The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 4,726 76,331 SH   SOLE 76,331 0 0
ABEONA THERAPEUTICS INC COM 00289Y107 429 181,818 SH   SOLE 181,818 0 0
ACHAOGEN INC COM COM 004449104 1,191 314,341 SH   SOLE 314,341 0 0
ACHILLION PHARMACEUTICALS COM 00448Q201 1,845 236,500 SH   SOLE 236,500 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 203 24,955 SH   SOLE 24,955 0 0
ADVERUM BIOTECHNOLOGIES INC COM ADDED 00773U108 444 140,600 SH   SOLE 140,600 0 0
AEGLEA BIOTHERAPEUTICS INC COM ADDED 00773J103 1,703 350,392 SH   SOLE 350,392 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 2,831 160,869 SH   SOLE 160,869 0 0
AKARI THERAPEUTICS PLC SPONSORED ADR 00972G108 6 458 SH   SOLE 458 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 185 24,700 SH   SOLE 24,700 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 4,128 165,313 SH   SOLE 165,313 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 14 2,499 SH   SOLE 2,499 0 0
ANTARES PHARMA INC COM 036642106 47 45,000 SH   SOLE 45,000 0 0
APPLIED GENETIC TECHNOL CORP COM 03820J100 2,362 167,192 SH   SOLE 167,192 0 0
ARBUTUS BIOPHARMA CORP COM 03879J100 261 75,000 SH   SOLE 75,000 0 0
ARDELYX INC COM 039697107 262 30,000 SH   SOLE 30,000 0 0
ASCENDIS PHARMA SPONSORED ADR 04351P101 707 53,241 SH   SOLE 53,241 0 0
ATRICURE INC COM 04963C209 7,262 513,946 SH   SOLE 513,946 0 0
AVEO PHARMACEUTICALS INC COM 053588109 249 259,067 SH   SOLE 259,067 0 0
BEIGENE LTD SPONSORED ADR ADDED 07725L102 596 20,000 SH   SOLE 20,000 0 0
BIOSPECIFICS TECHNOLOGIES COM 090931106 1,586 39,704 SH   SOLE 39,704 0 0
BIOTELEMETRY INC COM 090672106 1,630 100,000 SH   SOLE 100,000 0 0
BLUEBIRD BIO INC COM 09609G100 519 12,000 SH   SOLE 12,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 205 10,100 SH   SOLE 10,100 0 0
CARA THERAPEUTICS INC COM 140755109 1,284 267,046 SH   SOLE 267,046 0 0
CASCADIAN THERAPEUTICS INC COM ADDED 14740B101 165 175,000 SH   SOLE 175,000 0 0
CATALYST BIOSCIENCES INC COM 14888D109 108 70,903 SH   SOLE 70,903 0 0
CEL SCI CORP COM PAR $0.01 150837508 59 127,482 SH   SOLE 127,482 0 0
CHECK CAP LTD SHS M2361E112 123 88,220 SH   SOLE 88,220 0 0
CHECK CAP LTD *W EXP 02/28/202 M2361E120 5 53,488 SH   SOLE 53,488 0 0
COGENTIX MEDICAL INC COM 19243A104 339 352,882 SH   SOLE 352,882 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 752 66,968 SH   SOLE 66,968 0 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 1,196 400,000 SH   SOLE 400,000 0 0
CYNAPSUS THERAPEUTICS INC COM 23257Y156 564 33,995 SH   SOLE 33,995 0 0
CYNAPSUS THERAPEUTICS INC COM PAR NO PAR 23257Y859 671 40,468 SH   SOLE 40,468 0 0
CYNAPSUS THERAPEUTICS INC COM PAR NO PAR 23257Y859 3,047 181,891 SH   SOLE 181,891 0 0
CYTOKINETICS INC COM NEW 23282W605 1,424 150,000 SH   SOLE 150,000 0 0
DERMA SCIENCES INC COM PAR $.01 249827502 1,394 353,718 SH   SOLE 353,718 0 0
DERMIRA INC COM 24983L104 5,664 193,642 SH   SOLE 193,642 0 0
DEXTERA SURGICAL INC COM ADDED 252366109 252 140,275 SH   SOLE 140,275 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 358 119,300 SH   SOLE 119,300 0 0
ENTEROMEDICS INC COM PAR 0.01 COM PAR 0.01 ADDED 29365M307 10 33,334 SH   SOLE 33,334 0 0
ESSA PHARMA INC COM 29668H104 810 202,496 SH   SOLE 202,496 0 0
EXACTECH INC COM 30064E109 846 31,636 SH   SOLE 31,636 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 1,223 192,567 SH   SOLE 192,567 0 0
GALAPAGOS NV SPON ADR 36315X101 3,526 63,568 SH   SOLE 63,568 0 0
GENVEC INC COM NEW 37246C307 55 95,800 SH   SOLE 95,800 0 0
GERON CORP COM 374163103 764 285,000 SH   SOLE 285,000 0 0
GLYCOMIMETICS INC COM 38000Q102 204 27,996 SH   SOLE 27,996 0 0
IMMUNOMEDICS INC COM 452907108 1,891 815,000 SH   SOLE 815,000 0 0
INNOCOLL HLDGS PLC SHS ADDED G4783X105 551 100,000 SH   SOLE 100,000 0 0
INSULET CORP COM 45784P101 2,787 92,164 SH   SOLE 92,164 0 0
INSULET CORP NOTE 2.000% 6/1 45784PAD3 2,294 2,407,000 PRN   SOLE 2,407,000 0 0
INTEC PHARMA LTD JERUSALEM SHS M53644106 549 119,296 SH   SOLE 119,296 0 0
IRONWOOD PHARMACEUTICALS INC DBCV 2.250% 6/1 ADDED 46333XAD0 620 600,000 PRN   SOLE 600,000 0 0
ISHARES TR NASDQ BIOTEC ETF 464287556 1,544 6,000 SH   SOLE 6,000 0 0
JOHNSON AND JOHNSON COM 478160104 1,140 9,400 SH   SOLE 9,400 0 0
LDR HLDG CORP COM 50185U105 1,109 30,000 SH   SOLE 30,000 0 0
LOXO ONCOLOGY INC COM 548862101 2,364 101,966 SH   SOLE 101,966 0 0
MACROGENICS INC COM 556099109 1,463 54,200 SH   SOLE 54,200 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 115 90,237 SH   SOLE 90,237 0 0
MASIMO CORPORATION COM 574795100 525 10,000 SH   SOLE 10,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 818 80,100 SH   SOLE 80,100 0 0
NEMUS BIOSCIENCE INC COM 64046J100 252 511,508 SH   SOLE 511,508 0 0
NEOS THERAPEUTICS INC COM 64052L106 361 38,873 SH   SOLE 38,873 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 3,432 75,503 SH   SOLE 75,503 0 0
NEURODERM LTD ORD SHS M74231107 234 14,421 SH   SOLE 14,421 0 0
NIVALIS THERAPEUTICS INC COM 65481J109 69 15,000 SH   SOLE 15,000 0 0
NOVADAQ TECHNOLOGIES INC COM 66987G102 1,002 101,841 SH   SOLE 101,841 0 0
NOVAVAX INC COM 670002104 3,999 550,000 SH   SOLE 550,000 0 0
NXSTAGE MEDICAL INC COM 67072V103 7,729 356,509 SH   SOLE 356,509 0 0
ONCONOVA THERAPEUTICS INC COM NEW ADDED 68232V306 1 200 SH   SOLE 200 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 360 223,325 SH   SOLE 223,325 0 0
PROTALIX BIOTHERAPEUTICS INC NOTE 4.500% 9/1 74365AAB7 1,644 2,500,000 PRN   SOLE 2,500,000 0 0
RADIUS HEALTH INC COM NEW 750469207 1,382 37,600 SH   SOLE 37,600 0 0
REGULUS THERAPEUTICS INC COM 75915K101 1,218 421,500 SH   SOLE 421,500 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 4,119 1,847,087 SH   SOLE 1,847,087 0 0
SCYNEXIS INC COM 811292101 579 266,904 SH   SOLE 266,904 0 0
SPECTRANETICS CORP COM 84760C107 1,493 79,812 SH   SOLE 79,812 0 0
STEREOTAXIS INC COM NEW 85916J409 1,345 1,372,862 SH   SOLE 1,372,862 0 0
SUNESIS PHARMACEUTICALS INC COM NEW 867328601 232 423,336 SH   SOLE 423,336 0 0
SYNERGY PHARMACEUTICALS COM 871639308 1,214 319,563 SH   SOLE 319,563 0 0
SYNERON MEDICAL LTD ORD SHS M87245102 661 85,947 SH   SOLE 85,947 0 0
TANDEM DIABETES CARE INC COM 875372104 2,358 312,756 SH   SOLE 312,756 0 0
TARGACEPT INC NOTE 2/1 87611RAA6 531 530,821 PRN   SOLE 530,821 0 0
TENAX THERAPEUTICS INC COM 88032L100 204 79,509 SH   SOLE 79,509 0 0
TESARO INC COM 881569107 2,522 30,000 SH   SOLE 30,000 0 0
TETRAPHASE PHARMACEUTICALS I COM 88165N105 446 103,690 SH   SOLE 103,690 0 0
UNIQURE B.V. NV SHS N90064101 1,171 158,907 SH   SOLE 158,907 0 0
VISTAGEN THERAPEUTICS INC COM NEW ADDED 92840H202 183 46,900 SH   SOLE 46,900 0 0
VITAE PHARMACEUTICALS INC COM 92847N103 7,123 660,188 SH   SOLE 660,188 0 0
VTV THERAPEUTICS INC CL A 918385105 423 73,000 SH   SOLE 73,000 0 0
WINDTREE THERAPEUTICS INC COM ADDED 97382D105 1,029 533,358 SH   SOLE 533,358 0 0
XENON PHARMACEUTICALS INC COM 98420N105 1,263 214,091 SH   SOLE 214,091 0 0
ZOGENIX INC COM 98978L204 1,590 197,538 SH   SOLE 197,538 0 0