The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AAC HLDGS INC | COM | 000307108 | 45,417 | 2,294,936 | SH | DFND | 1 | 2,294,936 | 0 | 0 | |
| ABIOMED INC | COM | 003654100 | 4,721 | 49,797 | SH | DFND | 1 | 49,797 | 0 | 0 | |
| ACCELERON PHARMA INC | COM | 00434H108 | 9,329 | 353,491 | SH | DFND | 1 | 353,491 | 0 | 0 | |
| ACORDA THERAPEUTICS INC | COM | 00484M106 | 27,228 | 1,029,410 | SH | DFND | 1 | 1,029,410 | 0 | 0 | |
| ACURA PHARMACEUTICALS INC | COM PAR $0.01 | 00509L802 | 2,903 | 1,025,641 | SH | DFND | 1 | 1,025,641 | 0 | 0 | |
| ADEPTUS HEALTH INC | CL A | 006855100 | 53,126 | 956,533 | SH | DFND | 1 | 956,533 | 0 | 0 | |
| AERIE PHARMACEUTICALS INC | COM | 00771V108 | 32,011 | 2,632,482 | SH | DFND | 1 | 2,632,482 | 0 | 0 | |
| AETNA INC NEW | COM | 00817Y108 | 66,451 | 591,465 | SH | DFND | 1 | 591,465 | 0 | 0 | |
| AGILE THERAPEUTICS INC | COM | 00847L100 | 1,553 | 250,000 | SH | DFND | 1 | 250,000 | 0 | 0 | |
| AKARI THERAPEUTICS PLC | SPONSORED ADR | 00972G108 | 16,110 | 1,150,700 | SH | DFND | 1 | 1,150,700 | 0 | 0 | |
| ALCOBRA LTD | SHS | M2239P109 | 4,055 | 1,069,914 | SH | DFND | 1 | 1,069,914 | 0 | 0 | |
| ALDEYRA THERAPEUTICS INC | COM | 01438T106 | 1,975 | 471,259 | SH | DFND | 1 | 471,259 | 0 | 0 | |
| ALIMERA SCIENCES INC | COM | 016259103 | 10,287 | 5,878,015 | SH | DFND | 1 | 5,878,015 | 0 | 0 | |
| ALLERGAN PLC | SHS | G0177J108 | 938 | 3,500 | SH | DFND | 1 | 3,500 | 0 | 0 | |
| ALLIQUA BIOMEDICAL INC | COM NEW | 019621200 | 547 | 667,246 | SH | DFND | 1 | 667,246 | 0 | 0 | |
| ALPHATEC HOLDINGS INC | COM | 02081G102 | 1,196 | 4,982,738 | SH | DFND | 1 | 4,982,738 | 0 | 0 | |
| ANTHEM INC | COM | 036752103 | 14,177 | 102,000 | SH | DFND | 1 | 102,000 | 0 | 0 | |
| ARALEZ PHARMACEUTICALS INC | COM | 03852X100 | 5,838 | 1,644,583 | SH | DFND | 1 | 1,644,583 | 0 | 0 | |
| ARDELYX INC | COM | 039697107 | 2,137 | 275,000 | SH | DFND | 1 | 275,000 | 0 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 28,112 | 9,529,361 | SH | DFND | 1 | 9,529,361 | 0 | 0 | |
| ARRAY BIOPHARMA INC | NOTE 3.000% 6/0 | 04269XAA3 | 35,876 | 45,000,000 | PRN | DFND | 1 | 45,000,000 | 0 | 0 | |
| AVEXIS INC | COM | 05366U100 | 60,928 | 2,236,701 | SH | DFND | 1 | 2,236,701 | 0 | 0 | |
| AXOGEN INC | COM | 05463X106 | 18,125 | 3,381,439 | SH | DFND | 1 | 3,381,439 | 0 | 0 | |
| CAREDX INC | COM | 14167L103 | 1,136 | 229,000 | SH | DFND | 1 | 229,000 | 0 | 0 | |
| CAS MED SYS INC | COM PAR $0.004 | 124769209 | 4,544 | 3,200,000 | SH | DFND | 1 | 3,200,000 | 0 | 0 | |
| CATABASIS PHARMACEUTICALS IN | COM | 14875P107 | 3,244 | 643,580 | SH | DFND | 1 | 643,580 | 0 | 0 | |
| CEPHEID | DBCV 1.250% 2/0 | 15670RAC1 | 6,917 | 7,750,000 | PRN | DFND | 1 | 7,750,000 | 0 | 0 | |
| CIDARA THERAPEUTICS INC | COM | 171757107 | 873 | 68,779 | SH | DFND | 1 | 68,779 | 0 | 0 | |
| CORSICANTO LTD | NOTE 3.500% 1/1 | 220480AB3 | 821 | 1,000,000 | PRN | DFND | 1 | 1,000,000 | 0 | 0 | |
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 12,170 | 943,433 | SH | DFND | 1 | 943,433 | 0 | 0 | |
| DAVITA HEALTHCARE PARTNERS I | COM | 23918K108 | 60,318 | 822,000 | SH | DFND | 1 | 822,000 | 0 | 0 | |
| DBV TECHNOLOGIES S A | SPONSORED ADR | 23306J101 | 26,620 | 817,806 | SH | DFND | 1 | 817,806 | 0 | 0 | |
| EDITAS MEDICINE INC | COM | 28106W103 | 59,043 | 1,709,400 | SH | DFND | 1 | 1,709,400 | 0 | 0 | |
| EGALET CORP | COM | 28226B104 | 4,096 | 597,123 | SH | DFND | 1 | 597,123 | 0 | 0 | |
| EHEALTH INC | COM | 28238P109 | 30,654 | 3,264,588 | SH | DFND | 1 | 3,264,588 | 0 | 0 | |
| ENDOCHOICE HLDGS INC | COM | 29272U103 | 9,499 | 1,823,309 | SH | DFND | 1 | 1,823,309 | 0 | 0 | |
| ENDOLOGIX INC | COM | 29266S106 | 4,764 | 569,895 | SH | DFND | 1 | 569,895 | 0 | 0 | |
| ENDOLOGIX INC | NOTE 2.250%12/1 | 29266SAA4 | 29,871 | 40,941,000 | PRN | DFND | 1 | 40,941,000 | 0 | 0 | |
| ENDOLOGIX INC | NOTE 3.250%11/0 | 29266SAB2 | 38,632 | 40,000,000 | PRN | DFND | 1 | 40,000,000 | 0 | 0 | |
| ESSA PHARMA INC | COM | 29668H104 | 8,408 | 2,587,215 | SH | DFND | 1 | 2,587,215 | 0 | 0 | |
| FIVE PRIME THERAPEUTICS INC | COM | 33830X104 | 27,628 | 680,000 | SH | DFND | 1 | 680,000 | 0 | 0 | |
| FLAMEL TECHNOLOGIES SA | SPONSORED ADR | 338488109 | 44,964 | 4,072,809 | SH | DFND | 1 | 4,072,809 | 0 | 0 | |
| FLUIDIGM CORP DEL | NOTE 2.750% 2/0 | 34385PAA6 | 15,353 | 27,715,000 | PRN | DFND | 1 | 27,715,000 | 0 | 0 | |
| FOAMIX PHARMACEUTICALS LTD | SHS | M46135105 | 6,187 | 948,934 | SH | DFND | 1 | 948,934 | 0 | 0 | |
| GALAPAGOS NV | SPON ADR | 36315X101 | 13,701 | 327,626 | SH | DFND | 1 | 327,626 | 0 | 0 | |
| GENOCEA BIOSCIENCES INC | COM | 372427104 | 6,093 | 787,257 | SH | DFND | 1 | 787,257 | 0 | 0 | |
| GLAXOSMITHKLINE PLC | SPONSORED ADR | 37733W105 | 67,937 | 1,675,385 | SH | DFND | 1 | 1,675,385 | 0 | 0 | |
| GLOBAL BLOOD THERAPEUTICS IN | COM | 37890U108 | 18,934 | 1,193,811 | SH | DFND | 1 | 1,193,811 | 0 | 0 | |
| GW PHARMACEUTICALS PLC | ADS | 36197T103 | 48,656 | 674,373 | SH | DFND | 1 | 674,373 | 0 | 0 | |
| HEALTHWAYS INC | COM | 422245100 | 24,977 | 2,475,387 | SH | DFND | 1 | 2,475,387 | 0 | 0 | |
| HEALTHWAYS INC | NOTE 1.500% 7/0 | 422245AB6 | 70,595 | 76,925,000 | PRN | DFND | 1 | 76,925,000 | 0 | 0 | |
| HEARTWARE INTL INC | COM | 422368100 | 27,355 | 870,634 | SH | DFND | 1 | 870,634 | 0 | 0 | |
| HEARTWARE INTL INC | NOTE 3.500%12/1 | 422368AA8 | 36,498 | 39,226,000 | PRN | DFND | 1 | 39,226,000 | 0 | 0 | |
| HORIZON PHARMA INVT LTD | NOTE 2.500% 3/1 | 44052TAB7 | 70,475 | 82,600,000 | PRN | DFND | 1 | 82,600,000 | 0 | 0 | |
| HORIZON PHARMA PLC | SHS | G4617B105 | 227,676 | 13,740,261 | SH | DFND | 1 | 13,740,261 | 0 | 0 | |
| IMPRIVATA INC | COM | 45323J103 | 12,420 | 983,366 | SH | DFND | 1 | 983,366 | 0 | 0 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 23,182 | 4,398,862 | SH | DFND | 1 | 4,398,862 | 0 | 0 | |
| INVUITY INC | COM NEW | 46187J205 | 9,581 | 1,327,009 | SH | DFND | 1 | 1,327,009 | 0 | 0 | |
| JAZZ INVESTMENTS I LTD | NOTE 1.875% 8/1 | 472145AB7 | 5,111 | 5,000,000 | PRN | DFND | 1 | 5,000,000 | 0 | 0 | |
| KEMPHARM INC | COM | 488445107 | 20,597 | 1,420,497 | SH | DFND | 1 | 1,420,497 | 0 | 0 | |
| LOXO ONCOLOGY INC | COM | 548862101 | 6,862 | 251,000 | SH | DFND | 1 | 251,000 | 0 | 0 | |
| MACROGENICS INC | COM | 556099109 | 9,711 | 517,920 | SH | DFND | 1 | 517,920 | 0 | 0 | |
| MCKESSON CORP | COM | 58155Q103 | 27,519 | 175,000 | SH | DFND | 1 | 175,000 | 0 | 0 | |
| MYLAN N V | SHS EURO | N59465109 | 84,938 | 1,832,535 | SH | DFND | 1 | 1,832,535 | 0 | 0 | |
| MYOKARDIA INC | COM | 62857M105 | 4,014 | 374,800 | SH | DFND | 1 | 374,800 | 0 | 0 | |
| NANOSTRING TECHNOLOGIES INC | COM | 63009R109 | 9,227 | 606,222 | SH | DFND | 1 | 606,222 | 0 | 0 | |
| NEOS THERAPEUTICS INC | COM | 64052L106 | 4,945 | 458,332 | SH | DFND | 1 | 458,332 | 0 | 0 | |
| NIVALIS THERAPEUTICS INC | COM | 65481J109 | 15,564 | 3,732,412 | SH | DFND | 1 | 3,732,412 | 0 | 0 | |
| NOVAVAX INC | COM | 670002104 | 12,674 | 2,456,261 | SH | DFND | 1 | 2,456,261 | 0 | 0 | |
| NXSTAGE MEDICAL INC | COM | 67072V103 | 82,535 | 5,506,028 | SH | DFND | 1 | 5,506,028 | 0 | 0 | |
| OCERA THERAPEUTICS INC | COM | 67552A108 | 221 | 75,293 | SH | DFND | 1 | 75,293 | 0 | 0 | |
| OXFORD IMMUNOTEC GLOBAL PLC | ORD SHS | G6855A103 | 4,604 | 464,541 | SH | DFND | 1 | 464,541 | 0 | 0 | |
| PALATIN TECHNOLOGIES INC | COM PAR $ .01 | 696077403 | 532 | 985,693 | SH | DFND | 1 | 985,693 | 0 | 0 | |
| PFIZER INC | COM | 717081103 | 741 | 25,000 | SH | DFND | 1 | 25,000 | 0 | 0 | |
| PORTOLA PHARMACEUTICALS INC | COM | 737010108 | 63,032 | 3,089,785 | SH | DFND | 1 | 3,089,785 | 0 | 0 | |
| PRONAI THERAPEUTICS INC | COM | 74346L101 | 20,229 | 3,001,302 | SH | DFND | 1 | 3,001,302 | 0 | 0 | |
| PROTEON THERAPEUTICS INC | COM | 74371L109 | 9,794 | 1,265,343 | SH | DFND | 1 | 1,265,343 | 0 | 0 | |
| PSIVIDA CORP | COM | 74440J101 | 4,001 | 1,492,824 | SH | DFND | 1 | 1,492,824 | 0 | 0 | |
| RELYPSA INC | COM | 759531106 | 25,386 | 1,873,471 | SH | DFND | 1 | 1,873,471 | 0 | 0 | |
| REGENXBIO INC | COM | 75901B107 | 12,626 | 1,169,042 | SH | DFND | 1 | 1,169,042 | 0 | 0 | |
| RENNOVA HEALTH INC | *W EXP 12/30/202 | 759757115 | 51 | 645,161 | SH | DFND | 1 | 645,161 | 0 | 0 | |
| RENNOVA HEALTH INC | COM | 759757107 | 265 | 353,933 | SH | DFND | 1 | 353,933 | 0 | 0 | |
| RIGEL PHARMACEUTICALS INC | COM NEW | 766559603 | 4,988 | 2,397,855 | SH | DFND | 1 | 2,397,855 | 0 | 0 | |
| RITE AID CORP | COM | 767754104 | 19,504 | 2,393,072 | SH | DFND | 1 | 2,393,072 | 0 | 0 | |
| SAGE THERAPEUTICS INC | COM | 78667J108 | 35,704 | 1,113,654 | SH | DFND | 1 | 1,113,654 | 0 | 0 | |
| SCYNEXIS INC | COM | 811292101 | 3,417 | 848,000 | SH | DFND | 1 | 848,000 | 0 | 0 | |
| SELECT MED HLDGS CORP | COM | 81619Q105 | 6,603 | 559,097 | SH | DFND | 1 | 559,097 | 0 | 0 | |
| SPECTRANETICS CORP | MTNF 2.625% 6/0 | 84760CAA5 | 23,643 | 29,831,000 | PRN | DFND | 1 | 29,831,000 | 0 | 0 | |
| STEADYMED LTD | SHS | M84920103 | 3,313 | 1,346,744 | SH | DFND | 1 | 1,346,744 | 0 | 0 | |
| STREAMLINE HEALTH SOLUTIONS | COM | 86323X106 | 935 | 662,971 | SH | DFND | 1 | 662,971 | 0 | 0 | |
| TONIX PHARMACEUTICALS HLDG C | COM NEW | 890260201 | 3,170 | 1,315,551 | SH | DFND | 1 | 1,315,551 | 0 | 0 | |
| TRACON PHARMACEUTICALS INC | COM | 89237H100 | 2,776 | 397,085 | SH | DFND | 1 | 397,085 | 0 | 0 | |
| TRILLIUM THERAPEUTICS INC | COM NEW | 89620X506 | 1,594 | 172,307 | SH | DFND | 1 | 172,307 | 0 | 0 | |
| TRUPANION INC | COM | 898202106 | 1,529 | 155,236 | SH | DFND | 1 | 155,236 | 0 | 0 | |
| UNIVERSAL AMERN CORP NEW | COM | 91338E101 | 37,738 | 5,285,500 | SH | DFND | 1 | 5,285,500 | 0 | 0 | |
| VANDA PHARMACEUTICALS INC | COM | 921659108 | 50,132 | 5,996,691 | SH | DFND | 1 | 5,996,691 | 0 | 0 | |
| VERACYTE INC | COM | 92337F107 | 892 | 165,097 | SH | DFND | 1 | 165,097 | 0 | 0 | |
| VOYAGER THERAPEUTICS INC | COM | 92915B106 | 2,054 | 235,294 | SH | DFND | 1 | 235,294 | 0 | 0 | |
| WALGREENS BOOTS ALLIANCE INC | COM | 931427108 | 43,085 | 511,457 | SH | DFND | 1 | 511,457 | 0 | 0 | |
| WRIGHT MED GROUP INC | NOTE 2.000% 2/1 | 98235TAE7 | 35,961 | 40,050,000 | PRN | DFND | 1 | 40,050,000 | 0 | 0 | |
| WRIGHT MED GROUP N V | ORD SHS 0.03 PAR | N96617118 | 498 | 30,000 | SH | DFND | 1 | 30,000 | 0 | 0 | |
| XENCOR INC | COM | 98401F105 | 46,534 | 3,467,512 | SH | DFND | 1 | 3,467,512 | 0 | 0 | |
| XENOPORT INC | COM | 98411C100 | 52,190 | 11,572,125 | SH | DFND | 1 | 11,572,125 | 0 | 0 | |
| ZAFGEN INC | COM | 98885E103 | 20,411 | 3,055,603 | SH | DFND | 1 | 3,055,603 | 0 | 0 | |
| ZELTIQ AESTHETICS INC | COM | 98933Q108 | 29,996 | 1,104,417 | SH | DFND | 1 | 1,104,417 | 0 | 0 | |