The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACELYRIN INC COM 00445A100   4,180,000 200,000 SH   SOLE   200,000 0 0
ACRIVON THERAPEUTICS INC COMMON STOCK 004890109   38,981,840 3,007,858 SH   SOLE   3,007,858 0 0
ADMA BIOLOGICS INC COM 000899104   43,911,941 11,900,255 SH   SOLE   11,900,255 0 0
AKERO THERAPEUTICS INC COM 00973Y108   90,610,116 1,940,675 SH   SOLE   1,940,675 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106   95,227,213 11,350,085 SH   SOLE   11,350,085 0 0
AMICUS THERAPEUTICS INC COM 03152W109   347,446,237 27,662,917 SH   SOLE   27,662,917 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   105,130,433 4,873,919 SH   SOLE   4,873,919 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   73,976,570 812,037 SH   SOLE   812,037 0 0
ARCELLX INC COMMON STOCK 03940C100   126,998,473 4,016,397 SH   SOLE   4,016,397 0 0
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108   1,417,500 300,000 SH Put SOLE   300,000 0 0
ARGENX SE SPONSORED ADR 04016X101   26,891,370 69,000 SH   SOLE   69,000 0 0
ARTIVION INC COM 228903100   16,009,941 931,352 SH   SOLE   931,352 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   18,238,218 2,189,462 SH   SOLE   2,189,462 0 0
ATHIRA PHARMA INC COM 04746L104   14,151,970 4,797,278 SH   SOLE   4,797,278 0 0
AXOGEN INC COM 05463X106   13,373,825 1,464,822 SH   SOLE   1,464,822 0 0
AXSOME THERAPEUTICS INC COM 05464T104   19,509,487 271,493 SH   SOLE   271,493 0 0
BIOHAVEN LTD COM G1110E107   7,674,014 320,820 SH   SOLE   320,820 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   22,814,783 263,207 SH   SOLE   263,207 0 0
BIOMEA FUSION INC COM 09077A106   15,725,879 716,441 SH   SOLE   716,441 0 0
BIOXCEL THERAPEUTICS INC COM 09075P105   10,987 439,500 SH Call SOLE   439,500 0 0
BRIDGEBIO PHARMA INC COM 10806X102   30,081,647 1,748,933 SH   SOLE   1,748,933 0 0
CABALETTA BIO INC COM 12674W109   19,945,950 1,545,000 SH   SOLE   1,545,000 0 0
CAREMAX INC COM CL A 14171W103   11,872,126 3,817,404 SH   SOLE   3,817,404 0 0
CAREMAX INC *W EXP 06/08/202 14171W111   23,400 60,000 SH   SOLE   60,000 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128   320,709,759 10,088,385 SH   SOLE   10,088,385 0 0
COGENT BIOSCIENCES INC COM 19240Q201   31,488,125 2,659,470 SH   SOLE   2,659,470 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107   35,083,805 1,946,937 SH   SOLE   1,946,937 0 0
CYMABAY THERAPEUTICS INC COM 23257D103   40,879,142 3,733,255 SH   SOLE   3,733,255 0 0
DISC MEDICINE INC COM 254604101   32,982,007 742,838 SH   SOLE   742,838 0 0
ENVVENO MEDICAL CORPORATION COM 29415J106   2,407,374 781,615 SH   SOLE   781,615 0 0
EQRX INC *W EXP 12/17/202 26886C115   42,500 250,000 SH   SOLE   250,000 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108   29,154,036 424,924 SH   SOLE   424,924 0 0
FUSION PHARMACEUTICALS INC COM 36118A100   12,849,014 2,751,395 SH   SOLE   2,751,395 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104   31,367,310 891,370 SH   SOLE   891,370 0 0
ILLUMINA INC COM 452327109   27,186,050 145,000 SH   SOLE   145,000 0 0
IMMATICS N.V SHS N44445109   40,291,910 3,491,500 SH   SOLE   3,491,500 0 0
IMMUNOVANT INC COM 45258J102   47,876,164 2,523,783 SH   SOLE   2,523,783 0 0
INHIBRX INC COM 45720L107   94,083,765 3,624,182 SH   SOLE   3,624,182 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101   15,564,056 245,800 SH   SOLE   245,800 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100   98,816,326 14,036,410 SH   SOLE   14,036,410 0 0
IVERIC BIO INC COM 46583P102   6,609,120 168,000 SH   SOLE   168,000 0 0
KRONOS BIO INC COM 50107A104   3,014,721 1,752,745 SH   SOLE   1,752,745 0 0
LANDOS BIOPHARMA INC COM NEW 515069201   6,255,771 1,486,991 SH   SOLE   1,486,991 0 0
LEAP THERAPEUTICS INC COM NEW 52187K200   1,836,474 586,733 SH   SOLE   586,733 0 0
LIANBIO SPONSORED ADS 53000N108   131,233,268 57,558,451 SH   SOLE   57,558,451 0 0
LYRA THERAPEUTICS INC COM 55234L105   52,433,579 12,757,562 SH   SOLE   12,757,562 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   69,989,997 302,987 SH   SOLE   302,987 0 0
MEDTRONIC PLC SHS G5960L103   41,142,700 467,000 SH   SOLE   467,000 0 0
MEIRAGTX HLDGS PLC COM G59665102   76,145,012 11,331,103 SH   SOLE   11,331,103 0 0
MIRATI THERAPEUTICS INC COM 60468T105   690,000 200,000 SH Call SOLE   200,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105   25,981,191 719,103 SH   SOLE   719,103 0 0
MIRUM PHARMACEUTICALS INC COM 604749101   15,562,512 601,566 SH   SOLE   601,566 0 0
MOTUS GI HLDGS INC COM NEW 62014P405   60,318 90,027 SH   SOLE   90,027 0 0
NANOBIOTIX SPONSORED ADS 63009J107   5,373,186 1,059,800 SH   SOLE   1,059,800 0 0
NATERA INC COM 632307104   19,720,390 405,269 SH   SOLE   405,269 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108   35,260,154 9,111,151 SH   SOLE   9,111,151 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109   9,434,715 100,050 SH   SOLE   100,050 0 0
NUVALENT INC COM 670703107   92,555,602 2,194,821 SH   SOLE   2,194,821 0 0
ORCHESTRA BIOMED HLDGS INC COM 68572M106   14,370,076 2,052,868 SH   SOLE   2,052,868 0 0
OUTSET MED INC COM 690145107   19,734,613 902,360 SH   SOLE   902,360 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109   675,000 500,000 SH Put SOLE   500,000 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102   40,594,799 1,469,761 SH   SOLE   1,469,761 0 0
PROTHENA CORP PLC SHS G72800108   12,605,512 184,615 SH   SOLE   184,615 0 0
QUANTERIX CORP COM 74766Q101   2,931,500 130,000 SH   SOLE   130,000 0 0
RAPT THERAPEUTICS INC COM 75382E109   42,794,819 2,288,493 SH   SOLE   2,288,493 0 0
REATA PHARMACEUTICALS INC CL A 75615P103   68,334,204 670,206 SH   SOLE   670,206 0 0
RELAY THERAPEUTICS INC COM 75943R102   24,405,298 1,943,097 SH   SOLE   1,943,097 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   23,215,373 1,168,363 SH   SOLE   1,168,363 0 0
ROIVANT SCIENCES LTD SHS G76279101   31,567,899 3,131,736 SH   SOLE   3,131,736 0 0
SAREPTA THERAPEUTICS INC COM 803607100   9,284,594 81,074 SH   SOLE   81,074 0 0
SINGULAR GENOMICS SYSTEMS IN COM 82933R100   1,961,468 2,363,214 SH   SOLE   2,363,214 0 0
SOLENO THERAPEUTICS INC COM 834203309   9,471,260 2,207,753 SH   SOLE   2,207,753 0 0
SOLID BIOSCIENCES INC COM NEW 83422E204   18,318,688 3,495,933 SH   SOLE   3,495,933 0 0
SOMALOGIC INC CLASS A COM 83444K105   3,465,000 1,500,000 SH   SOLE   1,500,000 0 0
SPDR SER TR S&P BIOTECH 78464A870   137,500 150,000 SH Put SOLE   150,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107   40,311,440 1,537,431 SH   SOLE   1,537,431 0 0
SURROZEN INC *W EXP 08/01/203 86889P117   10,000 166,666 SH   SOLE   166,666 0 0
TACTILE SYS TECHNOLOGY INC COM 87357P100   15,017,259 602,377 SH   SOLE   602,377 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103   23,426,237 1,296,416 SH   SOLE   1,296,416 0 0
TERNS PHARMACEUTICALS INC COM 880881107   9,406,250 1,075,000 SH Put SOLE   1,075,000 0 0
TRAVERE THERAPEUTICS INC COM 89422G107   1,393,889 90,748 SH   SOLE   90,748 0 0
TREACE MED CONCEPTS INC COM 89455T109   56,717,255 2,217,250 SH   SOLE   2,217,250 0 0
TYRA BIOSCIENCES INC COM 90240B106   6,130,800 360,000 SH   SOLE   360,000 0 0
VAXCYTE INC COM 92243G108   80,609,253 1,614,122 SH   SOLE   1,614,122 0 0
VBI VACCINES INC CDA COM NEW 91822J202   4,544,657 1,381,355 SH   SOLE   1,381,355 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106   675,000 500,000 SH Call SOLE   500,000 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106   92,955,032 4,397,116 SH   SOLE   4,397,116 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108   29,074,931 5,038,983 SH   SOLE   5,038,983 0 0
VERU INC COM 92536C103   106,955 89,878 SH   SOLE   89,878 0 0
VIKING THERAPEUTICS INC COM 92686J106   7,150,993 441,147 SH   SOLE   441,147 0 0
VIR BIOTECHNOLOGY INC COM 92764N102   48,036,216 1,958,264 SH   SOLE   1,958,264 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   42,260,223 1,776,386 SH   SOLE   1,776,386 0 0
X4 PHARMACEUTICALS INC COM 98420X103   6,878,181 3,545,454 SH   SOLE   3,545,454 0 0
XENON PHARMACEUTICALS INC COM 98420N105   47,100,015 1,223,377 SH   SOLE   1,223,377 0 0
ZYMEWORKS INC COM 98985Y108   20,876,244 2,416,232 SH   SOLE   2,416,232 0 0