The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIOMED INC COMMON 003654100 5,082 53,600 SH   SOLE   0 0 53,600
ACADIA HEALTHCARE COMMON 00404A109 23,080 418,805 SH   SOLE   216,005 0 202,800
ACADIA PHARMACEUTCLS COMMON 004225108 19,312 690,700 SH   SOLE   622,600 0 68,100
ACCELERON PHARMA COMMON 00434H108 37,929 1,437,235 SH   SOLE   1,048,935 0 388,300
ACCURAY INC COMMON 004397105 4,462 771,950 SH   SOLE   1,050 0 770,900
ADEPTUS HEALTH INC CL A 006855100 24,703 444,783 SH   SOLE   235,983 0 208,800
ADVAXIS INC COMMON 007624208 19,631 2,174,015 SH   SOLE   1,697,015 0 477,000
AIMMUNE THERAPEUTICS COMMON 00900T107 13,318 982,133 SH   SOLE   889,633 0 92,500
AKORN INC COMMON 009728106 794 33,744 SH   SOLE   1,444 0 32,300
ALDER BIOPHARMACEU COMMON 014339105 31,620 1,291,153 SH   SOLE   959,753 0 331,400
ALEXION PHARM INC COMMON 015351109 91,469 657,013 SH   SOLE   547,255 0 109,758
ALIGN TECH INC COMMON 016255101 30,711 422,486 SH   SOLE   214,149 0 208,337
ALLERGAN PLC SHS G0177J108 2,849 10,631 SH   SOLE   569 0 10,062
AMGEN INC COMMON 031162100 102,372 682,797 SH   SOLE   613,246 0 69,551
AMICUS THERAPEUTICS COMMON 03152W109 77,961 9,226,145 SH   SOLE   7,022,545 0 2,203,600
AMPHASTAR PHARMACTLS COMMON 03209R103 467 38,905 SH   SOLE   3,305 0 35,600
AMSURG CORP COMMON 03232P405 7,191 96,400 SH   SOLE   0 0 96,400
ANACOR PHARMACEUTI COMMON 032420101 2,485 46,500 SH   SOLE   0 0 46,500
ASCENDIS PHARMA A S SP ADR 04351P101 577 31,100 SH   SOLE   0 0 31,100
AVEXIS INC COMMON 05366U100 8,107 297,600 SH   SOLE   270,000 0 27,600
BIOGEN INC COMMON 09062X103 61,064 234,572 SH   SOLE   210,705 0 23,867
BIOMARIN PHARMAC INC COMMON 09061G101 122,824 1,489,137 SH   SOLE   1,256,534 0 232,603
CARA THERAPEUTICS COMMON 140755109 7,542 1,212,578 SH   SOLE   1,095,878 0 116,700
CELGENE CORP COMMON 151020104 150,009 1,498,738 SH   SOLE   1,264,566 0 234,172
CHINA BIOLOGIC PROD COMMON 16938C106 674 5,890 SH   SOLE   5,890 0 0
COLLEGIUM PHARMACEUT COMMON 19459J104 5,343 294,400 SH   SOLE   0 0 294,400
DEXCOM INC COMMON 252131107 38,815 571,559 SH   SOLE   300,695 0 270,864
DR REDDYS LABS LTD ADR 256135203 4,162 92,105 SH   SOLE   47,140 0 44,965
EDWARDS LIFESCIENCE COMMON 28176E108 9,751 110,541 SH   SOLE   68,541 0 42,000
ELI LILLY & CO COMMON 532457108 36,487 506,695 SH   SOLE   351,895 0 154,800
ENTELLUS MED INC COMMON 29363K105 2,722 149,665 SH   SOLE   265 0 149,400
GILEAD SCIENCES INC COMMON 375558103 149,435 1,626,764 SH   SOLE   1,373,148 0 253,616
IMMUNE DESIGN CORP COMMON 45252L103 11,139 856,867 SH   SOLE   770,767 0 86,100
INCYTE CORPORATION COMMON 45337C102 83,597 1,153,540 SH   SOLE   985,940 0 167,600
INTEGRA LIFESCIENCE COMMON 457985208 4,079 60,560 SH   SOLE   60 0 60,500
INTERCEPT PHARMACE COMMON 45845P108 31,533 245,447 SH   SOLE   198,847 0 46,600
INTERSECT ENT INC COMMON 46071F103 2,195 115,540 SH   SOLE   340 0 115,200
INTUITIVE SURGIC INC COMMON 46120E602 14,045 23,367 SH   SOLE   18,909 0 4,458
IONIS PHARMACEUTICAL COMMON 462222100 17,549 433,300 SH   SOLE   298,500 0 134,800
IRONWOOD PHARMACEUCL COM CL A 46333X108 117 10,725 SH   SOLE   10,725 0 0
LANNETT CO INC COMMON 516012101 2,330 129,957 SH   SOLE   2,357 0 127,600
MALLINCKRODT PLC SHS G5785G107 1,683 27,467 SH   SOLE   2,667 0 24,800
MEDTRONIC PLC SHS G5960L103 35,695 475,931 SH   SOLE   332,884 0 143,047
MERCK & CO INC COMMON 58933Y105 39,678 749,914 SH   SOLE   518,214 0 231,700
MOLINA HEALTHCARE COMMON 60855R100 5,224 81,000 SH   SOLE   0 0 81,000
MOMENTA PHARMACEUTIC COMMON 60877T100 6,288 680,552 SH   SOLE   14,752 0 665,800
MYLAN N V SHS EURO N59465109 27,329 589,627 SH   SOLE   386,357 0 203,270
NEKTAR THERAPEUTICS COMMON 640268108 175 12,760 SH   SOLE   12,760 0 0
NEUROCRINE BIOSCIENC COMMON 64125C109 65,256 1,649,963 SH   SOLE   1,094,863 0 555,100
NOVARTIS AG SP ADR 66987V109 8,968 123,805 SH   SOLE   123,805 0 0
NOVAVAX INC COMMON 670002104 2,129 412,500 SH   SOLE   0 0 412,500
NOVO-NORDISK AS ADR 670100205 11,715 216,175 SH   SOLE   216,175 0 0
NUVASIVE INC COMMON 670704105 8,090 166,300 SH   SOLE   0 0 166,300
NXSTAGE MEDICAL COMMON 67072V103 24,693 1,647,309 SH   SOLE   823,053 0 824,256
OPHTHOTECH CORP COMMON 683745103 15,095 357,106 SH   SOLE   260,706 0 96,400
PERRIGO CO SHS G97822103 2,179 17,030 SH   SOLE   1,204 0 15,826
PORTOLA PHARMACEUTIC COMMON 737010108 32,498 1,593,039 SH   SOLE   1,048,639 0 544,400
PRA HEALTH SCIENCE COMMON 69354M108 4,182 97,800 SH   SOLE   0 0 97,800
PROFOUND MEDICAL COMMON 74319B106 917 1,031,700 SH   SOLE   1,031,700 0 0
PRONAI THERAPEUTICS COMMON 074346L10 1,359 201,660 SH   SOLE   201,660 0 0
PRONAI THERAPEUTICS COMMON 74346L101 7,664 1,137,073 SH   SOLE   771,773 0 365,300
PROTHENA CORP PLC SHS G72800108 16,386 398,100 SH   SOLE   275,000 0 123,100
PTC THERAPEUTICS I COMMON 69366J200 16,842 2,615,241 SH   SOLE   2,117,341 0 497,900
REGENERON PHARMCTCLS COMMON 75886F107 83,900 232,770 SH   SOLE   209,020 0 23,750
REGENXBIO INC COMMON 75901B107 7,347 680,241 SH   SOLE   471,741 0 208,500
SAGE THERAPEUTICS COMMON 78667J108 13,500 421,084 SH   SOLE   379,784 0 41,300
SAGENT PHARMACEUTI COMMON 786692103 18,271 1,501,296 SH   SOLE   471,713 0 1,029,583
SHIRE PLC SP ADR 82481R106 69,679 405,347 SH   SOLE   367,870 0 37,477
ST JUDE MEDICAL INC COMMON 790849103 18,402 334,584 SH   SOLE   243,084 0 91,500
SURGICAL CARE AFFI COMMON 86881L106 3,675 79,400 SH   SOLE   0 0 79,400
TANDEM DIABETES CA COMMON 875372104 2,340 268,690 SH   SOLE   790 0 267,900
TEAM HEALTH HLDGS COMMON 87817A107 11,247 269,000 SH   SOLE   0 0 269,000
TELADOC INC COMMON 87918A105 9,365 975,533 SH   SOLE   431,033 0 544,500
TESARO INC COMMON 881569107 30,375 689,869 SH   SOLE   504,369 0 185,500
TEVA PHARMACEUTICAL ADR 881624209 27,242 509,110 SH   SOLE   452,808 0 56,302
TG THERAPEUTICS COMMON 88322Q108 12,965 1,521,667 SH   SOLE   1,379,267 0 142,400
THERMO FISHER SCI COMMON 883556102 52,442 370,376 SH   SOLE   332,651 0 37,725
UNIQURE N.V. SHS N90064101 16,956 1,427,313 SH   SOLE   1,041,213 0 386,100
UNITEDHEALTH GRP INC COMMON 91324P102 22,634 175,590 SH   SOLE   123,990 0 51,600
VERTEX PHARMACEUTICL COMMON 92532F100 71,261 896,479 SH   SOLE   766,747 0 129,732
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 3,020 181,935 SH   SOLE   235 0 181,700