The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 6,659 116,581 SH   SOLE 116,581 0 0
ABEONA THERAPEUTICS INC COM 00289Y107 465 181,818 SH   SOLE 181,818 0 0
ACHILLION PHARMACEUTICALS COM 00448Q201 1,826 236,500 SH   SOLE 236,500 0 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 687 47,500 SH   SOLE 47,500 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 716 88,100 SH   SOLE 88,100 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 2,186 179,769 SH   SOLE 179,769 0 0
AFFIMED THERAPEUTICS BV COM N01045108 175 46,701 SH   SOLE 46,701 0 0
AKARI THERAPEUTICS PLC SPONSORED ADR ADDED 00972G108 66 4,741 SH   SOLE 4,741 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 592 65,700 SH   SOLE 65,700 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 3,436 140,313 SH   SOLE 140,313 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 738 176,232 SH   SOLE 176,232 0 0
ANTARES PHARMA INC COM 036642106 39 45,000 SH   SOLE 45,000 0 0
APPLIED GENETIC TECHNOL CORP COM 03820J100 2,337 167,192 SH   SOLE 167,192 0 0
ARBUTUS BIOPHARMA CORP COM 03879J100 476 115,230 SH   SOLE 115,230 0 0
ARDELYX INC COM 039697107 1,090 140,265 SH   SOLE 140,265 0 0
ASCENDIS PHARMA ADR ADDED 04351P101 988 53,241 SH   SOLE 53,241 0 0
ATRICURE INC COM 04963C209 8,221 488,446 SH   SOLE 488,446 0 0
AVALANCHE BIOTECHNOLOGIES IN COM 05337G107 727 140,600 SH   SOLE 140,600 0 0
BEIGENE LTD SPONSORED ADR ADDED 07725L102 586 20,000 SH   SOLE 20,000 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 423 149,642 SH   SOLE 149,642 0 0
BIOPHARMX CORP COM 09072X101 160 146,800 SH   SOLE 146,800 0 0
BIOSPECIFICS TECHNOLOGIES COM 090931106 1,382 39,704 SH   SOLE 39,704 0 0
BIOTELEMETRY INC COM 090672106 2,752 235,645 SH   SOLE 235,645 0 0
BLUEBIRD BIO INC COM 09609G100 510 12,000 SH   SOLE 12,000 0 0
CARA THERAPEUTICS INC COM 140755109 1,661 267,046 SH   SOLE 267,046 0 0
CARDICA INC COM COM NEW ADDED 14141R309 499 140,275 SH   SOLE 140,275 0 0
CAREDX INC COM 14167L103 675 136,047 SH   SOLE 136,047 0 0
CATALYST BIOSCIENCES INC COM ADDED 14888D109 119 70,903 SH   SOLE 70,903 0 0
CEL SCI CORP COM PAR $0.01 150837508 68 127,482 SH   SOLE 127,482 0 0
CELYAD ADR 151205200 1,325 30,000 SH   SOLE 30,000 0 0
CHECK CAP LTD SHS ADDED M2361E112 245 89,220 SH   SOLE 89,220 0 0
CHECK CAP LTD *W EXP 02/28/202 ADDED M2361E120 42 53,690 SH   SOLE 53,690 0 0
COGENTIX MEDICAL INC COM 19243A104 388 352,882 SH   SOLE 352,882 0 0
CYNAPSUS THERAPEUTICS INC COM 23257Y156 416 33,995 SH   SOLE 33,995 0 0
CYNAPSUS THERAPEUTICS INC COM PAR NO PAR 23257Y859 549 44,824 SH   SOLE 44,824 0 0
CYNAPSUS THERAPEUTICS INC COM PAR NO PAR 23257Y859 97 8,117 SH   SOLE 8,117 0 0
CYTOKINETICS INC COM NEW 23282W605 392 55,600 SH   SOLE 55,600 0 0
DERMA SCIENCES INC COM PAR $.01 249827502 1,097 353,718 SH   SOLE 353,718 0 0
DERMIRA INC COM 24983L104 3,554 171,881 SH   SOLE 171,881 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 646 120,600 SH   SOLE 120,600 0 0
DISCOVERY LABORATORIES INC N COM PAR COM PAR ADDED 254668502 891 533,358 SH   SOLE 533,358 0 0
EDGE THERAPEUTICS INC COM 279870109 633 69,177 SH   SOLE 69,177 0 0
ENDOLOGIX INC NOTE 3.250%11/0 ADDED 29266SAB2 496 500,000 PRN   SOLE 500,000 0 0
ENTEROMEDICS INC COM PAR 0.01 COM PAR 0.01 ADDED 29365M307 32 33,334 SH   SOLE 33,334 0 0
ESSA PHARMA INC COM 29668H104 662 202,496 SH   SOLE 202,496 0 0
EXACTECH INC COM 30064E109 641 31,636 SH   SOLE 31,636 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 774 118,671 SH   SOLE 118,671 0 0
GALAPAGOS NV SPON ADR 36315X101 2,742 65,568 SH   SOLE 65,568 0 0
GALMED PHARMACEUTICALS LTD SHS M47238106 66 13,488 SH   SOLE 13,488 0 0
GENVEC INC COM NEW 37246C307 77 95,800 SH   SOLE 95,800 0 0
INSULET CORP COM 45784P101 3,516 106,018 SH   SOLE 106,018 0 0
INSULET CORP NOTE 2.000% 6/1 45784PAD3 2,330 2,407,000 PRN   SOLE 2,407,000 0 0
INTEC PHARMA LTD JERUSALEM SHS ADDED M53644106 491 119,296 SH   SOLE 119,296 0 0
IRONWOOD PHARMA NOTE 2.25% 15-Jun-2022 144A SR UNSECURED CONV 46333XAC2 548 600,000 PRN   SOLE 600,000 0 0
ISHARES TR NASDQ BIOTEC ETF 464287556 1,565 6,000 SH   SOLE 6,000 0 0
JOHNSON AND JOHNSON COM 478160104 1,017 9,400 SH   SOLE 9,400 0 0
LDR HLDG CORP COM 50185U105 1,282 50,300 SH   SOLE 50,300 0 0
LIPOCINE INC COM NEW 53630X104 972 95,731 SH   SOLE 95,731 0 0
LOXO ONCOLOGY INC COM 548862101 1,066 39,000 SH   SOLE 39,000 0 0
MACROGENICS INC COM 556099109 1,016 54,200 SH   SOLE 54,200 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 3,048 566,498 SH   SOLE 566,498 0 0
MASIMO CORPORATION COM 574795100 1,925 46,010 SH   SOLE 46,010 0 0
MEDICINOVA INC COM NEW 58468P206 918 125,000 SH   SOLE 125,000 0 0
NEMUS BIOSCIENCE INC COM 64046J100 400 580,382 SH   SOLE 580,382 0 0
NEOS THERAPEUTICS INC COM ADDED 64052L106 419 38,873 SH   SOLE 38,873 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 3,018 76,300 SH   SOLE 76,300 0 0
NEURODERM LTD ORD SHS M74231107 17 1,202 SH   SOLE 1,202 0 0
NIVALIS THERAPEUTICS INC COM 65481J109 63 15,000 SH   SOLE 15,000 0 0
NOVADAQ TECHNOLOGIES INC COM 66987G102 1,129 101,841 SH   SOLE 101,841 0 0
NOVAVAX INC COM 670002104 2,856 553,500 SH   SOLE 553,500 0 0
NXSTAGE MEDICAL INC COM 67072V103 5,944 396,554 SH   SOLE 396,554 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 95 50,214 SH   SOLE 50,214 0 0
PRONAI THERAPEUTICS INC COM ADDED 74346L101 67 10,000 SH   SOLE 10,000 0 0
PROTALIX BIOTHERAPEUTICS INC NOTE 4.500% 9/1 74365AAB7 1,644 2,500,000 PRN   SOLE 2,500,000 0 0
RADIUS HEALTH INC COM NEW 750469207 1,339 42,600 SH   SOLE 42,600 0 0
REGULUS THERAPEUTICS INC COM 75915K101 2,713 391,500 SH   SOLE 391,500 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 3,903 1,876,492 SH   SOLE 1,876,492 0 0
SCYNEXIS INC COM 811292101 632 156,904 SH   SOLE 156,904 0 0
SPECTRANETICS CORP COM 84760C107 1,159 79,812 SH   SOLE 79,812 0 0
STEMCELLS INC COM NEW 85857R204 182 699,563 SH   SOLE 699,563 0 0
STEREOTAXIS INC COM NEW 85916J409 1,510 1,372,862 SH   SOLE 1,372,862 0 0
SUNESIS PHARMACEUTICALS INC COM NEW 867328601 229 423,336 SH   SOLE 423,336 0 0
SYNERGY PHARMACEUTICALS COM 871639308 813 294,563 SH   SOLE 294,563 0 0
SYNERON MEDICAL LTD ORD SHS M87245102 628 85,947 SH   SOLE 85,947 0 0
TANDEM DIABETES CARE INC COM 875372104 318 36,551 SH   SOLE 36,551 0 0
TARGACEPT INC NOTE 2/1 ADDED 87611RAA6 531 530,821 PRN   SOLE 530,821 0 0
TENAX THERAPEUTICS INC COM 88032L100 163 79,509 SH   SOLE 79,509 0 0
TOBIRA THERAPEUTICS INC COM 88883P101 666 81,402 SH   SOLE 81,402 0 0
UNIQURE B.V. NV SHS N90064101 1,888 158,907 SH   SOLE 158,907 0 0
VENAXIS INC COM NEW ADDED 92262A206 201 74,350 SH   SOLE 74,350 0 0
VITAE PHARMACEUTICALS INC COM 92847N103 5,220 787,373 SH   SOLE 787,373 0 0
VTV THERAPEUTICS INC CL A ADDED 918385105 377 73,000 SH   SOLE 73,000 0 0
XENON PHARMACEUTICALS INC COM 98420N105 1,350 193,195 SH   SOLE 193,195 0 0
ZOGENIX INC COM 98978L204 734 79,400 SH   SOLE 79,400 0 0