The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | |||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | ||||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | (to the nearest dollar) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ABBVIE INC | COM | 00287Y109 | BBG0025Y4RY4 | 67,971,016 | 504,498 | SH | DFND | 0 | 504,498 | 0 | ||
| ABCAM PLC | ADS | 000380204 | BBG00XRJJLG2 | 11,658,242 | 476,430 | SH | DFND | 0 | 476,430 | 0 | ||
| ACADIA HEALTHCARE COMPANY IN | COM | 00404A109 | BBG000FPNN38 | 30,366,891 | 381,302 | SH | DFND | 0 | 381,302 | 0 | ||
| ADAPTIMMUNE THERAPEUTICS PLC | SPONDS ADR | 00653A107 | BBG008G65WC2 | 7,730,449 | 8,357,242 | SH | DFND | 0 | 8,357,242 | 0 | ||
| ALKERMES PLC | SHS | G01767105 | BBG000C9F2F9 | 36,038,319 | 1,151,384 | SH | DFND | 0 | 1,151,384 | 0 | ||
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 | BBG007KGRPY4 | 25,006,768 | 274,498 | SH | DFND | 0 | 274,498 | 0 | ||
| ARCELLX INC | COMMON STOCK | 03940C100 | BBG00QHJM4S9 | 8,089,408 | 255,832 | SH | DFND | 0 | 255,832 | 0 | ||
| ARCUS BIOSCIENCES INC | COM | 03969F109 | BBG00DQD26W3 | 28,536,687 | 1,405,056 | SH | DFND | 0 | 1,405,056 | 0 | ||
| ARGENX SE | SPONSORED ADR | 04016X101 | BBG00GHB88X9 | 40,817,202 | 104,732 | SH | DFND | 0 | 104,732 | 0 | ||
| AXSOME THERAPEUTICS INC | COM | 05464T104 | BBG00B6G7GL7 | 14,372,000 | 200,000 | SH | Call | DFND | 0 | 200,000 | 0 | |
| AXSOME THERAPEUTICS INC | COM | 05464T104 | BBG00B6G7GL7 | 35,612,523 | 495,582 | SH | DFND | 0 | 495,582 | 0 | ||
| BECTON DICKINSON & CO | COM | 075887109 | BBG000BCZYD3 | 40,645,660 | 153,955 | SH | DFND | 0 | 153,955 | 0 | ||
| BIOGEN INC | COM | 09062X103 | BBG000C17X76 | 56,495,440 | 198,334 | SH | DFND | 0 | 198,334 | 0 | ||
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | BBG000CZWZ05 | 30,363,831 | 350,298 | SH | DFND | 0 | 350,298 | 0 | ||
| BIOMARIN PHARMACEUTICAL INC | NOTE 0.599% 8/0 | 09061GAH4 | BBG00HDDJ641 | 14,771,520 | 15,000,000 | PRN | DFND | 0 | 15,000,000 | 0 | ||
| BLUEBIRD BIO INC | COM | 09609G100 | BBG000QGWY50 | 23,968,048 | 7,285,121 | SH | DFND | 0 | 7,285,121 | 0 | ||
| BOSTON SCIENTIFIC CORP | COM | 101137107 | BBG000C0LW92 | 14,517,594 | 268,397 | SH | DFND | 0 | 268,397 | 0 | ||
| CARDINAL HEALTH INC | COM | 14149Y108 | BBG000D898T9 | 60,504,278 | 639,783 | SH | DFND | 0 | 639,783 | 0 | ||
| CARIBOU BIOSCIENCES INC | COM | 142038108 | BBG008G28LJ5 | 23,676,193 | 5,570,869 | SH | DFND | 0 | 5,570,869 | 0 | ||
| CELCUITY INC | COM | 15102K100 | BBG00HKBW045 | 2,829,689 | 257,713 | SH | DFND | 0 | 257,713 | 0 | ||
| CENTENE CORP DEL | COM | 15135B101 | BBG000BDXCJ5 | 75,036,776 | 1,112,480 | SH | DFND | 0 | 1,112,480 | 0 | ||
| COMPASS PATHWAYS PLC | SPONSORED ADS | 20451W101 | BBG00X0VY2N1 | 1,451,327 | 175,281 | SH | DFND | 0 | 175,281 | 0 | ||
| CYTOKINETICS INC | COM NEW | 23282W605 | BBG000F0R4N9 | 78,273,158 | 2,399,545 | SH | DFND | 0 | 2,399,545 | 0 | ||
| DANAHER CORPORATION | COM | 235851102 | BBG000BH3JF8 | 42,165,600 | 175,690 | SH | DFND | 0 | 175,690 | 0 | ||
| DAY ONE BIOPHARMACEUTICALS I | COM | 23954D109 | BBG00V1KSN04 | 13,696,852 | 1,147,140 | SH | DFND | 0 | 1,147,140 | 0 | ||
| DEXCOM INC | COM | 252131107 | BBG000QTF8K1 | 48,124,168 | 374,478 | SH | DFND | 0 | 374,478 | 0 | ||
| DYNAVAX TECHNOLOGIES CORP | COM NEW | 268158201 | BBG000BFX694 | 34,947,528 | 2,704,917 | SH | DFND | 0 | 2,704,917 | 0 | ||
| EDITAS MEDICINE INC | COM | 28106W103 | BBG005MX5GZ2 | 3,630,829 | 441,170 | SH | DFND | 0 | 441,170 | 0 | ||
| EDWARDS LIFESCIENCES CORP | COM | 28176E108 | BBG000BRXP69 | 66,275,126 | 702,588 | SH | DFND | 0 | 702,588 | 0 | ||
| ELEVANCE HEALTH INC | COM | 036752103 | BBG000BCG930 | 33,375,953 | 75,122 | SH | DFND | 0 | 75,122 | 0 | ||
| ERASCA INC | COM | 29479A108 | BBG00MTSR883 | 13,240,990 | 4,797,460 | SH | DFND | 0 | 4,797,460 | 0 | ||
| ESSA PHARMA INC | COM NEW | 29668H708 | BBG0088NJ8D1 | 11,353,373 | 4,204,953 | SH | DFND | 0 | 4,204,953 | 0 | ||
| GENERATION BIO CO | COM | 37148K100 | BBG00K698K88 | 14,285,898 | 2,597,436 | SH | DFND | 0 | 2,597,436 | 0 | ||
| HCA HEALTHCARE INC | COM | 40412C101 | BBG000QW7VC1 | 48,184,127 | 158,772 | SH | DFND | 0 | 158,772 | 0 | ||
| HORIZON THERAPEUTICS PUB L | SHS | G46188101 | BBG0014FFY08 | 112,295,744 | 1,091,840 | SH | DFND | 0 | 1,091,840 | 0 | ||
| HUMANA INC | COM | 444859102 | BBG000BLKK03 | 74,253,091 | 166,066 | SH | DFND | 0 | 166,066 | 0 | ||
| ICON PLC | SHS | G4705A100 | BBG000CTSZQ6 | 53,432,462 | 213,559 | SH | DFND | 0 | 213,559 | 0 | ||
| IMMUNOVANT INC | COM | 45258J102 | BBG00P5MC0Q8 | 7,377,774 | 388,918 | SH | DFND | 0 | 388,918 | 0 | ||
| INHIBRX INC | COM | 45720L107 | BBG00P80N9T9 | 3,315,170 | 127,703 | SH | DFND | 0 | 127,703 | 0 | ||
| INTUITIVE SURGICAL INC | COM NEW | 46120E602 | BBG000BJPDZ1 | 58,828,383 | 172,043 | SH | DFND | 0 | 172,043 | 0 | ||
| INVESCO EXCHANGE TRADED FD T | S&P500 EQL WGT | 46137V357 | BBG00KJR2MY7 | 61,367,364 | 410,100 | SH | Put | DFND | 0 | 410,100 | 0 | |
| IO BIOTECH INC | COM | 449778109 | BBG0131XRY31 | 1,197,854 | 612,713 | SH | DFND | 0 | 612,713 | 0 | ||
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | BBG000FTLBV7 | 6,661,987 | 946,305 | SH | DFND | 0 | 946,305 | 0 | ||
| IQVIA HLDGS INC | COM | 46266C105 | BBG00333FYS2 | 45,187,086 | 201,037 | SH | DFND | 0 | 201,037 | 0 | ||
| IRHYTHM TECHNOLOGIES INC | COM | 450056106 | BBG001J19V24 | 2,086,400 | 20,000 | SH | Call | DFND | 0 | 20,000 | 0 | |
| IRHYTHM TECHNOLOGIES INC | COM | 450056106 | BBG001J19V24 | 50,644,022 | 485,468 | SH | DFND | 0 | 485,468 | 0 | ||
| ISHARES TR | CHINA LG-CAP ETF | 464287184 | BBG000Q8RVM1 | 11,022,826 | 405,400 | SH | Call | DFND | 0 | 405,400 | 0 | |
| ISHARES TR | CHINA LG-CAP ETF | 464287184 | BBG000Q8RVM1 | 10,841,197 | 398,720 | SH | DFND | 0 | 398,720 | 0 | ||
| KARUNA THERAPEUTICS INC | COM | 48576A100 | BBG00NN875G0 | 29,970,622 | 138,209 | SH | DFND | 0 | 138,209 | 0 | ||
| KEROS THERAPEUTICS INC | COM | 492327101 | BBG00H1HP9G9 | 817,663 | 20,350 | SH | DFND | 0 | 20,350 | 0 | ||
| LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 | BBG00TTGH5W4 | 46,876,616 | 679,076 | SH | DFND | 0 | 679,076 | 0 | ||
| LILLY ELI & CO | COM | 532457108 | BBG000BNBDC2 | 140,057,594 | 298,643 | SH | DFND | 0 | 298,643 | 0 | ||
| MCKESSON CORP | COM | 58155Q103 | BBG000DYGNW7 | 45,214,098 | 105,811 | SH | DFND | 0 | 105,811 | 0 | ||
| MERCK & CO INC | COM | 58933Y105 | BBG000BPD168 | 68,802,557 | 596,261 | SH | DFND | 0 | 596,261 | 0 | ||
| MOLINA HEALTHCARE INC | COM | 60855R100 | BBG000MBHNC8 | 43,311,986 | 143,779 | SH | DFND | 0 | 143,779 | 0 | ||
| NEVRO CORP | NOTE 2.750% 4/0 | 64157FAC7 | BBG00SZTDMX7 | 16,192,610 | 17,500,000 | PRN | DFND | 0 | 17,500,000 | 0 | ||
| OSCAR HEALTH INC | CL A | 687793109 | BBG00YMWFTZ2 | 2,709,498 | 336,166 | SH | DFND | 0 | 336,166 | 0 | ||
| PENUMBRA INC | COM | 70975L107 | BBG001BP92V1 | 123,871,922 | 360,030 | SH | DFND | 0 | 360,030 | 0 | ||
| PMV PHARMACEUTICALS INC | COM | 69353Y103 | BBG007NM47G3 | 1,429,847 | 228,410 | SH | DFND | 0 | 228,410 | 0 | ||
| POINT BIOPHARMA GLOBAL INC | COM | 730541109 | BBG00VHK26D8 | 11,773,388 | 1,299,491 | SH | DFND | 0 | 1,299,491 | 0 | ||
| PRAXIS PRECISION MEDICINES I | COM | 74006W108 | BBG00W9LF2G5 | 10,225,526 | 8,891,762 | SH | DFND | 0 | 8,891,762 | 0 | ||
| PROCEPT BIOROBOTICS CORP | COM | 74276L105 | BBG009KD84H4 | 10,447,480 | 295,544 | SH | DFND | 0 | 295,544 | 0 | ||
| PROTHENA CORP PLC | SHS | G72800108 | BBG003PDKJF7 | 52,886,001 | 774,546 | SH | DFND | 0 | 774,546 | 0 | ||
| REATA PHARMACEUTICALS INC | CL A | 75615P103 | BBG000R33BD1 | 14,799,188 | 145,147 | SH | DFND | 0 | 145,147 | 0 | ||
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 | BBG000WG3567 | 4,744,201 | 238,762 | SH | DFND | 0 | 238,762 | 0 | ||
| ROIVANT SCIENCES LTD | SHS | G76279101 | BBG007STW2B8 | 3,880,709 | 384,991 | SH | DFND | 0 | 384,991 | 0 | ||
| SANA BIOTECHNOLOGY INC | COM | 799566104 | BBG00N5BMH61 | 83,237 | 13,966 | SH | DFND | 0 | 13,966 | 0 | ||
| SAREPTA THERAPEUTICS INC | COM | 803607100 | BBG000BCJ161 | 18,983,408 | 165,765 | SH | DFND | 0 | 165,765 | 0 | ||
| SEAGEN INC | COM | 81181C104 | BBG000BH0FR6 | 49,327,306 | 256,299 | SH | DFND | 0 | 256,299 | 0 | ||
| STRYKER CORPORATION | COM | 863667101 | BBG000DN7P92 | 41,193,862 | 135,022 | SH | DFND | 0 | 135,022 | 0 | ||
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | BBG000R33JY1 | 45,469,106 | 2,172,437 | SH | DFND | 0 | 2,172,437 | 0 | ||
| TENET HEALTHCARE CORP | COM NEW | 88033G407 | BBG000CPHYL4 | 41,617,244 | 511,394 | SH | DFND | 0 | 511,394 | 0 | ||
| THERMO FISHER SCIENTIFIC INC | COM | 883556102 | BBG000BVDLH9 | 32,423,110 | 62,143 | SH | DFND | 0 | 62,143 | 0 | ||
| UNIQURE NV | SHS | N90064101 | BBG005SSJYH3 | 694,671 | 60,617 | SH | DFND | 0 | 60,617 | 0 | ||
| UNITEDHEALTH GROUP INC | COM | 91324P102 | BBG000CH5208 | 55,786,443 | 116,067 | SH | DFND | 0 | 116,067 | 0 | ||
| UNIVERSAL HLTH SVCS INC | CL B | 913903100 | BBG000CB8Q50 | 44,689,457 | 283,257 | SH | DFND | 0 | 283,257 | 0 | ||
| VEEVA SYS INC | CL A COM | 922475108 | BBG001CGB489 | 7,399,254 | 37,421 | SH | DFND | 0 | 37,421 | 0 | ||
| VERVE THERAPEUTICS INC | COM | 92539P101 | BBG00P33TCZ8 | 3,489,131 | 186,087 | SH | DFND | 0 | 186,087 | 0 | ||
| VIRIDIAN THERAPEUTICS INC | COM | 92790C104 | BBG002H242Z5 | 6,973,801 | 293,140 | SH | DFND | 0 | 293,140 | 0 | ||
| WATERS CORP | COM | 941848103 | BBG000FQRVM3 | 25,221,081 | 94,624 | SH | DFND | 0 | 94,624 | 0 | ||
| WEREWOLF THERAPEUTICS INC | COM | 95075A107 | BBG00QXQ9XK4 | 7,026,868 | 2,303,891 | SH | DFND | 0 | 2,303,891 | 0 | ||
| XENON PHARMACEUTICALS INC | COM | 98420N105 | BBG0073DM784 | 3,855,660 | 100,147 | SH | DFND | 0 | 100,147 | 0 | ||
| ZAI LAB LTD | ADR | 98887Q104 | BBG00HFX3N90 | 6,841,157 | 246,706 | SH | DFND | 0 | 246,706 | 0 | ||