The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACHILLION PHARMACEUTICALS INC COM 00448Q201 92,896 12,033,220 SH   SOLE   12,033,220 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 49,795 2,627,719 SH   SOLE   2,627,719 0 0
ACORDA THERAPEUTICS INC COM 00484M106 13,176 498,159 SH   SOLE   498,159 0 0
AGILE THERAPEUTICS INC COM 00847L100 6,609 1,064,217 SH   SOLE   1,064,217 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 17,532 1,292,940 SH   SOLE   1,292,940 0 0
AKARI THERAPEUTICS PLC SPONSORED ADR 00972G108 2,598 257,721 SH   SOLE   257,721 0 0
ALCOBRA LTD SHS M2239P109 11,495 3,032,911 SH   SOLE   3,032,911 0 0
AMPLIPHI BIOSCIENCES CORP COM NEW 03211P202 211 53,600 SH   SOLE   53,600 0 0
APPLIED GENETIC TECHNOL CORP COM 03820J100 3,300 236,059 SH   SOLE   236,059 0 0
AQUINOX PHARMACEUTICALS INC COM 03842B101 14,923 1,691,977 SH   SOLE   1,691,977 0 0
ARCA BIOPHARMA INC COM PAR$.001 00211Y407 2,700 778,211 SH   SOLE   778,211 0 0
ARDELYX INC COM 039697107 17,875 2,300,481 SH   SOLE   2,300,481 0 0
ARENA PHARMACEUTICAL S INC COM 040047102 18,447 9,364,105 SH   SOLE   9,364,105 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 40,093 2,161,366 SH   SOLE   2,161,366 0 0
AVEXIS INC COM 05366U100 37,089 1,361,582 SH   SOLE   1,361,582 0 0
AXOVANT SCIENCES LTD COM G0750W104 57,400 5,000,000 SH   SOLE   5,000,000 0 0
BEIGENE LTD SPONSORED ADR 07725L102 4,983 170,000 SH   SOLE   170,000 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 8,461 2,989,795 SH   SOLE   2,989,795 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 1,019 56,442 SH   SOLE   56,442 0 0
CELATOR PHARMACEUTICALS INC COM 15089R102 15,598 1,414,114 SH   SOLE   1,414,114 0 0
CIDARA THERAPEUTICS INC COM 171757107 14,913 1,174,219 SH   SOLE   1,174,219 0 0
COHERUS BIOSCIENCES INC COM 19249H103 27,006 1,272,048 SH   SOLE   1,272,048 0 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 8,831 486,557 SH   SOLE   486,557 0 0
DERMA SCIENCES INC COM PAR $.01 249827502 252 81,239 SH   SOLE   81,239 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 13,017 2,428,571 SH   SOLE   2,428,571 0 0
DIMENSION THERAPEUTICS INC COM 25433V105 12,121 1,548,033 SH   SOLE   1,548,033 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 4,892 291,700 SH   SOLE   291,700 0 0
NATERA INC COM 632307104 7,459 783,520 SH   SOLE   783,520 0 0
NEKTAR THERAPEUTICS COM 640268108 43,709 3,178,854 SH   SOLE   3,178,854 0 0
NEURODERM LTD ORD SHS M74231107 2,043 144,671 SH   SOLE   144,671 0 0
NIVALIS THERAPEUTICS INC COM 65481J109 2,556 612,863 SH   SOLE   612,863 0 0
PRONAI THERAPEUTICS INC COM 74346L101 4,078 604,982 SH   SOLE   604,982 0 0
PROTEON THERAPEUTICS INC COM 74371L109 12,592 1,626,931 SH   SOLE   1,626,931 0 0
REGULUS THERAPEUTICS INC COM 75915K101 7,243 1,045,119 SH   SOLE   1,045,119 0 0
SANGAMO BIOSCIENCES INC COM 800677106 13,383 2,212,036 SH   SOLE   2,212,036 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 12,270 2,690,702 SH   SOLE   2,690,702 0 0
TENAX THERAPEUTICS INC COM 88032L100 4,899 2,389,700 SH   SOLE   2,389,700 0 0
TG THERAPEUTICS INC COM 88322Q108 38,610 4,531,714 SH   SOLE   4,531,714 0 0
VITAE PHARMACEUTICALS INC COM 92847N103 10,442 1,575,000 SH   SOLE   1,575,000 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 98,390 7,088,651 SH   SOLE   7,088,651 0 0
ZOGENIX INC COM NEW 98978L204 22,649 2,451,237 SH   SOLE   2,451,237 0 0
ZYNERBA PHARMACEUTICALS INC COM 98986X109 4,793 507,191 SH   SOLE   507,191 0 0