COM 670704105 12,791 265,272 SH   DFND 1 265,272 0 0
NXSTAGE MEDICAL INC COM 67072V103 99,636 6,318,050 SH   DFND 1 6,318,050 0 0
OPHTHOTECH CORP COM 683745103 405 10,000 SH   DFND 1 10,000 0 0
ORTHOFIX INTL N V COM N6748L102 12,165 360,459 SH   DFND 1 360,459 0 0
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 7,016 519,670 SH   DFND 1 519,670 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 8,000 2,185,771 SH   DFND 1 2,185,771 0 0
PACIRA PHARMACEUTICALS INC COM 695127100 28,872 702,485 SH   DFND 1 702,485 0 0
PALATIN TECHNOLOGIES INC COM PAR $ .01 696077403 1,620 2,000,000 SH   DFND 1 2,000,000 0 0
PENUMBRA INC COM 70975L107 4,010 100,000 SH   DFND 1 100,000 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 14,058 329,837 SH   DFND 1 329,837 0 0
POZEN INC COM 73941U102 260 44,583 SH   DFND 1 44,583 0 0
PRONAI THERAPEUTICS INC COM 74346L101 27,669 1,348,401 SH   DFND 1 1,348,401 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 3,051 209,398 SH   DFND 1 209,398 0 0
PROTEON THERAPEUTICS INC COM 74371L109 17,601 1,265,343 SH   DFND 1 1,265,343 0 0
PSIVIDA CORP COM 74440J101 3,548 972,110 SH   DFND 1 972,110 0 0
REGENXBIO INC COM 75901B107 29,444 1,336,542 SH   DFND 1 1,336,542 0 0
RELYPSA INC COM 759531106 20,380 1,101,000 SH   DFND 1 1,101,000 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 5,923 2,397,855 SH   DFND 1 2,397,855 0 0
RITE AID CORP COM 767754104 25,632 4,222,800 SH   DFND 1 4,222,800 0 0
SAGE THERAPEUTICS INC COM 78667J108 27,468 649,064 SH   DFND 1 649,064 0 0
SCYNEXIS INC COM 811292101 5,043 692,781 SH   DFND 1 692,781 0 0
SELECT MED HLDGS CORP COM 81619Q105 593 55,000 SH   DFND 1 55,000 0 0
SPECTRANETICS CORP MTNF 2.625% 6/0 84760CAA5 30,252 39,831,000 PRN   DFND 1 39,831,000 0 0
STEADYMED LTD SHS M84920103 4,669 1,315,169 SH   DFND 1 1,315,169 0 0
STREAMLINE HEALTH SOLUTIONS COM 86323X106 5,205 2,272,759 SH   DFND 1 2,272,759 0 0
SYNERON MEDICAL LTD ORD SHS M87245102 14,865 2,079,013 SH   DFND 1 2,079,013 0 0
TENET HEALTHCARE CORP COM NEW 88033G407 1,019 27,602 SH   DFND 1 27,602 0 0
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 34,723 615,000 SH   DFND 1 615,000 0 0
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 31,053 550,000 SH Call DFND 1 550,000 0 0
TONIX PHARMACEUTICALS HLDG C COM NEW 890260201 6,959 1,315,551 SH   DFND 1 1,315,551 0 0
TRACON PHARMACEUTICALS INC COM 89237H100 4,738 485,000 SH   DFND 1 485,000 0 0
TRANSENTERIX INC COM NEW 89366M201 140 61,819 SH   DFND 1 61,819 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 2,245 172,307 SH   DFND 1 172,307 0 0
TRINITY BIOTECH PLC SPON ADR NEW 896438306 2,814 246,000 SH   DFND 1 246,000 0 0
TRUPANION INC COM 898202106 11,921 1,578,925 SH   DFND 1 1,578,925 0 0
UNIVERSAL AMERN CORP NEW COM 91338E101 33,727 4,930,787 SH   DFND 1 4,930,787 0 0
VALEANT PHARMACEUTICALS INTL COM 91911K102 281 1,575 SH   DFND 1 1,575 0 0
VANDA PHARMACEUTICALS INC COM 921659108 53,965 4,784,157 SH   DFND 1 4,784,157 0 0
VERACYTE INC COM 92337F107 1,797 383,256 SH   DFND 1 383,256 0 0
VERSARTIS INC COM 92529L102 3,194 277,000 SH   DFND 1 277,000 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 1,927 18,500 SH   DFND 1 18,500 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 38,513 463,457 SH   DFND 1 463,457 0 0
WEBMD HEALTH CORP NOTE 1.500%12/0 94770VAK8 23,640 23,000,000 PRN   DFND 1 23,000,000 0 0
XENCOR INC COM 98401F105 21,855 1,787,000 SH   DFND 1 1,787,000 0 0
XENOPORT INC COM 98411C100 11,955 3,445,374 SH   DFND 1 3,445,374 0 0
ZAFGEN INC COM 98885E103 17,683 553,472 SH   DFND 1 553,472 0 0
ZELTIQ AESTHETICS INC COM 98933Q108 13,455 420,063 SH   DFND 1 420,063 0 0